Travel optionsfrom Domodossola to Florence
How to get from Domodossola to Florence by train, bus or flight.
Our recommendation
The best way to travel from Domodossola to Florence is by taking a train because it’s the best combination of price and speed.
Regionale TRENORD 2431 · Regionale Veloce TTPER 2475 · Regionale 17851Cheapest
Regionale TRENORD 2431 · Regionale Veloce TTPER 2475 · Regionale 17851Fastest
Regionale TRENORD 2435+
FRECCIAROSSA 1000 9563Other options
Regionale TRENORD 2419+
9931
Regionale TRENORD 2411+
Intercity 1589
Regionale TRENORD 2411 · Regionale 2293 · Tuscany Line 18288
Regionale 10203+
Regionale TRENORD 14342+
LX1629+
LX1680
Regionale TRENORD 2419+
Regionale TRENORD 10336+
EN8275 · EN8196
Regionale TRENORD 2419+
Regionale TRENORD 10336+
LX1629+
LX1680Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Domodossola to Florence
Travel to Florence easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Domodossola to Florence.

This is compared to other travel options from Domodossola to Florence:
A train is $15 (€12) less than a bus for this route with tickets for a bus from Domodossola to Florence costing on average $45 (€36).
A train is $148 (€118) less than a flight for this route with tickets for a flight from Domodossola to Florence costing on average $178 (€142).
Other travel options to Florence take longer:
Bus takes on average 4h 34m.
Flight takes on average 5h 40m.
- Around 18 flights per day.
- Around 13 trains per day.
- Around 6 buses per day.
However, we recommend checking specific travel dates for your route between Domodossola and Florence as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Milan Malpensa Airport and arrive in Florence Peretola Airport.
- Trains mostly depart from Domodossola station and arrive in Florence Santa Maria Novella.
- Travel with Frecciarossa, Regionale, Italo, Intercity, Trenitalia, Intercity Notte to go to Florence by train.
- Travel with VCO Trasporti, Autoservizi Comazzi srl to go to Florence by bus.
Travelling from Domodossola to Florence: related information
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