Travel Information
Compare train and bus for Domodossola to Florence
Omio recommends booking the train as it is the most popular option from Domodossola to Florence among Omio's users. If you are prioritising price take the train with prices starting from $33. For those with little time consider booking a train which can get you there in 5h 18m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.3kg. The ticket price range depends on the travel mode: a train costs an average of $33, and a train costs an average of $33.
Distance: 217 miles (350 km)
Compare train with
Most popular Train | Driving |
|---|---|
$46 Average price Cheapest | $129 Average price (fuel + tolls) |
5h 48m Average total duration Fastest 5h 18m Onboard + 30m Additional time* | 4h 37m Average total duration (door-to-door) |
0.1 - 0.3kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Domodossola to Florence:
A train is $46 (€38) less than a bus for this route with tickets for a bus from Domodossola to Florence costing on average $93 (€75).
Other travel options to Florence take longer:
Bus takes on average 6h 3m.
Travel optionsfrom Domodossola to Florence
How to get from Domodossola to Florence by train, bus or flight.
Our recommendation
The best way to travel from Domodossola to Florence is by taking a train because it’s the best combination of price and speed.
Regionale TRENORD 2431 · Regionale Veloce TTPER 2475 · Regionale 178512:55 PM7h15Domodossola station10:10 PMFlorence Santa Maria Novella$421One-way2 transfers
Cheapest
Regionale TRENORD 2431 · Regionale Veloce TTPER 2475 · Regionale 178512:55 PM7h15Domodossola station10:10 PMFlorence Santa Maria Novella$421One-way2 transfers
Fastest
AZ2055 · AZ16757:30 AM3h05Milan Linate Airport10:35 AMFlorence Peretola Airport$3521One-way1 transfer
Other options
Regionale TRENORD 2411+
99174:55 AM4h40Domodossola station9:35 AMFlorence Santa Maria Novella$831One-way1 transfer
Regionale TRENORD 2437+
99635:55 PM4h40Domodossola station10:35 PMFlorence Santa Maria Novella$831One-way1 transfer
Regionale TRENORD 2433+
99593:55 PM4h40Domodossola station8:35 PMFlorence Santa Maria Novella$831One-way1 transfer
AZ2013 · AZ16757:00 AM3h35Milan Linate Airport10:35 AMFlorence Peretola Airport$4201One-way1 transfer
AZ2133 · AZ16791:00 PM5h15Milan Linate Airport6:15 PMFlorence Peretola Airport$4201One-way1 transfer
AZ1195 · AZ1156 · AZ16799:35 AM8h40Milan Linate Airport6:15 PMFlorence Peretola Airport$5971One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Domodossola to Florence
Travel to Florence easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Domodossola to Florence.

This is compared to other travel options from Domodossola to Florence:
A train is $46 (€38) less than a bus for this route with tickets for a bus from Domodossola to Florence costing on average $93 (€75).
Other travel options to Florence take longer:
Bus takes on average 6h 3m.
- Around 18 flights per day.
- Around 13 trains per day.
- Around 6 buses per day.
However, we recommend checking specific travel dates for your route between Domodossola and Florence as scheduled services by train and bus can vary by season or day of the week.
- Flights mostly depart from Milan Malpensa Airport and arrive in Florence Peretola Airport.
- Trains mostly depart from Domodossola station and arrive in Florence Santa Maria Novella.
- Travel with Autoservizi Comazzi srl to go to Florence by bus.
- Travel with Frecciarossa, Italo, Regionale, Intercity, Trenitalia, Intercity Notte, Trenord to go to Florence by train.
Travelling from Domodossola to Florence: related information
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