- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
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Journey information
Overview: Knoxville, TN to St. Louis, MO flight
USAUSA
Flights from Knoxville, TN to St. Louis, MO depart on average 22 times per day, taking around 4h 29m. Cheap flight tickets for this journey start at $147 but you can travel from only $89 by bus.
The earliest flight runs at 05:15, the last at 19:23. The fastest flight covers the 390 miles (629 km) distance in 3h 16m. May is the cheapest month to fly.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $89
Plan this route
Journey facts
- Distance390 miles (629 km)
- Average flight duration4h 29m
- Cheapest ticket price$147
- Flights per day22
- Fastest flight3h 16m
- First flight5:15 AM
- Last flight7:23 PM
- Cheapest MonthMay
- Cheapest DaySat
- High SeasonJul - Sep
- Low SeasonJan - Mar
Understand & plan this route
- Operators on this routeUnited • American Airlines
- Departure & arrivalKnoxville → St. Louis Lambert International Airport
- Airport trains to St. Louis, MOFrom St. Louis Lambert International Airport
- Airport buses to St. Louis, MOFrom St. Louis Lambert International Airport
- Arrival airportSt. Louis Lambert International Airport
- Flights with a stopAvailable on this route
Book with confidence
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $89
Frequently asked questions about your Knoxville, TN to St. Louis, MO trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Knoxville, TN to St. Louis, MO.
Cheap plane tickets from Knoxville, TN to St. Louis, MO can start from as little as $147 when you book in advance. The average flight ticket price for Knoxville, TN to St. Louis, MO is $562 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The earliest flight from Knoxville, TN to St. Louis, MO leaves at 5:15 AM. Plan your trip with the Journey Planner from Omio.
The latest flight from Knoxville, TN to St. Louis, MO leaves at 7:23 PM.
There are {frequency} flights a day from Knoxville, TN to St. Louis, MO which require at least one change with {providers}. Schedules can vary on holidays or weekends with fewer flights.
Why should you book Knoxville, TN to St. Louis, MO flights with Omio?
United as well as American Airlines offer flights services from Knoxville, TN to St. Louis, MO.
Omio is an official ticket reseller for all your travel options from Knoxville, TN to St. Louis, MO.
Why book with Omio vs United?
- Compare with other providers: On Omio, you can not only buy tickets for United, but also compare tickets for the likes of American Airlines to find the best option for your trip from Knoxville, TN to St. Louis, MO.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare United with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Knoxville, TN to St. Louis, MO.
Why book with Omio over Kayak, Skyscanner or Trip?
- Compare with other providers: On Omio, you can also compare tickets for the likes of American Airlines to find the best option for your trip from Knoxville, TN to St. Louis, MO.
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Knoxville, TN to St. Louis, MO.
Airlines
Airlines from Knoxville, TN to St. Louis, MO
Flights from Knoxville, TN to St. Louis, MO with United and American Airlines. Flights with a stop available on this route with United and American Airlines. Use the details below to compare onboard facilities.
United
About
United Airlines, established in 1926, is a major U.S. airline headquartered in Chicago, Illinois. Operating an extensive domestic and international network, United serves more destinations than any other airline, connecting travelers across six continents. The airline's eight hubs include Chicago–O'Hare, Denver, Houston–Intercontinental, Los Angeles, Newark, San Francisco, Washington–Dulles, and Guam. As a founding member of the Star Alliance, United offers a comprehensive range of services, including regional flights through United Express, catering to both leisure and business travelers. The airline is committed to sustainability, investing in sustainable aviation fuel and innovative technologies to reduce its environmental impact.
Luggage & cancellation policy
Average United Duration
3h 16m
Cheapest United Price
$147
United frequency
32 a day
Luggage included
Carry-on baggage allowance is 7kg total (2 pieces max. ) for both Choice and Flex fares on United Airlines and Virgin Australia flights.
Additional luggage
Excess baggage fees apply for additional checked luggage beyond the standard allowance.
Luggage storage
Both airlines provide checked baggage services for storing luggage during flights.
Cancellation Policy
Cancellation fees apply per person, per booking, with specific fees for different fare types.
Refund
Not applicable to flights; however, full refunds are available if flights are canceled by the airline.
Pregnant on board
Pregnant passengers are permitted to travel, with specific guidelines and medical certificates required after a certain gestational period.
