- Must visit
Art Institute of Chicago
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
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The cheapest and fastest buses from Jefferson City, MO to Chicago, IL
Showing times, prices and bookable tickets for Sep 19
Cheapest price on Sep 19
฿72
Average ticket price on Sep 19
฿78
Fastest journey on Sep 19
10 h 20 m
Average journey duration on Sep 19
14 h 25 m
Buses on Sep 19
2
Distance
529 km
Cheap tickets
The best way to find a cheap bus ticket from Jefferson City, MO to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Jefferson City, MO to Chicago, IL will cost around ฿78 if you buy it on the day, but the cheapest tickets can be found for only ฿72.
Fast buses
It's difficult to get from Jefferson City, MO to Chicago, IL without transferring at least once.
FlixBus+
7:15 PM10h20Jefferson City, Eastland Dr (Greyhound Bus Station), MO5:35 AMChicago, Greyhound Bus Station฿721One-way1 transfer- · · 7:15 PM18h30Jefferson City, Eastland Dr (Greyhound Bus Station), MO1:45 PMChicago, Union Station (Amtrak), IL฿841One-way2 transfers
- FlixBus+7:15 PM10h20Jefferson City, Eastland Dr (Greyhound Bus Station), MO5:35 AMChicago, Greyhound Bus Station฿721One-way1 transfer
- · · 7:15 PM18h30Jefferson City, Eastland Dr (Greyhound Bus Station), MO1:45 PMChicago, Union Station (Amtrak), IL฿841One-way2 transfers
Travel Information
Compare train, bus, and flight for Jefferson City, MO to Chicago, IL
Omio recommends booking the train as it is the most popular option from Jefferson City, MO to Chicago, IL among Omio's users. If you are prioritising price, take the train, with an average ticket price of ฿77 For those with little time, consider booking a flight, which has an average total journey time of 6h 25m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.2 - 0.5kg. Average ticket prices depend on the travel mode: a train costs an average of ฿77, while a flight costs an average of ฿522.
Distance: 328 miles (529 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
฿85 Average price | ฿77 Average price Cheapest | ฿522 Average price | ฿65 Average price (fuel + tolls) |
11h 53m Average total duration 11h 23m Onboard + 30m Additional time* | 8h 22m Average total duration 7h 52m Onboard + 30m Additional time* | 6h 25m Average total duration Fastest 4h 25m Onboard + 2h 0m Additional time* | 6h 14m Average total duration (door-to-door) |
0.5 - 1.3kg CO2 emissions | 0.2 - 0.5kg CO2 emissions Lowest | - CO2 emissions | - CO2 emissions |
Most popular bus company |  Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
The cheapest way to travel from Jefferson City, MO to Chicago, IL is a train with an average price of ฿77.
This is compared to other travel options from Jefferson City, MO to Chicago, IL:
A train is ฿8 less than a bus for this route with tickets for a bus from Jefferson City, MO to Chicago, IL costing on average ฿85.
A train is ฿446 less than a flight for this route with tickets for a flight from Jefferson City, MO to Chicago, IL costing on average ฿522.
The fastest way to travel from Jefferson City, MO to Chicago, IL is by flight with an average journey time of 4h 25m.
Other travel options to Chicago, IL take longer:
Train takes on average 7h 52m.
Bus takes on average 11h 23m.
It's helpful to compare your options as there are 3 ways to travel between Jefferson City, MO and Chicago, IL including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from Jefferson City, MO to Chicago, IL among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around ฿85 compared to roughly ฿65 in fuel and tolls — a saving of about ฿-19.29. The journey takes 11h 23m versus 6h 14m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Jefferson City, MO to Chicago, IL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:15AM | Arrival Time 07:10PM | Duration 18h55 | Departure days Wed | Cheapest price ฿66 |
Operator FlixBus | Departure Time 12:15AM | Arrival Time 10:45AM | Duration 10h30 | Departure days Mon, Tue, Thu, Fri, Sat | Cheapest price ฿96 |
Operator FlixBus | Departure Time 01:15AM | Arrival Time 11:45AM | Duration 10h30 | Departure days Mon, Tue, Fri, Sat | Cheapest price ฿79 |
Operator Greyhound | Departure Time 01:15AM | Arrival Time 08:10PM | Duration 18h55 | Departure days Wed, Thu | Cheapest price ฿101 |
Operator FlixBus | Departure Time 07:15PM | Arrival Time 05:35AM | Duration 10h20 | Departure days Sat | Cheapest price ฿72 |
Operator Greyhound | Departure Time 07:15PM | Arrival Time 01:45PM | Duration 18h30 | Departure days Sat | Cheapest price ฿84 |
Compare prices and tickets Jefferson City, MO to Chicago, IL by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Jefferson City, MO to Chicago, IL buses with Omio?
Greyhound as well as FlixBus offer buses services from Jefferson City, MO to Chicago, IL.
