The cheapest and fastest buses from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA
Cheapest price
$22
Average price
$45
Fastest journey
1 h 5 m
Average duration
1 h 5 m
Buses per day
28
Distance
132 km
The best way to find a cheap bus ticket from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA will cost around $45 if you buy it on the day, but the cheapest tickets can be found for only $22.
Of the 28 buses that leave Santa Ana Station, Santa Ana, CA for Santa Fe Depot, San Diego, CA on Sun, Jun 28, 28 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 28 the direct buses cover the 132 km distance in an average of 1 h 5 m but if you time it right, some buses will get you there in just 1 h 5 m .
On Sun, Jun 28 the slowest buses will take 1 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus8:30 PM1h45Santa Ana, E Santa Ana Blvd (Train Station)10:15 PMSan Diego, West Harbor Drive (The Headquarters at Seaport District), CA$221One-way0 transfers
FlixBus8:30 PM1h15Santa Ana, E Santa Ana Blvd (Train Station)9:45 PMLa Jolla, UCSD Health La Jolla Station, CA$221One-way0 transfers
FlixBus12:10 PM2h00Irvine, UCI Crawford Hall (West Peltason Dr), CA2:10 PMSan Diego, Congress Street (Old Town Park), CA$221One-way0 transfers
FlixBus12:10 PM1h30Irvine, UCI Crawford Hall (West Peltason Dr), CA1:40 PMLa Jolla, UCSD Health La Jolla Station, CA$221One-way0 transfers
FlixBus2:35 PM1h20Santa Ana, E Santa Ana Blvd (Train Station)3:55 PMLa Jolla, UCSD Health La Jolla Station, CA$231One-way0 transfers
07:14 PM1h05Tustin, CA8:19 PMSan Diego, CA$471One-way0 transfers
09:14 PM1h05Tustin, CA10:19 PMSan Diego, CA$471One-way0 transfers
02:44 PM1h05Tustin, CA3:49 PMSan Diego, CA$471One-way0 transfers
06:29 AM1h05Tustin, CA7:34 AMSan Diego, CA$471One-way0 transfers
08:44 AM1h05Tustin, CA9:49 AMSan Diego, CA$471One-way0 transfers
Travel Information
Compare train and bus for Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA
Omio recommends booking the train as it is the most popular option from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA among Omio's users. If you are prioritising price take the bus with prices starting from $15. For those with little time consider booking a bus which can get you there in 1h 56m. The ticket price range depends on the travel mode: a bus costs an average of $15, and a train costs an average of $31.
Distance: 82 miles (132 km)
Compare bus with
| Bus | Most popular Train | Driving |
|---|---|---|
$24 Average price Cheapest | $32 Average price | $19 Average price (fuel + tolls) |
2h 26m Average total duration Fastest 1h 56m Onboard + 30m Additional time* | 2h 34m Average total duration 2h 4m Onboard + 30m Additional time* | 1h 24m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA:
A bus is $8 (€7) less than a train for this route with tickets for a train from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA costing on average $32 (€26).
Other travel options to Santa Fe Depot, San Diego, CA take longer:
Train takes on average 2h 4m.
