Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA bus with FlixBus

Sat, Sep 19
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Tufesa Internacional
Greyhound
Futura Net
FlixBus
Alsa
2,000+ travel companies
Tufesa Internacional
Greyhound
Futura Net
FlixBus
Alsa
2,000+ travel companies
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The cheapest and fastest buses from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA

Showing times, prices and bookable tickets for Sep 19

Cheapest price on Sep 19

€40

Average ticket price on Sep 19

€43

Fastest journey on Sep 19

2 h 19 m

Average journey duration on Sep 19

2 h 24 m

Buses on Sep 19

9

Distance

204 km

Cheap tickets

The best way to find a cheap bus ticket from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA will cost around €43 if you buy it on the day, but the cheapest tickets can be found for only €40.

Fast buses

On Sat, Sep 19, we found 9 buses from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA, including 9 direct services.

On Sat, Sep 19 the direct buses cover the 204 km distance in an average of 2 h 24 m but if you time it right, some buses will get you there in just 2 h 19 m .

On Sat, Sep 19 the slowest buses will take 2 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

  • Futura Net0
    8:00 PM2h19
    Van Nuys, Metrolink Station, Los Angeles, CA
    10:19 PMSanta Fe Depot, San Diego, CA
    401One-way
    0 transfers
  • Futura Net0
    4:00 PM2h19
    Van Nuys, Metrolink Station, Los Angeles, CA
    6:19 PMSanta Fe Depot, San Diego, CA
    401One-way
    0 transfers
  • Futura Net0
    7:30 AM2h49
    Van Nuys, Metrolink Station, Los Angeles, CA
    10:19 AMSanta Fe Depot, San Diego, CA
    401One-way
    0 transfers
  • Futura Net0
    6:00 PM2h19
    Van Nuys, Metrolink Station, Los Angeles, CA
    8:19 PMSanta Fe Depot, San Diego, CA
    401One-way
    0 transfers
  • Futura Net0
    5:15 AM2h49
    Van Nuys, Metrolink Station, Los Angeles, CA
    8:04 AMSanta Fe Depot, San Diego, CA
    401One-way
    0 transfers

Travel Information

Compare train, bus, and flight for Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA

Omio recommends booking the flight as it is the most popular option from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €39 For those with little time, consider booking a bus, which has an average total journey time of 4h 11m. Average ticket prices depend on the travel mode: a bus costs an average of €39, while a flight costs an average of €481.

Distance: 126 miles (204 km)

Compare bus with

Bus
Most popular
Flight
Train
Driving

€39

Average price

Cheapest

€481

Average price

€49

Average price

€30

Average price

(fuel + tolls)

4h 11m

Average total duration

Fastest

3h 41m

Onboard

+

30m

Additional time*

5h 26m

Average total duration

3h 26m

Onboard

+

2h 0m

Additional time*

5h 48m

Average total duration

5h 18m

Onboard

+

30m

Additional time*

2h 38m

Average total duration

(door-to-door)

FlixBus

Most popular bus company

United

Most popular airline

Amtrak

Most popular train company

Your own car or car rental

Direct Options

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA is a bus with an average price of €39.

This is compared to other travel options from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA:

A bus is €10 less than a train for this route with tickets for a train from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA costing on average €49.

A bus is €442 less than a flight for this route with tickets for a flight from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA costing on average €481.

The fastest way to travel from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA is by flight with an average journey time of 3h 26m.

Other travel options to Santa Fe Depot, San Diego, CA take longer:

Bus takes on average 3h 41m.

Train takes on average 5h 18m.

It's helpful to compare your options as there are 3 ways to travel between Van Nuys, Metrolink Station, Los Angeles, CA and Santa Fe Depot, San Diego, CA including taking a train, bus, and flight.
We recommend using the flight as it is the most popular way to get from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.

Tickets start at around €39 compared to roughly €30 in fuel and tolls — a saving of about €-9.18. The journey takes 3h 41m versus 2h 38m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.

Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.

Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
FlixBus
Departure Time
01:30AM
Arrival Time
04:45AM
Duration
3h15
Departure days
Fri, Sat
Cheapest price
28
Operator
Tufesa Internacional
Departure Time
02:15AM
Arrival Time
05:00AM
Duration
2h45
Departure days
Wed
Cheapest price
40
Operator
FlixBus
Departure Time
02:30AM
Arrival Time
05:45AM
Duration
3h15
Departure days
Mon
Cheapest price
23
Operator
Tufesa Internacional
Departure Time
04:00AM
Arrival Time
06:45AM
Duration
2h45
Departure days
Sat
Cheapest price
40
Operator
Amtrak
Departure Time
05:09AM
Arrival Time
09:20AM
Duration
4h11
Departure days
Sat
Cheapest price
35
Operator
Futura Net
Departure Time
05:15AM
Arrival Time
07:34AM
Duration
2h19
Departure days
Wed, Sat
Cheapest price
40
Operator
Futura Net
Departure Time
07:30AM
Arrival Time
10:19AM
Duration
2h49
Departure days
Wed, Sat
Cheapest price
40
Operator
Futura Net
Departure Time
09:30AM
Arrival Time
11:49AM
Duration
2h19
Departure days
Sat
Cheapest price
40
Operator
Futura Net
Departure Time
10:00AM
Arrival Time
01:19PM
Duration
3h19
Departure days
Wed
Cheapest price
62
Operator
Futura Net
Departure Time
01:30PM
Arrival Time
04:19PM
Duration
2h49
Departure days
Wed, Sat
Cheapest price
40
Operator
Tufesa Internacional
Departure Time
02:15PM
Arrival Time
05:00PM
Duration
2h45
Departure days
Wed, Sat
Cheapest price
40
Operator
FlixBus
Departure Time
02:20PM
Arrival Time
05:40PM
Duration
3h20
Departure days
Mon
Cheapest price
28
Operator
Futura Net
Departure Time
04:00PM
Arrival Time
06:19PM
Duration
2h19
Departure days
Wed, Sat
Cheapest price
40
Operator
Futura Net
Departure Time
06:00PM
Arrival Time
08:19PM
Duration
2h19
Departure days
Wed, Sat
Cheapest price
40
Operator
FlixBus
Departure Time
06:15PM
Arrival Time
10:55PM
Duration
4h40
Departure days
Mon, Thu, Fri, Sun
Cheapest price
18
Operator
FlixBus
Departure Time
06:55PM
Arrival Time
10:10PM
Duration
3h15
Departure days
Thu
Cheapest price
19
Operator
Amtrak
Departure Time
07:07PM
Arrival Time
11:55PM
Duration
4h48
Departure days
Sun
Cheapest price
35
Operator
FlixBus
Departure Time
07:15PM
Arrival Time
11:55PM
Duration
4h40
Departure days
Fri
Cheapest price
27
Operator
Futura Net
Departure Time
08:00PM
Arrival Time
10:49PM
Duration
2h49
Departure days
Wed, Sat
Cheapest price
40

Live departures

Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA bus times

The table below shows live departures for Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
FlixBus6:15 PM Van Nuys, Metrolink Station, Los Angeles, CA
4h40
10:55 PM Santa Fe Depot, San Diego, CA0 transfersDirect
FlixBus7:15 PM Van Nuys, Metrolink Station, Los Angeles, CA
4h40
11:55 PM Santa Fe Depot, San Diego, CA0 transfersDirect
Saturday, September 19
Tufesa Internacional04:00 AM Van Nuys, Metrolink Station, Los Angeles, CA
2h45
6:45 AM Santa Fe Depot, San Diego, CA0 transfersDirect
Futura Net05:15 AM Van Nuys, Metrolink Station, Los Angeles, CA
2h49
8:04 AM Santa Fe Depot, San Diego, CA0 transfersDirect
Futura Net07:30 AM Van Nuys, Metrolink Station, Los Angeles, CA
2h49
10:19 AM Santa Fe Depot, San Diego, CA0 transfersDirect
Futura Net09:30 AM Van Nuys, Metrolink Station, Los Angeles, CA
2h19
11:49 AM Santa Fe Depot, San Diego, CA0 transfersDirect
Futura Net01:30 PM Van Nuys, Metrolink Station, Los Angeles, CA
3h19
4:49 PM Santa Fe Depot, San Diego, CA0 transfersDirect
Tufesa Internacional02:15 PM Van Nuys, Metrolink Station, Los Angeles, CA
2h45
5:00 PM Santa Fe Depot, San Diego, CA0 transfersDirect

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA by train, bus, or flight

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sat
Sep 19
Sun
Sep 20
Mon
Sep 21
Tue
Sep 22
Wed
Sep 23
Thu
Sep 24
Fri
Sep 25

Why should you book Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA buses with Omio?

