Travel Information
Compare bus and flight for Port Saint Lucie, FL to San Francisco, CA
Omio recommends booking the flight as it is the most popular option from Port Saint Lucie, FL to San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from €263. For those with little time consider booking a flight which can get you there in 10h 6m. The ticket price range depends on the travel mode: a bus costs an average of €263, and a flight costs an average of €352.
Distance: 2532 miles (4075 km)
Compare bus with
| Bus | Most popular Flight |
|---|---|
€263 Average price Cheapest | €352 Average price |
90h 25m Average total duration 89h 55m Onboard + 30m Additional time* | 13h 6m Average total duration Fastest 10h 6m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Compare prices and tickets Port Saint Lucie, FL to San Francisco, CA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Port Saint Lucie, FL to San Francisco, CA
Buses from Port Saint Lucie, FL to San Francisco, CA run on average 6 times per day, taking around 89h 55m. Cheap bus tickets for this journey start at $328 (€263) if you book in advance.
The earliest bus runs at 19:45, the last at 19:45. The fastest bus covers the 2532 miles (4075 km) distance in 89h 55m.
Distance 2532 miles (4075 km) |
Average bus duration 89h 55m |
Cheapest ticket price $328 (€263) |
Buses per day 6 |
Fastest bus 89h 55m |
First bus 19:45 |
Last bus 19:45 |
FAQs: Bus from Port Saint Lucie, FL to San Francisco, CA
Find answers to the most common questions about traveling from Port Saint Lucie, FL to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

- Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
- Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
- Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
- Golden Gate Park, a large urban park with gardens, museums, and recreational activities
- Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
- Ride a cable car through the steep streets of San Francisco for a classic city experience
- Explore the vibrant murals and street art in the Mission District
- Visit the Exploratorium, an interactive science museum perfect for all ages
- Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
- Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
To find the cheapest bus tickets for your trip from Port Saint Lucie, FL to San Francisco, CA, follow these tips:
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Popular bus stations from Port Saint Lucie, FL to San Francisco, CA
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