Port Saint Lucie, FL to San Francisco, CA bus

Fri, Dec 19
+ Add return
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
Itabus
1,000+ travel companies
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
Itabus
1,000+ travel companies
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Travel Information

Compare bus and flight for Port Saint Lucie, FL to San Francisco, CA

Omio recommends booking the flight as it is the most popular option from Port Saint Lucie, FL to San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from €263. For those with little time consider booking a flight which can get you there in 10h 6m. The ticket price range depends on the travel mode: a bus costs an average of €263, and a flight costs an average of €352.

Distance: 2532 miles (4075 km)

Compare bus with

Bus
Most popular
Flight

€263

Average price

Cheapest

€352

Average price

90h 25m

Average total duration

89h 55m

Onboard

+

30m

Additional time*

13h 6m

Average total duration

Fastest

10h 6m

Onboard

+

3h 0m

Additional time*

Direct Options

Direct Options

Compare prices and tickets Port Saint Lucie, FL to San Francisco, CA by bus or flight

Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

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Journey information

Overview: Bus from Port Saint Lucie, FL to San Francisco, CA

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Buses from Port Saint Lucie, FL to San Francisco, CA run on average 6 times per day, taking around 89h 55m. Cheap bus tickets for this journey start at $328 (€263) if you book in advance.

The earliest bus runs at 19:45, the last at 19:45. The fastest bus covers the 2532 miles (4075 km) distance in 89h 55m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
2532 miles (4075 km)
Average bus duration
89h 55m
Cheapest ticket price
$328 (€263)
Buses per day
6
Fastest bus
89h 55m
First bus
19:45
Last bus
19:45
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

FAQs: Bus from Port Saint Lucie, FL to San Francisco, CA

Find answers to the most common questions about traveling from Port Saint Lucie, FL to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Port Saint Lucie, FL to San Francisco, CA can start from as little as $265 (€212) when you book in advance. The average bus ticket price for Port Saint Lucie, FL to San Francisco, CA is $362 (€290); however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
On average the Port Saint Lucie, FL to San Francisco, CA bus travel time is 73 h 20 min   for the 2526 mile (4074 km) long journey, but the duration can vary if you travel on weekends and holidays.
The bus from Port Saint Lucie, FL to San Francisco, CA leaves at 1: 55PM. Plan your trip with the Journey Planner   from Omio.
The cheapest month to travel from Port Saint Lucie, FL to San Francisco, CA by bus is November.
You have options as you can travel from Port Saint Lucie, FL to San Francisco, CA 2 different ways: bus or flight.
No, the bus from Port Saint Lucie, FL to San Francisco, CA has no accessibility options.
No, there are no bathrooms on board the bus from Port Saint Lucie, FL to San Francisco, CA.
Some of the most interesting sights to explore in San Francisco, CA are:
  • Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
  • Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
  • Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
  • Golden Gate Park, a large urban park with gardens, museums, and recreational activities
  • Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
The best things to do in San Francisco, CA include:
  • Ride a cable car through the steep streets of San Francisco for a classic city experience
  • Explore the vibrant murals and street art in the Mission District
  • Visit the Exploratorium, an interactive science museum perfect for all ages
  • Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
  • Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
No, bikes are not allowed on board the bus from Port Saint Lucie, FL to San Francisco, CA.

To find the cheapest bus tickets for your trip from Port Saint Lucie, FL to San Francisco, CA, follow these tips:

  • Book in advance: Tickets are often cheaper when booked early.
  • Be flexible with dates and times: Traveling during off-peak hours or on weekdays can help you save money.
  • Use our search filters: Sort results by price to quickly identify the most affordable options.
  • Look for special deals or discounts: Check for promotions or discounts available on our website and app.
  • Start your search now and compare ticket prices to find the best deal!

    Yes, there is food available to purchase on board the bus from Port Saint Lucie, FL to San Francisco, CA.
    No, luggage for the bus from Port Saint Lucie, FL to San Francisco, CA needs to be booked in addition.
    No, there are no additional luggage options for the bus from Port Saint Lucie, FL to San Francisco, CA.
    Unfortunately, pets are not allowed on the bus from Port Saint Lucie, FL to San Francisco, CA.
    No, there are no USB plugs on board the bus from Port Saint Lucie, FL to San Francisco, CA.
    No, there is no WiFi on board the bus from Port Saint Lucie, FL to San Francisco, CA.

    popular bus stations

    Popular bus stations from Port Saint Lucie, FL to San Francisco, CA

    Port Saint Lucie
    San Francisco
    The major bus station for departures in Port Saint Lucie is Port St Lucie, SW Gatlin Blvd (Bus Transfer Station Park & Ride Lot). Find all the information you need to know about services, amenities and connections at Port St Lucie, SW Gatlin Blvd (Bus Transfer Station Park & Ride Lot) for your trip from Port Saint Lucie to San Francisco.
    Port St Lucie, SW Gatlin Blvd (Bus Transfer Station Park & Ride Lot)
    information

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