The cheapest and fastest buses from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA
Cheapest price
$33
Average price
$58
Fastest journey
1 h 44 m
Average duration
2 h 2 m
Buses per day
36
Distance
179 km
The best way to find a cheap bus ticket from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA will cost around $58 if you buy it on the day, but the cheapest tickets can be found for only $33.
Of the 36 buses that leave Union Station, Los Angeles, CA for Santa Fe Depot, San Diego, CA on Thu, Feb 05, 31 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Feb 05 the direct buses cover the 179 km distance in an average of 2 h 2 m but if you time it right, some buses will get you there in just 1 h 44 m .
On Thu, Feb 05 the slowest buses will take 2 h 14 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
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0Travel Information
Compare train, bus, and flight for Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA
Omio recommends booking the train as it is the most popular option from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA among Omio's users. If you are prioritising price take the bus with prices starting from €16. For those with little time consider booking a flight which can get you there in 2h 29m. The ticket price range depends on the travel mode: a bus costs an average of €16, and a flight costs an average of €108.
Distance: 111 miles (179 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€29 Average price Cheapest | €33 Average price | €330 Average price |
3h 35m Average total duration 3h 5m Onboard + 30m Additional time* | 3h 25m Average total duration 2h 55m Onboard + 30m Additional time* | 5h 29m Average total duration Fastest 2h 29m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Infobus | Departure Time 12:45AM | Arrival Time 03:30AM | Duration 2h45 | Departure days Wed, Thu | Cheapest price $72 |
Operator Infobus | Departure Time 02:15AM | Arrival Time 05:30AM | Duration 3h15 | Departure days Wed, Thu | Cheapest price $67 |
Operator Infobus | Departure Time 02:30AM | Arrival Time 05:00AM | Duration 2h30 | Departure days Wed | Cheapest price $85 |
Operator Infobus | Departure Time 04:15AM | Arrival Time 06:45AM | Duration 2h30 | Departure days Thu | Cheapest price $72 |
Operator Infobus | Departure Time 05:20AM | Arrival Time 09:00AM | Duration 3h40 | Departure days Wed, Thu | Cheapest price $67 |
Operator Infobus | Departure Time 05:50AM | Arrival Time 08:34AM | Duration 2h44 | Departure days Wed, Thu | Cheapest price $71 |
Operator Infobus | Departure Time 08:05AM | Arrival Time 10:19AM | Duration 2h14 | Departure days Wed, Thu | Cheapest price $62 |
Operator Greyhound | Departure Time 08:20AM | Arrival Time 11:45AM | Duration 3h25 | Departure days Wed, Thu | Cheapest price $40 |
Operator Infobus | Departure Time 08:25AM | Arrival Time 12:15PM | Duration 3h50 | Departure days Wed, Thu | Cheapest price $67 |
Operator Infobus | Departure Time 10:05AM | Arrival Time 12:19PM | Duration 2h14 | Departure days Wed, Thu | Cheapest price $62 |
Operator FlixBus | Departure Time 10:25AM | Arrival Time 02:10PM | Duration 3h45 | Departure days Thu | Cheapest price $35 |
Operator Infobus | Departure Time 10:30AM | Arrival Time 02:00PM | Duration 3h30 | Departure days Wed, Thu | Cheapest price $67 |
Operator FlixBus | Departure Time 10:55AM | Arrival Time 01:40PM | Duration 2h45 | Departure days Thu | Cheapest price $35 |
Operator Infobus | Departure Time 11:30AM | Arrival Time 07:00PM | Duration 7h30 | Departure days Wed, Thu | Cheapest price $67 |
Operator Infobus | Departure Time 12:05PM | Arrival Time 02:19PM | Duration 2h14 | Departure days Wed, Thu | Cheapest price $62 |
Operator FlixBus | Departure Time 12:25PM | Arrival Time 03:55PM | Duration 3h30 | Departure days Wed, Thu | Cheapest price $33 |
Operator Infobus | Departure Time 12:30PM | Arrival Time 07:45PM | Duration 7h15 | Departure days Wed, Thu | Cheapest price $67 |
