- Recommended
Bay County History Museum
Local history museum in a waterfront estate with exhibits on Native cultures, settlement, industry, and life in Bay County.
The best way to find a cheap bus ticket from Orlando, FL to Panama City, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Orlando, FL to Panama City, FL will cost around €134 if you buy it on the day, but the cheapest tickets can be found for only €134.
On Wed, Nov 04, we found 1 buses from Orlando, FL to Panama City, FL, including 1 direct services.
On Wed, Nov 04 the direct buses cover the 452 km distance in an average of 15 h 25 m but if you time it right, some buses will get you there in just 15 h 25 m .
On Wed, Nov 04 the slowest buses will take 15 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Orlando, FL to Panama City, FL run on average 3 times per day, taking around 8h 9m. Cheap bus tickets for this journey start at €45 if you book in advance.
The earliest bus runs at 04:40, the last at 23:40. The fastest bus covers the 280 miles (452 km) distance in 7h 0m.
Distance 280 miles (452 km) |
Average bus duration 8h 9m |
Cheapest ticket price €45 |
Buses per day 3 |
Fastest bus 7h 0m |
First bus 4:40 AM |
Last bus 11:40 PM |
Cheapest Month Sep |
Cheapest Day Thu |
High Season Jul - Sep |
Low Season Jan - Mar |
Best time to book 21 days |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Orlando, FL to Panama City, FL.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 05:40AM | Arrival Time 02:00PM | Duration 9h20 | Departure days Sun | Cheapest price €59 |
Operator Greyhound | Departure Time 11:10AM | Arrival Time 02:35AM | Duration 15h25 | Departure days Wed, Sat | Cheapest price €95 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 09:35PM | Duration 9h30 | Departure days Sun | Cheapest price €58 |
Operator FlixBus | Departure Time 01:50PM | Arrival Time 09:35PM | Duration 8h45 | Departure days Sun | Cheapest price €59 |
Operator FlixBus | Departure Time 05:05PM | Arrival Time 02:35AM | Duration 9h30 | Departure days Mon | Cheapest price €83 |
Operator FlixBus | Departure Time 05:50PM | Arrival Time 02:35AM | Duration 8h45 | Departure days Mon | Cheapest price €91 |
Operator FlixBus | Departure Time 06:50PM | Arrival Time 03:35AM | Duration 8h45 | Departure days Fri | Cheapest price €119 |
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Panama City, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Panama City, FL trip today.
Local history museum in a waterfront estate with exhibits on Native cultures, settlement, industry, and life in Bay County.
Compact museum dedicated to military and civilian aviation, featuring aircraft displays, artifacts, and regional flight history.
Specialty museum exploring diving technology and underwater exploration through helmets, submersibles, and hands-on displays.
Walkable waterfront district with shops, murals, events, and a marina atmosphere that captures the character of old St. Andrews.
Central green space downtown with paths, shade, and community events, ideal for a short stroll near museums and shops.
Waterfront park on St. Andrews Bay with a pier, boardwalk, and broad views, popular for sunsets and relaxed walks.
Smoked mullet is a Panhandle staple, prepared from local Gulf fish and traditionally eaten as a simple smoky seafood snack or meal.
Oysters from nearby Apalachicola Bay are a regional classic, prized for their fresh briny flavor and served raw, baked, or lightly cooked.
Shrimp and grits is a Southern Gulf Coast favorite with local shrimp over creamy grits, often enriched with bacon, gravy, or cheese.
Established local seafood restaurant in Historic St. Andrews serving Gulf fish, oysters, and Southern coastal favorites.
Refined waterfront dining with steaks, seafood, and a polished atmosphere overlooking the marina.
Long-running bakery and cafe popular for breakfast, sandwiches, pastries, and a relaxed local feel.
Moderate for a U.S. beach city; hotels rise in peak season, dining is reasonable, and getting around by car adds to visitor costs.
Restaurants: tip 18-20% before tax. Cafes: round up or tip $1. Taxis and rideshares: tip 10-15% or round up for good service.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Panama City, FL.
Find answers to the most common questions about traveling from Orlando, FL to Panama City, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Panama City, FL, this guide helps you travel smarter and with confidence.

Most Orlando, FL to Panama City, FL buses use the Orlando, N John Young Pkwy (Greyhound Bus Station) to station pair. Use this guide to compare Orlando, FL and Panama City, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Orlando, N John Young Pkwy (Greyhound Bus Station) is 3 km from Orlando city centre. Public transport options include:
Orlando, N John Young Pkwy (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Orlando, N John Young Pkwy (Greyhound Bus Station). ATMs are available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Ticket office support is available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Available at Orlando, N John Young Pkwy (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Orlando, N John Young Pkwy (Greyhound Bus Station): The station is accessible for individuals with disabilities.
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