The cheapest and fastest buses from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA
Cheapest price
$42
Average price
$69
Fastest journey
2 h
Average duration
2 h 30 m
Buses per day
31
Distance
179 km
The best way to find a cheap bus ticket from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA will cost around $69 if you buy it on the day, but the cheapest tickets can be found for only $42.
Of the 31 buses that leave Santa Fe Depot, San Diego, CA for Union Station, Los Angeles, CA on Sat, Mar 21, 31 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Mar 21 the direct buses cover the 179 km distance in an average of 2 h 30 m but if you time it right, some buses will get you there in just 2 h .
On Sat, Mar 21 the slowest buses will take 2 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

FlixBus
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0Travel Information
Compare train, bus, and flight for Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA
Omio recommends booking the train as it is the most popular option from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA among Omio's users. If you are prioritising price take the bus with prices starting from $23. For those with little time consider booking a flight which can get you there in 2h 34m. The ticket price range depends on the travel mode: a bus costs an average of $23, and a flight costs an average of $120.
Distance: 111 miles (179 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
$35 Average price Cheapest | $40 Average price | $388 Average price |
3h 44m Average total duration 3h 14m Onboard + 30m Additional time* | 3h 21m Average total duration 2h 51m Onboard + 30m Additional time* | 5h 34m Average total duration Fastest 2h 34m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Infobus | Departure Time 06:30AM | Arrival Time 09:30AM | Duration 3h00 | Departure days Fri, Sat | Cheapest price $74 |
Operator Greyhound | Departure Time 06:45AM | Arrival Time 10:40AM | Duration 3h55 | Departure days Fri, Sat | Cheapest price $44 |
Operator FlixBus | Departure Time 07:35AM | Arrival Time 11:35AM | Duration 4h00 | Departure days Fri, Sat | Cheapest price $69 |
Operator Infobus | Departure Time 07:51AM | Arrival Time 10:56AM | Duration 3h05 | Departure days Fri, Sat | Cheapest price $106 |
Operator FlixBus | Departure Time 07:55AM | Arrival Time 11:35AM | Duration 3h40 | Departure days Fri, Sat | Cheapest price $69 |
Operator FlixBus | Departure Time 08:20AM | Arrival Time 11:20AM | Duration 3h00 | Departure days Sat | Cheapest price $61 |
Operator FlixBus | Departure Time 08:45AM | Arrival Time 11:20AM | Duration 2h35 | Departure days Sat | Cheapest price $61 |
Operator FlixBus | Departure Time 09:25AM | Arrival Time 12:45PM | Duration 3h20 | Departure days Fri, Sat | Cheapest price $58 |
Operator FlixBus | Departure Time 09:50AM | Arrival Time 12:45PM | Duration 2h55 | Departure days Fri, Sat | Cheapest price $58 |
Operator Infobus | Departure Time 09:51AM | Arrival Time 12:56PM | Duration 3h05 | Departure days Fri, Sat | Cheapest price $106 |
Operator Infobus | Departure Time 10:45AM | Arrival Time 01:45PM | Duration 3h00 | Departure days Fri, Sat | Cheapest price $74 |
Operator Infobus | Departure Time 11:30AM | Arrival Time 02:30PM | Duration 3h00 | Departure days Fri, Sat | Cheapest price $74 |
Operator Infobus | Departure Time 11:51AM | Arrival Time 02:36PM | Duration 2h45 | Departure days Fri, Sat | Cheapest price $106 |
Operator FlixBus | Departure Time 11:55AM | Arrival Time 03:30PM | Duration 3h35 | Departure days Fri, Sat | Cheapest price $56 |
Operator FlixBus | Departure Time 12:15PM | Arrival Time 03:30PM | Duration 3h15 | Departure days Fri, Sat | Cheapest price $56 |
Operator FlixBus | Departure Time 12:40PM | Arrival Time 03:30PM | Duration 2h50 | Departure days Fri, Sat | Cheapest price $56 |
Operator FlixBus | Departure Time 01:10PM | Arrival Time 04:55PM | Duration 3h45 | Departure days Fri, Sat | Cheapest price $43 |
Operator FlixBus | Departure Time 01:35PM | Arrival Time 04:55PM | Duration 3h20 | Departure days Fri, Sat | Cheapest price $43 |
Operator Infobus | Departure Time 01:51PM | Arrival Time 04:56PM | Duration 3h05 | Departure days Fri, Sat | Cheapest price $106 |
Operator Infobus | Departure Time 03:51PM | Arrival Time 06:56PM | Duration 3h05 | Departure days Fri, Sat | Cheapest price $106 |
Operator FlixBus | Departure Time 03:55PM | Arrival Time 07:10PM | Duration 3h15 | Departure days Fri, Sat | Cheapest price $43 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 07:35PM | Duration 3h20 | Departure days Fri, Sat | Cheapest price $43 |
Operator Infobus | Departure Time 05:51PM | Arrival Time 08:56PM | Duration 3h05 | Departure days Fri, Sat | Cheapest price $106 |
Operator Greyhound | Departure Time 07:35PM | Arrival Time 10:20PM | Duration 2h45 | Departure days Fri, Sat | Cheapest price $42 |
Operator Infobus | Departure Time 07:51PM | Arrival Time 10:56PM | Duration 3h05 | Departure days Fri, Sat | Cheapest price $106 |
Operator Infobus | Departure Time 08:20PM | Arrival Time 12:20AM | Duration 4h00 | Departure days Fri, Sat | Cheapest price $74 |
Live departures
Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA bus times
The table below shows live departures for Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA buses for tomorrow, Friday, March 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
0 | 12:51 AM San Diego, CA | 3h05 | 3:56 AM Los Angeles, CA | 0 transfersDirect | |
![]() | 2:35 AM San Diego, Congress Street (Old Town Park), CA | 2h45 | 5:20 AM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
0 | 2:51 AM San Diego, CA | 2h45 | 5:36 AM Los Angeles, CA | 0 transfersDirect | |
