The cheapest and fastest buses from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA
Cheapest price
$26
Average price
$41
Fastest journey
48 m
Average duration
59 m
Buses per day
19
Distance
117 km
The best way to find a cheap bus ticket from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA will cost around $41 if you buy it on the day, but the cheapest tickets can be found for only $26.
Of the 19 buses that leave Irvine Transportation Center, Irvine, CA for Santa Fe Depot, San Diego, CA on Sun, Jun 21, 19 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 21 the direct buses cover the 117 km distance in an average of 59 m but if you time it right, some buses will get you there in just 48 m .
On Sun, Jun 21 the slowest buses will take 1 h 18 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus8:30 PM1h45Santa Ana, E Santa Ana Blvd (Train Station)10:15 PMSan Diego, West Harbor Drive (The Headquarters at Seaport District), CA$261One-way0 transfers
FlixBus12:10 PM2h00Irvine Transportation Center, Irvine, CA2:10 PMSan Diego, Congress Street (Old Town Park), CA$261One-way0 transfers
FlixBus2:35 PM1h50Santa Ana, E Santa Ana Blvd (Train Station)4:25 PMSan Diego, Congress Street (Old Town Park), CA$261One-way0 transfers
FlixBus12:10 PM1h30Irvine Transportation Center, Irvine, CA1:40 PMLa Jolla, UCSD Health La Jolla Station, CA$261One-way0 transfers
FlixBus8:30 PM1h15Santa Ana, E Santa Ana Blvd (Train Station)9:45 PMLa Jolla, UCSD Health La Jolla Station, CA$261One-way0 transfers
011:01 AM0h48Mission Viejo, CA11:49 AMSan Diego, CA$491One-way0 transfers
06:46 AM0h48Mission Viejo, CA7:34 AMSan Diego, CA$491One-way0 transfers
09:01 AM0h48Mission Viejo, CA9:49 AMSan Diego, CA$491One-way0 transfers
FlixBus8:30 PM1h15Santa Ana, E Santa Ana Blvd (Train Station)9:45 PMLa Jolla, UCSD Health La Jolla Station, CA$261One-way0 transfers
09:31 PM1h18Mission Viejo, CA10:49 PMSan Diego, CA$561One-way0 transfers
Travel Information
Compare train and bus for Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA
Omio recommends booking the train as it is the most popular option from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA among Omio's users. If you are prioritising price take the bus with prices starting from $15. For those with little time consider booking a train which can get you there in 1h 53m. The ticket price range depends on the travel mode: a bus costs an average of $15, and a train costs an average of $29.
Distance: 72 miles (117 km)
Compare bus with
| Bus | Most popular Train | Driving |
|---|---|---|
$22 Average price Cheapest | $30 Average price | $17 Average price (fuel + tolls) |
2h 35m Average total duration 2h 5m Onboard + 30m Additional time* | 2h 23m Average total duration Fastest 1h 53m Onboard + 30m Additional time* | 1h 19m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA:
A bus is $8 (€7) less than a train for this route with tickets for a train from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA costing on average $30 (€25).
Other travel options to Santa Fe Depot, San Diego, CA take longer:
Bus takes on average 2h 5m.
You'll arrive about -1h -46m sooner (2h 5m by bus vs 1h 19m by car) and save roughly $-5.14 (€-4.21) compared to fuel and tolls ($22 (€18) vs $17 (€14)). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by FlixBus, Greyhound.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:30AM | Arrival Time 04:45AM | Duration 1h15 | Departure days Tue, Wed, Thu, Fri, Sat | Cheapest price $19 |
Operator FlixBus | Departure Time 04:30AM | Arrival Time 05:45AM | Duration 1h15 | Departure days Tue, Wed, Thu, Fri, Sat | Cheapest price $19 |
Operator Infobus | Departure Time 05:31AM | Arrival Time 06:19AM | Duration 0h48 | Departure days Sat | Cheapest price $47 |
Operator Futura Net | Departure Time 06:46AM | Arrival Time 07:34AM | Duration 0h48 | Departure days Sat, Sun | Cheapest price $49 |
Operator Futura Net | Departure Time 09:01AM | Arrival Time 09:49AM | Duration 0h48 | Departure days Sat, Sun | Cheapest price $49 |
Operator Greyhound | Departure Time 09:40AM | Arrival Time 11:45AM | Duration 2h05 | Departure days Sat, Sun | Cheapest price $41 |
Operator Greyhound | Departure Time 10:00AM | Arrival Time 11:45AM | Duration 1h45 | Departure days Sat, Sun | Cheapest price $41 |
Operator Futura Net | Departure Time 11:01AM | Arrival Time 11:49AM | Duration 0h48 | Departure days Sat, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 12:10PM | Arrival Time 02:10PM | Duration 2h00 | Departure days Sat, Sun | Cheapest price $23 |
Operator FlixBus | Departure Time 02:35PM | Arrival Time 04:25PM | Duration 1h50 | Departure days Sat, Sun | Cheapest price $23 |
Operator Futura Net | Departure Time 03:01PM | Arrival Time 04:49PM | Duration 1h48 | Departure days Sat, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 04:00PM | Arrival Time 05:25PM | Duration 1h25 | Departure days Sat, Sun | Cheapest price $25 |
Operator Futura Net | Departure Time 05:31PM | Arrival Time 06:49PM | Duration 1h18 | Departure days Sat, Sun | Cheapest price $56 |
Operator FlixBus | Departure Time 07:10PM | Arrival Time 08:40PM | Duration 1h30 | Departure days Mon, Thu, Fri | Cheapest price $15 |
Operator Futura Net | Departure Time 07:31PM | Arrival Time 08:49PM | Duration 1h18 | Departure days Sat, Sun | Cheapest price $56 |
