- Must visit
Antonino Salinas Regional Archaeological Museum
Palermo’s top museum displays Sicilian archaeology, including the famous Punic Stone and Selinunte finds, in a former convent complex.





Cheapest price
$158
Average price
$177
Fastest journey
18h 5m
Average duration
20h 57m
Buses per day
5
Distance
691 km
Omio recommends booking the train as it is the most popular option from Ancona to Palermo among Omio's users. If you are prioritising price take the bus with prices starting from $43. For those with little time consider booking a train which can get you there in 16h 42m. The ticket price range depends on the travel mode: a bus costs an average of $43, and a train costs an average of $51.
Distance: 379 miles (610 km)
| Bus | Most popular Train | Driving |
|---|---|---|
$95 Average price Cheapest | $120 Average price | $131 Average price (fuel + tolls) |
19h 15m Average total duration 18h 45m Onboard + 30m Additional time* | 17h 12m Average total duration Fastest 16h 42m Onboard + 30m Additional time* | 11h 42m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Ancona to Palermo:
A bus is $24 (€20) less than a train for this route with tickets for a train from Ancona to Palermo costing on average $120 (€98).
Other travel options to Palermo take longer:
Train takes on average 16h 42m.
Bus takes on average 18h 45m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 09:15AM | Arrival Time 11:15AM | Duration 26h00 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $146 |
Operator FlixBus | Departure Time 02:45PM | Arrival Time 11:00AM | Duration 20h15 | Departure days Everyday | Cheapest price $128 |
Operator FlixBus | Departure Time 04:55PM | Arrival Time 03:15PM | Duration 22h20 | Departure days Everyday | Cheapest price $118 |
The table below shows live departures for Ancona to Palermo buses for today, Saturday, July 18. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 9:15 AM Ancona, Piazza Rosselli (Stazione Ferroviaria) | 25h45 | 11:00 AM Palermo, Via Tommaso Fazello (Terminal Bus) | 2 transfers | |
FlixBus · FlixBus · FlixBus | 2:45 PM Ancona, Via Guglielmo Marconi / SS681 | 20h15 | 11:00 AM Palermo, Via Tommaso Fazello (Terminal Bus) | 2 transfers | |
FlixBus · FlixBus | 4:55 PM Ancona, Via Guglielmo Marconi / SS681 | 18h05 | 11:00 AM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
FlixBus · FlixBus | 4:55 PM Ancona, Via Guglielmo Marconi / SS681 | 18h20 | 11:15 AM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
FlixBus · FlixBus | 4:55 PM Ancona, Via Guglielmo Marconi / SS681 | 22h20 | 3:15 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer |
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Ancona to Palermo run on average 2 times per day, taking around 18h 45m. Cheap bus tickets for this journey start at $43 (€35) if you book in advance.
The earliest bus runs at 04:21, the last at 21:10. The fastest bus covers the 379 miles (610 km) distance in 20h 5m.
Distance 379 miles (610 km) |
Average bus duration 18h 45m |
Cheapest ticket price $43 (€35) |
Buses per day 2 |
Fastest bus 20h 5m |
First bus 4:21 AM |
Last bus 9:10 PM |
Cheapest Month Mar |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jan - Mar |
Busiest Day Thu |
Least Busy Day Thu |
Best time to book 5 days |
Discover the best of Palermo — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Palermo trip today.
Palermo’s top museum displays Sicilian archaeology, including the famous Punic Stone and Selinunte finds, in a former convent complex.
Historic rooms and vivid majolica floors showcase aristocratic Palermo. Visit for decorative arts, period interiors and city history.
Housed in the grand Steri Palace, this museum presents the Sicilian Inquisition’s story through cells, graffiti and historical documents.
Palermo’s elegant main boulevard links major monuments, shops and theaters. Ideal for first walks and observing the city’s layered architecture.
This historic street cuts across the old center and hosts markets, churches and daily life. A lively route for exploring local Palermo.
A bustling old quarter famous for layered street life, churches and market culture. Best explored on foot for atmosphere and urban history.
Crisp fried rice ball stuffed with ragù, peas and caciocavallo. A Sicilian street food icon widely loved in Palermo.
Soft sesame-topped bun filled with spleen and lung, often with caciocavallo or ricotta. A classic Palermo street food with deep local roots.
Pasta with sardines, wild fennel, pine nuts and raisins. Its sweet-savory flavor reflects Palermo's Arab-Norman culinary heritage.
Refined Michelin-starred restaurant known for creative Sicilian tasting menus in an elegant, intimate setting.
Historic seafood restaurant near the port, praised for fresh catch, raw dishes and classic Palermo fish recipes.
Legendary no-frills street-food stop celebrated for pane con la milza and authentic local sandwiches loved by residents.
Moderate for Italy. Street food and local meals are affordable, while hotels in peak season cost more. Public transport is cheap, keeping overall tourist costs reasonable.
Service is often included or modest. Round up or leave 5-10% for great restaurant service. Taxis are usually rounded up. Small change is fine in cafes.
Find answers to the most common questions about traveling from Ancona to Palermo by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Palermo, this guide helps you travel smarter and with confidence.

Most Ancona to Palermo buses use the Ancona, Via Guglielmo Marconi / SS681 to Palermo, Via Tommaso Fazello (Terminal Bus) station pair. Use this guide to compare Ancona and Palermo bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need