Unaccompagned minor
Unaccompanied minors are permitted to travel, with specific age restrictions and services provided.
Amenities on board the airplane
Wifi
Food sold onboard
Meals and snacks are included on international flights operated by United Airlines and Virgin Australia.
Seat reservation
Seat selection may incur additional fees, depending on the fare type and airline.
Toilets
USB plugs
Accessibility
United Airlines and Virgin Australia offer services to and within Australia, providing accessible travel options for passengers with mobility needs.
Bikes
Both airlines permit bicycles onboard, with specific guidelines and fees.
Pets
United Airlines and Virgin Australia allow pets onboard, subject to specific policies and fees.
American Airlines
About
American Airlines is one of the largest airlines in the world, connecting travelers to hundreds of destinations across the United States, Latin America, Europe, Asia, and beyond. Operating from major hubs such as Dallas/Fort Worth, Miami, and Charlotte, American offers a wide range of travel options. Passengers can choose from Economy with affordable fares, Premium Economy with extra space, or Business and First Class featuring flat-bed seats, premium dining, and lounge access. With a modern fleet and membership in the oneworld alliance, American Airlines combines global reach with comfort and reliability.
Luggage & cancellation policy
Average American Airlines Duration
4h 17m
Cheapest American Airlines Price
$541
American Airlines frequency
2 a day
Luggage included
1 carry-on bag (22 x 14 x 9 inches) and 1 personal item (18 x 14 x 8 inches) included in most fares
Additional luggage
Checked bags fees vary by route. First checked bag typically $30, second $40 on domestic flights
Cancellation Policy
Basic Economy tickets cannot be changed or refunded. Other fares allow changes with fee, refunds subject to fare rules.
Pregnant on board
Passengers can fly up to 36 weeks for single pregnancies, 32 weeks for multiple pregnancies. Medical certificate required within 7 days of departure if within 4 weeks of due date.
Unaccompagned minor
Children ages 5-14 can travel alone using American Airlines Unaccompanied Minor Service. Service fee is $150 each way.
Amenities on board the airplane
Wifi
Food sold onboard
USB plugs
Accessibility
American Airlines provides wheelchair assistance and special services for passengers with disabilities. Assistance must be requested at least 48 hours before departure.
Pets
Small dogs and cats allowed in cabin for $125 fee. Must be in approved carrier under seat. Service animals allowed.
Companies, tickets, and onboard amenities between Knoxville, TN and St. Louis, MO
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
When taking a flight from Knoxville, TN to St. Louis, MO, you can count on United, American Airlines for the best way to get you to St. Louis, MO. You can also check all possible airlines who offer a service between Knoxville, TN and St. Louis, MO and compare the amenities they offer before buying a plane ticket.
For international flights we recommend to arrive 2.5 to 3 hours before departure. Please check the website of your departure airport if in doubt. Some airports may offer booking time slots for security checks or offer additional information on when to get there based on time of day.
Most airlines permit carry-on bags that fit within specific dimensions (e.g., 22 x 14 x 9 inches or 56 x 36 x 23 cm), including handles and wheels. Bags must fit in the overhead bin or under the seat in front of you.
Many airlines impose weight limits, commonly ranging between 7 kg (15 lbs) and 12 kg (26 lbs). Typically, passengers are allowed one carry-on bag and one personal item (for example a purse, laptop bag, or backpack). Personal items must fit under the seat in front of you. Budget Airlines (like Ryanair or Wizz Air) have stricter size and weight limits, often requiring fees for larger carry-ons. Full-Service Airlines have more lenient policies, sometimes including more spacious dimensions or higher weight limits depending on your ticket class.
The list of items prohibited on an airplane varies by country and airline, but in general, the following items are not allowed in carry-on or checked baggage: Weapons and self-defence items, sharp objects, flammable materials, explosives, toxic substances, or liquids over 100ml (except for medications and baby essentials). In checked baggage, firearms (without authorization), explosives, large lithium batteries, and hazardous chemicals are prohibited. Electronic cigarettes must be in carry-on bags, while alcohol and dry ice have restrictions. Always check with your airline for specific regulations.