Omio is an official ticket reseller for all your travel options from Jefferson City, MO to Chicago, IL.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Jefferson City, MO to Chicago, IL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Jefferson City, MO to Chicago, IL.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Jefferson City, MO to Chicago, IL.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Jefferson City, MO to Chicago, IL.
Journey information
Overview: Bus from Jefferson City, MO to Chicago, IL
USAUSA
Buses from Jefferson City, MO to Chicago, IL run on average 2 times per day, taking around 11h 23m. Cheap bus tickets for this journey start at ฿55 but you can travel from only ฿42 by train.
The earliest bus runs at 00:15, the last at 23:45. The fastest bus covers the 328 miles (529 km) distance in 9h 45m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from ฿42
Distance 328 miles (529 km) |
Average bus duration 11h 23m |
Cheapest ticket price ฿55 |
Buses per day 2 |
Fastest bus 9h 45m |
First bus 12:15 AM |
Last bus 11:45 PM |
Cheapest Month May |
Cheapest Day Mon |
High Season Jan - Mar |
Low Season Jul - Sep |
Busiest Day Sat |
Least Busy Day Sun |
Best time to book 1 day |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from ฿42
Complete guide to Chicago, IL
Things to do in Chicago, IL
Discover the best of Chicago, IL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago, IL trip today.
- Must visit
Field Museum
Major natural history museum with Sue the T. rex, ancient cultures, and strong family appeal.
- Must visit
Museum of Science and Industry
Hands-on science museum in a grand former fair building, popular for exhibits and a U-505 submarine.
- Must visit
Millennium Park
Lively lakefront park with Cloud Gate, Crown Fountain, gardens, and major public art in central Chicago.
- Must visit
Magnificent Mile
Famous shopping boulevard lined with architecture, hotels, riverfront views, and major city energy.
- Must visit
Chicago Riverwalk
Scenic pedestrian-friendly riverwalk with boat docks, public art, bridges, and standout skyline perspectives.
Deep-Dish Pizza
Deep-dish pizza is Chicago’s iconic pie with a tall buttery crust, layers of cheese and toppings, and chunky tomato sauce baked on top.
Chicago-Style Hot Dog
The Chicago-style hot dog is an all-beef frank on a poppy seed bun with mustard, relish, onion, tomato, pickle, peppers, and celery salt.
Italian Beef Sandwich
Italian beef is thin-sliced roast beef piled onto a roll, often dipped in savory juices and topped with sweet peppers or spicy giardiniera.
Johnnie's Beef
Classic spot for juicy Italian beef sandwiches, especially dipped and topped with spicy giardiniera, with a casual local feel.
Superdawg Drive-In
Legendary stand for Chicago-style hot dogs and char-grilled sausages, served fast in a no-frills local landmark.
Alinea
World-famous fine dining destination offering a highly creative tasting menu and refined service in an elegant setting.
US dollar ($)
Moderate for a major US city: hotels can be pricey, but transit is affordable and dining ranges from cheap eats to upscale options.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a restaurant meal.
- Fine dining
- $75+ per person for upscale restaurants.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and optional small change at cafes.
FAQs: Bus from Jefferson City, MO to Chicago, IL
Find answers to the most common questions about traveling from Jefferson City, MO to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Jefferson City, MO to Chicago, IL can start from as little as ฿55 when you book in advance. The average bus ticket price for Jefferson City, MO to Chicago, IL is ฿85 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Jefferson City, MO to Chicago, IL is 9h 45m to travel the 328 miles (529 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Jefferson City, MO to Chicago, IL leaves at 12:15 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Jefferson City, MO to Chicago, IL leaves at 11:45 PM.
When departing from Jefferson City, MO , you have various bus station options to start your journey from including Jefferson City, Eastland Dr (Greyhound Bus Station), MO . When arriving in Chicago, IL , you can end your journey in bus stations like Chicago, Greyhound Bus Station, Chicago, Union Station (Amtrak), IL, Chicago, 95th Red Line Station .Passengers board the bus most frequently from Jefferson City, Eastland Dr (Greyhound Bus Station), MO, which is located around 1 miles (3 km) away from the city centre, and they get off the bus at Chicago, Greyhound Bus Station, located 2 away from the city centre.
A trip to Chicago, IL from Jefferson City, MO is worth doing but not as a day trip with a journey time of 9h 45m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Jefferson City, MO to Chicago, IL is May.
It's helpful to compare your options as there are 3 ways to travel between Jefferson City, MO and Chicago, IL including taking a train, bus, and flight.
No, the bus from Jefferson City, MO to Chicago, IL has no accessibility options.
No, there are no bathrooms on board the bus from Jefferson City, MO to Chicago, IL.
