- Must visit
Art Institute Of Chicago
One of the world’s leading art museums, famous for Impressionist masterpieces, American art, and major special exhibitions.
Take a flight from Cape Girardeau, MO to Chicago, IL and enjoy the approximately 329 miles (530 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
Distance 329 miles (530 km) |
High Season Oct - Dec |
Low Season Jul - Sep |
Omio recommends booking the train as it is the most popular option from Cape Girardeau, MO to Chicago, IL among Omio's users. If you are prioritising price take the train with prices starting from $38. For those with little time consider booking a train which can get you there in 5h 34m. The ticket price range depends on the travel mode: a train costs an average of $38, and a bus costs an average of $57.
Distance: 329 miles (530 km)
Most popular Train | Bus | Driving |
|---|---|---|
$91 Average price Cheapest | $102 Average price | $75 Average price (fuel + tolls) |
6h 4m Average total duration Fastest 5h 34m Onboard + 30m Additional time* | 11h 5m Average total duration 10h 35m Onboard + 30m Additional time* | 5h 33m Average total duration (door-to-door) |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Cape Girardeau, MO to Chicago, IL:
A train is $12 (€10) less than a bus for this route with tickets for a bus from Cape Girardeau, MO to Chicago, IL costing on average $102 (€84).
Other travel options to Chicago, IL take longer:
Bus takes on average 10h 35m.
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Chicago — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago trip today.
One of the world’s leading art museums, famous for Impressionist masterpieces, American art, and major special exhibitions.
A top natural history museum known for Sue the T. rex, ancient cultures, fossils, and broad science collections.
A large hands-on science museum with a German submarine, space exhibits, and interactive engineering displays.
Chicago’s signature downtown park, home to Cloud Gate, gardens, public art, and major seasonal events.
The city’s best-known avenue for architecture, shopping, and bustling urban energy along North Michigan Avenue.
A popular pedestrian waterfront with excellent skyline views, bridges, and easy access to boat architecture tours.
A thick, buttery crust pizza baked in a deep pan with layers of cheese, toppings, and chunky tomato sauce. It is one of Chicago’s most iconic and debated local specialties.
An all-beef hot dog on a poppy seed bun topped with yellow mustard, relish, onions, tomato, pickle spear, sport peppers, and celery salt. It is a classic local street food served without ketchup.
Thinly sliced seasoned roast beef piled onto an Italian roll, often dipped in its juices and topped with sweet peppers or giardiniera. It is a defining working-class Chicago sandwich.
Chicago’s world-famous fine-dining restaurant known for highly creative tasting menus and theatrical presentation. It offers one of the city’s most celebrated upscale dining experiences.
A beloved casual institution best known for breaded steak sandwiches and hearty Italian-American comfort food. It has a loyal local following and an old-school atmosphere.
A legendary Chicago chain celebrated for buttery-crust deep-dish pizza and a classic casual atmosphere. One of the city’s best-known places to try this signature dish.
Chicago is pricey for hotels and dining, but budget eats and public transit help keep daily costs manageable.
Tip 18-20% at restaurants; 15-20% for taxis and rideshares; USD 1-2 per drink at bars; USD 1-2 per bag for bellhops; USD 2-5 per night for housekeeping.
Find answers to the most common questions about traveling from Cape Girardeau, MO to Chicago, IL by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

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