The cheapest and fastest buses from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA
Cheapest price
$33
Average price
$47
Fastest journey
1 h 15 m
Average duration
1 h 31 m
Buses per day
18
Distance
138 km
The best way to find a cheap bus ticket from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA will cost around $47 if you buy it on the day, but the cheapest tickets can be found for only $33.
Of the 18 buses that leave Anaheim Regional Transportation Intermodal Center, Anaheim, CA for Santa Fe Depot, San Diego, CA on Tue, Dec 23, 18 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Dec 23 the direct buses cover the 138 km distance in an average of 1 h 31 m but if you time it right, some buses will get you there in just 1 h 15 m .
On Tue, Dec 23 the slowest buses will take 1 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus
FlixBus
FlixBus
FlixBus
FlixBus
FlixBus
FlixBus
FlixBus
FlixBus
Anaheim Regional Transportation Intermodal Center, Anaheim, CA - Santa Fe Depot, San Diego, CACompare FlixBus, Greyhound


Travel Information
Compare bus and train for Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA
Omio recommends booking the train as it is the most popular option from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA among Omio's users. If you are prioritising price take the bus with prices starting from €27. For those with little time consider booking a bus which can get you there in 2h 14m. The ticket price range depends on the travel mode: a bus costs an average of €27, and a train costs an average of €69.
Distance: 85 miles (138 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
€27 Average price Cheapest | €69 Average price |
2h 44m Average total duration Fastest 2h 14m Onboard + 30m Additional time* | 2h 46m Average total duration 2h 16m Onboard + 30m Additional time* |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 09:40AM | Arrival Time 11:45AM | Duration 2h05 | Departure days Mon, Tue, Thu, Sun | Cheapest price $51 |
Operator Greyhound | Departure Time 10:00AM | Arrival Time 11:45AM | Duration 1h45 | Departure days Mon, Tue, Thu, Sun | Cheapest price $51 |
Operator FlixBus | Departure Time 12:10PM | Arrival Time 01:40PM | Duration 1h30 | Departure days Mon, Thu, Sun | Cheapest price $32 |
Operator FlixBus | Departure Time 02:35PM | Arrival Time 03:55PM | Duration 1h20 | Departure days Mon, Tue, Thu, Sun | Cheapest price $32 |
Operator FlixBus | Departure Time 03:25PM | Arrival Time 05:20PM | Duration 1h55 | Departure days Tue, Sun | Cheapest price $34 |
Operator FlixBus | Departure Time 08:30PM | Arrival Time 09:45PM | Duration 1h15 | Departure days Mon, Tue, Thu, Sun | Cheapest price $31 |
Operator Greyhound | Departure Time 09:40PM | Arrival Time 11:50PM | Duration 2h10 | Departure days Mon, Tue, Thu, Sun | Cheapest price $48 |
Operator Greyhound | Departure Time 10:05PM | Arrival Time 11:50PM | Duration 1h45 | Departure days Mon, Tue, Thu, Sun | Cheapest price $48 |
Live departures
Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA bus times
The table below shows live departures for Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA buses for today, Monday, December 22. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:40 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 2h05 | 7:45 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
![]() | 5:40 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 2h40 | 8:20 PM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
![]() | 6:00 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h45 | 7:45 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
![]() | 6:00 PM Santa Ana, E Santa Ana Blvd (Train Station) | 2h20 | 8:20 PM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
FlixBus | 8:10 PM Irvine, West Peltason Dr (UCI Crawford Hall), CA | 1h30 | 9:40 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 8:10 PM Irvine, West Peltason Dr (UCI Crawford Hall), CA | 2h00 | 10:10 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
FlixBus | 8:10 PM Irvine, West Peltason Dr (UCI Crawford Hall), CA | 2h30 | 10:40 PM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
FlixBus | 10:35 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h20 | 11:55 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 10:35 PM Santa Ana, E Santa Ana Blvd (Train Station) | 2h35 | 1:10 AM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
FlixBus | 10:35 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h50 | 12:25 AM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
FlixBus | 4:30 AM Santa Ana, E Santa Ana Blvd (Train Station) | 1h15 | 5:45 AM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 4:30 AM Santa Ana, E Santa Ana Blvd (Train Station) | 2h15 | 6:45 AM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
FlixBus | 4:30 AM Santa Ana, E Santa Ana Blvd (Train Station) | 1h45 | 6:15 AM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 0 transfersDirect | |
![]() | 5:40 AM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 2h10 | 7:50 AM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
![]() | 5:40 AM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 2h45 | 8:25 AM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
![]() | 6:05 AM Santa Ana, E Santa Ana Blvd (Train Station) | 2h20 | 8:25 AM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
![]() | 6:05 AM Santa Ana, E Santa Ana Blvd (Train Station) | 1h45 | 7:50 AM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA
Buses from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA run on average 21 times per day, taking around 2h 14m. Cheap bus tickets for this journey start at $34 (€27) if you book in advance.
There are 20 buses per day. The earliest bus runs at 19:49, the last at 19:49. The fastest bus covers the 85 miles (138 km) distance in 3h 6m.
Distance 85 miles (138 km) |
Average bus duration 2h 14m |
Cheapest ticket price $34 (€27) |
Buses per day 21 |
Direct buses 20 |
Fastest bus 3h 6m |
First bus 19:49 |
Last bus 19:49 |
Bus providers: FlixBus, Greyhound from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CAYou can travel by bus between Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA with FlixBus, Greyhound for as low as $34 (€27). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
FAQs: Bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA
Find answers to the most common questions about traveling from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Fe Depot, San Diego, CA, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- Additional luggage can be purchased for a fee.
- Greyhound
- $15 per additional bag.
- FlixBus
- Small pets in carriers allowed
- Guide dogs travel for free.
More options for your journey from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA
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