Travel Information
Compare bus, train, and flight for Lyon to Palermo
Omio recommends booking the bus as it is the most popular option from Lyon to Palermo among Omio's users. If you are prioritising price, take the train, with an average ticket price of $140 For those with little time, consider booking a flight, which has an average total journey time of 6h 22m. Average ticket prices depend on the travel mode: a train costs an average of $140, while a flight costs an average of $369.
Distance: 684 miles (1102 km)
Compare bus with
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
$199 Average price | $369 Average price | $140 Average price Cheapest | $322 Average price (fuel + tolls) |
28h 36m Average total duration 28h 6m Onboard + 30m Additional time* | 6h 22m Average total duration Fastest 4h 22m Onboard + 2h 0m Additional time* | 24h 29m Average total duration 23h 59m Onboard + 30m Additional time* | 19h 26m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Lyon to Palermo:
A train is $58 (€48) less than a bus for this route with tickets for a bus from Lyon to Palermo costing on average $199 (€163).
A train is $228 (€188) less than a flight for this route with tickets for a flight from Lyon to Palermo costing on average $369 (€303).
Other travel options to Palermo take longer:
Train takes on average 24h 29m.
Bus takes on average 28h 36m.
You'll arrive about 15h 4m sooner (4h 22m by flight vs 19h 26m by car). Tickets start at around $369 (€303) compared to roughly $322 (€265) in fuel and tolls — a bit more, but you get time back and avoid a long drive.
Driving makes more sense if you're travelling as a group, want flexibility on timing, or plan to stop en route.
Travel optionsfrom Lyon to Palermo
How to get from Lyon to Palermo by train, bus or flight.
Our recommendation
The best way to travel from Lyon to Palermo is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus10:50 AM28h25Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)3:15 PMPalermo, Via Tommaso Fazello (Terminal Bus)$1131One-way1 transfer
Cheapest
FlixBus · FlixBus10:50 AM28h25Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)3:15 PMPalermo, Via Tommaso Fazello (Terminal Bus)$1131One-way1 transfer
Fastest
LH2249 · LH19161:00 PM4h20Lyon Saint Exupery Airport5:20 PMPalermo Airport$2081One-way1 transfer
Other options
FlixBus · FlixBus · FlixBus11:00 PM36h00Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)11:00 AMPalermo, Via Tommaso Fazello (Terminal Bus)$1281One-way2 transfers
FlixBus · FlixBus3:15 AM31h45Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)11:00 AMPalermo, Via Tommaso Fazello (Terminal Bus)$1281One-way1 transfer
VY1223 · VY660011:00 PM14h30Lyon Saint Exupery Airport1:30 PMPalermo Airport$1341One-way1 transfer
FR 5840+
44217:15 PM5h50Lyon Saint Exupery Airport1:05 AMPalermo Airport$1951One-way1 transfer
FR 5840+
U244217:15 PM5h50Lyon Saint Exupery Airport1:05 AMPalermo Airport$1951One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Lyon to Palermo
Travel to Palermo easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Lyon to Palermo.

This is compared to other travel options from Lyon to Palermo:
A train is $58 (€48) less than a bus for this route with tickets for a bus from Lyon to Palermo costing on average $199 (€163).
A train is $228 (€188) less than a flight for this route with tickets for a flight from Lyon to Palermo costing on average $369 (€303).
Other travel options to Palermo take longer:
Train takes on average 24h 29m.
Bus takes on average 28h 36m.
- Around 58 flights per day.
- Around 5 trains per day.
- Around 3 buses per day.
However, we recommend checking specific travel dates for your route between Lyon and Palermo as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Lyon Saint Exupery Airport and arrive in Palermo Airport.
- Buses mostly depart from Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) and arrive in Palermo, Via Tommaso Fazello (Terminal Bus).
- Trains mostly depart from Lyon Part Dieu and arrive in Palermo Centrale.
- Travel with FlixBus to go to Palermo by bus.
- Travel with Lufthansa Cityline, KLM Cityhopper, CitizenPlane, Swiss, Transavia France, Brussels Airlines, Lufthansa City Airlines, KLM, Air France, Air Dolomiti, Austrian Airlines, Lufthansa, Vueling, Air Baltic, Helvetic Airways, Volotea, Malta Air, ITA, British Airways, Edelweiss Air, easyJet to go to Palermo by flight.
- Travel with Intercity, Intercity Notte to go to Palermo by train.
- 1 direct flights per day with Transavia France, Volotea, easyJet.
Travelling from Lyon to Palermo: related information
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