Knoxville, TN TYS to St. Louis, MO STL flight with United

Tue, Sep 15
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Journey information

Overview: Knoxville, TN to St. Louis, MO flight

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Flights from Knoxville, TN to St. Louis, MO depart on average 32 times per day, taking around 4h 29m. Cheap flight tickets for this journey start at kr1408 but you can travel from only kr863 by bus.

The earliest flight runs at 05:15, the last at 19:23. The fastest flight covers the 390 miles (629 km) distance in 3h 16m. May is the cheapest month to fly.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from kr863
Distance
390 miles (629 km)
Average flight duration
4h 29m
Cheapest ticket price
kr1408
Flights per day
32
Fastest flight
3h 16m
First flight
5:15 AM
Last flight
7:23 PM
Cheapest Month
May
Cheapest Day
Sat
High Season
Jul - Sep
Low Season
Jan - Mar
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from kr863

Travel Information

Compare bus and flight for Knoxville, TN to St. Louis, MO

Omio recommends booking the flight as it is the most popular option from Knoxville, TN to St. Louis, MO among Omio's users. If you are prioritising price, take the bus, with an average ticket price of kr1385 For those with little time, consider booking a flight, which has an average total journey time of 6h 29m. Average ticket prices depend on the travel mode: a bus costs an average of kr1385, while a flight costs an average of kr5414.

Distance: 390 miles (629 km)

Compare flight with

Most popular
Flight
Bus
Driving

kr5414

Average price

kr1385

Average price

Cheapest

kr925

Average price

(fuel + tolls)

6h 29m

Average total duration

Fastest

4h 29m

Onboard

+

2h 0m

Additional time*

15h 15m

Average total duration

14h 45m

Onboard

+

30m

Additional time*

7h 5m

Average total duration

(door-to-door)

United

Most popular airline

Greyhound

Most popular bus company

Your own car or car rental

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Knoxville, TN to St. Louis, MO is a bus with an average price of kr1385.

This is compared to other travel options from Knoxville, TN to St. Louis, MO:

A bus is kr4029 less than a flight for this route with tickets for a flight from Knoxville, TN to St. Louis, MO costing on average kr5414.

The fastest way to travel from Knoxville, TN to St. Louis, MO is by flight with an average journey time of 4h 29m.

Other travel options to St. Louis, MO take longer:

Bus takes on average 14h 45m.

It's helpful to compare your options as there are 2 ways to travel between Knoxville, TN and St. Louis, MO including taking a bus and flight.
We recommend using the bus as it is the most popular way to get from Knoxville, TN to St. Louis, MO among Omio's users.

Live departures

Knoxville, TN to St. Louis, MO flight times

The table below shows live departures for Knoxville, TN to St. Louis, MO flights for today, Monday, September 14. You can also manually refresh the results below to see updated flight journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
United9:55 PM Knoxville, TN
6h22
4:17 AM St. Louis, MO0 transfersDirect

This is the last flight of the day.

Find all the dates and times for this journey

Compare prices and tickets Knoxville, TN to St. Louis, MO by bus or flight

Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Tue
Sep 15
Wed
Sep 16
Thu
Sep 17
Fri
Sep 18
Sat
Sep 19
Sun
Sep 20
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Sep 21

Complete guide to St. Louis, MO

Things to do in St. Louis, MO

Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.

  • Must visit

Saint Louis Art Museum

Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.

  • Recommended

Missouri History Museum

Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.

  • Recommended

Saint Louis Science Center

Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.

United States dollar ($)

Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.

Average meal costs

Budget
$10-15 for fast food or casual lunch.
Mid-range
$20-35 per person for a mid-range restaurant meal.
Fine dining
$60+ per person at upscale restaurants.
Coffee
$3-5 for coffee or cappuccino.

Tipping culture

Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.

FAQs: Knoxville, TN to St. Louis, MO Flight

Find answers to the most common questions about traveling from Knoxville, TN to St. Louis, MO by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

