- Must visit
Smithsonian American Art Museum
Major collection of American art from colonial works to contemporary pieces, located in the nearby Penn Quarter district.
Cheapest price
$33
Average price
$52
Fastest journey
1 h 55 m
Average duration
2 h 25 m
Buses per day
31
Distance
179 km
The best way to find a cheap bus ticket from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA will cost around $52 if you buy it on the day, but the cheapest tickets can be found for only $33.
Of the 31 buses that leave Santa Fe Depot, San Diego, CA for Union Station, Los Angeles, CA on Sat, Jun 20, 31 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Jun 20 the direct buses cover the 179 km distance in an average of 2 h 25 m but if you time it right, some buses will get you there in just 1 h 55 m .
On Sat, Jun 20 the slowest buses will take 2 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

FlixBus
FlixBus
FlixBus
FlixBus
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FlixBus
0Omio recommends booking the train as it is the most popular option from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA among Omio's users. If you are prioritising price take the bus with prices starting from $23. For those with little time consider booking a flight which can get you there in 2h 40m. The ticket price range depends on the travel mode: a bus costs an average of $23, and a flight costs an average of $128.
Distance: 111 miles (179 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$35 Average price Cheapest | $40 Average price | $413 Average price | $10 Average price (fuel + tolls) |
3h 43m Average total duration 3h 13m Onboard + 30m Additional time* | 3h 39m Average total duration 3h 9m Onboard + 30m Additional time* | 5h 40m Average total duration Fastest 2h 40m Onboard + 3h 0m Additional time* | 2h 27m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA:
A bus is $5 (€4) less than a train for this route with tickets for a train from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA costing on average $40 (€33).
A bus is $378 (€309) less than a flight for this route with tickets for a flight from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA costing on average $413 (€338).
Other travel options to Union Station, Los Angeles, CA take longer:
Train takes on average 3h 9m.
Bus takes on average 3h 13m.
You'll arrive about -1h -46m sooner (3h 13m by bus vs 2h 27m by car) and save roughly $-25.53 (€-20.92) compared to fuel and tolls ($35 (€29) vs $10 (€8)). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by FlixBus, Greyhound, Infobus.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:35AM | Arrival Time 05:20AM | Duration 2h45 | Departure days Tue | Cheapest price $44 |
Operator Greyhound | Departure Time 03:35AM | Arrival Time 06:20AM | Duration 2h45 | Departure days Tue | Cheapest price $35 |
Operator Greyhound | Departure Time 04:55AM | Arrival Time 09:15AM | Duration 4h20 | Departure days Wed | Cheapest price $30 |
Operator Greyhound | Departure Time 05:40AM | Arrival Time 09:15AM | Duration 3h35 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $24 |
Operator Greyhound | Departure Time 06:00AM | Arrival Time 10:40AM | Duration 4h40 | Departure days Tue | Cheapest price $49 |
Operator Infobus | Departure Time 06:30AM | Arrival Time 09:30AM | Duration 3h00 | Departure days Wed | Cheapest price $56 |
Operator Tufesa Internacional | Departure Time 06:30AM | Arrival Time 09:30AM | Duration 3h00 | Departure days Thu, Sat, Sun | Cheapest price $49 |
Operator Greyhound | Departure Time 06:45AM | Arrival Time 10:40AM | Duration 3h55 | Departure days Tue | Cheapest price $47 |
Operator FlixBus | Departure Time 06:55AM | Arrival Time 11:35AM | Duration 4h40 | Departure days Tue, Wed | Cheapest price $34 |
Operator FlixBus | Departure Time 07:35AM | Arrival Time 11:35AM | Duration 4h00 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $32 |
