- Must visit
Galleria degli Uffizi
World-famous Renaissance gallery with masterpieces by Botticelli, Leonardo, Michelangelo, and Caravaggio. One of Florence’s essential art museums and often requires advance booking.
Cheapest price
$33
Average price
$57
Fastest journey
5 h 12 m
Average duration
6 h 56 m
Trains per day
5
Distance
349 km
The best way to find a cheap train ticket from Domodossola station to Florence Santa Maria Novella is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Domodossola station to Florence Santa Maria Novella will cost around $57 if you buy it on the day, but the cheapest tickets can be found for only $33.
Of the 5 trains that leave Domodossola station for Florence Santa Maria Novella on Sun, May 17, 5 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, May 17 the direct trains cover the 349 km distance in an average of 6 h 56 m but if you time it right, some trains will get you there in just 5 h 12 m .
On Sun, May 17 the slowest trains will take 8 h 16 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.










Omio recommends booking the train as it is the most popular option from Domodossola station to Florence Santa Maria Novella among Omio's users. If you are prioritising price take the train with prices starting from $33. For those with little time consider booking a bus which can get you there in 4h 19m. The ticket price range depends on the travel mode: a train costs an average of $33, and a bus costs an average of $46.
Distance: 216 miles (349 km)
Most popular Train | Bus | Driving |
|---|---|---|
$46 Average price Cheapest | $88 Average price | $129 Average price (fuel + tolls) |
5h 7m Average total duration 4h 37m Onboard + 30m Additional time* | 4h 49m Average total duration Fastest 4h 19m Onboard + 30m Additional time* | 4h 15m Average total duration (door-to-door) |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Domodossola station to Florence Santa Maria Novella:
A train is $42 (€34) less than a bus for this route with tickets for a bus from Domodossola station to Florence Santa Maria Novella costing on average $88 (€71).
Other travel options to Florence Santa Maria Novella take longer:
Train takes on average 4h 37m.
Tickets start at around $46 (€37) compared to roughly $129 (€104) in fuel and tolls — a saving of about $83 (€67). The journey takes 4h 37m versus 4h 15m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Domodossola station to Florence Santa Maria Novella trains for today, Saturday, May 16. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Regionale TRENORD 2419+ 9931 | On time 8:55 AM Domodossola station | 4h40 | 1:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2419+ 9939 | On time 8:55 AM Domodossola station | 6h40 | 3:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2419+ 9935 | On time 8:55 AM Domodossola station | 5h40 | 2:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 10203 · Regionale TRENORD 2941+ 9939 | On time 10:06 AM Domodossola station | 5h29 | 3:35 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 10203 · Regionale TRENORD 2941+ 9947 | On time 10:06 AM Domodossola station | 7h29 | 5:35 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 10203 · Regionale Veloce 2023+ 9939 | On time 10:06 AM Domodossola station | 5h29 | 3:35 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 10207+ FRECCIAROSSA 9321 | 12:06 PM Domodossola station | 4h44 | 4:50 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2407+ 9955 | On time 12:55 PM Domodossola station | 6h40 | 7:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2407+ 9951 | On time 12:55 PM Domodossola station | 5h40 | 6:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2407+ 9947 | On time 12:55 PM Domodossola station | 4h40 | 5:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 10201+ FRECCIAROSSA 9325 | 2:06 PM Domodossola station | 4h44 | 6:50 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2431 · Regionale Veloce TTPER 2475 · Regionale 17851 | 2:55 PM Domodossola station | 7h15 | 10:10 PM Florence Santa Maria Novella | 2 transfers | |