FAQs
Cheap plane tickets from Knoxville, TN to St. Louis, MO can start from as little as kr1408 when you book in advance. The average flight ticket price for Knoxville, TN to St. Louis, MO is kr5414 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by plane from Knoxville, TN to St. Louis, MO is 3h 16m to travel the 390 miles (629 km) long route. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest flight from Knoxville, TN to St. Louis, MO leaves at 5:15 AM. Plan your trip with the Journey Planner from Omio.
The latest flight from Knoxville, TN to St. Louis, MO leaves at 7:23 PM.
Flights from Knoxville, TN to St. Louis, MO generally leave from Knoxville and arrive in St. Louis Lambert International Airport.Knoxville is 1 miles (2 km) away from Knoxville, TN city centre and St. Louis Lambert International Airport is 1 miles (2 km) from St. Louis, MO city centre.
The cheapest month for a flight from Knoxville, TN to St. Louis, MO is May.
It's helpful to compare your options as there are 2 ways to travel between Knoxville, TN and St. Louis, MO including taking a bus and flight.
Since neither Knoxville, TN nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
There is a time difference of 1 h between Knoxville, TN and St. Louis, MO all year round.
The best events to attend in St. Louis, MO include:
  • St. Louis Mardi Gras, a vibrant celebration featuring parades, live music, and festive activities in the Soulard neighborhood
  • St. Louis Art Fair, an annual event showcasing local and national artists with art exhibits, live performances, and culinary delights
  • Fair St. Louis, a multi-day Independence Day festival with fireworks, concerts, and family-friendly activities along the Gateway Arch.
The best holidays to experience in St. Louis, MO include:
  • Independence Day, vibrant fireworks and festive celebrations throughout the city
  • Labor Day, pleasant weather and various outdoor activities
  • Thanksgiving, a time for family gatherings with a charming autumn atmosphere.
The best season to visit St. Louis, MO is Spring or Fall. The best weather to explore St. Louis, MO is during April-May or September-October.
We recommend using the bus as it is the most popular way to get from Knoxville, TN to St. Louis, MO among Omio's users.
For domestic flights we recommend to arrive 1.5 to 2 hours before departure. Please check the website of your departure airport if in doubt. Some airports may offer booking time slots for security checks or offer additional information on when to get there based on time of day.
Most airlines permit carry-on bags that fit within specific dimensions (e.g., 22 x 14 x 9 inches or 56 x 36 x 23 cm), including handles and wheels. Bags must fit in the overhead bin or under the seat in front of you.
Many airlines impose weight limits, commonly ranging between 7 kg (15 lbs) and 12 kg (26 lbs). Typically, passengers are allowed one carry-on bag and one personal item (for example a purse, laptop bag, or backpack). Personal items must fit under the seat in front of you. Budget Airlines (like Ryanair or Wizz Air) have stricter size and weight limits, often requiring fees for larger carry-ons. Full-Service Airlines have more lenient policies, sometimes including more spacious dimensions or higher weight limits depending on your ticket class.
The list of items prohibited on an airplane varies by country and airline, but in general, the following items are not allowed in carry-on or checked baggage: Weapons and self-defence items, sharp objects, flammable materials, explosives, toxic substances, or liquids over 100ml (except for medications and baby essentials). In checked baggage, firearms (without authorization), explosives, large lithium batteries, and hazardous chemicals are prohibited. Electronic cigarettes must be in carry-on bags, while alcohol and dry ice have restrictions. Always check with your airline for specific regulations.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular airports

Popular airports from Knoxville, TN to St. Louis, MO

Most Knoxville, TN to St. Louis, MO flights use the Knoxville to St. Louis Lambert International Airport airport pair. Use this guide to compare Knoxville, TN and St. Louis, MO airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.

Departure airports in Knoxville
Arrival airports in St. Louis

Which Knoxville, TN airport do flights to St. Louis, MO leave from?

Flights from Knoxville, TN to St. Louis, MO depart from Knoxville. The airport is 1 miles (2 km) from Knoxville, TN city centre at McGhee Tyson Airport, 2055 Alcoa Hwy, Alcoa, TN 37701, USA.
Knoxville (TYS)McGhee Tyson Airport, 2055 Alcoa Hwy, Alcoa, TN 37701, USAWifiShoppingParkingDiningATMTaxisAccessibilityWCHotelLoungeLost and Found OfficeCar Rental
City-centre transport

Getting to Knoxville from Knoxville city centre

Knoxville is 2 km from Knoxville city centre. Public transport options include:

Bus Route 20, Knoxville Station, 12 miles

Knoxville airport facilities and services

Knoxville has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, and Car Rental.

Food and drink

Food options include: Restaurants in Concourse A and B, including Ruby Tuesday and Quiznos

Wi-Fi and ATMs

Free Wi-Fi available throughout the airport. ATMs are located near ticketing and baggage claim.

Luggage and lost property

Lost and found is available at the station.

Parking, taxis and toilets

Available at Knoxville: Parking, Taxis, WC.

Bike and car services

Available at Knoxville: Car Rental.

Accessibility

Accessibility facilities are available at Knoxville.

Shops, hotels and contact

Nearby hotels include Hotels within walking distance, including Hilton Knoxville Airport..

More options for your journey from Knoxville, TN to St. Louis, MO

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