Travel Information
Compare bus and flight for Frankfurt am Main to Santander
Omio recommends booking the bus as it is the most popular option from Frankfurt am Main to Santander among Omio's users. If you are prioritising price take the bus with prices starting from $57. For those with little time consider booking a flight which can get you there in 4h 0m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 1.2 - 3.0kg. The ticket price range depends on the travel mode: a bus costs an average of $57, and a flight costs an average of $150.
Distance: 746 miles (1202 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
$121 Average price Cheapest | $526 Average price | $493 Average price (fuel + tolls) |
22h 10m Average total duration 21h 40m Onboard + 30m Additional time* | 7h 0m Average total duration Fastest 4h 0m Onboard + 3h 0m Additional time* | 16h 12m Average total duration (door-to-door) |
1.2 - 3.0kg CO2 emissions Lowest | 3.6 - 7.2kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Frankfurt am Main to Santander:
A bus is $405 (€328) less than a flight for this route with tickets for a flight from Frankfurt am Main to Santander costing on average $526 (€425).
Other travel options to Santander take longer:
Bus takes on average 21h 40m.
Travel optionsfrom Frankfurt am Main to Santander
How to get from Frankfurt am Main to Santander by train, bus or flight.
Our recommendation
The best way to travel from Frankfurt am Main to Santander is by taking a bus because it’s the best combination of price and speed.
6:30 AM25h50Frankfurt am Main8:20 AMSantander$861One-way0 transfers
Cheapest
6:30 AM25h50Frankfurt am Main8:20 AMSantander$861One-way0 transfers
Fastest
6:30 AM25h50Frankfurt am Main8:20 AMSantander$861One-way0 transfers
Other options
4:45 AM27h35Frankfurt am Main8:20 AMSantander$1311One-way0 transfers
5:30 AM25h50Frankfurt am Main7:20 AMSantander$1531One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Frankfurt am Main to Santander
Travel to Santander easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Frankfurt am Main to Santander.

This is compared to other travel options from Frankfurt am Main to Santander:
A bus is $405 (€328) less than a flight for this route with tickets for a flight from Frankfurt am Main to Santander costing on average $526 (€425).
Other travel options to Santander take longer:
Bus takes on average 21h 40m.
- Around 3 flights per day.
- Around 3 buses per day.
- Around 1 trains per day.
However, we recommend checking specific travel dates for your route between Frankfurt am Main and Santander as scheduled services by bus and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Santander Airport.
- Buses mostly depart from Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) and arrive in Santander, Estación de Autobuses.
- Travel with Iberia, Air Nostrum to go to Santander by flight.
- Travel with FlixBus to go to Santander by bus.
Travelling from Frankfurt am Main to Santander: related information
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