Travel Information
Compare train, bus, and flight for Heilbronn to Prague
Omio recommends booking the bus as it is the most popular option from Heilbronn to Prague among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $49 For those with little time, consider booking a flight, which has an average total journey time of 4h 47m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.4kg. Average ticket prices depend on the travel mode: a bus costs an average of $49, while a flight costs an average of $485.
Distance: 241 miles (389 km)
Compare bus with
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$49 Average price Cheapest | $158 Average price | $485 Average price | $97 Average price (fuel + tolls) |
7h 0m Average total duration 6h 30m Onboard + 30m Additional time* | 7h 46m Average total duration 7h 16m Onboard + 30m Additional time* | 4h 47m Average total duration Fastest 2h 47m Onboard + 2h 0m Additional time* | 4h 58m Average total duration (door-to-door) |
0.4 - 1.0kg CO2 emissions | 0.1 - 0.4kg CO2 emissions Lowest | 1.2 - 2.3kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Heilbronn to Prague
Compare the available ways to get from Heilbronn to Prague, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Heilbronn to Prague:
A bus is $109 less than a train for this route with tickets for a train from Heilbronn to Prague costing on average $158.
A bus is $436 less than a flight for this route with tickets for a flight from Heilbronn to Prague costing on average $485.
Other travel options to Prague take longer:
Bus takes on average 7h 0m.
Train takes on average 7h 46m.
Tickets start at around $49 compared to roughly $97 in fuel and tolls — a saving of about $48. The journey takes 6h 30m versus 4h 58m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Travel optionsfrom Heilbronn to Prague
How to get from Heilbronn to Prague by train, bus or flight.
Our recommendation
The best way to travel from Heilbronn to Prague is by taking a bus because it’s the best combination of price and speed.
FlixBus3:30 PM 6h20 Heilbronn, Hbf (Central station) 9:50 PM Praha, ÚAN Florenc $50 1 One-way 0 transfers
Cheapest
FlixBus3:30 PM 6h20 Heilbronn, Hbf (Central station) 9:50 PM Praha, ÚAN Florenc $50 1 One-way 0 transfers
Fastest
DE44118:10 PM 1h00 Frankfurt am Main Airport 9:10 PM Prague Vaclav Havel Airport $286 1 One-way 0 transfers
Other options
19072 · ICE 589 · 3577+
3632:48 PM 7h34 Heilbronn Hbf 10:22 PM Prague hlavní nádraží $88 1 One-way 3 transfers
19066 · ICE 27 · 5289 · IC 56311:48 AM 7h33 Heilbronn Hbf 7:21 PM Prague hlavní nádraží $89 1 One-way 3 transfers
19068 · ICE 587 · 3573 · Bus RE2512:48 PM 7h33 Heilbronn Hbf 8:21 PM Prague hlavní nádraží $101 1 One-way 4 transfers
FlixBus · FlixBus3:30 PM 7h25 Heilbronn, Hbf (Central station) 10:55 PM Praha, Na Knížecí $62 1 One-way 1 transfer
FlixBus · FlixBus1:25 AM 7h30 Heilbronn, Hbf (Central station) 8:55 AM Praha, Na Knížecí $71 1 One-way 1 transfer
FlixBus8:55 AM 6h30 Heilbronn, Hbf (Central station) 3:25 PM Praha, ÚAN Florenc $78 1 One-way 0 transfers
LO382 · LO52110:35 AM 6h40 Frankfurt am Main Airport 5:15 PM Prague Vaclav Havel Airport $241 1 One-way 1 transfer
LO380 · LO5217:55 PM 21h20 Frankfurt am Main Airport 5:15 PM Prague Vaclav Havel Airport $241 1 One-way 1 transfer
LH139612:55 PM 1h05 Frankfurt am Main Airport 2:00 PM Prague Vaclav Havel Airport $252 1 One-way 0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Heilbronn to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Heilbronn to Prague.

This is compared to other travel options from Heilbronn to Prague:
A bus is $109 less than a train for this route with tickets for a train from Heilbronn to Prague costing on average $158.
A bus is $436 less than a flight for this route with tickets for a flight from Heilbronn to Prague costing on average $485.
Other travel options to Prague take longer:
Bus takes on average 7h 0m.
Train takes on average 7h 46m.
- Around 67 flights per day.
- Around 9 buses per day.
- Around 8 trains per day.
However, we recommend checking specific travel dates for your route between Heilbronn and Prague as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Prague Vaclav Havel Airport.
- Trains mostly depart from Heilbronn Hbf and arrive in Prague hlavní nádraží.
- Buses mostly depart from Heilbronn, Hbf (Central station) and arrive in Praha, ÚAN Florenc.
- Travel with FlixBus, KLR, AMI-Tour, Infobus to go to Prague by bus.
- Travel with Lufthansa, Lot Polish Airlines, KLM, Turkish Airlines, Condor Flugdienst, Austrian Airlines, British Airways, Swiss, Air Baltic, Eurowings, Qatar Airways, Air Dolomiti, KLM Cityhopper, Lufthansa Cityline, Brussels Airlines, Helvetic Airways, braathens regional aviation, CitizenPlane, TAP Portugal, Edelweiss Air to go to Prague by flight.
- Travel with alex-Länderbahn und Vogtlandbahn-GmbH, České dráhy, Deutsche Bahn to go to Prague by train.
- 6 direct buses per day with FlixBus, KLR, AMI-Tour, Infobus.
- 8 direct flights per day with Lufthansa, Condor Flugdienst, Air Dolomiti.
Travelling from Heilbronn to Prague: related information
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