Operator FlixBus | Departure Time 01:30PM | Arrival Time 05:35PM | Duration 4h05 | Departure days Wed, Thu | Cheapest price $40 |
Operator Infobus | Departure Time 01:30PM | Arrival Time 09:30PM | Duration 8h00 | Departure days Wed, Thu | Cheapest price $67 |
Operator Infobus | Departure Time 02:00PM | Arrival Time 05:45PM | Duration 3h45 | Departure days Wed, Thu | Cheapest price $67 |
Operator Infobus | Departure Time 02:05PM | Arrival Time 04:19PM | Duration 2h14 | Departure days Wed, Thu | Cheapest price $62 |
Operator Infobus | Departure Time 02:15PM | Arrival Time 05:35PM | Duration 3h20 | Departure days Wed, Thu | Cheapest price $72 |
Operator Infobus | Departure Time 04:00PM | Arrival Time 07:30PM | Duration 3h30 | Departure days Wed, Thu | Cheapest price $67 |
Operator Infobus | Departure Time 04:35PM | Arrival Time 07:19PM | Duration 2h44 | Departure days Wed, Thu | Cheapest price $71 |
Operator Infobus | Departure Time 04:50PM | Arrival Time 01:00AM | Duration 8h10 | Departure days Wed, Thu | Cheapest price $67 |
Operator FlixBus | Departure Time 06:30PM | Arrival Time 10:15PM | Duration 3h45 | Departure days Wed, Thu | Cheapest price $33 |
Operator Infobus | Departure Time 06:35PM | Arrival Time 08:19PM | Duration 1h44 | Departure days Wed, Thu | Cheapest price $62 |
Operator Infobus | Departure Time 06:50PM | Arrival Time 10:30PM | Duration 3h40 | Departure days Wed, Thu | Cheapest price $67 |
Operator Greyhound | Departure Time 08:20PM | Arrival Time 11:50PM | Duration 3h30 | Departure days Wed, Thu | Cheapest price $41 |
Operator Infobus | Departure Time 08:35PM | Arrival Time 10:19PM | Duration 1h44 | Departure days Wed, Thu | Cheapest price $62 |
Operator Infobus | Departure Time 09:00PM | Arrival Time 03:30AM | Duration 6h30 | Departure days Wed, Thu | Cheapest price $67 |
Operator Infobus | Departure Time 09:50PM | Arrival Time 12:30AM | Duration 2h40 | Departure days Wed, Thu | Cheapest price $67 |
Live departures
Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA bus times
The table below shows live departures for Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA buses for today, Wednesday, February 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
0 | 1:50 PM Union Station, Los Angeles, CA | 2h14 | 4:04 PM San Diego, CA | 0 transfersDirect | |
0 | 4:05 PM Union Station, Los Angeles, CA | 2h14 | 6:19 PM San Diego, CA | 0 transfersDirect | |
![]() | 4:20 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 3h25 | 7:45 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
0 | 4:25 PM Hantington Park, CA | 3h35 | 8:00 PM San Diego, CA | 0 transfersDirect | |
0 | 6:05 PM Union Station, Los Angeles, CA | 1h44 | 7:49 PM San Diego, CA | 0 transfersDirect | |
0 | 6:30 PM Hantington Park, CA | 4h00 | 10:30 PM San Diego, CA | 0 transfersDirect | |
undefined · undefined | 7:30 PM Hantington Park, CA | 7h30 | 3:00 AM San Diego, CA | 1 transfer | |
0 | 8:05 PM Union Station, Los Angeles, CA | 2h14 | 10:19 PM San Diego, CA | 0 transfersDirect | |
FlixBus | 8:25 PM Los Angeles, Cesar E Chavez / Vignes, CA | 3h30 | 11:55 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 8:25 PM Los Angeles, Cesar E Chavez / Vignes, CA | 4h00 | 12:25 AM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
undefined · undefined | 8:30 PM Hantington Park, CA | 8h10 | 4:40 AM San Diego, CA | 1 transfer | |
undefined · undefined | 9:30 PM Hantington Park, CA | 8h25 | 5:55 AM San Diego, CA | 1 transfer | |
FlixBus | 9:30 PM Los Angeles, Cesar E Chavez / Vignes, CA | 4h05 | 1:35 AM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 9:30 PM Los Angeles, Cesar E Chavez / Vignes, CA | 4h40 | 2:10 AM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
0 | 10:00 PM Hantington Park, CA | 3h45 | 1:45 AM San Diego, CA | 0 transfersDirect | |
0 | 10:05 PM Union Station, Los Angeles, CA | 2h14 | 12:19 AM San Diego, CA | 0 transfersDirect | |