0 | 3:20 AM San Diego, CA | 4h00 | 7:20 AM Los Angeles, CA | 0 transfersDirect | |
0 | 1:30 PM San Diego, CA | 3h00 | 4:30 PM Los Angeles, CA | 0 transfersDirect | |
0 | 1:30 PM San Diego, CA | 3h15 | 4:45 PM Los Angeles, CA | 0 transfersDirect | |
![]() | 1:45 PM San Diego, Congress Street (Old Town Park), CA | 3h55 | 5:40 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
FlixBus | 2:35 PM San Diego, Congress Street (Old Town Park), CA | 4h00 | 6:35 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
0 | 2:51 PM San Diego, CA | 3h05 | 5:56 PM Los Angeles, CA | 0 transfersDirect | |
FlixBus | 2:55 PM La Jolla, UCSD Health La Jolla Station, CA | 3h40 | 6:35 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 3:20 PM San Diego, Congress Street (Old Town Park), CA | 3h00 | 6:20 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 3:20 PM San Diego, Congress Street (Old Town Park), CA | 2h25 | 5:45 PM Downey, Stonewood Center (251 Stonewood St), CA | 0 transfersDirect | |
FlixBus | 3:45 PM La Jolla, UCSD Health La Jolla Station, CA | 2h35 | 6:20 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 3:45 PM La Jolla, UCSD Health La Jolla Station, CA | 2h00 | 5:45 PM Downey, Stonewood Center (251 Stonewood St), CA | 0 transfersDirect | |
FlixBus | 4:25 PM San Diego, Congress Street (Old Town Park), CA | 3h20 | 7:45 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
FlixBus | 4:50 PM La Jolla, UCSD Health La Jolla Station, CA | 2h55 | 7:45 PM Los Angeles, Cesar E Chavez / Vignes, CA | 0 transfersDirect | |
0 | 4:51 PM San Diego, CA | 3h05 | 7:56 PM Los Angeles, CA | 0 transfersDirect | |
0 | 5:45 PM San Diego, CA | 3h00 | 8:45 PM Los Angeles, CA | 0 transfersDirect | |
0 | 6:30 PM San Diego, CA | 3h00 | 9:30 PM Los Angeles, CA | 0 transfersDirect | |
0 | 6:51 PM San Diego, CA | 2h45 | 9:36 PM Los Angeles, CA | 0 transfersDirect | |
FlixBus | 6:55 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 3h35 | 10:30 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
FlixBus | 7:15 PM San Diego, Congress Street (Old Town Park), CA | 3h15 | 10:30 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
FlixBus | 7:40 PM La Jolla, UCSD Health La Jolla Station, CA | 2h50 | 10:30 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
FlixBus | 8:10 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 3h45 | 11:55 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
FlixBus | 8:35 PM La Jolla, UCSD Health La Jolla Station, CA | 3h20 | 11:55 PM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
0 | 8:51 PM San Diego, CA | 3h05 | 11:56 PM Los Angeles, CA | 0 transfersDirect | |
0 | 10:51 PM San Diego, CA | 3h05 | 1:56 AM Los Angeles, CA | 0 transfersDirect | |
FlixBus | 10:55 PM San Diego, Congress Street (Old Town Park), CA | 3h15 | 2:10 AM Los Angles, S Hope St. USC Parking, CA | 0 transfersDirect | |
FlixBus | 10:55 PM San Diego, Congress Street (Old Town Park), CA | 3h40 | 2:35 AM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
FlixBus | 11:15 PM La Jolla, UCSD Health La Jolla Station, CA | 3h20 | 2:35 AM Los Angeles, Patsaouras Transit Plaza (Union Station), CA | 0 transfersDirect | |
FlixBus | 11:15 PM La Jolla, UCSD Health La Jolla Station, CA | 2h55 | 2:10 AM Los Angles, S Hope St. USC Parking, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
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Compare prices and tickets Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Greyhound or Infobus to find the best option for your trip from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA.
Why book with Omio over Wanderu, Trainline or Busbud?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Greyhound or Infobus to find the best option for your trip from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA.
Journey information
Overview: Bus from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA
Buses from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA run on average 30 times per day, taking around 3h 14m. Cheap bus tickets for this journey start at $23 (€19) if you book in advance.
There are 29 buses per day. The earliest bus runs at 03:35, the last at 23:55. The fastest bus covers the 111 miles (179 km) distance in 2h 30m.
Distance 111 miles (179 km) |
Average bus duration 3h 14m |
Cheapest ticket price $23 (€19) |
Buses per day 30 |
Direct buses 29 |
Fastest bus 2h 30m |
First bus 03:35 |
Last bus 23:55 |
Cheapest month Jul |
Cheapest day Wed |
High season Oct - Dec |
Low season Apr - Jun |
Busiest day Sat |
Least busy day Fri |
Bus providers: FlixBus, Greyhound, Infobus from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CAYou can travel by bus between Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA with FlixBus, Greyhound, Infobus for as low as $23 (€19). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Infobus
Greyhound
FAQs: Bus from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA
Find answers to the most common questions about traveling from Santa Fe Depot, San Diego, CA to Union Station, Los Angeles, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Union Station, Los Angeles, CA, this guide helps you travel smarter and with confidence.

- Infobus
- Assistance
- Priority seating
- Transport for wheelchairs and mobility aids.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Infobus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Infobus
- One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Infobus
- 10€ per additional bag.
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- Infobus
- Small pets allowed in carriers
- larger pets may require a separate ticket.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
Most popular bus connections from Santa Fe Depot, San Diego, CA
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