Some of the most interesting sights to explore in Chicago, IL are:
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
The best things to do in Chicago, IL include:
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
No, bikes are not allowed on board the bus from Jefferson City, MO to Chicago, IL.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Jefferson City, MO to Chicago, IL.
No, luggage for the bus from Jefferson City, MO to Chicago, IL needs to be booked in addition.
No, there are no additional luggage options for the bus from Jefferson City, MO to Chicago, IL.
Unfortunately, pets are not allowed on the bus from Jefferson City, MO to Chicago, IL.
No, there are no USB plugs on board the bus from Jefferson City, MO to Chicago, IL.
No, there is no WiFi on board the bus from Jefferson City, MO to Chicago, IL.
Since neither Jefferson City, MO nor Chicago, IL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Jefferson City, MO to Chicago, IL among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Chicago, IL, travelers should be cautious of pickpocketing and purse snatching, especially in crowded areas like public transit and popular tourist spots. Common scams include fake charity solicitations and distraction thefts. It is advisable to stay alert in neighborhoods outside downtown after dark and use authorized transportation services to avoid unlicensed taxi scams. Keeping valuables secure and being aware of surroundings helps mitigate these risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Jefferson City, MO to Chicago, IL
Most Jefferson City, MO to Chicago, IL buses use the Jefferson City, Eastland Dr (Greyhound Bus Station) to Chicago, Greyhound Bus Station station pair, with some services arriving at Chicago, Union Station (Amtrak). Use this guide to compare Jefferson City, MO and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Jefferson City
Arrival bus stations in Chicago
Which Jefferson City, MO station do buses to Chicago, IL leave from?
Buses from Jefferson City, MO to Chicago, IL leave from Jefferson City, Eastland Dr (Greyhound Bus Station). The station is 2 miles (4 km) from Jefferson City, MO city centre at 701 Eastland Dr, Jefferson City, MO 65101, USA.
Jefferson City, Eastland Dr (Greyhound Bus Station)701 Eastland Dr, Jefferson City, MO 65101, USA
City-centre transport
Getting to Jefferson City, Eastland Dr (Greyhound Bus Station) from Jefferson City city centre
Jefferson City, Eastland Dr (Greyhound Bus Station) is 3 km from Jefferson City city centre. Public transport options include:
TRUE
Jefferson City, Eastland Dr (Greyhound Bus Station) bus station facilities and services
Jefferson City, Eastland Dr (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Jefferson City, Eastland Dr (Greyhound Bus Station). ATMs are available at Jefferson City, Eastland Dr (Greyhound Bus Station).
Tickets and information
Ticket office support is available at Jefferson City, Eastland Dr (Greyhound Bus Station).
Parking, taxis and toilets
Available at Jefferson City, Eastland Dr (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Jefferson City, Eastland Dr (Greyhound Bus Station): Wheelchair ramps are available.
Which Chicago, IL station do buses from Jefferson City, MO arrive at?
Buses from Jefferson City, MO to Chicago, IL most often arrive at Chicago, Greyhound Bus Station. Some services arrive at Chicago, Union Station (Amtrak), so check your ticket before travel to confirm your Chicago, IL arrival station.
Chicago, Greyhound Bus Station630 W Harrison St, Chicago, IL 60607, USA
City-centre transport
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Bus7 · 8m · ฿3 · every ~6 min
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Chicago, Union Station (Amtrak)Chicago Union Station, 225 S Canal St, Chicago, IL 60606, USA
City-centre transport
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Bus28, 151 · 7m · ฿3 · every ~13 min
Chicago, Union Station (Amtrak) bus station facilities and services
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options are available inside the station.
Wi-Fi and ATMs
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Tickets and information
Ticket office support is available at Chicago, Union Station (Amtrak).
Parking, taxis and toilets
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Chicago, 95th Red Line Station95th Red Line Station, Chicago, IL 60620, USA
City-centre transport
Getting to Chicago, 95th Red Line Station from Chicago city centre
Chicago, 95th Red Line Station is 14 km from Chicago city centre. Public transport options include:
BusGreyhound US0100 · 20m · ฿2
29 · 47m · ฿3 · every ~11 min
29 · 48m · ฿3 · every ~11 min
SubwayRed Line · 24m · ฿5 · every ~23 min
Red Line · 25m · ฿5 · every ~23 min
Chicago, 95th Red Line Station bus station facilities and services
Chicago, 95th Red Line Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Chicago, 95th Red Line Station. ATMs are available at Chicago, 95th Red Line Station.
Tickets and information
Ticket office support is available at Chicago, 95th Red Line Station.
Parking, taxis and toilets
Available at Chicago, 95th Red Line Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, 95th Red Line Station: Wheelchair accessible entrances available.
More options for your journey from Jefferson City, MO to Chicago, IL
Here are some other resources that might have the information you need
Most popular buses to and from Chicago, IL and Jefferson City, MO
Most popular bus connections to Chicago, IL
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