Travel Information
Compare bus and flight for Santander to Rome
Omio recommends booking the flight as it is the most popular option from Santander to Rome among Omio's users. If you are prioritising price take the bus with prices starting from $98. For those with little time consider booking a flight which can get you there in 2h 50m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 1.3 - 3.4kg. The ticket price range depends on the travel mode: a bus costs an average of $98, and a flight costs an average of $71.
Distance: 833 miles (1341 km)
Compare flight with
Most popular Flight | Bus | Driving |
|---|---|---|
$288 Average price | $199 Average price Cheapest | $364 Average price (fuel + tolls) |
5h 50m Average total duration Fastest 2h 50m Onboard + 3h 0m Additional time* | 34h 25m Average total duration 33h 55m Onboard + 30m Additional time* | 17h 58m Average total duration (door-to-door) |
4.0 - 8.0kg CO2 emissions | 1.3 - 3.4kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Santander to Rome:
A bus is $89 (€72) less than a flight for this route with tickets for a flight from Santander to Rome costing on average $288 (€232).
Other travel options to Rome take longer:
Bus takes on average 33h 55m.
Travel optionsfrom Santander to Rome
How to get from Santander to Rome by train, bus or flight.
Our recommendation
The best way to travel from Santander to Rome is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus · FlixBus6:50 PM41h25Santander, Estación de Autobuses12:15 PMRoma, Autostazione (Metro Anagnina)$1971One-way2 transfers
Cheapest
FlixBus · FlixBus · FlixBus6:50 PM41h25Santander, Estación de Autobuses12:15 PMRoma, Autostazione (Metro Anagnina)$1971One-way2 transfers
Fastest
FlixBus · FlixBus · FlixBus6:50 PM39h10Santander, Estación de Autobuses10:00 AMRoma, Autostazione Tiburtina$2011One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Santander to Rome
Travel to Rome easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Santander to Rome.

This is compared to other travel options from Santander to Rome:
A bus is $89 (€72) less than a flight for this route with tickets for a flight from Santander to Rome costing on average $288 (€232).
Other travel options to Rome take longer:
Bus takes on average 33h 55m.
- Around 12 flights per day.
- Around 2 buses per day.
However, we recommend checking specific travel dates for your route between Santander and Rome as scheduled services by bus and flight can vary by season or day of the week.
- Buses mostly depart from Santander, Estación de Autobuses and arrive in Roma, Autostazione Tiburtina.
- Flights mostly depart from Santander Airport and arrive in Rome Leonardo da Vinci Fiumicino Airport.
- Travel with FlixBus to go to Rome by bus.
- Travel with Vueling, Malta Air, Ryanair, Iberia to go to Rome by flight.
- 0 direct flights per day with Malta Air.
Travelling from Santander to Rome: related information
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