You'll arrive about -1h -32m sooner (1h 56m by bus vs 1h 24m by car) and save roughly $-5.09 (€-4.20) compared to fuel and tolls ($24 (€20) vs $19 (€15)). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by Greyhound, FlixBus, Infobus.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:30AM | Arrival Time 04:45AM | Duration 1h15 | Departure days Fri, Sat | Cheapest price $25 |
Operator FlixBus | Departure Time 04:30AM | Arrival Time 05:45AM | Duration 1h15 | Departure days Fri, Sat | Cheapest price $22 |
Operator Infobus | Departure Time 06:24AM | Arrival Time 07:34AM | Duration 1h10 | Departure days Tue, Wed, Sun | Cheapest price $47 |
Operator Futura Net | Departure Time 06:24AM | Arrival Time 08:34AM | Duration 2h10 | Departure days Mon, Sat | Cheapest price $77 |
Operator Infobus | Departure Time 06:29AM | Arrival Time 08:04AM | Duration 1h35 | Departure days Tue, Wed, Sun | Cheapest price $47 |
Operator Futura Net | Departure Time 06:29AM | Arrival Time 08:34AM | Duration 2h05 | Departure days Mon, Sat | Cheapest price $50 |
Operator Amtrak | Departure Time 07:15AM | Arrival Time 09:20AM | Duration 2h05 | Departure days Sat | Cheapest price $32 |
Operator Infobus | Departure Time 08:39AM | Arrival Time 09:49AM | Duration 1h10 | Departure days Tue, Wed, Sun | Cheapest price $47 |
Operator Futura Net | Departure Time 08:39AM | Arrival Time 09:49AM | Duration 1h10 | Departure days Mon, Sat | Cheapest price $42 |
Operator Futura Net | Departure Time 08:44AM | Arrival Time 10:49AM | Duration 2h05 | Departure days Mon, Sat | Cheapest price $42 |
Operator Infobus | Departure Time 08:44AM | Arrival Time 10:19AM | Duration 1h35 | Departure days Tue, Wed, Sun | Cheapest price $47 |
Operator Greyhound | Departure Time 09:40AM | Arrival Time 11:45AM | Duration 2h05 | Departure days Mon, Tue, Wed, Sat, Sun | Cheapest price $31 |
Operator Greyhound | Departure Time 10:00AM | Arrival Time 11:45AM | Duration 1h45 | Departure days Mon, Tue, Wed, Sat, Sun | Cheapest price $31 |
Operator Infobus | Departure Time 10:39AM | Arrival Time 12:19PM | Duration 1h40 | Departure days Tue, Wed, Sun | Cheapest price $55 |
Operator Futura Net | Departure Time 10:39AM | Arrival Time 12:49PM | Duration 2h10 | Departure days Mon, Sat | Cheapest price $77 |
Operator Futura Net | Departure Time 10:44AM | Arrival Time 11:49AM | Duration 1h05 | Departure days Mon, Sat | Cheapest price $42 |
Operator Infobus | Departure Time 10:44AM | Arrival Time 12:19PM | Duration 1h35 | Departure days Tue, Wed, Sun | Cheapest price $55 |
Operator FlixBus | Departure Time 12:10PM | Arrival Time 02:10PM | Duration 2h00 | Departure days Mon, Sat, Sun | Cheapest price $22 |
Operator Infobus | Departure Time 12:39PM | Arrival Time 01:49PM | Duration 1h10 | Departure days Tue, Wed, Sun | Cheapest price $47 |
Operator Infobus | Departure Time 12:44PM | Arrival Time 02:49PM | Duration 2h05 | Departure days Tue, Wed, Sun | Cheapest price $47 |
Operator FlixBus | Departure Time 02:35PM | Arrival Time 04:25PM | Duration 1h50 | Departure days Mon, Tue, Wed, Sat, Sun | Cheapest price $18 |
Operator Futura Net | Departure Time 02:39PM | Arrival Time 04:19PM | Duration 1h40 | Departure days Mon, Sat | Cheapest price $50 |
Operator Infobus | Departure Time 02:39PM | Arrival Time 04:19PM | Duration 1h40 | Departure days Tue, Wed, Sun | Cheapest price $55 |
Operator Infobus | Departure Time 02:44PM | Arrival Time 04:19PM | Duration 1h35 | Departure days Tue, Wed, Sun | Cheapest price $47 |
Operator Futura Net | Departure Time 02:44PM | Arrival Time 04:49PM | Duration 2h05 | Departure days Mon, Sat | Cheapest price $42 |
Operator FlixBus | Departure Time 04:00PM | Arrival Time 05:50PM | Duration 1h50 | Departure days Mon, Tue, Sat, Sun | Cheapest price $23 |
Operator Futura Net | Departure Time 05:09PM | Arrival Time 06:19PM | Duration 1h10 | Departure days Mon, Sat | Cheapest price $42 |
Operator Infobus | Departure Time 05:09PM | Arrival Time 06:49PM | Duration 1h40 | Departure days Tue, Wed, Sun | Cheapest price $49 |
Operator Futura Net | Departure Time 05:14PM | Arrival Time 07:19PM | Duration 2h05 | Departure days Mon, Sat | Cheapest price $42 |
