- Must visit
San Diego Museum of Art
Major Balboa Park museum with works from Spanish old masters to modern art, plus strong regional and international exhibitions.
Omio recommends booking the bus as it is the most popular option from Brentwood, MO to San Diego, CA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $578 For those with little time, consider booking a train, which has an average total journey time of 50h 55m. Average ticket prices depend on the travel mode: a bus costs an average of $578, while a train costs an average of $995.
Distance: 1552 miles (2499 km)
| Train | Most popular Bus | Driving |
|---|---|---|
$995 Average price | $578 Average price Cheapest | $373 Average price (fuel + tolls) |
50h 55m Average total duration Fastest 50h 25m Onboard + 30m Additional time* | 51h 22m Average total duration 50h 52m Onboard + 30m Additional time* | 26h 26m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Brentwood, MO to San Diego, CA:
A bus is $417 less than a train for this route with tickets for a train from Brentwood, MO to San Diego, CA costing on average $995.
Other travel options to San Diego, CA take longer:
Bus takes on average 50h 52m.
Tickets start at around $995 compared to roughly $373 in fuel and tolls — a saving of about $-622.06. The journey takes 50h 25m versus 26h 26m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Brentwood, MO to San Diego, CA run on average 1 times per day, taking around 50h 25m. Cheap train tickets for this journey start at $995 but you can travel from only $578 by bus.
The earliest train runs at 00:44, the last at 14:34. The fastest train covers the 1552 miles (2499 km) distance in 43h 30m.
Distance 1552 miles (2499 km) |
Average train duration 50h 25m |
Cheapest ticket price $995 |
Trains per day 1 |
Fastest train 43h 30m |
First train 12:44 AM |
Last train 2:34 PM |
Cheapest Month Feb |
Cheapest Day Fri |
High Season Jan - Mar |
Low Season Jan - Mar |
Discover the best of San Diego, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego, CA trip today.
Major Balboa Park museum with works from Spanish old masters to modern art, plus strong regional and international exhibitions.
Acclaimed contemporary art museum in La Jolla featuring oceanfront settings, modern works, and rotating global exhibitions.
Museum aboard a historic aircraft carrier with restored aircraft, naval exhibits, and immersive views of life at sea.
Balboa Park is San Diego's grand cultural park, packed with gardens, architecture, museums, and walkable plazas worth lingering in.
Historic Gaslamp Quarter offers Victorian-era streets, nightlife energy, and preserved downtown architecture for an atmospheric walk.
Dramatic seaside cliffs and walking paths in La Jolla, famous for waves, sea lions, and sweeping Pacific views.
A San Diego staple: grilled fish in a soft tortilla with cabbage, crema, and salsa. Popularized by Baja influence and coastal seafood culture.
French fries, carne asada, cheese, guacamole, and crema wrapped in a flour tortilla. A late-night local favorite born in San Diego taquerias.
Fresh local sea urchin served raw, prized for its rich, buttery taste. It reflects San Diego's access to Pacific seafood and sushi culture.
Celebrated sushi restaurant specializing in omakase and pristine seafood, including uni. Intimate, polished, and highly respected by locals.
Iconic casual seafood counter known for fish tacos, smoked fish, and harbor views. A classic stop for San Diego's Baja-inspired seafood style.
Refined fine-dining restaurant showcasing local seafood and seasonal California ingredients. Elegant room with one of the city's strongest reputations.
San Diego is pricey for US travel, with higher hotel rates, dining, and parking than many cities, though casual food and buses stay manageable.
Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 for coffee drinks or small cafe orders.
Find answers to the most common questions about traveling from Brentwood, MO to San Diego, CA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.

Most Brentwood, MO to San Diego, CA trains use the St. Louis Station to Santa Fe Depot station pair. Use this guide to compare Brentwood, MO and San Diego, CA train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Santa Fe Depot is 1 km from San Diego city centre. Public transport options include:
Santa Fe Depot has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food options include: The Fish Market, Karl Strauss Brewing Company
Free. ATMs are available in the train station.
Ticket office support is available at Santa Fe Depot. Information desks are located in the main hall.
Luggage storage is available at Santa Fe Depot. Lost and found is available at the station.
Available at Santa Fe Depot: Parking, Taxis, WC.
Available at Santa Fe Depot: Bike Parking, Car Rental.
Accessibility facilities are available at Santa Fe Depot: Ramps.
Nearby hotels include The Westin San Diego, The Guild Hotel, San Diego, a Tribute Portfolio Hotel, Embassy Suites by Hilton San Diego Bay Downtown.
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