The cheapest and fastest buses from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA
Cheapest price
$35
Average price
$52
Fastest journey
2 h
Average duration
2 h 22 m
Buses per day
31
Distance
179 km
The best way to find a cheap bus ticket from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA will cost around $52 if you buy it on the day, but the cheapest tickets can be found for only $35.
Of the 31 buses that leave Union Station, Los Angeles, CA for Santa Fe Depot, San Diego, CA on Sun, Jun 21, 29 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 21 the direct buses cover the 179 km distance in an average of 2 h 22 m but if you time it right, some buses will get you there in just 2 h .
On Sun, Jun 21 the slowest buses will take 2 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
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FlixBus6:25 AM3h15Los Angeles, Patsaouras Transit Plaza (Union Station), CA9:40 AMLa Jolla, UCSD Health La Jolla Station, CA$351One-way1 transfer
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FlixBus6:25 AM3h40Los Angeles, Patsaouras Transit Plaza (Union Station), CA10:05 AMSan Diego, West Harbor Drive (The Headquarters at Seaport District), CA$351One-way1 transfer
FlixBus2:30 PM2h55Los Angeles, Cesar E Chavez / Vignes, CA5:25 PMLa Jolla, UCSD Health La Jolla Station, CA$421One-way0 transfers
FlixBus2:30 PM3h20Los Angeles, Cesar E Chavez / Vignes, CA5:50 PMSan Diego, Congress Street (Old Town Park), CA$421One-way0 transfers
FlixBus6:30 PM3h15Los Angeles, Patsaouras Transit Plaza (Union Station), CA9:45 PMLa Jolla, UCSD Health La Jolla Station, CA$481One-way0 transfers
FlixBus3:25 PM2h00Downey, Stonewood Center (251 Stonewood St), CA5:25 PMLa Jolla, UCSD Health La Jolla Station, CA$481One-way0 transfers
04:00 PM2h19Los Angeles, CA6:19 PMSan Diego, CA$491One-way0 transfers
08:00 PM2h19Los Angeles, CA10:19 PMSan Diego, CA$491One-way0 transfers
FlixBus3:25 PM2h25Downey, Stonewood Center (251 Stonewood St), CA5:50 PMSan Diego, Congress Street (Old Town Park), CA$481One-way0 transfers
FlixBus10:55 AM2h45Los Angeles, Cesar E Chavez / Vignes, CA1:40 PMLa Jolla, UCSD Health La Jolla Station, CA$511One-way0 transfers
Travel Information
Compare bus, train, and flight for Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA
Omio recommends booking the train as it is the most popular option from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA among Omio's users. If you are prioritising price take the bus with prices starting from $24. For those with little time consider booking a flight which can get you there in 2h 32m. The ticket price range depends on the travel mode: a bus costs an average of $24, and a flight costs an average of $127.
Distance: 111 miles (179 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$35 Average price Cheapest | $40 Average price | $420 Average price | $2 Average price (fuel + tolls) |
3h 35m Average total duration 3h 5m Onboard + 30m Additional time* | 3h 52m Average total duration 3h 22m Onboard + 30m Additional time* | 5h 32m Average total duration Fastest 2h 32m Onboard + 3h 0m Additional time* | 2h 32m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA:
A bus is $5 (€4) less than a train for this route with tickets for a train from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA costing on average $40 (€33).
A bus is $385 (€315) less than a flight for this route with tickets for a flight from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA costing on average $420 (€343).
Other travel options to Santa Fe Depot, San Diego, CA take longer:
Bus takes on average 3h 5m.
Train takes on average 3h 22m.