Operator Infobus | Departure Time 05:14PM | Arrival Time 06:19PM | Duration 1h05 | Departure days Tue, Wed, Sun | Cheapest price $47 |
Operator Infobus | Departure Time 07:09PM | Arrival Time 08:49PM | Duration 1h40 | Departure days Tue, Wed, Sun | Cheapest price $49 |
Operator Futura Net | Departure Time 07:09PM | Arrival Time 08:49PM | Duration 1h40 | Departure days Mon, Sat | Cheapest price $50 |
Operator FlixBus | Departure Time 07:10PM | Arrival Time 09:10PM | Duration 2h00 | Departure days Fri | Cheapest price $27 |
Operator Infobus | Departure Time 07:14PM | Arrival Time 09:19PM | Duration 2h05 | Departure days Tue, Wed, Sun | Cheapest price $47 |
Operator Futura Net | Departure Time 07:14PM | Arrival Time 09:19PM | Duration 2h05 | Departure days Mon, Sat | Cheapest price $50 |
Operator FlixBus | Departure Time 08:10PM | Arrival Time 09:40PM | Duration 1h30 | Departure days Thu | Cheapest price $20 |
Operator FlixBus | Departure Time 08:30PM | Arrival Time 10:15PM | Duration 1h45 | Departure days Mon, Tue, Wed, Sat, Sun | Cheapest price $18 |
Operator Futura Net | Departure Time 09:09PM | Arrival Time 11:19PM | Duration 2h10 | Departure days Mon, Sat | Cheapest price $50 |
Operator Infobus | Departure Time 09:09PM | Arrival Time 10:49PM | Duration 1h40 | Departure days Tue, Wed, Sun | Cheapest price $55 |
Operator Futura Net | Departure Time 09:14PM | Arrival Time 10:49PM | Duration 1h35 | Departure days Mon, Sat | Cheapest price $50 |
Operator Infobus | Departure Time 09:14PM | Arrival Time 11:19PM | Duration 2h05 | Departure days Tue, Wed, Sun | Cheapest price $47 |
Operator Greyhound | Departure Time 09:40PM | Arrival Time 11:50PM | Duration 2h10 | Departure days Mon, Tue, Wed, Sat, Sun | Cheapest price $29 |
Operator Greyhound | Departure Time 10:05PM | Arrival Time 11:50PM | Duration 1h45 | Departure days Mon, Tue, Wed, Sat, Sun | Cheapest price $29 |
Operator FlixBus | Departure Time 10:35PM | Arrival Time 12:25AM | Duration 1h50 | Departure days Fri | Cheapest price $23 |
Live departures
Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA bus times
The table below shows live departures for Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA buses for today, Saturday, June 27. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
0 | 10:39 AM Santa Ana, CA | 2h10 | 12:49 PM San Diego, CA | 0 transfersDirect | |
0 | 10:44 AM Tustin, CA | 1h05 | 11:49 AM San Diego, CA | 0 transfersDirect | |
FlixBus | 12:10 PM Irvine, UCI Crawford Hall (West Peltason Dr), CA | 1h30 | 1:40 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 12:10 PM Irvine, UCI Crawford Hall (West Peltason Dr), CA | 2h00 | 2:10 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
FlixBus | 2:35 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h20 | 3:55 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 2:35 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h50 | 4:25 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
FlixBus | 2:35 PM Santa Ana, E Santa Ana Blvd (Train Station) | 2h35 | 5:10 PM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
0 | 2:39 PM Santa Ana, CA | 1h40 | 4:19 PM San Diego, CA | 0 transfersDirect | |
0 | 2:44 PM Tustin, CA | 1h05 | 3:49 PM San Diego, CA | 0 transfersDirect | |
FlixBus | 4:00 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 1h25 | 5:25 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 4:00 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 1h50 | 5:50 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
FlixBus | 4:00 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 2h20 | 6:20 PM San Diego, Rail Ct / E San Ysidro Blvd (McDonald`s), CA | 0 transfersDirect | |
FlixBus | 4:00 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 2h20 | 6:20 PM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
0 | 5:09 PM Santa Ana, CA | 1h10 | 6:19 PM San Diego, CA | 0 transfersDirect | |
0 | 5:14 PM Tustin, CA | 1h05 | 6:19 PM San Diego, CA | 0 transfersDirect | |
0 | 7:09 PM Santa Ana, CA | 2h10 | 9:19 PM San Diego, CA | 0 transfersDirect | |
0 | 7:14 PM Tustin, CA | 1h35 | 8:49 PM San Diego, CA | 0 transfersDirect | |
