Journey information
Overview: Port Saint Lucie, FL to San Francisco, CA flight
Flights from Port Saint Lucie, FL to San Francisco, CA depart on average 40 times per day, taking around 10h 6m. Cheap flight tickets for this journey start at $443 (€352) but you can travel from only $331 (€263) by bus.
The earliest flight runs at 16:56, the last at 16:56. The fastest flight covers the 2532 miles (4075 km) distance in 10h 6m. June is the cheapest month to fly.
Distance 2532 miles (4075 km) |
Average flight duration 10h 6m |
Cheapest ticket price $443 (€352) |
Flights per day 40 |
Fastest flight 10h 6m |
Cheapest month to travel June |
First flight 16:56 |
Last flight 16:56 |
The cheapest and fastest flights from Port Saint Lucie, FL to San Francisco, CA
Cheapest price
$443
Average price
$443
Fastest journey
10 h 6 m
Average duration
10 h 6 m
Flights per day
1
Distance
4075 km
The best way to find a cheap flight ticket from Port Saint Lucie, FL to San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Port Saint Lucie, FL to San Francisco, CA will cost around $443 if you buy it on the day, but the cheapest tickets can be found for only $443.
Of the 1 flights that leave Port Saint Lucie, FL for San Francisco, CA onFri, Feb 06, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Feb 06 the direct flights cover the 4075 km distance in an average of 10 h 6 m but if you time it right, some flights will get you there in just 10 h 6 m .
On Fri, Feb 06 the longest flights will take 10 h 6 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus and flight for Port Saint Lucie, FL to San Francisco, CA
Omio recommends booking the flight as it is the most popular option from Port Saint Lucie, FL to San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from €263. For those with little time consider booking a flight which can get you there in 10h 6m. The ticket price range depends on the travel mode: a bus costs an average of €263, and a flight costs an average of €352.
Distance: 2532 miles (4075 km)
Compare flight with
Most popular Flight | Bus |
|---|---|
€352 Average price | €263 Average price Cheapest |
13h 6m Average total duration Fastest 10h 6m Onboard + 3h 0m Additional time* | 90h 25m Average total duration 89h 55m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Compare prices and tickets Port Saint Lucie, FL to San Francisco, CA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Port Saint Lucie, FL to San Francisco, CA flights with Omio?
Why book with Omio vs American Airlines?
- Compare with other providers: On Omio, you can not only buy tickets for American Airlines, but also compare tickets for the likes of to find the best option for your trip from Port Saint Lucie, FL to San Francisco, CA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare American Airlines with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Port Saint Lucie, FL to San Francisco, CA.
Why book with Omio over Trip, Edreams or Skyscanner?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Port Saint Lucie, FL to San Francisco, CA.
Airlines: American Airlines from Port Saint Lucie, FL to San Francisco, CAFind the best flights between Port Saint Lucie, FL to San Francisco, CA with Omio's travel partners American Airlines from $331 (€263). We can find you the best deals, schedules and tickets when comparing and booking the best trip.
American Airlines
FAQs: Port Saint Lucie, FL to San Francisco, CA Flight
Find answers to the most common questions about traveling from Port Saint Lucie, FL to San Francisco, CA by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

- Fleet Week, a maritime celebration featuring the Blue Angels and naval ship tours
- Outside Lands, a major music festival showcasing top artists and local food
- Chinese New Year Parade, the largest Lunar New Year celebration outside Asia with colorful floats and performances
- Hardly Strictly Bluegrass, a free music festival in Golden Gate Park featuring a diverse lineup of bluegrass and folk artists.
- Thanksgiving, mild weather and a festive atmosphere with family gatherings
- Christmas, beautiful decorations and holiday spirit throughout the city
- Memorial Day, the start of summer with outdoor activities and parades
- Labor Day, a long weekend perfect for enjoying the city's parks and beaches.
popular airports
Popular airports from Port Saint Lucie, FL to San Francisco, CA
- Free Wi-Fi available throughout the airport.
- Shops are located in all terminals, including DFS Duty-Free and Burberry.
- Parking available in the Domestic and International Garages, approximately 1.9€ ($2) per 15 minutes.
- Available outside the terminal.
- Elevators, ramps, toilets.
- Available throughout the airport.
- Yes
- Lounges available, including the United Club and Delta Sky Club.
- Located in the main hall of the Domestic Terminal.
- Buses: SamTrans 292, 397, 398, KX
- Metro: BART Yellow Line
Most popular flights from Port Saint Lucie, FL
More options for your journey from Port Saint Lucie, FL to San Francisco, CA
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