The cheapest and fastest buses from Harrisburg, PA to Myrtle Beach, SC
Cheapest price
$134
Average price
$134
Fastest journey
22 h 20 m
Average duration
22 h 20 m
Buses per day
1
Distance
753 km
The best way to find a cheap bus ticket from Harrisburg, PA to Myrtle Beach, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to Myrtle Beach, SC will cost around $134 if you buy it on the day, but the cheapest tickets can be found for only $134.
It's difficult to get from Harrisburg, PA to Myrtle Beach, SC without transferring at least 4 times.
FlixBus · FlixBus+
· 5:30 PM22h20Harrisburg, Market St (Bus Station), PA3:50 PMMyrtle Beach, N Oak St (Bus Station)$1341One-way4 transfers
FlixBus · FlixBus+
· 5:30 PM22h20Harrisburg, Market St (Bus Station), PA3:50 PMMyrtle Beach, N Oak St (Bus Station)$1341One-way4 transfers
Travel Information
Compare bus for Harrisburg, PA to Myrtle Beach, SC
Omio recommends booking the bus as it is the most popular option from Harrisburg, PA to Myrtle Beach, SC among Omio's users. If you are prioritising price take the bus with prices starting from $205. For those with little time consider booking a bus which can get you there in 15h 41m. The ticket price range depends on the travel mode: a bus costs an average of $205, and a bus costs an average of $205.
Distance: 467 miles (753 km)
Compare bus with
Most popular Bus | Driving |
|---|---|
$231 Average price Cheapest | $107 Average price (fuel + tolls) |
16h 11m Average total duration Fastest 15h 41m Onboard + 30m Additional time* | 9h 1m Average total duration (door-to-door) |
![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Harrisburg, PA to Myrtle Beach, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 03:55PM | Arrival Time 03:50PM | Duration 23h55 | Departure days Thu | Cheapest price $144 |
Operator Greyhound | Departure Time 05:30PM | Arrival Time 03:50PM | Duration 22h20 | Departure days Mon, Tue, Wed, Fri, Sat, Sun | Cheapest price $120 |
Live departures
Harrisburg, PA to Myrtle Beach, SC bus times
The table below shows live departures for Harrisburg, PA to Myrtle Beach, SC buses for today, Friday, June 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus+ · | 5:30 PM Harrisburg, Market St (Bus Station), PA | 22h20 | 3:50 PM Myrtle Beach, N Oak St (Bus Station) | 4 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Harrisburg, PA to Myrtle Beach, SC by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jun 20
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Jun 26
Why should you book Harrisburg, PA to Myrtle Beach, SC buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Journey information
Overview: Bus from Harrisburg, PA to Myrtle Beach, SC
Buses from Harrisburg, PA to Myrtle Beach, SC run on average 1 times per day, taking around 15h 41m. Cheap bus tickets for this journey start at $205 (€168) if you book in advance.
The earliest bus runs at 12:45, the last at 13:55. The fastest bus covers the 467 miles (753 km) distance in 25h 0m.
Distance 467 miles (753 km) |
Average bus duration 15h 41m |
Cheapest ticket price $205 (€168) |
Buses per day 1 |
Fastest bus 25h 0m |
First bus 12:45 PM |
Last bus 1:55 PM |
Cheapest Month May |
Cheapest Day Thu |
High Season Jan - Mar |
Low Season Jul - Sep |
Bus providers: Greyhound from Harrisburg, PA to Myrtle Beach, SCYou can travel by bus between Harrisburg, PA to Myrtle Beach, SC with Greyhound for as low as $205 (€168). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Harrisburg, PA to Myrtle Beach, SC
Find answers to the most common questions about traveling from Harrisburg, PA to Myrtle Beach, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Myrtle Beach, SC, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Harrisburg, PA to Myrtle Beach, SC
Most popular bus connections from Harrisburg, PA
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