Travel Information
Compare train, flight, and bus for Domodossola to Florence
Omio recommends booking the train as it is the most popular option from Domodossola to Florence among Omio's users. If you are prioritising price, take the train, with an average ticket price of $29 For those with little time, consider booking a train, which has an average total journey time of 4h 47m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.3kg. Average ticket prices depend on the travel mode: a train costs an average of $29, while a flight costs an average of $359.
Distance: 217 miles (350 km)
Compare train with
Most popular Train | Flight | Driving |
|---|---|---|
$29 Average price Cheapest | $359 Average price | $125 Average price (fuel + tolls) |
4h 47m Average total duration Fastest 4h 17m Onboard + 30m Additional time* | 5h 3m Average total duration 3h 3m Onboard + 2h 0m Additional time* | 4h 37m Average total duration (door-to-door) |
0.1 - 0.3kg CO2 emissions Lowest | - CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Domodossola to Florence:
A train is $330 (€276) less than a flight for this route with tickets for a flight from Domodossola to Florence costing on average $359 (€301).
Other travel options to Florence take longer:
Flight takes on average 5h 3m.
The journey is about 20m faster (4h 17m by train vs 4h 37m by car) and roughly $96 (€80) cheaper once you factor in fuel and tolls ($29 (€25) vs $125 (€105)). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
Travel optionsfrom Domodossola to Florence
How to get from Domodossola to Florence by train, bus or flight.
Our recommendation
The best way to travel from Domodossola to Florence is by taking a train because it’s the best combination of price and speed.
Regionale TRENORD 2419+
81438:55 AM7h40Domodossola station4:35 PMFlorence Santa Maria Novella$351One-way1 transfer
Cheapest
Regionale TRENORD 2419+
81438:55 AM7h40Domodossola station4:35 PMFlorence Santa Maria Novella$351One-way1 transfer
Fastest
AZ2055 · AZ16757:30 AM3h05Milan Linate Airport10:35 AMFlorence Peretola Airport$4111One-way1 transfer
Other options
Regionale TRENORD 2417+
81437:55 AM8h40Domodossola station4:35 PMFlorence Santa Maria Novella$351One-way1 transfer
Autobus TRENORD 2427A · Regionale TRENORD 2427+
996112:10 PM9h25Domodossola station9:35 PMFlorence Santa Maria Novella$351One-way2 transfers
Regionale TRENORD 2415+
81436:53 AM9h42Domodossola station4:35 PMFlorence Santa Maria Novella$351One-way1 transfer
AZ1793 · AZ1794 · AZ16815:00 PM5h40Milan Linate Airport10:40 PMFlorence Peretola Airport$2551One-way2 transfers
AZ1641 · AZ1634 · AZ16812:40 PM8h00Milan Linate Airport10:40 PMFlorence Peretola Airport$2651One-way2 transfers
AZ2071 · AZ16793:00 PM3h15Milan Linate Airport6:15 PMFlorence Peretola Airport$2731One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Domodossola to Florence
Travel to Florence easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Domodossola to Florence.

This is compared to other travel options from Domodossola to Florence:
A train is $330 (€276) less than a flight for this route with tickets for a flight from Domodossola to Florence costing on average $359 (€301).
Other travel options to Florence take longer:
Flight takes on average 5h 3m.
- Around 27 trains per day.
- Around 12 flights per day.
However, we recommend checking specific travel dates for your route between Domodossola and Florence as scheduled services by train, flight, and bus can vary by season or day of the week.
- Flights mostly depart from Milan Linate Airport and arrive in Florence Peretola Airport.
- Trains mostly depart from Domodossola station and arrive in Florence Santa Maria Novella.
- Travel with Lufthansa, ITA, Air Dolomiti to go to Florence by flight.
- Travel with Frecciarossa, Italo, Regionale, Intercity, Intercity Notte to go to Florence by train.
Travelling from Domodossola to Florence: related information
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