Travel Information
Compare bus, train, and flight for Florence to Domodossola
Omio recommends booking the train as it is the most popular option from Florence to Domodossola among Omio's users. If you are prioritising price, take the train, with an average ticket price of €38 For those with little time, consider booking a train, which has an average total journey time of 5h 17m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.3kg. Average ticket prices depend on the travel mode: a train costs an average of €38, while a bus costs an average of €75.
Distance: 217 miles (350 km)
Compare train with
Most popular Train | Bus | Driving |
|---|---|---|
€38 Average price Cheapest | €75 Average price | €104 Average price (fuel + tolls) |
5h 17m Average total duration Fastest 4h 47m Onboard + 30m Additional time* | 5h 24m Average total duration 4h 54m Onboard + 30m Additional time* | 4h 31m Average total duration (door-to-door) |
0.1 - 0.3kg CO2 emissions Lowest | 0.3 - 0.9kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | Your own car or car rental | |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Florence to Domodossola:
A train is €37 less than a bus for this route with tickets for a bus from Florence to Domodossola costing on average €75.
A train is €145 less than a flight for this route with tickets for a flight from Florence to Domodossola costing on average €184.
Other travel options to Domodossola take longer:
Bus takes on average 5h 24m.
Flight takes on average 6h 26m.
Tickets start at around €38 compared to roughly €104 in fuel and tolls — a saving of about €66. The journey takes 4h 47m versus 4h 31m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Travel optionsfrom Florence to Domodossola
How to get from Florence to Domodossola by train, bus or flight.
Our recommendation
The best way to travel from Florence to Domodossola is by taking a train because it’s the best combination of price and speed.
Regionale 17800 · Regionale Veloce TTPER 2460+
Autobus EC0424:32 AM9h48Florence Santa Maria Novella2:20 PMDomodossola station€421One-way2 transfers
Cheapest
Regionale 17800 · Regionale Veloce TTPER 2460+
Autobus EC0424:32 AM9h48Florence Santa Maria Novella2:20 PMDomodossola station€421One-way2 transfers
Fastest
AZ1684 · AZ20587:00 PM3h10Florence Peretola Airport10:10 PMMilan Linate Airport€1741One-way1 transfer
Other options
9912+
Regionale Veloce 2028 · Regionale 114329:25 AM7h52Florence Santa Maria Novella5:17 PMDomodossola station€481One-way2 transfers
9916+
Regionale Veloce 2028 · Regionale 1143210:25 AM6h52Florence Santa Maria Novella5:17 PMDomodossola station€521One-way2 transfers
Intercity 580+
Autobus EC0648:21 AM7h59Florence Santa Maria Novella4:20 PMDomodossola station€531One-way1 transfer
9912+
Autobus EC0429:25 AM4h55Florence Santa Maria Novella2:20 PMDomodossola station€521One-way1 transfer
9912+
Autobus EC0649:25 AM6h55Florence Santa Maria Novella4:20 PMDomodossola station€521One-way1 transfer
9912+
Autobus EC0669:25 AM9h55Florence Santa Maria Novella7:20 PMDomodossola station€521One-way1 transfer
AZ1678 · AZ204411:20 AM3h50Florence Peretola Airport3:10 PMMilan Linate Airport€1941One-way1 transfer
AZ1682 · AZ20563:30 PM4h40Florence Peretola Airport8:10 PMMilan Linate Airport€1941One-way1 transfer
AZ1678 · AZ203811:20 AM4h50Florence Peretola Airport4:10 PMMilan Linate Airport€1941One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Florence to Domodossola
Travel to Domodossola easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Florence to Domodossola.

This is compared to other travel options from Florence to Domodossola:
A train is €37 less than a bus for this route with tickets for a bus from Florence to Domodossola costing on average €75.
A train is €145 less than a flight for this route with tickets for a flight from Florence to Domodossola costing on average €184.
Other travel options to Domodossola take longer:
Bus takes on average 5h 24m.
Flight takes on average 6h 26m.
- Around 15 flights per day.
- Around 12 trains per day.
- Around 5 buses per day.
However, we recommend checking specific travel dates for your route between Florence and Domodossola as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Florence Peretola Airport and arrive in Milan Linate Airport.
- Trains mostly depart from Florence Santa Maria Novella and arrive in Domodossola station.
- Travel with FlixBus to go to Domodossola by bus.
- Travel with Frecciarossa, Italo, Regionale, Intercity, Trenitalia, Intercity Notte to go to Domodossola by train.
Travelling from Florence to Domodossola: related information
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