The cheapest and fastest buses from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA
Cheapest price
$23
Average price
$24
Fastest journey
1 h 15 m
Average duration
1 h 23 m
Buses per day
2
Distance
132 km
The best way to find a cheap bus ticket from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA will cost around $24 if you buy it on the day, but the cheapest tickets can be found for only $23.
Of the 2 buses that leave Santa Ana Station, Santa Ana, CA for Santa Fe Depot, San Diego, CA on Mon, Mar 23, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Mar 23 the direct buses cover the 132 km distance in an average of 1 h 23 m but if you time it right, some buses will get you there in just 1 h 15 m .
On Mon, Mar 23 the slowest buses will take 1 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare train and bus for Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA
Omio recommends booking the train as it is the most popular option from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA among Omio's users. If you are prioritising price take the bus with prices starting from $15. For those with little time consider booking a bus which can get you there in 1h 57m. The ticket price range depends on the travel mode: a bus costs an average of $15, and a train costs an average of $32.
Distance: 82 miles (132 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
$25 Average price Cheapest | $32 Average price |
2h 27m Average total duration Fastest 1h 57m Onboard + 30m Additional time* | 2h 34m Average total duration 2h 4m Onboard + 30m Additional time* |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Live departures
Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA bus times
The table below shows live departures for Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA buses for today, Sunday, March 22. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:10 PM Santa Ana Station, Santa Ana, CA | 1h30 | 9:40 PM Santa Fe Depot, San Diego, CA | 0 transfersDirect | |
| Monday, March 23 | |||||
![]() | 4:30 AM Santa Ana Station, Santa Ana, CA | 1h15 | 5:45 AM Santa Fe Depot, San Diego, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 23
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Why should you book Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus or Infobus to find the best option for your trip from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA.
Why book with Omio over Wanderu, Trainline or Busbud?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus or Infobus to find the best option for your trip from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA.
Journey information
Overview: Bus from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA
Buses from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA run on average 17 times per day, taking around 1h 57m. Cheap bus tickets for this journey start at $15 (€12) if you book in advance.
There are 16 buses per day. The earliest bus runs at 04:20, the last at 22:35. The fastest bus covers the 82 miles (132 km) distance in 1h 15m.
Distance 82 miles (132 km) |
Average bus duration 1h 57m |
Cheapest ticket price $15 (€12) |
Buses per day 17 |
Direct buses 16 |
Fastest bus 1h 15m |
First bus 04:20 |
Last bus 22:35 |
Cheapest month Apr |
Cheapest day Mon |
High season Jan - Mar |
Low season Apr - Jun |
Busiest day Sun |
Least busy day Wed |
Bus providers: Greyhound, FlixBus, Infobus from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CAYou can travel by bus between Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA with Greyhound, FlixBus, Infobus for as low as $15 (€12). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Infobus
Greyhound
FAQs: Bus from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA
Find answers to the most common questions about traveling from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Fe Depot, San Diego, CA, this guide helps you travel smarter and with confidence.

- Infobus
- Assistance
- Priority seating
- Transport for wheelchairs and mobility aids.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Infobus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Infobus
- One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Infobus
- 10€ per additional bag.
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- Infobus
- Small pets allowed in carriers
- larger pets may require a separate ticket.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.