Operator FlixBus | Departure Time 07:45AM | Arrival Time 11:25AM | Duration 3h40 | Departure days Wed | Cheapest price $50 |
Operator Infobus | Departure Time 07:51AM | Arrival Time 10:36AM | Duration 2h45 | Departure days Wed | Cheapest price $83 |
Operator Futura Net | Departure Time 07:51AM | Arrival Time 10:36AM | Duration 2h45 | Departure days Thu, Sat, Sun | Cheapest price $76 |
Operator FlixBus | Departure Time 07:55AM | Arrival Time 11:35AM | Duration 3h40 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $32 |
Operator FlixBus | Departure Time 08:30AM | Arrival Time 11:25AM | Duration 2h55 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $29 |
Operator FlixBus | Departure Time 08:40AM | Arrival Time 12:45PM | Duration 4h05 | Departure days Tue, Wed | Cheapest price $28 |
Operator FlixBus | Departure Time 08:55AM | Arrival Time 10:50AM | Duration 1h55 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $29 |
Operator FlixBus | Departure Time 09:25AM | Arrival Time 12:45PM | Duration 3h20 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $26 |
Operator FlixBus | Departure Time 09:50AM | Arrival Time 12:45PM | Duration 2h55 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $26 |
Operator Futura Net | Departure Time 09:51AM | Arrival Time 12:36PM | Duration 2h45 | Departure days Thu, Sat, Sun | Cheapest price $76 |
Operator Infobus | Departure Time 09:51AM | Arrival Time 12:36PM | Duration 2h45 | Departure days Wed | Cheapest price $83 |
Operator Tufesa Internacional | Departure Time 10:45AM | Arrival Time 01:55PM | Duration 3h10 | Departure days Thu, Sat, Sun | Cheapest price $49 |
Operator Infobus | Departure Time 10:45AM | Arrival Time 02:45PM | Duration 4h00 | Departure days Wed | Cheapest price $81 |
Operator Tufesa Internacional | Departure Time 11:30AM | Arrival Time 02:30PM | Duration 3h00 | Departure days Thu, Fri, Sat, Sun | Cheapest price $49 |
Operator Infobus | Departure Time 11:30AM | Arrival Time 02:30PM | Duration 3h00 | Departure days Wed | Cheapest price $56 |
Operator Infobus | Departure Time 11:51AM | Arrival Time 02:56PM | Duration 3h05 | Departure days Wed | Cheapest price $83 |
Operator Futura Net | Departure Time 11:51AM | Arrival Time 02:56PM | Duration 3h05 | Departure days Thu, Fri, Sat, Sun | Cheapest price $76 |
Operator FlixBus | Departure Time 11:55AM | Arrival Time 03:30PM | Duration 3h35 | Departure days Thu, Fri, Sat, Sun | Cheapest price $34 |
Operator FlixBus | Departure Time 12:15PM | Arrival Time 03:30PM | Duration 3h15 | Departure days Thu, Fri, Sat, Sun | Cheapest price $34 |
Operator FlixBus | Departure Time 12:40PM | Arrival Time 04:55PM | Duration 4h15 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $26 |
Operator FlixBus | Departure Time 01:10PM | Arrival Time 04:55PM | Duration 3h45 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $21 |
Operator FlixBus | Departure Time 01:35PM | Arrival Time 04:55PM | Duration 3h20 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $21 |
Operator Infobus | Departure Time 01:51PM | Arrival Time 04:36PM | Duration 2h45 | Departure days Wed | Cheapest price $83 |
Operator Futura Net | Departure Time 01:51PM | Arrival Time 04:36PM | Duration 2h45 | Departure days Thu, Fri, Sat, Sun | Cheapest price $76 |
Operator FlixBus | Departure Time 02:45PM | Arrival Time 06:20PM | Duration 3h35 | Departure days Mon | Cheapest price $27 |
Operator Futura Net | Departure Time 03:51PM | Arrival Time 06:56PM | Duration 3h05 | Departure days Thu, Fri, Sat, Sun | Cheapest price $76 |
Operator Infobus | Departure Time 03:51PM | Arrival Time 06:36PM | Duration 2h45 | Departure days Wed | Cheapest price $83 |
Operator FlixBus | Departure Time 03:55PM | Arrival Time 07:10PM | Duration 3h15 | Departure days Thu, Fri, Sat, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 07:10PM | Duration 2h55 | Departure days Thu, Fri, Sat, Sun | Cheapest price $44 |
