Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA bus with Greyhound

Thu, May 14
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The cheapest and fastest buses from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA

Showing times and prices for May 14

Cheapest price

$21

Average price

$42

Fastest journey

1 h 15 m

Average duration

1 h 27 m

Buses per day

20

Distance

138 km

Cheap tickets

The best way to find a cheap bus ticket from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA will cost around $42 if you buy it on the day, but the cheapest tickets can be found for only $21.

Fast buses

Of the 20 buses that leave Anaheim Regional Transportation Intermodal Center, Anaheim, CA for Santa Fe Depot, San Diego, CA on Thu, May 14, 20 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.

On Thu, May 14 the direct buses cover the 138 km distance in an average of 1 h 27 m but if you time it right, some buses will get you there in just 1 h 15 m .

On Thu, May 14 the slowest buses will take 1 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

  • FlixBusFlixBus
    12:10 PM1h30
    Anaheim Regional Transportation Intermodal Center, Anaheim, CA
    1:40 PMLa Jolla, UCSD Health La Jolla Station, CA
    $211One-way
    0 transfers
  • FlixBusFlixBus
    8:30 PM1h15
    Santa Ana, E Santa Ana Blvd (Train Station)
    9:45 PMLa Jolla, UCSD Health La Jolla Station, CA
    $211One-way
    0 transfers
  • FlixBusFlixBus
    12:10 PM2h00
    Anaheim Regional Transportation Intermodal Center, Anaheim, CA
    2:10 PMSan Diego, Congress Street (Old Town Park), CA
    $211One-way
    0 transfers
  • FlixBusFlixBus
    8:30 PM1h45
    Santa Ana, E Santa Ana Blvd (Train Station)
    10:15 PMSan Diego, West Harbor Drive (The Headquarters at Seaport District), CA
    $211One-way
    0 transfers
  • FlixBusFlixBus
    2:35 PM1h50
    Santa Ana, E Santa Ana Blvd (Train Station)
    4:25 PMSan Diego, Congress Street (Old Town Park), CA
    $221One-way
    0 transfers

Travel Information

Compare train and bus for Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA

Omio recommends booking the train as it is the most popular option from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA among Omio's users. If you are prioritising price take the bus with prices starting from $15. For those with little time consider booking a bus which can get you there in 2h 14m. The ticket price range depends on the travel mode: a bus costs an average of $15, and a train costs an average of $33.

Distance: 85 miles (138 km)

Compare bus with

Bus
Most popular
Train
Driving

$22

Average price

Cheapest

$34

Average price

$19

Average price

(fuel + tolls)

2h 44m

Average total duration

Fastest

2h 14m

Onboard

+

30m

Additional time*

2h 47m

Average total duration

2h 17m

Onboard

+

30m

Additional time*

1h 57m

Average total duration

(door-to-door)

Greyhound

Most popular bus company

Amtrak

Most popular train company

Your own car or car rental

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA is a bus with an average price of $22 (€17).

This is compared to other travel options from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA:

A bus is $12 (€10) less than a train for this route with tickets for a train from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA costing on average $34 (€27).

The fastest way to travel from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA is by bus with an average journey time of 2h 14m.

Other travel options to Santa Fe Depot, San Diego, CA take longer:

Train takes on average 2h 17m.

It's helpful to compare your options as there are 2 ways to travel between Anaheim Regional Transportation Intermodal Center, Anaheim, CA and Santa Fe Depot, San Diego, CA including taking a train and bus.
We recommend using the train as it is the most popular way to get from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.

You'll arrive about -1h -17m sooner (2h 14m by bus vs 1h 57m by car) and save roughly $-2.49 (€-1.99) compared to fuel and tolls ($22 (€17) vs $19 (€15)). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.

Direct coaches are operated by Greyhound, FlixBus, Infobus.

Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.

Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Amtrak
Departure Time
11:00PM
Arrival Time
01:20AM
Duration
2h20
Departure days
Fri
Cheapest price
$15

Live departures

Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA bus times

The table below shows live departures for Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA buses for today, Wednesday, May 13. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
FlixBus9:35 PM Anaheim Regional Transportation Intermodal Center, Anaheim, CA
1h50
11:25 PM Santa Fe Depot, San Diego, CA0 transfersDirect
FlixBus10:35 PM Anaheim Regional Transportation Intermodal Center, Anaheim, CA
1h50
12:25 AM Santa Fe Depot, San Diego, CA0 transfersDirect
Thursday, May 14
FlixBus3:30 AM Anaheim Regional Transportation Intermodal Center, Anaheim, CA
1h15
4:45 AM Santa Fe Depot, San Diego, CA0 transfersDirect
FlixBus4:30 AM Anaheim Regional Transportation Intermodal Center, Anaheim, CA
1h15
5:45 AM Santa Fe Depot, San Diego, CA0 transfersDirect

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA by train or bus

Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

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Why should you book Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA buses with Omio?

Greyhound as well as FlixBus or Infobus offer buses services from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA.
Omio is an official ticket reseller for all your travel options from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA.

Why book with Omio vs Greyhound?

  • Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus or Infobus to find the best option for your trip from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA.

