- Must visit
Saint Louis Art Museum
Major art museum in Forest Park with strong collections spanning ancient to contemporary works. A top cultural stop in the city.
Flights from Niles, MI to St. Louis, MO depart on average 57 times per day, taking around 5h 28m. Cheap flight tickets for this journey start at $437 (€356) but you can travel from only $69 (€56) by train.
There are 9 flights per day. The earliest flight runs at 06:00, the last at 22:30. The fastest flight covers the 303 miles (489 km) distance in 5h 28m. July is the cheapest month to fly.
Distance 303 miles (489 km) |
Average flight duration 5h 28m |
Cheapest ticket price $437 (€356) |
Flights per day 57 |
Direct flights 9 |
Fastest flight 5h 28m |
First flight 6:00 AM |
Last flight 10:30 PM |
Cheapest Month Jul |
Cheapest Day Sun |
High Season Jan - Mar |
Low Season Jul - Sep |
Omio recommends booking the train as it is the most popular option from Niles, MI to St. Louis, MO among Omio's users. If you are prioritising price take the train with prices starting from $69. For those with little time consider booking a flight which can get you there in 5h 28m. The ticket price range depends on the travel mode: a train costs an average of $69, and a flight costs an average of $437.
Distance: 303 miles (489 km)
| Flight | Most popular Train | Bus | Driving |
|---|---|---|---|
$437 Average price | $69 Average price Cheapest | $91 Average price | $73 Average price (fuel + tolls) |
8h 28m Average total duration Fastest 5h 28m Onboard + 3h 0m Additional time* | 7h 27m Average total duration 6h 57m Onboard + 30m Additional time* | 13h 0m Average total duration 12h 30m Onboard + 30m Additional time* | 5h 31m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Niles, MI to St. Louis, MO:
A train is $22 (€18) less than a bus for this route with tickets for a bus from Niles, MI to St. Louis, MO costing on average $91 (€74).
A train is $368 (€300) less than a flight for this route with tickets for a flight from Niles, MI to St. Louis, MO costing on average $437 (€356).
Other travel options to St. Louis, MO take longer:
Train takes on average 6h 57m.
Bus takes on average 12h 30m.
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of St. Louis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis trip today.
Major art museum in Forest Park with strong collections spanning ancient to contemporary works. A top cultural stop in the city.
Highly original artist-built museum and playground with architectural salvage, tunnels, slides, and installations. One of St. Louis's most famous attractions.
History museum in Forest Park covering St. Louis, Missouri, and regional stories through permanent and rotating exhibitions.
Huge urban park with museums, trails, lakes, and major attractions. One of the city's essential places for walking and relaxing.
Historic riverfront district with cobblestone streets, old warehouses, and easy access to the Arch and Mississippi views.
Popular entertainment and walking district known for public art, music history, shops, and a lively street atmosphere.
A local pizza style with a very thin, cracker-like crust, square-cut slices, and signature Provel cheese. It is one of the city’s most recognizable comfort foods.
Breaded and fried ravioli, usually filled with meat or cheese and served with marinara. Despite the name, it is fried, not toasted, and is a classic St. Louis starter.
A rich, sweet cake with a dense, buttery topping over a soft base. It is a beloved St. Louis dessert found in bakeries across the city.
Popular barbecue restaurant known for Memphis-style ribs, pulled pork, and smoky sides in a lively, casual setting.
Historic St. Louis dessert stand famous for frozen custard concretes and a nostalgic roadside feel.
Established fine-dining restaurant serving refined American cuisine in a polished but welcoming atmosphere.
St. Louis is generally affordable by U.S. city standards, with moderate hotel and restaurant prices and many low-cost attractions.
Tip 18-20% at restaurants, 20%+ for great service. Tip bartenders USD 1-2 per drink, round up taxis, and tip hotel staff and delivery drivers.
Find answers to the most common questions about traveling from Niles, MI to St. Louis, MO by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

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