Travel Information
Compare bus and flight for Santander to Rome
Omio recommends booking the flight as it is the most popular option from Santander to Rome among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €194 For those with little time, consider booking a flight, which has an average total journey time of 5h 24m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 1.3 - 3.4kg. Average ticket prices depend on the travel mode: a bus costs an average of €194, while a flight costs an average of €247.
Distance: 833 miles (1341 km)
Compare flight with
Most popular Flight | Bus | Driving |
|---|---|---|
€247 Average price | €194 Average price Cheapest | €296 Average price (fuel + tolls) |
5h 24m Average total duration Fastest 3h 24m Onboard + 2h 0m Additional time* | 33h 32m Average total duration 33h 2m Onboard + 30m Additional time* | 17h 58m Average total duration (door-to-door) |
4.0 - 8.0kg CO2 emissions | 1.3 - 3.4kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Santander to Rome:
A bus is €53 less than a flight for this route with tickets for a flight from Santander to Rome costing on average €247.
Other travel options to Rome take longer:
Bus takes on average 33h 32m.
You'll arrive about 14h 34m sooner (3h 24m by flight vs 17h 58m by car) and save roughly €50 compared to fuel and tolls (€247 vs €296). You also avoid a long drive, giving you more time to relax or get on with your plans.
Driving is still worth considering if you want to stop along the way, are travelling with bulky luggage, or need a car at your destination.
Travel optionsfrom Santander to Rome
How to get from Santander to Rome by train, bus or flight.
Our recommendation
The best way to travel from Santander to Rome is by taking a bus because it’s the best combination of price and speed.
4:50 PM35h15Santander4:05 AMRome€1591One-way0 transfers
Cheapest
4:50 PM35h15Santander4:05 AMRome€1591One-way0 transfers
Fastest
4:50 PM35h15Santander4:05 AMRome€1591One-way0 transfers
Other options
8:25 AM68h40Santander5:05 AMRome€2011One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Oct 13
Oct 14
Oct 15
Oct 16
Oct 17
Oct 18
Oct 19
More than 1,000 travel companies trust us to sell their tickets all in one place.
FAQs: Travel from Santander to Rome
Travel to Rome easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Santander to Rome.

This is compared to other travel options from Santander to Rome:
A bus is €53 less than a flight for this route with tickets for a flight from Santander to Rome costing on average €247.
Other travel options to Rome take longer:
Bus takes on average 33h 32m.
- Around 12 flights per day.
- Around 2 buses per day.
However, we recommend checking specific travel dates for your route between Santander and Rome as scheduled services by bus and flight can vary by season or day of the week.
- Flights mostly depart from Santander Airport and arrive in Rome Leonardo da Vinci Fiumicino Airport.
- Buses mostly depart from Santander, Estación de Autobuses and arrive in Roma, Autostazione Tiburtina.
- Travel with Vueling, Malta Air, Iberia to go to Rome by flight.
- Travel with FlixBus to go to Rome by bus.
- 0 direct flights per day with Malta Air.
Travelling from Santander to Rome: related information
Here are some other resources that might have the information you need

