Travel Information
Compare bus and flight for Rome to Santander
Omio recommends booking the flight as it is the most popular option from Rome to Santander among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $191 For those with little time, consider booking a flight, which has an average total journey time of 5h 31m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 1.3 - 3.4kg. Average ticket prices depend on the travel mode: a bus costs an average of $191, while a flight costs an average of $400.
Distance: 833 miles (1341 km)
Compare flight with
Most popular Flight | Bus | Driving |
|---|---|---|
$400 Average price | $191 Average price Cheapest | $553 Average price (fuel + tolls) |
5h 31m Average total duration Fastest 3h 31m Onboard + 2h 0m Additional time* | 31h 9m Average total duration 30h 39m Onboard + 30m Additional time* | 18h 0m Average total duration (door-to-door) |
4.0 - 8.0kg CO2 emissions | 1.3 - 3.4kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Rome to Santander:
A bus is $210 (€175) less than a flight for this route with tickets for a flight from Rome to Santander costing on average $400 (€335).
Other travel options to Santander take longer:
Bus takes on average 31h 9m.
You'll arrive about 14h 29m sooner (3h 31m by flight vs 18h 0m by car) and save roughly $153 (€128) compared to fuel and tolls ($400 (€335) vs $553 (€462)). You also avoid a long drive, giving you more time to relax or get on with your plans.
Driving is still worth considering if you want to stop along the way, are travelling with bulky luggage, or need a car at your destination.
Travel optionsfrom Rome to Santander
How to get from Rome to Santander by train, bus or flight.
Our recommendation
The best way to travel from Rome to Santander is by taking a flight because it’s the best combination of price and speed.
04143+
W460116:00 AM11h47Rome Leonardo da Vinci Fiumicino Airport5:47 PMSantander station$1391One-way1 transfer
Cheapest
04143+
W460116:00 AM11h47Rome Leonardo da Vinci Fiumicino Airport5:47 PMSantander station$1391One-way1 transfer
Fastest
IB648 · IB49312:00 PM5h00Rome Leonardo da Vinci Fiumicino Airport5:00 PMSantander Airport$7591One-way1 transfer
Other options
FlixBus · FlixBus · FlixBus5:25 PM39h55Roma, Autostazione (Metro Anagnina)9:20 AMSantander, Estación de Autobuses$1391One-way2 transfers
FlixBus · FlixBus · FlixBus7:35 PM37h45Roma, Autostazione Tiburtina9:20 AMSantander, Estación de Autobuses$1501One-way2 transfers
04193+
W460116:00 AM17h12Rome Leonardo da Vinci Fiumicino Airport11:12 PMSantander station$1391One-way1 transfer
VY6101 · VY15969:10 AM7h55Rome Leonardo da Vinci Fiumicino Airport5:05 PMSantander Airport$2401One-way1 transfer
UX1040+
0419310:30 AM12h42Rome Leonardo da Vinci Fiumicino Airport11:12 PMSantander station$2651One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Rome to Santander
Travel to Santander easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Rome to Santander.

This is compared to other travel options from Rome to Santander:
A bus is $210 (€175) less than a flight for this route with tickets for a flight from Rome to Santander costing on average $400 (€335).
Other travel options to Santander take longer:
Bus takes on average 31h 9m.
- Around 9 flights per day.
- Around 2 buses per day.
However, we recommend checking specific travel dates for your route between Rome and Santander as scheduled services by bus and flight can vary by season or day of the week.
- Flights mostly depart from Rome Leonardo da Vinci Fiumicino Airport and arrive in Santander Airport.
- Buses mostly depart from Roma, Autostazione (Metro Anagnina) and arrive in Santander, Estación de Autobuses.
- Travel with FlixBus to go to Santander by bus.
- Travel with Vueling, Malta Air, Iberia to go to Santander by flight.
- 0 direct flights per day with Malta Air.
Travelling from Rome to Santander: related information
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