Why book with Omio over Wanderu, Trainline or Busbud?

  • Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus or Infobus to find the best option for your trip from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA.
  • Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA.

Journey information

Overview: Bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA

USAUSA
USAUSA
Icon of bus

Buses from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA run on average 22 times per day, taking around 2h 14m. Cheap bus tickets for this journey start at $15 (€12) if you book in advance.

There are 21 buses per day. The earliest bus runs at 03:20, the last at 22:35. The fastest bus covers the 85 miles (138 km) distance in 1h 15m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
85 miles (138 km)
Average bus duration
2h 14m
Cheapest ticket price
$15 (€12)
Buses per day
22
Direct buses
21
Fastest bus
1h 15m
First bus
3:20 AM
Last bus
10:35 PM
Cheapest Month
Aug
Cheapest Day
Tue
High Season
Jan - Mar
Low Season
Jul - Sep
Busiest Day
Sun
Least Busy Day
Wed
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound, FlixBus, Infobus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CAYou can travel by bus between Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA with Greyhound, FlixBus, Infobus for as low as $15 (€12). When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
1h 15m
Cheapest Price
$15 (€12)
FlixBus frequency
10 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Learn more about FlixBus

Infobus

About
Infobus is an international IT company that operates as an online service for finding and purchasing bus, train, and plane tickets, rather than being a bus company itself. Established in 2002, Infobus acts as an intermediary between passengers and various transport carriers, particularly helping smaller bus companies offer online booking services. They utilize their own "BusSystem" to manage routes and ticket sales globally. Infobus covers over 30 countries and 300 cities, offering a wide range of routes and daily departures. While amenities can vary by carrier, Infobus aims to provide affordable and convenient travel with features like online booking, 24/7 support, and prompt notifications.
Luggage & cancellation policy
Infobus frequency
20 a day
Luggage included
One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
Additional luggage
10€ per additional bag.
Cancellation Policy
You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Transport for wheelchairs and mobility aids.
Bikes
Bikes are allowed; may require prior reservation and an additional fee.
Pets
Small pets allowed in carriers; larger pets may require a separate ticket.
Learn more about Infobus

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
1h 45m
Cheapest Price
$42 (€34)
Greyhound frequency
5 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Learn more about Greyhound

FAQs: Bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA

Find answers to the most common questions about traveling from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Fe Depot, San Diego, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA can start from as little as $15 (€12) when you book in advance. The average bus ticket price for Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA is $22 (€17) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA is 1h 15m to travel the 85 miles (138 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA leaves at 3:20 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA leaves at 10:35 PM.
Yes, there are 21 direct buses a day from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA with Greyhound, FlixBus, Infobus. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA, you can count on Greyhound, FlixBus, Infobus for the best way to get you to Santa Fe Depot, San Diego, CA. You can also check all possible bus companies who offer a service between Anaheim Regional Transportation Intermodal Center, Anaheim, CA and Santa Fe Depot, San Diego, CA and compare the amenities they offer before buying a bus ticket.
A day trip to Santa Fe Depot, San Diego, CA from Anaheim Regional Transportation Intermodal Center, Anaheim, CA is worth doing with a journey time of 1h 15m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA is August.
It's helpful to compare your options as there are 2 ways to travel between Anaheim Regional Transportation Intermodal Center, Anaheim, CA and Santa Fe Depot, San Diego, CA including taking a train and bus.
Yes, the following accessibility options are available when taking the bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA:
  • Infobus
    • Assistance
    • Priority seating
    • Transport for wheelchairs and mobility aids.
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA for bus company Greyhound, FlixBus, Infobus.
Whether you can cancel your bus ticket from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA depends on the bus companies:
  • Infobus
    • You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus, Infobus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA.
Yes, the following luggage options are included when booking a bus ticket from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA:
  • Infobus
    • One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA:
  • Infobus
    • 10€ per additional bag.
  • Greyhound
    • $15 per additional bag.
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA. The following conditions apply:
  • Infobus
    • Small pets allowed in carriers
    • larger pets may require a separate ticket.
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA with the following bus company: Greyhound, FlixBus, Infobus
Yes, there are USB plugs on board the bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA with the following bus company: Greyhound, FlixBus, Infobus.
Yes, there is Wifi on board the bus from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA with the following bus company: Greyhound, FlixBus, Infobus.
Since neither Anaheim Regional Transportation Intermodal Center, Anaheim, CA nor Santa Fe Depot, San Diego, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

More options for your journey from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA

Here are some other resources that might have the information you need

Trains from Anaheim Regional Transportation Intermodal Center, Anaheim, CA to Santa Fe Depot, San Diego, CA

Most popular buses to and from Santa Fe Depot, San Diego, CA and Anaheim Regional Transportation Intermodal Center, Anaheim, CA

Bus Union Station, Los Angeles, CA - Santa Fe Depot, San Diego, CA
Bus Santa Ana Station, Santa Ana, CA - Santa Fe Depot, San Diego, CA

Most popular bus connections to Santa Fe Depot, San Diego, CA

Bus Union Station, Los Angeles, CA - Santa Fe Depot, San Diego, CA
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