- Must visit
Portland Art Museum
Major art museum in downtown Portland with Native American, modern, and Northwest collections. A core cultural stop for first-time visitors.
Omio recommends booking the flight as it is the most popular option from Greenville, SC to Portland, ME among Omio's users. If you are prioritising price take the bus with prices starting from $269. For those with little time consider booking a flight which can get you there in 4h 5m. The ticket price range depends on the travel mode: a bus costs an average of $269, and a flight costs an average of $501.
Distance: 888 miles (1430 km)
Most popular Flight | Bus | Driving |
|---|---|---|
$501 Average price | $269 Average price Cheapest | $204 Average price (fuel + tolls) |
7h 5m Average total duration Fastest 4h 5m Onboard + 3h 0m Additional time* | 49h 40m Average total duration 49h 10m Onboard + 30m Additional time* | 15h 41m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Greenville, SC to Portland, ME:
A bus is $232 (€190) less than a flight for this route with tickets for a flight from Greenville, SC to Portland, ME costing on average $501 (€410).
Other travel options to Portland, ME take longer:
Bus takes on average 49h 10m.
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Take a train from Greenville, SC to Portland, ME and enjoy the approximately 888 miles (1430 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest train runs at 04:15, the last at 18:00.
Distance 888 miles (1430 km) |
First train 4:15 AM |
Last train 6:00 PM |
High Season Jan - Mar |
Low Season Jul - Sep |
Discover the best of Portland — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Portland trip today.
Major art museum in downtown Portland with Native American, modern, and Northwest collections. A core cultural stop for first-time visitors.
Large science museum on the Willamette River with interactive exhibits, a planetarium, and family-friendly programming.
Historic house museum with period interiors and strong city history interpretation, plus one of Portland's best viewpoints.
Large urban park encompassing major attractions, trails, gardens, and forested scenery. One of Portland's essential outdoor destinations.
Highly regarded garden known for refined landscape design, seasonal beauty, and calm hillside setting above the city.
Vast urban forest with extensive hiking trails and a strong local following. Ideal for nature access close to downtown.
Portland is one of the leading craft beer cities in the United States, known for hop-forward IPAs, lagers, and experimental small-batch brews from many local breweries.
Portland has a major specialty coffee culture focused on carefully sourced beans, precise brewing, and independent roasters that helped define the city’s daily food ritual.
Portland-style doughnuts became nationally famous through creative toppings, oversized shapes, and quirky flavors, making them a recognizable local sweet treat.
A celebrated Portland restaurant known for inventive French-inspired cuisine, rich flavors, and an intimate, lively dining room.
A popular Southern restaurant famous for fried chicken and waffles, hearty brunches, and a bustling neighborhood atmosphere.
A reliable brewpub pouring respected Oregon craft beer alongside burgers, sandwiches, and pub fare in a spacious downtown setting.
Moderate by U.S. city standards. Food and coffee are reasonable, but hotels and fine dining can be pricey in peak season.
Tip 18-20% at restaurants; 20%+ for great service. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff USD 2-5.
Find answers to the most common questions about traveling from Greenville, SC to Portland, ME by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Portland, ME, this guide helps you travel smarter and with confidence.

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