- Must visit
Virginia Museum of Transportation
Hands-on transportation museum focused on Roanoke's rail history, with locomotives, model trains, and exhibits inside a former freight station.
Buses from Syracuse, NY to Roanoke, VA run on average 1 times per day, taking around 16h 0m. Cheap bus tickets for this journey start at €68 if you book in advance.
The earliest bus runs at 04:35, the last at 17:15. The fastest bus covers the 446 miles (719 km) distance in 15h 24m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Syracuse, NY to Roanoke, VA.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 09:25AM | Arrival Time 10:55AM | Duration 25h30 | Departure days Sun | Cheapest price €95 |
Operator Greyhound | Departure Time 02:00PM | Arrival Time 11:59AM | Duration 21h59 | Departure days Thu | Cheapest price €89 |
Operator Greyhound | Departure Time 03:55PM | Arrival Time 11:59AM | Duration 20h04 | Departure days Sun | Cheapest price €109 |
Operator Greyhound | Departure Time 06:15PM | Arrival Time 11:59AM | Duration 17h44 | Departure days Fri | Cheapest price €94 |
Operator FlixBus | Departure Time 09:00PM | Arrival Time 05:10PM | Duration 20h10 | Departure days Sun | Cheapest price €105 |
Operator Greyhound | Departure Time 09:15PM | Arrival Time 04:05PM | Duration 18h50 | Departure days Mon | Cheapest price €89 |
Buses from Syracuse, NY to Roanoke, VA with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Roanoke, VA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Roanoke, VA trip today.
Hands-on transportation museum focused on Roanoke's rail history, with locomotives, model trains, and exhibits inside a former freight station.
Contemporary and historic art museum in a striking modern building downtown. Its galleries and sculpture spaces make it a leading cultural stop.
Regional history museum covering southwest Virginia through artifacts, photographs, and changing exhibits in downtown Roanoke.
Downtown open-air market district with historic buildings, local shops, and frequent events. It is the city's liveliest area for walking and people-watching.
Mountain park with scenic overlooks, trails, and access to the Roanoke Star. A top outdoor area for views, short hikes, and sunset visits.
Urban greenway following the Roanoke River through parks and downtown. It is ideal for walking, cycling, and seeing the city at a relaxed pace.
Slow-cured Virginia country ham is saltier and drier than typical ham, often served in biscuits. It reflects the curing traditions of Virginia smokehouses.
Brunswick stew is a regional Virginia staple made with slow-cooked chicken or pork, tomatoes, beans, and corn. It is a classic comfort food in western Virginia.
Fried apples are a Southern side of tart apples cooked with butter and spices until tender. They are common in Virginia home cooking and mountain restaurants.
Long-running neighborhood spot serving Texas-style barbecue, smoked meats, and classic Southern sides in a casual setting.
Popular downtown brewery and restaurant with house beers, hearty pub food, and a lively warehouse-style space near the market district.
Stylish farm-to-table restaurant in downtown Roanoke known for seasonal Southern dishes, craft cocktails, and an energetic modern atmosphere.
Moderate by U.S. standards. Hotels and dining are usually cheaper than major cities, while car travel is common and public transit is limited for tourists.
Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or coffee in cafes if service is good.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Roanoke, VA.
Find answers to the most common questions about traveling from Syracuse, NY to Roanoke, VA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Roanoke, VA, this guide helps you travel smarter and with confidence.

Most Syracuse, NY to Roanoke, VA buses use the Syracuse, Walsh Cir (Syracuse Bus Station) to Roanoke, Third Street Station station pair. Use this guide to compare Syracuse, NY and Roanoke, VA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Syracuse, Walsh Cir (Syracuse Bus Station) is 3 km from Syracuse city centre. Public transport options include:
Syracuse, Walsh Cir (Syracuse Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free Wi-Fi available throughout the station. ATMs are aTMs are located near the entrance.
Ticket office support is available at Syracuse, Walsh Cir (Syracuse Bus Station).
Available at Syracuse, Walsh Cir (Syracuse Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Syracuse, Walsh Cir (Syracuse Bus Station): The station is wheelchair accessible.
Roanoke, Third Street Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Roanoke, Third Street Station. ATMs are available at Roanoke, Third Street Station.
Ticket office support is available at Roanoke, Third Street Station.
Available at Roanoke, Third Street Station: Parking, Taxis, WC.
Accessibility facilities are available at Roanoke, Third Street Station: Station is wheelchair accessible.
Check bus stations information for Syracuse, NY and Roanoke, VA, including where buses depart and arrive on this route.