- Must visit
Orlando Science Center
Hands-on science center popular with families, offering interactive exhibits, live programming, and observatory experiences.
The best way to find a cheap bus ticket from Panama City, FL to Orlando, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Panama City, FL to Orlando, FL will cost around $107 if you buy it on the day, but the cheapest tickets can be found for only $107.
On Tue, Nov 03, we found 1 buses from Panama City, FL to Orlando, FL, including 1 direct services.
On Tue, Nov 03 the direct buses cover the 452 km distance in an average of 8 h 50 m but if you time it right, some buses will get you there in just 8 h 50 m .
On Tue, Nov 03 the slowest buses will take 8 h 50 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Panama City, FL to Orlando, FL run on average 3 times per day, taking around 8h 23m. Cheap bus tickets for this journey start at $60 if you book in advance.
The earliest bus runs at 04:00, the last at 23:40. The fastest bus covers the 280 miles (452 km) distance in 7h 10m.
Distance 280 miles (452 km) |
Average bus duration 8h 23m |
Cheapest ticket price $60 |
Buses per day 3 |
Fastest bus 7h 10m |
First bus 4:00 AM |
Last bus 11:40 PM |
Cheapest Month Sep |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Jan - Mar |
Best time to book 14 days |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Panama City, FL to Orlando, FL.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 07:30AM | Arrival Time 05:20PM | Duration 8h50 | Departure days Fri | Cheapest price $74 |
Operator FlixBus | Departure Time 12:30PM | Arrival Time 08:30PM | Duration 8h00 | Departure days Sat | Cheapest price $66 |
Operator Greyhound | Departure Time 12:50PM | Arrival Time 11:59PM | Duration 10h09 | Departure days Fri | Cheapest price $75 |
Operator FlixBus | Departure Time 01:30PM | Arrival Time 10:20PM | Duration 8h50 | Departure days Tue | Cheapest price $107 |
Operator Greyhound | Departure Time 05:50PM | Arrival Time 03:59AM | Duration 10h09 | Departure days Mon | Cheapest price $125 |
Operator Greyhound | Departure Time 06:50PM | Arrival Time 05:55AM | Duration 11h05 | Departure days Wed | Cheapest price $112 |
The table below shows live departures for Panama City, FL to Orlando, FL buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:50 PM Panama City, FL | 10h09 | 3:59 AM Orlando, FL | 0 transfersDirect | |
This is the last bus of the day. | |||||
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Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Orlando, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Orlando, FL trip today.
Hands-on science center popular with families, offering interactive exhibits, live programming, and observatory experiences.
Major local history museum in a restored 1927 courthouse, covering Central Florida's past through engaging permanent and special exhibits.
Smithsonian-affiliated art museum with American, African, and ancient works, plus strong rotating exhibitions in Winter Park.
Orlando's signature urban park with lake views, swan boats, skyline scenes, and frequent festivals in the city center.
Upscale main street area famous for boutiques, brick streets, and a polished small-town atmosphere in nearby Winter Park.
Lively entertainment district with nightlife, murals, and historic architecture around downtown's Church Street corridor.
A Central Florida favorite of smoked or fried local catfish, often served with hushpuppies and grits. It reflects the region's freshwater fishing and Southern roots.
Fresh Atlantic or Gulf shrimp, commonly peel-and-eat, grilled, or fried. It is a staple across Florida and prized in Orlando seafood spots for its regional freshness.
Cuban coffee sweetened during brewing for a bold, syrupy shot. Popular in Central Florida's Latin communities, it is a daily ritual and local caffeine classic.
Popular Cuban cafe serving strong cafecito, Cuban sandwiches, and pastries in a busy, no-frills neighborhood setting.
Historic casual seafood house known for Florida gator tail, frog legs, and laid-back Old Florida charm near downtown Orlando.
Refined restaurant in Winter Park highlighting Florida seafood and seasonal Southern ingredients in an elegant but relaxed space.
Moderate for a major US tourist city. Theme parks and hotels raise trip costs, while casual dining and ride-hailing are widely available at typical US urban prices.
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis or ride-hailing, and small change or up to 10% at cafes if table service is provided.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Orlando, FL.
Find answers to the most common questions about traveling from Panama City, FL to Orlando, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Orlando, FL, this guide helps you travel smarter and with confidence.

Most Panama City, FL to Orlando, FL buses use the to Orlando, N John Young Pkwy (Greyhound Bus Station) station pair, with some services arriving at Orlando, The Florida Mall. Use this guide to compare Panama City, FL and Orlando, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Orlando, N John Young Pkwy (Greyhound Bus Station) is 3 km from Orlando city centre. Public transport options include:
Orlando, N John Young Pkwy (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Orlando, N John Young Pkwy (Greyhound Bus Station). ATMs are available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Ticket office support is available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Available at Orlando, N John Young Pkwy (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Orlando, N John Young Pkwy (Greyhound Bus Station): The station is accessible for individuals with disabilities.
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