0 | 10:15 PM Hantington Park, CA | 3h20 | 1:35 AM San Diego, CA | 0 transfersDirect | |
| Thursday, February 5 | |||||
0 | 12:00 AM Hantington Park, CA | 3h30 | 3:30 AM San Diego, CA | 0 transfersDirect | |
0 | 12:35 AM Union Station, Los Angeles, CA | 1h44 | 2:19 AM San Diego, CA | 0 transfersDirect | |
undefined · undefined · undefined | 12:50 AM Hantington Park, CA | 8h10 | 9:00 AM San Diego, CA | 2 transfers | |
FlixBus | 2:30 AM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 3h45 | 6:15 AM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 0 transfersDirect | |
FlixBus | 2:30 AM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 3h15 | 5:45 AM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
0 | 2:35 AM Union Station, Los Angeles, CA | 2h14 | 4:49 AM San Diego, CA | 0 transfersDirect | |
0 | 2:50 AM Hantington Park, CA | 3h40 | 6:30 AM San Diego, CA | 0 transfersDirect | |
![]() | 4:20 AM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 3h30 | 7:50 AM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
0 | 4:35 AM Union Station, Los Angeles, CA | 1h44 | 6:19 AM San Diego, CA | 0 transfersDirect | |
undefined · undefined | 5:00 AM Hantington Park, CA | 6h30 | 11:30 AM San Diego, CA | 1 transfer | |
0 | 5:50 AM Hantington Park, CA | 2h25 | 8:15 AM San Diego, CA | 0 transfersDirect | |
0 | 8:45 AM Hantington Park, CA | 2h45 | 11:30 AM San Diego, CA | 0 transfersDirect | |
0 | 10:15 AM Hantington Park, CA | 3h15 | 1:30 PM San Diego, CA | 0 transfersDirect | |
0 | 12:15 PM Hantington Park, CA | 2h30 | 2:45 PM San Diego, CA | 0 transfersDirect | |
0 | 1:20 PM Hantington Park, CA | 3h40 | 5:00 PM San Diego, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Infobus or Greyhound to find the best option for your trip from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.
Why book with Omio over Wanderu?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Infobus or Greyhound to find the best option for your trip from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.
Journey information
Overview: Bus from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA
Buses from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA run on average 28 times per day, taking around 3h 5m. Cheap bus tickets for this journey start at $20 (€16) if you book in advance.
There are 27 buses per day. The earliest bus runs at 02:10, the last at 22:45. The fastest bus covers the 111 miles (179 km) distance in 1h 44m.
Distance 111 miles (179 km) |
Average bus duration 3h 5m |
Cheapest ticket price $20 (€16) |
Buses per day 28 |
Direct buses 27 |
Fastest bus 1h 44m |
First bus 02:10 |
Last bus 22:45 |
Bus providers: FlixBus, Greyhound, Infobus from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CAYou can travel by bus between Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA with FlixBus, Greyhound, Infobus for as low as $20 (€16). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Infobus
Greyhound
FAQs: Bus from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA
Find answers to the most common questions about traveling from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Fe Depot, San Diego, CA, this guide helps you travel smarter and with confidence.

- Infobus
- Assistance
- Priority seating
- Transport for wheelchairs and mobility aids.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Infobus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Infobus
- One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Infobus
- 10€ per additional bag.
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- Infobus
- Small pets allowed in carriers
- larger pets may require a separate ticket.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
Most popular bus connections from Union Station, Los Angeles, CA
More options for your journey from Union Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA
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