You'll arrive about -1h -33m sooner (3h 5m by bus vs 2h 32m by car) and save roughly $-32.49 (€-26.58) compared to fuel and tolls ($35 (€28) vs $2 (€2)). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by FlixBus, Greyhound, Infobus.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Tufesa Internacional | Departure Time 02:15AM | Arrival Time 05:00AM | Duration 2h45 | Departure days Mon, Wed, Fri | Cheapest price $49 |
Operator Tufesa Internacional | Departure Time 04:00AM | Arrival Time 06:45AM | Duration 2h45 | Departure days Thu, Sun | Cheapest price $49 |
Operator Futura Net | Departure Time 05:15AM | Arrival Time 08:04AM | Duration 2h49 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 06:20AM | Arrival Time 09:40AM | Duration 3h20 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $31 |
Operator FlixBus | Departure Time 06:25AM | Arrival Time 10:05AM | Duration 3h40 | Departure days Sat, Sun | Cheapest price $35 |
Operator FlixBus | Departure Time 06:55AM | Arrival Time 10:05AM | Duration 3h10 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $31 |
Operator Futura Net | Departure Time 07:30AM | Arrival Time 10:49AM | Duration 3h19 | Departure days Mon, Wed, Thu, Fri, Sun | Cheapest price $49 |
Operator Greyhound | Departure Time 08:15AM | Arrival Time 11:45AM | Duration 3h30 | Departure days Everyday | Cheapest price $29 |
Operator Futura Net | Departure Time 09:30AM | Arrival Time 12:49PM | Duration 3h19 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 10:25AM | Arrival Time 02:10PM | Duration 3h45 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $34 |
Operator FlixBus | Departure Time 10:55AM | Arrival Time 01:40PM | Duration 2h45 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $34 |
Operator Futura Net | Departure Time 11:30AM | Arrival Time 02:19PM | Duration 2h49 | Departure days Mon, Wed, Thu, Fri | Cheapest price $49 |
Operator FlixBus | Departure Time 12:25PM | Arrival Time 04:25PM | Duration 4h00 | Departure days Everyday | Cheapest price $23 |
Operator Tufesa Internacional | Departure Time 01:30PM | Arrival Time 05:35PM | Duration 4h05 | Departure days Mon, Sat, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 01:30PM | Arrival Time 05:35PM | Duration 4h05 | Departure days Everyday | Cheapest price $29 |
Operator Futura Net | Departure Time 01:30PM | Arrival Time 04:19PM | Duration 2h49 | Departure days Wed, Thu, Fri | Cheapest price $49 |
Operator Tufesa Internacional | Departure Time 02:15PM | Arrival Time 05:00PM | Duration 2h45 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 02:30PM | Arrival Time 05:25PM | Duration 2h55 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $32 |
Operator FlixBus | Departure Time 03:25PM | Arrival Time 05:25PM | Duration 2h00 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $32 |
Operator Futura Net | Departure Time 04:00PM | Arrival Time 06:19PM | Duration 2h19 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $49 |
Operator Futura Net | Departure Time 06:00PM | Arrival Time 09:19PM | Duration 3h19 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 06:30PM | Arrival Time 09:45PM | Duration 3h15 | Departure days Everyday | Cheapest price $23 |
Operator Futura Net | Departure Time 08:00PM | Arrival Time 10:19PM | Duration 2h19 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $49 |
Operator Greyhound | Departure Time 08:20PM | Arrival Time 11:50PM | Duration 3h30 | Departure days Everyday | Cheapest price $29 |
Live departures
Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA bus times
The table below shows live departures for Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 6:55 AM Los Angeles, Cesar E Chavez / Vignes, CA | 2h45 | 9:40 AM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 6:55 AM Los Angeles, Cesar E Chavez / Vignes, CA | 3h10 | 10:05 AM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 0 transfersDirect | |
![]() | 8:15 AM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 3h30 | 11:45 AM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
0 | 9:30 AM Los Angeles, CA | 3h19 | 12:49 PM San Diego, CA | 0 transfersDirect | |
FlixBus | 10:25 AM Los Angles, S Hope St. USC Parking, CA | 3h45 | 2:10 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
FlixBus | 10:25 AM Los Angles, S Hope St. USC Parking, CA | 3h15 | 1:40 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 10:55 AM Los Angeles, Cesar E Chavez / Vignes, CA | 2h45 | 1:40 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 10:55 AM Los Angeles, Cesar E Chavez / Vignes, CA | 3h15 | 2:10 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
FlixBus | 12:25 PM Los Angeles, Cesar E Chavez / Vignes, CA | 4h00 | 4:25 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