Operator Futura Net | Departure Time 05:51PM | Arrival Time 08:56PM | Duration 3h05 | Departure days Thu, Fri, Sat, Sun | Cheapest price $76 |
Operator Infobus | Departure Time 05:51PM | Arrival Time 08:56PM | Duration 3h05 | Departure days Wed | Cheapest price $83 |
Operator Greyhound | Departure Time 07:00PM | Arrival Time 10:20PM | Duration 3h20 | Departure days Tue | Cheapest price $45 |
Operator Greyhound | Departure Time 07:10PM | Arrival Time 10:30PM | Duration 3h20 | Departure days Wed | Cheapest price $26 |
Operator Greyhound | Departure Time 07:35PM | Arrival Time 10:20PM | Duration 2h45 | Departure days Tue | Cheapest price $41 |
Operator FlixBus | Departure Time 07:40PM | Arrival Time 11:55PM | Duration 4h15 | Departure days Mon | Cheapest price $36 |
Operator Infobus | Departure Time 07:51PM | Arrival Time 10:56PM | Duration 3h05 | Departure days Wed | Cheapest price $83 |
Operator Futura Net | Departure Time 07:51PM | Arrival Time 10:56PM | Duration 3h05 | Departure days Thu, Fri, Sat, Sun | Cheapest price $76 |
Operator Greyhound | Departure Time 07:55PM | Arrival Time 10:30PM | Duration 2h35 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $20 |
Operator Tufesa Internacional | Departure Time 08:20PM | Arrival Time 12:20AM | Duration 4h00 | Departure days Thu, Fri, Sat, Sun | Cheapest price $49 |
Operator Infobus | Departure Time 08:20PM | Arrival Time 12:20AM | Duration 4h00 | Departure days Wed | Cheapest price $56 |
Operator FlixBus | Departure Time 08:35PM | Arrival Time 11:55PM | Duration 3h20 | Departure days Mon | Cheapest price $34 |
Operator FlixBus | Departure Time 09:35PM | Arrival Time 12:55AM | Duration 3h20 | Departure days Mon | Cheapest price $38 |
The table below shows live departures for Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA buses for today, Friday, June 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:40 AM San Diego, Congress Street (Old Town Park), CA | 3h35 | 9:15 AM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
FlixBus | 7:35 AM San Diego, Congress Street (Old Town Park), CA | 4h00 | 11:35 AM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 7:55 AM La Jolla, UCSD Health La Jolla Station, CA | 3h40 | 11:35 AM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 8:30 AM San Diego, Congress Street (Old Town Park), CA | 2h55 | 11:25 AM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 8:30 AM San Diego, Congress Street (Old Town Park), CA | 2h20 | 10:50 AM Downey, Stonewood Center (251 Stonewood St), CA | 0 transfersDirect | |
FlixBus | 8:55 AM La Jolla, UCSD Health La Jolla Station, CA | 1h55 | 10:50 AM Downey, Stonewood Center (251 Stonewood St), CA | 0 transfersDirect | |
FlixBus | 8:55 AM La Jolla, UCSD Health La Jolla Station, CA | 2h30 | 11:25 AM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 9:25 AM San Diego, Congress Street (Old Town Park), CA | 3h20 | 12:45 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 9:50 AM La Jolla, UCSD Health La Jolla Station, CA | 2h55 | 12:45 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
0 | 11:30 AM San Diego, CA | 3h00 | 2:30 PM Los Angeles, CA | 0 transfersDirect | |
0 | 11:51 AM San Diego, CA | 3h05 | 2:56 PM Los Angeles, CA | 0 transfersDirect | |
FlixBus | 11:55 AM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 3h35 | 3:30 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 12:15 PM San Diego, Congress Street (Old Town Park), CA | 3h15 | 3:30 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 12:40 PM La Jolla, UCSD Health La Jolla Station, CA | 2h50 | 3:30 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 1:10 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 3h45 | 4:55 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
FlixBus | 1:35 PM La Jolla, UCSD Health La Jolla Station, CA | 3h20 | 4:55 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
