Travel Information
Compare bus and flight for Frankfurt am Main to Santander
Omio recommends booking the flight as it is the most popular option from Frankfurt am Main to Santander among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $170 For those with little time, consider booking a flight, which has an average total journey time of 6h 0m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 1.2 - 3.0kg. Average ticket prices depend on the travel mode: a bus costs an average of $170, while a flight costs an average of $619.
Distance: 746 miles (1202 km)
Compare flight with
Most popular Flight | Bus | Driving |
|---|---|---|
$619 Average price | $170 Average price Cheapest | $481 Average price (fuel + tolls) |
6h 0m Average total duration Fastest 4h 0m Onboard + 2h 0m Additional time* | 25h 34m Average total duration 25h 4m Onboard + 30m Additional time* | 16h 12m Average total duration (door-to-door) |
3.6 - 7.2kg CO2 emissions | 1.2 - 3.0kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Frankfurt am Main to Santander:
A bus is $449 (€376) less than a flight for this route with tickets for a flight from Frankfurt am Main to Santander costing on average $619 (€517).
Other travel options to Santander take longer:
Bus takes on average 25h 34m.
You'll arrive about 12h 12m sooner (4h 0m by flight vs 16h 12m by car). Tickets start at around $619 (€517) compared to roughly $481 (€402) in fuel and tolls — a bit more, but you get time back and avoid a long drive.
Driving makes more sense if you're travelling as a group, want flexibility on timing, or plan to stop en route.
Travel optionsfrom Frankfurt am Main to Santander
How to get from Frankfurt am Main to Santander by train, bus or flight.
Our recommendation
The best way to travel from Frankfurt am Main to Santander is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus · FlixBus8:15 AM25h05Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)9:20 AMSantander, Estación de Autobuses$1701One-way2 transfers
Cheapest
FlixBus · FlixBus · FlixBus8:15 AM25h05Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof)9:20 AMSantander, Estación de Autobuses$1701One-way2 transfers
Fastest
IB1328 · IB49312:10 PM4h50Frankfurt am Main Airport5:00 PMSantander Airport$7771One-way1 transfer
Other options
FlixBus · FlixBus · FlixBus11:05 PM34h15Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)9:20 AMSantander, Estación de Autobuses$1701One-way2 transfers
FlixBus · FlixBus · FlixBus6:35 AM26h45Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36)9:20 AMSantander, Estación de Autobuses$1881One-way2 transfers
IB1328 · IB106512:10 PM9h40Frankfurt am Main Airport9:50 PMSantander Airport$3881One-way1 transfer
KL1818 · KL1505+
0419311:45 AM11h27Frankfurt am Main Airport11:12 PMSantander station$3981One-way2 transfers
KL1816 · KL1505+
0419310:15 AM12h57Frankfurt am Main Airport11:12 PMSantander station$3981One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Frankfurt am Main to Santander
Travel to Santander easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Frankfurt am Main to Santander.

This is compared to other travel options from Frankfurt am Main to Santander:
A bus is $527 (€440) less than a flight for this route with tickets for a flight from Frankfurt am Main to Santander costing on average $664 (€555).
Other travel options to Santander take longer:
Bus takes on average 25h 7m.
- Around 4 flights per day.
- Around 2 buses per day.
However, we recommend checking specific travel dates for your route between Frankfurt am Main and Santander as scheduled services by bus and flight can vary by season or day of the week.
- Buses mostly depart from Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) and arrive in Santander, Estación de Autobuses.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Santander Airport.
- Travel with Iberia to go to Santander by flight.
- Travel with FlixBus, BlaBlaCar Bus to go to Santander by bus.
Travelling from Frankfurt am Main to Santander: related information
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