- Must visit
Centro Botín
A modern art and cultural center with exhibitions and events in an iconic building on the seafront.
Cheapest price
$169
Average price
$169
Fastest journey
1 d 20 h 15 m
Average duration
1 d 20 h 15 m
Buses per day
1
Distance
1341 km
The best way to find a cheap bus ticket from Rome to Santander is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Rome to Santander will cost around $169 if you buy it on the day, but the cheapest tickets can be found for only $169.
It's difficult to get from Rome to Santander without transferring at least 3 times.
FlixBus · FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus · FlixBusOmio recommends booking the flight as it is the most popular option from Rome to Santander among Omio's users. If you are prioritising price take the bus with prices starting from $106. For those with little time consider booking a flight which can get you there in 3h 3m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 1.3 - 3.4kg. The ticket price range depends on the travel mode: a bus costs an average of $106, and a flight costs an average of $73.
Distance: 833 miles (1341 km)
| Bus | Most popular Flight | Driving |
|---|---|---|
$172 Average price Cheapest | $266 Average price | $565 Average price (fuel + tolls) |
38h 35m Average total duration 38h 5m Onboard + 30m Additional time* | 6h 3m Average total duration Fastest 3h 3m Onboard + 3h 0m Additional time* | 18h 0m Average total duration (door-to-door) |
1.3 - 3.4kg CO2 emissions Lowest | 4.0 - 8.0kg CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Rome to Santander:
A bus is $94 (€76) less than a flight for this route with tickets for a flight from Rome to Santander costing on average $266 (€215).
Other travel options to Santander take longer:
Bus takes on average 38h 5m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 11:05AM | Arrival Time 07:20AM | Duration 44h15 | Departure days Sun | Cheapest price $308 |
Operator FlixBus | Departure Time 12:05PM | Arrival Time 08:20AM | Duration 44h15 | Departure days Sun | Cheapest price $191 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 09:20AM | Duration 44h15 | Departure days Mon, Tue | Cheapest price $169 |
Operator FlixBus | Departure Time 03:25PM | Arrival Time 07:20AM | Duration 39h55 | Departure days Fri, Sat | Cheapest price $122 |
Operator FlixBus | Departure Time 04:25PM | Arrival Time 08:20AM | Duration 39h55 | Departure days Fri, Sat | Cheapest price $144 |
Operator FlixBus | Departure Time 05:25PM | Arrival Time 09:20AM | Duration 39h55 | Departure days Wed, Thu | Cheapest price $179 |
Operator FlixBus | Departure Time 06:00PM | Arrival Time 07:20AM | Duration 37h20 | Departure days Sun | Cheapest price $199 |
Operator FlixBus | Departure Time 06:35PM | Arrival Time 08:20AM | Duration 37h45 | Departure days Sat, Sun | Cheapest price $186 |
Operator FlixBus | Departure Time 07:00PM | Arrival Time 08:20AM | Duration 37h20 | Departure days Sat | Cheapest price $111 |
Operator FlixBus | Departure Time 07:55PM | Arrival Time 07:20AM | Duration 35h25 | Departure days Fri, Sat | Cheapest price $256 |
Operator FlixBus | Departure Time 08:55PM | Arrival Time 08:20AM | Duration 35h25 | Departure days Fri | Cheapest price $140 |
Operator FlixBus | Departure Time 09:55PM | Arrival Time 09:20AM | Duration 35h25 | Departure days Mon, Wed | Cheapest price $174 |
The table below shows live departures for Rome to Santander buses for today, Monday, May 18. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus · FlixBus | 1:05 PM Roma, Autostazione (Metro Anagnina) | 44h15 | 9:20 AM Santander, Estación de Autobuses | 3 transfers | |
FlixBus · FlixBus · FlixBus · FlixBus | 9:55 PM Roma, Autostazione Tiburtina | 35h25 | 9:20 AM Santander, Estación de Autobuses | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Rome to Santander run on average 2 times per day, taking around 38h 5m. Cheap bus tickets for this journey start at $106 (€86) but you can travel from only $73 (€59) by flight.
The earliest bus runs at 09:25, the last at 22:45. The fastest bus covers the 833 miles (1341 km) distance in 35h 15m.
Distance 833 miles (1341 km) |
Average bus duration 38h 5m |
Cheapest ticket price $106 (€86) |
Buses per day 2 |
Fastest bus 35h 15m |
First bus 9:25 AM |
Last bus 10:45 PM |
Cheapest Month Feb |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Sat |
Least Busy Day Sun |
Best time to book 56 days |
Discover the best of Santander — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Santander trip today.
A modern art and cultural center with exhibitions and events in an iconic building on the seafront.
A royal palace located on the Magdalena Peninsula with stunning views of the sea.
A modern architectural landmark that hosts cultural and artistic exhibitions.
One of Santander’s most famous beaches, ideal for sunbathing and water sports.
One of Santander’s most famous beaches, ideal for sunbathing and water sports.
A picturesque park offering hiking trails, beaches, and scenic views.
A hearty stew made with beans, cabbage, and assorted meats like pork ribs and blood sausage. It's a traditional dish from the Cantabria region, perfect for warming up on cold days.
Fried squid rings, often enjoyed as a tapa. Known for their tenderness and light, crispy coating, rabas are a staple in Santander.
A traditional butter cake from the Cantabrian Pas valley, known for its rich flavor and soft texture. Usually enjoyed as a dessert or snack.
Compared to other Spanish cities, Santander is moderately priced, with affordable accommodation and dining options.
Tipping is not mandatory, but rounding up or leaving small change in restaurants and cafes is appreciated.
Official public transport app
Aeropuerto+De+Santander, Santander -> Estacion+de+Autobuses+de+Santander, Santander
Find answers to the most common questions about traveling from Rome to Santander by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santander, this guide helps you travel smarter and with confidence.

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