- Must visit
Uffizi Gallery
World-famous gallery with Botticelli, Leonardo, and Michelangelo. Essential for understanding Renaissance painting and one of Florence’s top visits.
Omio recommends booking the train as it is the most popular option from Nyon to Florence among Omio's users. If you are prioritising price take the bus with prices starting from CHF51. For those with little time consider booking a train which can get you there in 6h 17m. The ticket price range depends on the travel mode: a bus costs an average of CHF51, and a train costs an average of CHF140.
Distance: 303 miles (489 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
CHF60 Average price Cheapest | CHF178 Average price | CHF172 Average price | CHF114 Average price (fuel + tolls) |
16h 1m Average total duration 15h 31m Onboard + 30m Additional time* | 6h 47m Average total duration Fastest 6h 17m Onboard + 30m Additional time* | 11h 15m Average total duration 8h 15m Onboard + 3h 0m Additional time* | 7h 8m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Nyon to Florence:
A bus is CHF112 less than a flight for this route with tickets for a flight from Nyon to Florence costing on average CHF172.
A bus is CHF118 less than a train for this route with tickets for a train from Nyon to Florence costing on average CHF178.
Other travel options to Florence take longer:
Flight takes on average 8h 15m.
Bus takes on average 15h 31m.
Tickets start at around CHF60 compared to roughly CHF114 in fuel and tolls — a saving of about CHF54. The journey takes 15h 31m versus 7h 8m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Gruppo Di Maio, Sellitto.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:50PM | Arrival Time 09:10AM | Duration 17h20 | Departure days Mon | Cheapest price CHF54 |
Operator FlixBus | Departure Time 03:55PM | Arrival Time 07:30AM | Duration 15h35 | Departure days Thu | Cheapest price CHF72 |
Operator FlixBus | Departure Time 07:35PM | Arrival Time 07:20AM | Duration 11h45 | Departure days Fri | Cheapest price CHF56 |
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Nyon to Florence run on average 4 times per day, taking around 15h 31m. Cheap bus tickets for this journey start at CHF51 if you book in advance.
The earliest bus runs at 02:20, the last at 23:25. The fastest bus covers the 303 miles (489 km) distance in 11h 45m.
Distance 303 miles (489 km) |
Average bus duration 15h 31m |
Cheapest ticket price CHF51 |
Buses per day 4 |
Fastest bus 11h 45m |
First bus 2:20 AM |
Last bus 11:25 PM |
Cheapest Month Mar |
Cheapest Day Mon |
High Season Jan - Mar |
Low Season Oct - Dec |
Busiest Day Wed |
Least Busy Day Wed |
Best time to book 35 days |
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
World-famous gallery with Botticelli, Leonardo, and Michelangelo. Essential for understanding Renaissance painting and one of Florence’s top visits.
Houses Michelangelo’s David alongside major Renaissance sculptures. A must for first-time visitors interested in Florence’s artistic legacy.
Monastic museum with Fra Angelico frescoes and tranquil cells. Ideal for experiencing spiritual art in one of Florence’s most atmospheric spaces.
Florence’s monumental main square, framed by civic buildings and sculpture. A must for first impressions, history, and lively urban atmosphere.
The cathedral square is Florence’s ceremonial heart, surrounded by the Duomo, Baptistery, and bell tower. Essential for architecture lovers.
Riverside viewpoint with one of Florence’s classic panoramas. Best at sunset for sweeping views over the Arno, domes, and historic center.
Thick Florentine T-bone steak from Chianina beef, grilled rare over coals. It is the city's signature celebratory dish and a classic of Tuscan cuisine.
A rustic Tuscan bread soup with black cabbage, cannellini beans, vegetables, and olive oil. A beloved frugal dish rooted in Florentine home cooking.
A thick soup of bread, tomatoes, basil, garlic, and olive oil, served warm or at room temperature. It celebrates simple Tuscan ingredients and stale bread.
Three-Michelin-star fine dining by Enoteca Pinchiorri, known for refined Italian cuisine and an exceptional wine cellar. Elegant and formal.
Legendary casual stop for Lampredotto sandwiches and other tripe specialties. Simple, authentic street food experience in central Florence.
Historic steakhouse famed for Bistecca Alla Fiorentina and classic Tuscan dishes. Traditional, bustling atmosphere near Santa Croce.
Moderate for Italy: hotels in the center are pricier, but dining and transit are reasonable versus Rome or Venice.
Service is often included. Round up or leave €1-2 at cafés, 5-10% for great restaurant service, and round up taxi fares.
Official public transport app
Firenze Santa Maria Novella -> Firenze Santa Maria Novella
Find answers to the most common questions about traveling from Nyon to Florence by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, this guide helps you travel smarter and with confidence.

Most Nyon to Florence buses use the Genève, Aéroport to Scandicci, Villa Costanza (Firenze) station pair, with some services arriving at Firenze, Piazzale Montelungo. Use this guide to compare Nyon and Florence bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Scandicci, Villa Costanza (Firenze) is 1 km from Florence city centre. Public transport options include:
Scandicci, Villa Costanza (Firenze) has practical services for this route, including Wifi, Parking, ATM, Accessibility, WC, and Ticket Office.
Free Wi-Fi. ATMs are located near the entrance.
Ticket office support is available at Scandicci, Villa Costanza (Firenze).
Available at Scandicci, Villa Costanza (Firenze): Parking, WC.
Accessibility facilities are available at Scandicci, Villa Costanza (Firenze): Elevators, ramps.
Firenze, Piazzale Montelungo is 1 km from Florence city centre. Public transport options include:
Firenze, Piazzale Montelungo has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, and Ticket Office.
Free Wi-Fi. ATMs are located near the entrance.
Ticket office support is available at Firenze, Piazzale Montelungo.
Available at Firenze, Piazzale Montelungo: Parking, Taxis, WC.
Accessibility facilities are available at Firenze, Piazzale Montelungo: Elevators, ramps.
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