The cheapest and fastest buses from Durham, NC to Gainesville, FL
Cheapest price
$154
Average price
$154
Fastest journey
15 h 10 m
Average duration
15 h 10 m
Buses per day
1
Distance
774 km
The best way to find a cheap bus ticket from Durham, NC to Gainesville, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Durham, NC to Gainesville, FL will cost around $154 if you buy it on the day, but the cheapest tickets can be found for only $154.
Of the 1 buses that leave Durham, NC for Gainesville, FL on Sat, Mar 07, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Mar 07 the direct buses cover the 774 km distance in an average of 15 h 10 m but if you time it right, some buses will get you there in just 15 h 10 m .
On Sat, Mar 07 the slowest buses will take 15 h 10 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Live departures
Durham, NC to Gainesville, FL bus times
The table below shows live departures for Durham, NC to Gainesville, FL buses for tomorrow, Sunday, March 1. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 3:05 AM Durham, NC | 15h10 | 6:15 PM Gainesville, FL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Durham, NC to Gainesville, FL by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 01
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Mar 07
Journey information
Overview: Bus from Durham, NC to Gainesville, FL
Buses from Durham, NC to Gainesville, FL run on average 8 times per day, taking around 15h 10m. Cheap bus tickets for this journey start at $154 (€122) if you book in advance.
The earliest bus runs at 00:35, the last at 22:40. The fastest bus covers the 480 miles (774 km) distance in 15h 10m.
Distance 480 miles (774 km) |
Average bus duration 15h 10m |
Cheapest ticket price $154 (€122) |
Buses per day 8 |
Fastest bus 15h 10m |
First bus 00:35 |
Last bus 22:40 |
FAQs: Bus from Durham, NC to Gainesville, FL
Find answers to the most common questions about traveling from Durham, NC to Gainesville, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Gainesville, FL, this guide helps you travel smarter and with confidence.

- Florida Museum of Natural History, featuring extensive exhibits on Florida's flora, fauna, and cultural heritage
- Kanapaha Botanical Gardens, a 62-acre garden showcasing diverse plant collections and scenic landscapes
- Devil's Millhopper Geological State Park, a unique geological formation with a large sinkhole and nature trails
- Paynes Prairie Preserve State Park, offering wildlife viewing, hiking, and panoramic views of the prairie ecosystem
- Samuel P. Harn Museum of Art, housing a diverse collection of artworks from around the world.
- Explore the vibrant local art scene at the Gainesville Artwalk, featuring galleries and live performances
- Visit the Santa Fe College Teaching Zoo, home to a variety of animal species and educational programs
- Enjoy a day of outdoor activities at Lake Wauburg, offering boating, picnicking, and climbing walls
- Discover the historic Haile Homestead, known for its "Talking Walls" filled with writings from the 19th century
- Attend a performance at the Hippodrome Theatre, showcasing plays, films, and special events.
popular bus stations
Popular bus stations from Durham, NC to Gainesville, FL
Most popular bus connections from Durham, NC
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