Complete guide to St. Louis, MO
Things to do in St. Louis, MO
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
- Recommended
Missouri History Museum
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
- Recommended
Saint Louis Science Center
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
- Must visit
Gateway Arch National Park Grounds
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
- Must visit
Forest Park
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
- Recommended
Tower Grove Park
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
- Vegetarian
St. Louis-Style Pizza
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
- Vegetarian
Toasted Ravioli
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
- Vegetarian
Gooey Butter Cake
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Bulrush
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Ted Drewes Frozen Custard
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Pappy's Smokehouse
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
United States dollar ($)
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $20-35 per person for a mid-range restaurant meal.
- Fine dining
- $60+ per person at upscale restaurants.
- Coffee
- $3-5 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
Plan your visit to St. Louis, MO
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in St. Louis, MO.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
FAQs: Knoxville, TN to St. Louis, MO Flight
Find answers to the most common questions about traveling from Knoxville, TN to St. Louis, MO by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.
It's helpful to compare your options as there are 2 ways to travel between Knoxville, TN and St. Louis, MO including taking a bus and flight.
popular airports
Popular airports from Knoxville, TN to St. Louis, MO
Most Knoxville, TN to St. Louis, MO flights use the Knoxville to St. Louis Lambert International Airport airport pair. Use this guide to compare Knoxville, TN and St. Louis, MO airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Departure airports in Knoxville
Arrival airports in St. Louis
Which Knoxville, TN airport do flights to St. Louis, MO leave from?
Flights from Knoxville, TN to St. Louis, MO depart from Knoxville. The airport is 1 miles (2 km) from Knoxville, TN city centre at McGhee Tyson Airport, 2055 Alcoa Hwy, Alcoa, TN 37701, USA.
Knoxville (TYS)McGhee Tyson Airport, 2055 Alcoa Hwy, Alcoa, TN 37701, USA
City-centre transport
Getting to Knoxville from Knoxville city centre
Knoxville is 2 km from Knoxville city centre. Public transport options include:
Bus Route 20, Knoxville Station, 12 miles
Knoxville airport facilities and services
Knoxville has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, and Car Rental.
Food and drink
Food options include: Restaurants in Concourse A and B, including Ruby Tuesday and Quiznos
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are located near ticketing and baggage claim.
Luggage and lost property
Lost and found is available at the station.
Parking, taxis and toilets
Available at Knoxville: Parking, Taxis, WC.
Bike and car services
Available at Knoxville: Car Rental.
Accessibility
Accessibility facilities are available at Knoxville.
Shops, hotels and contact
Nearby hotels include Hotels within walking distance, including Hilton Knoxville Airport..
Which St. Louis, MO airport do flights from Knoxville, TN arrive at?
Flights from Knoxville, TN to St. Louis, MO arrive at St. Louis Lambert International Airport. St. Louis Lambert International Airport is 1 miles (2 km) from St. Louis, MO city centre.
St. Louis Lambert International Airport (STL)10701 Lambert Intertiol Blvd, St. Louis, MO 63145, USA
City-centre transport
Getting to St. Louis Lambert International Airport from St. Louis city centre
St. Louis Lambert International Airport is 2 km from St. Louis city centre. Public transport options include:
TrainMlr · 31m · $4 · every ~7 min
BusGreyhound US1210 · 25m · $3
St. Louis Lambert International Airport airport facilities and services
St. Louis Lambert International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food and drink
Food options include: Restaurants in both terminals, including fast food and sit-down options like Starbucks and Chili's
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are located in both terminals.
Luggage and lost property
Lost and found is available at the station.
Parking, taxis and toilets
Available at St. Louis Lambert International Airport: Parking, Taxis, WC.
Bike and car services
Available at St. Louis Lambert International Airport: Car Rental.
Accessibility
Accessibility facilities are available at St. Louis Lambert International Airport: Elevators, ramps.
Shops, hotels and contact
Nearby hotels include Hotels nearby, such as Marriott St. Louis Airport within walking distance..
Airports for flights from Knoxville, TN to St. Louis, MO
See which airports are used for flights between Knoxville, TN and St. Louis, MO, including airport details.
Flights from Knoxville, TN to St. Louis, MO generally leave from Knoxville and arrive in St. Louis Lambert International Airport.Knoxville is 1 miles (2 km) away from Knoxville, TN city centre and St. Louis Lambert International Airport is 1 miles (2 km) from St. Louis, MO city centre.
Most popular flights to and from St. Louis, MO and Knoxville, TN
Most popular flights to St. Louis, MO
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