0 | 1:51 PM San Diego, CA | 2h45 | 4:36 PM Los Angeles, CA | 0 transfersDirect | |
0 | 3:51 PM San Diego, CA | 3h05 | 6:56 PM Los Angeles, CA | 0 transfersDirect | |
FlixBus | 3:55 PM San Diego, Congress Street (Old Town Park), CA | 3h15 | 7:10 PM Los Angles, S Hope St. USC Parking, CA | 0 transfersDirect | |
FlixBus | 3:55 PM San Diego, Congress Street (Old Town Park), CA | 3h40 | 7:35 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 4:15 PM La Jolla, UCSD Health La Jolla Station, CA | 2h55 | 7:10 PM Los Angles, S Hope St. USC Parking, CA | 0 transfersDirect | |
FlixBus | 4:15 PM La Jolla, UCSD Health La Jolla Station, CA | 3h20 | 7:35 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
0 | 5:51 PM San Diego, CA | 3h05 | 8:56 PM Los Angeles, CA | 0 transfersDirect | |
0 | 7:51 PM San Diego, CA | 3h05 | 10:56 PM Los Angeles, CA | 0 transfersDirect | |
![]() | 7:55 PM San Diego, Congress Street (Old Town Park), CA | 2h35 | 10:30 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
0 | 8:20 PM San Diego, CA | 4h00 | 12:20 AM Los Angeles, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA run on average 27 times per day, taking around 3h 13m. Cheap bus tickets for this journey start at $23 (€19) if you book in advance.
There are 26 buses per day. The earliest bus runs at 02:00, the last at 21:35. The fastest bus covers the 111 miles (179 km) distance in 2h 45m.
Distance 111 miles (179 km) |
Average bus duration 3h 13m |
Cheapest ticket price $23 (€19) |
Buses per day 27 |
Direct buses 26 |
Fastest bus 2h 45m |
First bus 2:00 AM |
Last bus 9:35 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Jan - Mar |
Low Season Apr - Jun |
Busiest Day Sat |
Least Busy Day Fri |
Discover the best of Union Station — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Union Station trip today.
Major collection of American art from colonial works to contemporary pieces, located in the nearby Penn Quarter district.
Celebrated museum of portraits of influential Americans, sharing a historic building with the Smithsonian American Art Museum.
World-class art museum with masterworks from Europe and America, plus sculpture garden and rotating exhibitions.
Historic neighborhood of row houses, political institutions, and leafy streets that is ideal for walking near Union Station.
Washington’s monumental park corridor lined with museums and memorials, essential for first-time visitors and long scenic walks.
Central district known for museums, theaters, and lively streets, popular with visitors exploring downtown on foot.
An All-Beef Hot Dog On A Poppy Seed Bun With Mustard, Relish, Onion, Tomato, Sport Peppers, Pickle, And Celery Salt. It Is A Classic Chicago Specialty.
Thin-Sliced Roast Beef Simmered In Jus And Served On A Roll, Often Dipped And Topped With Giardiniera Or Sweet Peppers. A Defining Chicago Sandwich.
A Thick, Pan-Baked Pizza With Layers Of Cheese, Toppings, And Chunky Tomato Sauce. It Is One Of Chicago's Most Famous Comfort Foods.
A Nationally Acclaimed Fine Dining Restaurant In The West Loop Offering A Refined Tasting Menu Experience.
A Celebrated West Loop Restaurant Known For Bold Small Plates, Creative Cooking, And A Lively Atmosphere.
A Historic Diner Near Union Station Known For Breakfast, Classic American Plates, And Old-School Chicago Hospitality.
Costs are moderate by major U.S. city standards. Fast food is affordable, but sit-down dining and station-area prices are higher.
Restaurants: tip 18-20% before tax for table service. Bars: USD 1-2 per drink. Cafes: optional small tip. Taxis/rideshares: 10-15% or round up. Hotel staff: USD 1-5 depending on service.
Find answers to the most common questions about traveling from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Union Station, Los Angeles, CA, this guide helps you travel smarter and with confidence.

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