- Must visit
Museo Nacional del Prado
Spain’s premier art museum, famous for masterpieces by Velázquez, Goya, El Greco, Rubens, and Bosch. A core stop on Madrid’s Golden Triangle of Art.
Omio recommends booking the bus as it is the most popular option from Santutxu to Madrid among Omio's users. If you are prioritising price take the train with prices starting from $27. For those with little time consider booking a flight which can get you there in 1h 8m. The ticket price range depends on the travel mode: a train costs an average of $27, and a flight costs an average of $146.
Distance: 200 miles (322 km)
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$52 Average price | $50 Average price Cheapest | $241 Average price | $82 Average price (fuel + tolls) |
5h 5m Average total duration 4h 35m Onboard + 30m Additional time* | 5h 13m Average total duration 4h 43m Onboard + 30m Additional time* | 4h 8m Average total duration Fastest 1h 8m Onboard + 3h 0m Additional time* | 4h 11m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Santutxu to Madrid:
A train is $1 (€1) less than a bus for this route with tickets for a bus from Santutxu to Madrid costing on average $52 (€42).
A train is $191 (€154) less than a flight for this route with tickets for a flight from Santutxu to Madrid costing on average $241 (€194).
Other travel options to Madrid take longer:
Bus takes on average 4h 35m.
Train takes on average 4h 43m.
Tickets start at around $52 (€42) compared to roughly $82 (€66) in fuel and tolls — a saving of about $30 (€24). The journey takes 4h 35m versus 4h 11m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Alsa, BlaBlaCar.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator ALSA | Departure Time 01:00AM | Arrival Time 05:45AM | Duration 4h45 | Departure days Mon, Fri, Sat, Sun | Cheapest price $62 |
Operator ALSA | Departure Time 02:00AM | Arrival Time 06:15AM | Duration 4h15 | Departure days Mon, Fri, Sat, Sun | Cheapest price $62 |
Operator ALSA | Departure Time 07:00AM | Arrival Time 11:45AM | Duration 4h45 | Departure days Mon, Fri, Sat, Sun | Cheapest price $62 |
Operator ALSA | Departure Time 08:00AM | Arrival Time 12:45PM | Duration 4h45 | Departure days Mon, Fri, Sat, Sun | Cheapest price $62 |
Operator ALSA | Departure Time 09:00AM | Arrival Time 01:10PM | Duration 4h10 | Departure days Mon, Fri, Sat, Sun | Cheapest price $62 |
Operator ALSA | Departure Time 10:00AM | Arrival Time 02:40PM | Duration 4h40 | Departure days Fri, Sat, Sun | Cheapest price $62 |
Operator ALSA | Departure Time 11:00AM | Arrival Time 03:25PM | Duration 4h25 | Departure days Fri, Sat, Sun | Cheapest price $62 |
Operator Alsa | Departure Time 12:00PM | Arrival Time 04:40PM | Duration 4h40 | Departure days Thu, Fri, Sat, Sun | Cheapest price $54 |
Operator ALSA | Departure Time 01:00PM | Arrival Time 05:45PM | Duration 4h45 | Departure days Fri, Sun | Cheapest price $62 |
Operator ALSA | Departure Time 02:00PM | Arrival Time 06:50PM | Duration 4h50 | Departure days Fri, Sat, Sun | Cheapest price $62 |
Operator Alsa | Departure Time 03:00PM | Arrival Time 07:45PM | Duration 4h45 | Departure days Thu, Fri, Sat, Sun | Cheapest price $54 |
Operator ALSA | Departure Time 03:30PM | Arrival Time 08:15PM | Duration 4h45 | Departure days Fri, Sun | Cheapest price $62 |
Operator ALSA | Departure Time 04:00PM | Arrival Time 08:45PM | Duration 4h45 | Departure days Fri, Sat, Sun | Cheapest price $62 |
Operator Alsa | Departure Time 06:00PM | Arrival Time 10:30PM | Duration 4h30 | Departure days Wed, Fri, Sat, Sun | Cheapest price $47 |
Operator ALSA | Departure Time 08:30PM | Arrival Time 12:45AM | Duration 4h15 | Departure days Fri, Sat, Sun | Cheapest price $62 |
Operator ALSA | Departure Time 10:00PM | Arrival Time 02:45AM | Duration 4h45 | Departure days Fri, Sun | Cheapest price $62 |
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Santutxu to Madrid run on average 24 times per day, taking around 4h 35m. Cheap bus tickets for this journey start at $47 (€38) but you can travel from only $27 (€22) by train.
There are 21 buses per day. The earliest bus runs at 00:30, the last at 23:45. The fastest bus covers the 200 miles (322 km) distance in 4h 30m.
Distance 200 miles (322 km) |
Average bus duration 4h 35m |
Cheapest ticket price $47 (€38) |
Buses per day 24 |
Direct buses 21 |
Fastest bus 4h 30m |
First bus 12:30 AM |
Last bus 11:45 PM |
Cheapest Month Jan |
Cheapest Day Sat |
High Season Jan - Mar |
Low Season Jul - Sep |
Busiest Day Thu |
Least Busy Day Thu |
Best time to book 28 days |
Discover the best of Madrid — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Madrid trip today.
Spain’s premier art museum, famous for masterpieces by Velázquez, Goya, El Greco, Rubens, and Bosch. A core stop on Madrid’s Golden Triangle of Art.
Spain’s leading museum of modern and contemporary art, best known for Picasso’s Guernica alongside works by Dalí and Miró.
Major collection spanning medieval to modern art, with celebrated works by Caravaggio, Monet, Van Gogh, Hopper, and Kandinsky.
Madrid’s most famous park, ideal for strolling, rowing, people-watching, and seeing monuments such as the Crystal Palace.
The symbolic center of Madrid and Spain’s radial road network, always busy and central to city life and celebrations.
Madrid’s best-known boulevard, lined with landmark architecture, theaters, shops, and rooftop viewpoints popular with visitors.
Madrid’s classic chickpea stew, traditionally served in stages with broth, vegetables, chickpeas, and assorted meats. It is one of the city’s signature comfort dishes.
A famous Madrid sandwich of fried squid rings in crusty bread, especially associated with bars around Plaza Mayor. It is a simple local staple and iconic snack.
A rich Madrid-style tripe stew cooked with chorizo, morcilla, and paprika. It is a traditional cold-weather dish with deep roots in local tavern cuisine.
Historic restaurant founded in the 18th century, famous for roast suckling pig and other classic Castilian dishes in an old-world setting.
Well-known traditional restaurant celebrated for huevos rotos and classic Madrid dining. The atmosphere is polished but rooted in old tavern tradition.
Historic tavern especially known for cocido madrileño cooked in individual clay pots. A strong choice for an authentic, traditional meal.
Moderate for Western Europe: tapas and transit are reasonable, while central hotels and fine dining cost more.
Service is usually included. Locals often round up or leave EUR 1-2 at cafes; about 5-10% in restaurants for great service. Taxis are usually rounded up.
Official public transport app
Madrid, Estación Sur de Autobuses -> Puerta del Sol, Madrid
Find answers to the most common questions about traveling from Santutxu to Madrid by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Madrid, this guide helps you travel smarter and with confidence.

Here are some other resources that might have the information you need