The cheapest and fastest buses from Panama City, FL to Orlando, FL
Cheapest price
$79
Average price
$79
Fastest journey
10 h 9 m
Average duration
10 h 9 m
Buses per day
1
Distance
452 km
The best way to find a cheap bus ticket from Panama City, FL to Orlando, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Panama City, FL to Orlando, FL will cost around $79 if you buy it on the day, but the cheapest tickets can be found for only $79.
Of the 1 buses that leave Panama City, FL for Orlando, FL on Sun, Mar 15, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Mar 15 the direct buses cover the 452 km distance in an average of 10 h 9 m but if you time it right, some buses will get you there in just 10 h 9 m .
On Sun, Mar 15 the slowest buses will take 10 h 9 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus and flight for Panama City, FL to Orlando, FL
Omio recommends booking the bus as it is the most popular option from Panama City, FL to Orlando, FL among Omio's users. If you are prioritising price take the bus with prices starting from $73. For those with little time consider booking a bus which can get you there in 9h 20m. The ticket price range depends on the travel mode: a bus costs an average of $73, and a flight costs an average of $189.
Distance: 280 miles (452 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
$103 Average price Cheapest | $482 Average price |
9h 50m Average total duration Fastest 9h 20m Onboard + 30m Additional time* | 13h 18m Average total duration 10h 18m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Live departures
Panama City, FL to Orlando, FL bus times
The table below shows live departures for Panama City, FL to Orlando, FL buses for today, Saturday, March 14. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:50 PM Panama City, FL | 10h09 | 4:59 AM Orlando, FL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Panama City, FL to Orlando, FL by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 15
Mar 16
Mar 17
Mar 18
Mar 19
Mar 20
Mar 21
Why should you book Panama City, FL to Orlando, FL buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Panama City, FL to Orlando, FL.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Panama City, FL to Orlando, FL.
Journey information
Overview: Bus from Panama City, FL to Orlando, FL
Buses from Panama City, FL to Orlando, FL run on average 2 times per day, taking around 9h 20m. Cheap bus tickets for this journey start at $73 (€60) if you book in advance.
The earliest bus runs at 05:40, the last at 23:40. The fastest bus covers the 280 miles (452 km) distance in 8h 0m.
Distance 280 miles (452 km) |
Average bus duration 9h 20m |
Cheapest ticket price $73 (€60) |
Buses per day 2 |
Fastest bus 8h 0m |
First bus 05:40 |
Last bus 23:40 |
Bus providers: Greyhound from Panama City, FL to Orlando, FLYou can travel by bus between Panama City, FL to Orlando, FL with Greyhound for as low as $73 (€60). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Panama City, FL to Orlando, FL
Find answers to the most common questions about traveling from Panama City, FL to Orlando, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Orlando, FL, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Walt Disney World Resort, a massive entertainment complex featuring theme parks, water parks, and resorts
- Universal Orlando Resort, a popular destination with thrilling rides, shows, and attractions based on movies and TV shows
- SeaWorld Orlando, a marine-themed park offering animal exhibits, shows, and rides
- Kennedy Space Center Visitor Complex, an educational attraction showcasing NASA's space exploration history and offering interactive exhibits
- Leu Gardens, a beautiful botanical garden with a variety of plant collections and scenic landscapes.
- ICON Park, a vibrant entertainment complex with dining, shopping, and the iconic Wheel for panoramic views
- Explore the vibrant nightlife and live entertainment at Church Street District
- Enjoy a day of shopping and dining at The Mall at Millenia
- Experience the natural beauty and wildlife at Wekiwa Springs State Park
- Visit the Orlando Science Center for interactive exhibits and planetarium shows.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Panama City, FL to Orlando, FL
Most popular bus connections from Panama City, FL
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