Travel Information
Compare bus and flight for Frankfurt am Main to Santander
Omio recommends booking the flight as it is the most popular option from Frankfurt am Main to Santander among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $132 For those with little time, consider booking a flight, which has an average total journey time of 6h 0m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 1.2 - 3.0kg. Average ticket prices depend on the travel mode: a bus costs an average of $132, while a flight costs an average of $380.
Distance: 746 miles (1202 km)
Compare flight with
Most popular Flight | Bus | Driving |
|---|---|---|
$380 Average price | $132 Average price Cheapest | $495 Average price (fuel + tolls) |
6h 0m Average total duration Fastest 4h 0m Onboard + 2h 0m Additional time* | 22h 10m Average total duration 21h 40m Onboard + 30m Additional time* | 16h 12m Average total duration (door-to-door) |
3.6 - 7.2kg CO2 emissions | 1.2 - 3.0kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Frankfurt am Main to Santander:
A bus is $248 (€201) less than a flight for this route with tickets for a flight from Frankfurt am Main to Santander costing on average $380 (€308).
Other travel options to Santander take longer:
Bus takes on average 22h 10m.
You'll arrive about 12h 12m sooner (4h 0m by flight vs 16h 12m by car) and save roughly $115 (€93) compared to fuel and tolls ($380 (€308) vs $495 (€401)). You also avoid a long drive, giving you more time to relax or get on with your plans.
Driving is still worth considering if you want to stop along the way, are travelling with bulky luggage, or need a car at your destination.
Travel optionsfrom Frankfurt am Main to Santander
How to get from Frankfurt am Main to Santander by train, bus or flight.
Our recommendation
The best way to travel from Frankfurt am Main to Santander is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus · FlixBus8:15 AM25h05Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)9:20 AMSantander, Estación de Autobuses$1151One-way2 transfers
Cheapest
FlixBus · FlixBus · FlixBus8:15 AM25h05Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)9:20 AMSantander, Estación de Autobuses$1151One-way2 transfers
Fastest
FlixBus · FlixBus · FlixBus8:15 AM25h05Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)9:20 AMSantander, Estación de Autobuses$1151One-way2 transfers
Other options
FlixBus · FlixBus · FlixBus6:35 AM26h45Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)9:20 AMSantander, Estación de Autobuses$1291One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sep 03
Sep 04
Sep 05
Sep 06
Sep 07
Sep 08
Sep 09
More than 1,000 travel companies trust us to sell their tickets all in one place.
FAQs: Travel from Frankfurt am Main to Santander
Travel to Santander easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Frankfurt am Main to Santander.

This is compared to other travel options from Frankfurt am Main to Santander:
A bus is $248 (€201) less than a flight for this route with tickets for a flight from Frankfurt am Main to Santander costing on average $380 (€308).
Other travel options to Santander take longer:
Bus takes on average 22h 10m.
- Around 3 buses per day.
- Around 3 flights per day.
- Around 1 trains per day.
However, we recommend checking specific travel dates for your route between Frankfurt am Main and Santander as scheduled services by bus and flight can vary by season or day of the week.
- Buses mostly depart from Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) and arrive in Santander, Estación de Autobuses.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Santander Airport.
- Travel with Iberia to go to Santander by flight.
- Travel with FlixBus to go to Santander by bus.
Travelling from Frankfurt am Main to Santander: related information
Here are some other resources that might have the information you need