Regionale TRENORD 2431+ 9961 | On time 2:55 PM Domodossola station | 6h40 | 9:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2431+ 9959 | On time 2:55 PM Domodossola station | 5h40 | 8:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2431+ 9955 | On time 2:55 PM Domodossola station | 4h40 | 7:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2433+ 9963 | 3:55 PM Domodossola station | 6h40 | 10:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2433+ 9959 | On time 3:55 PM Domodossola station | 4h40 | 8:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2433+ 9961 | On time 3:55 PM Domodossola station | 5h40 | 9:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2435+ FRECCIAROSSA 9563 | 4:55 PM Domodossola station | 4h09 | 9:04 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2435+ 9963 | 4:55 PM Domodossola station | 5h40 | 10:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2435+ 9961 | On time 4:55 PM Domodossola station | 4h40 | 9:35 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2437+ FRECCIAROSSA 9567 | 5:55 PM Domodossola station | 4h09 | 10:04 PM Florence Santa Maria Novella | 1 transfer | |
Regionale TRENORD 2437+ 9963 | 5:55 PM Domodossola station | 4h40 | 10:35 PM Florence Santa Maria Novella | 1 transfer | |
| Sunday, May 17 | |||||
![]() | 2:52 AM Domodossola station | 5h12 | 8:04 AM Florence Santa Maria Novella | 0 transfersDirect | |
![]() | 4:54 AM Domodossola station | 8h16 | 1:10 PM Florence Santa Maria Novella | 0 transfersDirect | |
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Domodossola station to Florence Santa Maria Novella run on average 12 times per day, taking around 4h 37m. Cheap train tickets for this journey start at $33 (€27) if you book in advance.
The earliest train runs at 02:52, the last at 16:56. The fastest train covers the 216 miles (349 km) distance in 4h 8m.
Distance 216 miles (349 km) |
Average train duration 4h 37m |
Cheapest ticket price $33 (€27) |
Trains per day 12 |
Fastest train 4h 8m |
First train 2:52 AM |
Last train 4:56 PM |
Cheapest Month Nov |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Thu |
Least Busy Day Sun |
Discover the best of Firenze Santa Maria Novella — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Firenze Santa Maria Novella trip today.
World-famous Renaissance gallery with masterpieces by Botticelli, Leonardo, Michelangelo, and Caravaggio. One of Florence’s essential art museums and often requires advance booking.
Best known for Michelangelo’s David, plus important Florentine paintings and sculpture. Extremely popular and commonly booked in advance.
Outstanding museum of original works from Florence Cathedral, Baptistery, and Giotto’s Bell Tower, including sculptures by Michelangelo and Donatello.
Florence’s monumental heart, surrounded by the cathedral, baptistery, and bell tower. Constantly lively and essential for first-time visitors.
Historic political square lined with sculptures and dominated by Palazzo Vecchio. One of the city’s most iconic public spaces.
The classic panoramic viewpoint over Florence, highly popular for sunset photos and sweeping skyline views.
Thick-cut T-bone steak from Chianina beef, grilled rare over coals. It is the city’s signature dish and a classic of Florentine cooking.
A hearty Tuscan bread and vegetable soup, usually made with cavolo nero, beans, and stale bread. It is one of Florence’s most traditional comfort foods.
Rustic tomato and bread soup flavored with garlic, basil, and olive oil. A beloved Tuscan staple with simple, local ingredients.
Established Michelin-starred restaurant offering refined Tuscan cuisine in an elegant contemporary setting not far from central Florence.
Historic, no-frills Florentine trattoria popular for traditional daily dishes, ribollita, and hearty meat plates in a classic local atmosphere.
Well-known traditional restaurant with a rustic dining room, famous for Tuscan antipasti and Bistecca Alla Fiorentina served in generous portions.
Moderate by Italian standards. Coffee and casual meals are reasonable, but hotels and tourist-area dining near the station cost more.
Service is often included or covered by coperto. Tipping is not required; round up or leave EUR 1-5 for good service. Taxis can be rounded up.
Official public transport app
Florence Santa Maria Novella, Florence -> Piazza del Duomo, Florence
Find answers to the most common questions about traveling from Domodossola station to Florence Santa Maria Novella by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence Santa Maria Novella, this guide helps you travel smarter and with confidence.

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