Operator FlixBus | Departure Time 08:10PM | Arrival Time 09:40PM | Duration 1h30 | Departure days Mon, Thu | Cheapest price $15 |
Operator FlixBus | Departure Time 08:30PM | Arrival Time 10:15PM | Duration 1h45 | Departure days Sat, Sun | Cheapest price $23 |
Operator Futura Net | Departure Time 09:31PM | Arrival Time 10:49PM | Duration 1h18 | Departure days Sat, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 09:35PM | Arrival Time 11:25PM | Duration 1h50 | Departure days Tue, Wed | Cheapest price $23 |
Operator Greyhound | Departure Time 09:40PM | Arrival Time 11:50PM | Duration 2h10 | Departure days Sat, Sun | Cheapest price $39 |
Operator Greyhound | Departure Time 10:05PM | Arrival Time 11:50PM | Duration 1h45 | Departure days Sat, Sun | Cheapest price $39 |
Operator FlixBus | Departure Time 10:35PM | Arrival Time 12:25AM | Duration 1h50 | Departure days Wed | Cheapest price $22 |
Live departures
Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA bus times
The table below shows live departures for Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
0 | 9:01 AM Mission Viejo, CA | 1h48 | 10:49 AM San Diego, CA | 0 transfersDirect | |
![]() | 9:40 AM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 2h05 | 11:45 AM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
![]() | 10:00 AM Santa Ana, E Santa Ana Blvd (Train Station) | 1h45 | 11:45 AM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
0 | 11:01 AM Mission Viejo, CA | 0h48 | 11:49 AM San Diego, CA | 0 transfersDirect | |
FlixBus | 12:10 PM Irvine Transportation Center, Irvine, CA | 2h00 | 2:10 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
FlixBus | 12:10 PM Irvine Transportation Center, Irvine, CA | 1h30 | 1:40 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 2:35 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h50 | 4:25 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
FlixBus | 2:35 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h20 | 3:55 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
0 | 3:01 PM Mission Viejo, CA | 0h48 | 3:49 PM San Diego, CA | 0 transfersDirect | |
FlixBus | 4:00 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 1h25 | 5:25 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 4:00 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 1h50 | 5:50 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
0 | 5:31 PM Mission Viejo, CA | 1h18 | 6:49 PM San Diego, CA | 0 transfersDirect | |
0 | 7:31 PM Mission Viejo, CA | 1h48 | 9:19 PM San Diego, CA | 0 transfersDirect | |
FlixBus | 8:30 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h45 | 10:15 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 0 transfersDirect | |
FlixBus | 8:30 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h15 | 9:45 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
0 | 9:31 PM Mission Viejo, CA | 0h48 | 10:19 PM San Diego, CA | 0 transfersDirect | |
![]() | 9:40 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 2h10 | 11:50 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
![]() | 10:05 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h45 | 11:50 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
| Sunday, June 21 | |||||
0 | 6:46 AM Mission Viejo, CA | 0h48 | 7:34 AM San Diego, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jun 21
Jun 22
Jun 23
Jun 24
Jun 25
Jun 26
Jun 27
Jun 28
Jun 29
Jun 30
Jul 01
Jul 02
Jul 03
Jul 04
Jul 05
Jul 06
Jul 07
Jul 08
Jul 09
Jul 10
Jul 11
Why should you book Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Greyhound to find the best option for your trip from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Greyhound to find the best option for your trip from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA.
Journey information
Overview: Bus from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA
Buses from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA run on average 13 times per day, taking around 2h 5m. Cheap bus tickets for this journey start at $15 (€12) if you book in advance.
There are 12 buses per day. The earliest bus runs at 03:30, the last at 22:35. The fastest bus covers the 72 miles (117 km) distance in 48m.
Distance 72 miles (117 km) |
Average bus duration 2h 5m |
Cheapest ticket price $15 (€12) |
Buses per day 13 |
Direct buses 12 |
Fastest bus 48m |
First bus 3:30 AM |
Last bus 10:35 PM |
Cheapest Month Jul |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Jul - Sep |
Busiest Day Fri |
Least Busy Day Thu |
Bus providers: FlixBus, Greyhound from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CAYou can travel by bus between Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA with FlixBus, Greyhound for as low as $15 (€12). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
FAQs: Bus from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA
Find answers to the most common questions about traveling from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Fe Depot, San Diego, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
Most popular bus connections from Irvine Transportation Center, Irvine, CA
More options for your journey from Irvine Transportation Center, Irvine, CA to Santa Fe Depot, San Diego, CA
Here are some other resources that might have the information you need


