Travel Information
Compare bus, train, and flight for Saint-Louis to Lyon
Omio recommends booking the train as it is the most popular option from Saint-Louis to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $36. For those with little time consider booking a train which can get you there in 3h 18m. The ticket price range depends on the travel mode: a bus costs an average of $36, and a flight costs an average of $192.
Distance: 180 miles (291 km)
Compare train with
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$91 Average price | $55 Average price Cheapest | $290 Average price | $87 Average price (fuel + tolls) |
3h 48m Average total duration Fastest 3h 18m Onboard + 30m Additional time* | 4h 36m Average total duration 4h 6m Onboard + 30m Additional time* | 10h 38m Average total duration 7h 38m Onboard + 3h 0m Additional time* | 4h 14m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Saint-Louis to Lyon:
A bus is $36 (€29) less than a train for this route with tickets for a train from Saint-Louis to Lyon costing on average $91 (€72).
A bus is $235 (€187) less than a flight for this route with tickets for a flight from Saint-Louis to Lyon costing on average $290 (€231).
Other travel options to Lyon take longer:
Bus takes on average 4h 6m.
Flight takes on average 7h 38m.
You'll arrive about 56m sooner (3h 18m by train vs 4h 14m by car). Tickets start at around $91 (€72) compared to roughly $87 (€70) in fuel and tolls — so you're paying a bit more, but getting hours of your day back, a city-centre arrival, and the freedom to work or relax instead of drive.
Driving makes more sense if you're travelling as a group (where fuel costs split several ways), want to stop along the way, or need a car once you arrive.
Compare prices and tickets Saint-Louis to Lyon by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Saint-Louis to Lyon trains with Omio?
Why book with Omio vs SNCF | TGV INOUI?
- Compare with other providers: On Omio, you can not only buy tickets for SNCF | TGV INOUI, but also compare tickets for the likes of SNCF TER | Operated by SNCF Voyageurs 1187 to find the best option for your trip from Saint-Louis to Lyon.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare SNCF | TGV INOUI with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Saint-Louis to Lyon.
Journey information
Overview: Train from Saint-Louis to Lyon
Trains from Saint-Louis to Lyon run on average 6 times per day, taking around 3h 18m. Cheap train tickets for this journey start at $61 (€49) but you can travel from only $36 (€28) by bus.
The earliest train runs at 06:17, the last at 20:10. The fastest train covers the 180 miles (291 km) distance in 3h 26m.
Distance 180 miles (291 km) |
Average train duration 3h 18m |
Cheapest ticket price $61 (€49) |
Trains per day 6 |
Fastest train 3h 26m |
First train 6:17 AM |
Last train 8:10 PM |
Cheapest Month Nov |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Fri |
Least Busy Day Fri |
Best time to book 35 days |
Train companies: SNCF | TGV INOUI, SNCF TER | Operated by SNCF Voyageurs 1187 from Saint-Louis to Lyon trainsSNCF | TGV INOUI, SNCF TER | Operated by SNCF Voyageurs 1187 trains will get you between Saint-Louis and Lyon from $36 (€28). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
SNCF | TGV INOUI
SNCF TER | Operated by SNCF Voyageurs 1187
FAQs: Trains from Saint-Louis to Lyon
Find answers to the most common questions about traveling from Saint-Louis to Lyon by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Saint-Louis to Lyon
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- The car park is open 7 days a week, 24 hours a day. Access is available via Avenue de Bâle.
- Restaurant La Diligence
- Le Trianon
- Outside the main entrance.
- Elevators, ramps, restrooms.
- €0.50
- Hotel Berlioz
- Ibis Styles Bâle-Mulhouse Aéroport
- Hotel Porte de France
- Located in the main hall
- 70 places, covered
- Avis
- Europcar
- Located in the main hall
- Free
- Hall 1: main entrance, ticket office, and platforms
- Hall 2: waiting area and shops
- Bus: Line 604, Line 604A
- Tram: Line 3 (via Basel)
- Train: Regional trains to Basel and Mulhouse
- Parking is available near the station, but details are limited.
- Outside the station.
- Restrooms.
- The station is a simple halt with minimal facilities, primarily serving regional train connections.
- Bus: Local bus services available
- Train: Regional trains to Mulhouse and Basel
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Free unlimited WiFi.
- Luggage lockers are available daily from 06:15 to 23:15. They are located near the station's reception desk.
- Alto Café
- Paul
- Paul The Café
- Starbucks
- Exki
- Sushi Shop
- Carrefour
- Complimentary personalized care is available.
- Radisson Blu Hotel Lyon
- Mercure Lyon Center
- ibis Styles Lyon Center
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Located in the station's main hall.
- Metro lines: A, B, C, D
- Tram lines: T4, K240, T3, K100
- Bus lines: 2960, C2, C3, C6, C9
- Train lines: TGV, TGV Lyria, TGV INOUI, OUIGO, TER, Intercités, Eurostar, AVE
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- Parking is available nearby with access from Avenue Jean Jaurès.
- Le Jean Moulin
- Brasserie de l'Est
- Outside the main entrance.
- Ramps.
- €0.50
- Ibis Lyon Centre
- Hotel des Facultés
- Comfort Suites Rive Gauche Lyon Centre
- Located in the main hall
- 100 places, covered
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-2 for regional and local trains
- Hall 2: access to metro and tramway connections
- Metro: Line B
- Tramway: Line T2
- Bus: Several lines available
Most popular train connections from Saint-Louis
More options for your journey from Saint-Louis to Lyon
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