Travel Information
Compare bus and flight for Santa Clara, CA to San Luis Obispo, CA
Omio recommends booking the flight as it is the most popular option from Santa Clara, CA to San Luis Obispo, CA among Omio's users. If you are prioritising price take the bus with prices starting from €59. For those with little time consider booking a bus which can get you there in 4h 18m. The ticket price range depends on the travel mode: a bus costs an average of €59, and a flight costs an average of €381.
Distance: 160 miles (258 km)
Compare bus with
| Bus | Most popular Flight |
|---|---|
€59 Average price Cheapest | €388 Average price |
4h 48m Average total duration Fastest 4h 18m Onboard + 30m Additional time* | 8h 13m Average total duration 5h 13m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Compare prices and tickets Santa Clara, CA to San Luis Obispo, CA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Santa Clara, CA to San Luis Obispo, CA
Buses from Santa Clara, CA to San Luis Obispo, CA run on average 3 times per day, taking around 4h 18m. Cheap bus tickets for this journey start at $72 (€59) if you book in advance.
The earliest bus runs at 00:30, the last at 16:10. The fastest bus covers the 160 miles (258 km) distance in 5h 3m.
Distance 160 miles (258 km) |
Average bus duration 4h 18m |
Cheapest ticket price $72 (€59) |
Buses per day 3 |
Fastest bus 5h 3m |
First bus 00:30 |
Last bus 16:10 |
FAQs: Bus from Santa Clara, CA to San Luis Obispo, CA
Find answers to the most common questions about traveling from Santa Clara, CA to San Luis Obispo, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Luis Obispo, CA, this guide helps you travel smarter and with confidence.

- Bubblegum Alley, a narrow alleyway famous for its walls covered in layers of chewed gum left by visitors
- Mission San Luis Obispo de Tolosa, a historic Spanish mission founded in 1772 with a museum and beautiful gardens
- Bishop Peak, a popular hiking destination offering panoramic views of the city and surrounding landscapes
- San Luis Obispo Museum of Art, a contemporary art museum showcasing works by regional and national artists
- Avila Beach, a nearby coastal spot known for its sandy shores and scenic pier.
- Stroll through Downtown SLO, a vibrant area with shops, restaurants, and the famous Thursday Night Farmers' Market
- Attend a performance at the Fremont Theater, a historic venue known for its art deco architecture and live events
- Visit the San Luis Obispo Children's Museum, offering interactive exhibits and activities for kids
- Explore the local wineries and vineyards, enjoying tastings and tours in the Edna Valley wine region
- Discover the natural beauty of Montana de Oro State Park, with its rugged cliffs, secluded beaches, and scenic hiking trails.
To find the cheapest bus tickets for your trip from Santa Clara, CA to San Luis Obispo, CA, follow these tips:
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