FlixBus | 12:25 PM Los Angeles, Cesar E Chavez / Vignes, CA | 3h30 | 3:55 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 1:30 PM Los Angeles, Cesar E Chavez / Vignes, CA | 4h05 | 5:35 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 1:30 PM Los Angeles, Cesar E Chavez / Vignes, CA | 4h40 | 6:10 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
0 | 1:30 PM Los Angeles, CA | 4h05 | 5:35 PM San Diego, CA | 0 transfersDirect | |
0 | 2:15 PM Los Angeles, CA | 2h45 | 5:00 PM San Diego, CA | 0 transfersDirect | |
FlixBus | 2:30 PM Los Angeles, Cesar E Chavez / Vignes, CA | 2h55 | 5:25 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 2:30 PM Los Angeles, Cesar E Chavez / Vignes, CA | 3h20 | 5:50 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
FlixBus | 3:25 PM Downey, Stonewood Center (251 Stonewood St), CA | 2h00 | 5:25 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 3:25 PM Downey, Stonewood Center (251 Stonewood St), CA | 2h25 | 5:50 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
0 | 4:00 PM Los Angeles, CA | 2h19 | 6:19 PM San Diego, CA | 0 transfersDirect | |
0 | 6:00 PM Los Angeles, CA | 3h19 | 9:19 PM San Diego, CA | 0 transfersDirect | |
FlixBus | 6:30 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 3h15 | 9:45 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 6:30 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 3h45 | 10:15 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 0 transfersDirect | |
0 | 8:00 PM Los Angeles, CA | 2h49 | 10:49 PM San Diego, CA | 0 transfersDirect | |
![]() | 8:20 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 3h30 | 11:50 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
| Sunday, June 21 | |||||
0 | 4:00 AM Los Angeles, CA | 2h45 | 6:45 AM San Diego, CA | 0 transfersDirect | |
0 | 5:15 AM Los Angeles, CA | 2h49 | 8:04 AM San Diego, CA | 0 transfersDirect | |
FlixBus | 6:20 AM Los Angeles, Gayley / Strathmore, CA | 3h20 | 9:40 AM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 6:20 AM Los Angeles, Gayley / Strathmore, CA | 3h45 | 10:05 AM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 0 transfersDirect | |
FlixBus+![]() | 6:25 AM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 3h40 | 10:05 AM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 1 transfer | |
FlixBus+![]() | 6:25 AM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 3h15 | 9:40 AM La Jolla, UCSD Health La Jolla Station, CA | 1 transfer | |
Find all the dates and times for this journey
Compare prices and tickets Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Greyhound or Infobus to find the best option for your trip from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.
Why book with Omio over Wanderu, Trainline or Busbud?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Greyhound or Infobus to find the best option for your trip from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.
Journey information
Overview: Bus from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA
Buses from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA run on average 27 times per day, taking around 3h 5m. Cheap bus tickets for this journey start at $24 (€19) if you book in advance.
There are 25 buses per day. The earliest bus runs at 01:30, the last at 22:45. The fastest bus covers the 111 miles (179 km) distance in 2h 10m.
Distance 111 miles (179 km) |
Average bus duration 3h 5m |
Cheapest ticket price $24 (€19) |
Buses per day 27 |
Direct buses 25 |
Fastest bus 2h 10m |
First bus 1:30 AM |
Last bus 10:45 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Fri |
Least Busy Day Mon |
Bus providers: FlixBus, Greyhound, Infobus from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CAYou can travel by bus between Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA with FlixBus, Greyhound, Infobus for as low as $24 (€19). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Infobus
Greyhound
FAQs: Bus from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA
Find answers to the most common questions about traveling from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Fe Depot, San Diego, CA, this guide helps you travel smarter and with confidence.

- Infobus
- Assistance
- Priority seating
- Transport for wheelchairs and mobility aids.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Infobus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Infobus
- One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Infobus
- 10€ per additional bag.
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- Infobus
- Small pets allowed in carriers
- larger pets may require a separate ticket.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
Most popular bus connections from Union Station, Los Angeles, CA
More options for your journey from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA
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