Travel Information
Compare train, flight, and bus for Greenville, SC to San Francisco, CA
Omio recommends booking the flight as it is the most popular option from Greenville, SC to San Francisco, CA among Omio's users. If you are prioritising price take the flight with prices starting from $175. For those with little time consider booking a flight which can get you there in 7h 54m. The ticket price range depends on the travel mode: a flight costs an average of $175, and a train costs an average of $333.
Distance: 2220 miles (3574 km)
Compare train with
| Train | Most popular Flight | Bus |
|---|---|---|
$1101 Average price | $433 Average price Cheapest | $491 Average price |
80h 30m Average total duration 80h 0m Onboard + 30m Additional time* | 10h 54m Average total duration Fastest 7h 54m Onboard + 3h 0m Additional time* | 58h 23m Average total duration 57h 53m Onboard + 30m Additional time* |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Greenville, SC to San Francisco, CA by train, flight, or bus
Compare train, flight, and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Train from Greenville, SC to San Francisco, CA
Trains from Greenville, SC to San Francisco, CA run on average 2 times per day, taking around 80h 0m. Cheap train tickets for this journey start at $333 (€266) but you can travel from only $175 (€140) by flight.
The earliest train runs at 07:00, the last at 08:25. The fastest train covers the 2220 miles (3574 km) distance in 89h 34m.
Distance 2220 miles (3574 km) |
Average train duration 80h 0m |
Cheapest ticket price $333 (€266) |
Trains per day 2 |
Fastest train 89h 34m |
First train 7:00 AM |
Last train 8:25 AM |
Cheapest Month Oct |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Apr - Jun |
Train companies: Amtrak from Greenville, SC to San Francisco, CA trainsAmtrak trains will get you between Greenville, SC and San Francisco, CA from $175 (€140). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
FAQs: Trains from Greenville, SC to San Francisco, CA
Find answers to the most common questions about traveling from Greenville, SC to San Francisco, CA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Greenville, SC to San Francisco, CA
- 6:00 AM - 11:00 PM Monday - Sunday
- Free
- Parking is available adjacent to the station, open 24/7.
- Soby's
- Larkin's on the River
- Outside the main entrance.
- Ramps, assistance.
- $1.00
- The Westin Poinsett, Greenville
- Courtyard Greenville Downtown
- Hyatt Regency Greenville
- Located in the main hall
- Located in the main hall
- Free
- The station has a single platform for Amtrak services and a waiting area.
- Bus: Greenlink Transit Route 3
- Taxi services available
Most popular train connections from Greenville, SC
More options for your journey from Greenville, SC to San Francisco, CA
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