Tufesa Internacional as well as Greyhound, Futura Net, FlixBus and more offer buses services from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.
Omio is the only official third party seller for Tufesa Internacional tickets.

Why book with Omio vs Tufesa Internacional?

  • Compare with other providers: On Omio, you can not only buy tickets for Tufesa Internacional, but also compare tickets for the likes of Greyhound, Futura Net or FlixBus to find the best option for your trip from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Tufesa Internacional with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.

Journey information

Overview: Bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA

USAUSA
USAUSA
Icon of bus

Buses from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA run on average 16 times per day, taking around 3h 41m. Cheap bus tickets for this journey start at €23 if you book in advance.

There are 13 buses per day. The earliest bus runs at 01:30, the last at 22:25. The fastest bus covers the 126 miles (204 km) distance in 2h 10m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
126 miles (204 km)
Average bus duration
3h 41m
Cheapest ticket price
€23
Buses per day
16
Direct buses
13
Fastest bus
2h 10m
First bus
1:30 AM
Last bus
10:25 PM
Cheapest Month
Mar
Cheapest Day
Sat
High Season
Jul - Sep
Low Season
Apr - Jun
Busiest Day
Thu
Least Busy Day
Thu
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: FlixBus, Futura Net, Greyhound, Tufesa Internacional from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CAYou can travel by bus between Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA with FlixBus, Futura Net, Greyhound, Tufesa Internacional for as low as €23. When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
2h 10m
Cheapest FlixBus Price
€23
FlixBus frequency
10 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
3h 20m
Cheapest Greyhound Price
€24
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

Futura Net

Luggage & cancellation policy
Average Futura Net Duration
2h 19m
Cheapest Futura Net Price
€40
Futura Net frequency
6 a day

Tufesa Internacional

Luggage & cancellation policy
Average Tufesa Internacional Duration
2h 45m
Cheapest Tufesa Internacional Price
€40
Tufesa Internacional frequency
2 a day

FAQs: Bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA

Find answers to the most common questions about traveling from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Fe Depot, San Diego, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA can start from as little as €23 when you book in advance. The average bus ticket price for Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA is €39 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA is 2h 10m to travel the 126 miles (204 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA leaves at 1:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA leaves at 10:25 PM.
Yes, there are 13 direct buses a day from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA with Tufesa Internacional, Greyhound, Futura Net, FlixBus. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA, you can count on Tufesa Internacional, Greyhound, Futura Net, FlixBus for the best way to get you to Santa Fe Depot, San Diego, CA. You can also check all possible bus companies who offer a service between Van Nuys, Metrolink Station, Los Angeles, CA and Santa Fe Depot, San Diego, CA and compare the amenities they offer before buying a bus ticket.
A trip to Santa Fe Depot, San Diego, CA from Van Nuys, Metrolink Station, Los Angeles, CA is worth doing but not as a day trip with a journey time of 2h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA is March.
It's helpful to compare your options as there are 3 ways to travel between Van Nuys, Metrolink Station, Los Angeles, CA and Santa Fe Depot, San Diego, CA including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA.
Yes, the following luggage options are included when booking a bus ticket from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA:
  • Greyhound
    • $15 per additional bag.
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA. The following conditions apply:
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA with the following bus company: Greyhound, FlixBus.
Since neither Van Nuys, Metrolink Station, Los Angeles, CA nor Santa Fe Depot, San Diego, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

More options for your journey from Van Nuys, Metrolink Station, Los Angeles, CA to Santa Fe Depot, San Diego, CA

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