- Recommended
The Franklin G. Burroughs-Simeon B. Chapin Art Museum
Compact museum sharing regional military history through uniforms, weapons, artifacts, and exhibits on local veterans and conflicts.
The best way to find a cheap bus ticket from Harrisburg, PA to Myrtle Beach, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to Myrtle Beach, SC will cost around €131 if you buy it on the day, but the cheapest tickets can be found for only €131.
It's difficult to get from Harrisburg, PA to Myrtle Beach, SC without transferring at least 3 times.

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Buses from Harrisburg, PA to Myrtle Beach, SC run on average 2 times per day, taking around 18h 36m. Cheap bus tickets for this journey start at €62 if you book in advance.
The earliest bus runs at 12:45, the last at 13:55. The fastest bus covers the 467 miles (753 km) distance in 14h 45m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Harrisburg, PA to Myrtle Beach, SC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 12:30PM | Arrival Time 05:10PM | Duration 28h40 | Departure days Tue, Sat, Sun | Cheapest price €131 |
Operator Greyhound | Departure Time 05:30PM | Arrival Time 03:50PM | Duration 22h20 | Departure days Mon, Fri | Cheapest price €85 |
Operator Greyhound | Departure Time 06:50PM | Arrival Time 07:50PM | Duration 25h00 | Departure days Thu | Cheapest price €168 |
Operator Greyhound | Departure Time 07:50PM | Arrival Time 08:50PM | Duration 25h00 | Departure days Wed | Cheapest price €206 |
Operator Greyhound | Departure Time 11:30PM | Arrival Time 12:15AM | Duration 24h45 | Departure days Mon, Fri | Cheapest price €83 |
The table below shows live departures for Harrisburg, PA to Myrtle Beach, SC buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus+ · · | 5:30 PM Harrisburg, Market St (Bus Station), PA | 22h20 | 3:50 PM Myrtle Beach, N Oak St (Bus Station) | 4 transfers | |
+ FlixBus+ · | 11:30 PM Harrisburg, Market St (Bus Station), PA | 24h45 | 12:15 AM Myrtle Beach, N Oak St (Bus Station) | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Harrisburg, PA to Myrtle Beach, SC with Greyhound. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Myrtle Beach, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Myrtle Beach, SC trip today.
Compact museum sharing regional military history through uniforms, weapons, artifacts, and exhibits on local veterans and conflicts.
Beachfront art museum with rotating exhibitions, community programs, and regional works in a former oceanfront residence.
Hands-on science museum for families with interactive exhibits on space, physics, and natural science at Broadway at the Beach.
Popular entertainment district around a lake with wide walking paths, shops, attractions, and evening activity close to the beach.
Oceanfront district combining the boardwalk, beach access, entertainment, and public spaces for an easy first visit to the city.
Upscale shopping and walking area with landscaped streets, boutiques, lakefront paths, and seasonal events in a relaxed setting.
Lowcountry boil with shrimp, sausage, corn, and potatoes, seasoned and boiled together. A Carolina coast staple popular at beach gatherings and seafood feasts.
She-crab soup is a rich coastal soup made with crab meat, crab roe, cream, and sherry. It is a classic South Carolina specialty served along the Grand Strand.
Shrimp and grits pairs local shrimp with creamy grits, often with bacon or gravy. It is one of the most iconic dishes in South Carolina coastal cooking.
Casual local favorite for Southern breakfast and brunch, especially shrimp and grits, biscuits, and hearty comfort food.
Upscale seafood restaurant known for refined Lowcountry dishes, steaks, and a polished dining room near the ocean.
Lively, long-running waterfront spot on the MarshWalk serving fresh local seafood, sushi, and regional favorites in a casual setting.
Moderate for a US beach city: hotels rise in peak season, dining is mid-priced, and car-based travel adds parking and fuel costs.
Tip 18-20% at restaurants, more for excellent service. Taxis usually 10-15%. Small tips are optional at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Myrtle Beach, SC.
Find answers to the most common questions about traveling from Harrisburg, PA to Myrtle Beach, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Myrtle Beach, SC, this guide helps you travel smarter and with confidence.

Most Harrisburg, PA to Myrtle Beach, SC buses use the Harrisburg, Market St (Bus Station) to Myrtle Beach, N Oak St (Bus Station) station pair. Use this guide to compare Harrisburg, PA and Myrtle Beach, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Harrisburg, Market St (Bus Station) is 1 km from Harrisburg city centre. Public transport options include:
Harrisburg, Market St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free WiFi inside the station. ATMs are available at Harrisburg, Market St (Bus Station).
Ticket office support is available at Harrisburg, Market St (Bus Station).
Available at Harrisburg, Market St (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Harrisburg, Market St (Bus Station): Wheelchair accessible with ramps.
Myrtle Beach, N Oak St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Myrtle Beach, N Oak St (Bus Station). ATMs are available at Myrtle Beach, N Oak St (Bus Station).
Ticket office support is available at Myrtle Beach, N Oak St (Bus Station).
Available at Myrtle Beach, N Oak St (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Myrtle Beach, N Oak St (Bus Station): Wheelchair accessible entry available.
Check bus stations information for Harrisburg, PA and Myrtle Beach, SC, including where buses depart and arrive on this route.