Travel Information
Compare bus, train, and flight for San Luis Obispo, CA to Santa Clara, CA
Omio recommends booking the bus as it is the most popular option from San Luis Obispo, CA to Santa Clara, CA among Omio's users. If you are prioritising price take the bus with prices starting from €58. For those with little time consider booking a bus which can get you there in 4h 8m. The ticket price range depends on the travel mode: a bus costs an average of €58, and a train costs an average of €90.
Distance: 160 miles (258 km)
Compare bus with
Most popular Bus | Train |
|---|---|
€58 Average price Cheapest | €90 Average price |
4h 38m Average total duration Fastest 4h 8m Onboard + 30m Additional time* | 12h 49m Average total duration 12h 19m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
San Luis Obispo, CA to Santa Clara, CA bus times
The table below shows live departures for San Luis Obispo, CA to Santa Clara, CA buses for today, Monday, November 24. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:15 PM San Luis Obispo, CA | 4h45 | 10:00 PM Santa Clara, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Luis Obispo, CA to Santa Clara, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from San Luis Obispo, CA to Santa Clara, CA
Buses from San Luis Obispo, CA to Santa Clara, CA run on average 7 times per day, taking around 4h 8m. Cheap bus tickets for this journey start at $71 (€58) if you book in advance.
The earliest bus runs at 00:30, the last at 14:48. The fastest bus covers the 160 miles (258 km) distance in 4h 45m.
Distance 160 miles (258 km) |
Average bus duration 4h 8m |
Cheapest ticket price $71 (€58) |
Buses per day 7 |
Fastest bus 4h 45m |
First bus 00:30 |
Last bus 14:48 |
Bus providers: Amtrak from San Luis Obispo, CA to Santa Clara, CAYou can travel by bus between San Luis Obispo, CA to Santa Clara, CA with Amtrak for as low as $71 (€58). When you search for schedules and tickets, Omio will show you the best journey
Amtrak
FAQs: Bus from San Luis Obispo, CA to Santa Clara, CA
Find answers to the most common questions about traveling from San Luis Obispo, CA to Santa Clara, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santa Clara, CA, this guide helps you travel smarter and with confidence.

To find the cheapest bus tickets for your trip from San Luis Obispo, CA to Santa Clara, CA, follow these tips:
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popular bus stations
Popular bus stations from San Luis Obispo, CA to Santa Clara, CA
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