FlixBus | 8:30 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h15 | 9:45 PM La Jolla, UCSD Health La Jolla Station, CA | 0 transfersDirect | |
FlixBus | 8:30 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h45 | 10:15 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 0 transfersDirect | |
FlixBus | 8:30 PM Santa Ana, E Santa Ana Blvd (Train Station) | 2h15 | 10:45 PM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
0 | 9:09 PM Santa Ana, CA | 1h40 | 10:49 PM San Diego, CA | 0 transfersDirect | |
0 | 9:14 PM Tustin, CA | 1h35 | 10:49 PM San Diego, CA | 0 transfersDirect | |
![]() | 9:40 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 2h10 | 11:50 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
![]() | 9:40 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 2h45 | 12:25 AM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
![]() | 10:05 PM Santa Ana, E Santa Ana Blvd (Train Station) | 1h45 | 11:50 PM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
![]() | 10:05 PM Santa Ana, E Santa Ana Blvd (Train Station) | 2h20 | 12:25 AM San Diego, San Ysidro Transit Center | 0 transfersDirect | |
| Sunday, June 28 | |||||
0 | 6:24 AM Santa Ana, CA | 1h40 | 8:04 AM San Diego, CA | 0 transfersDirect | |
0 | 6:29 AM Tustin, CA | 1h05 | 7:34 AM San Diego, CA | 0 transfersDirect | |
0 | 8:39 AM Santa Ana, CA | 1h10 | 9:49 AM San Diego, CA | 0 transfersDirect | |
0 | 8:44 AM Tustin, CA | 1h05 | 9:49 AM San Diego, CA | 0 transfersDirect | |
![]() | 9:40 AM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 2h05 | 11:45 AM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
![]() | 10:00 AM Santa Ana, E Santa Ana Blvd (Train Station) | 1h45 | 11:45 AM San Diego, Congress Street (Old Town Park), CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jun 27
Jun 28
Jun 29
Jun 30
Jul 01
Jul 02
Jul 03
Jul 04
Jul 05
Jul 06
Jul 07
Jul 08
Jul 09
Jul 10
Why should you book Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus or Infobus to find the best option for your trip from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA.
Why book with Omio over Wanderu, Trainline or Busbud?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus or Infobus to find the best option for your trip from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA.
Journey information
Overview: Bus from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA
Buses from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA run on average 19 times per day, taking around 1h 56m. Cheap bus tickets for this journey start at $15 (€12) if you book in advance.
There are 17 buses per day. The earliest bus runs at 02:14, the last at 22:35. The fastest bus covers the 82 miles (132 km) distance in 1h 5m.
Distance 82 miles (132 km) |
Average bus duration 1h 56m |
Cheapest ticket price $15 (€12) |
Buses per day 19 |
Direct buses 17 |
Fastest bus 1h 5m |
First bus 2:14 AM |
Last bus 10:35 PM |
Cheapest Month Nov |
Cheapest Day Mon |
High Season Jan - Mar |
Low Season Jul - Sep |
Busiest Day Thu |
Least Busy Day Mon |
Bus providers: Greyhound, FlixBus, Infobus from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CAYou can travel by bus between Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA with Greyhound, FlixBus, Infobus for as low as $15 (€12). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Infobus
Greyhound
FAQs: Bus from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA
Find answers to the most common questions about traveling from Santa Ana Station, Santa Ana, CA to Santa Fe Depot, San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Fe Depot, San Diego, CA, this guide helps you travel smarter and with confidence.

- Infobus
- Assistance
- Priority seating
- Transport for wheelchairs and mobility aids.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Infobus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Infobus
- One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Infobus
- 10€ per additional bag.
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- Infobus
- Small pets allowed in carriers
- larger pets may require a separate ticket.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.



