- Must visit
Uffizi Galleries
Florence’s premier art museum, famed for Renaissance masterpieces by Botticelli, Leonardo, Michelangelo, and Raphael. One of Italy’s essential museum visits.
Omio recommends booking the train as it is the most popular option from Nyon to Florence among Omio's users. If you are prioritising price take the bus with prices starting from $62. For those with little time consider booking a train which can get you there in 6h 17m. The ticket price range depends on the travel mode: a bus costs an average of $62, and a train costs an average of $172.
Distance: 303 miles (489 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$74 Average price Cheapest | $219 Average price | $211 Average price | $140 Average price (fuel + tolls) |
16h 1m Average total duration 15h 31m Onboard + 30m Additional time* | 6h 47m Average total duration Fastest 6h 17m Onboard + 30m Additional time* | 11h 15m Average total duration 8h 15m Onboard + 3h 0m Additional time* | 7h 8m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Nyon to Florence:
A bus is $138 (€113) less than a flight for this route with tickets for a flight from Nyon to Florence costing on average $211 (€173).
A bus is $145 (€119) less than a train for this route with tickets for a train from Nyon to Florence costing on average $219 (€179).
Other travel options to Florence take longer:
Flight takes on average 8h 15m.
Bus takes on average 15h 31m.
Tickets start at around $74 (€60) compared to roughly $140 (€115) in fuel and tolls — a saving of about $67 (€55). The journey takes 15h 31m versus 7h 8m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Gruppo Di Maio, Sellitto.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:50PM | Arrival Time 09:10AM | Duration 17h20 | Departure days Mon | Cheapest price $66 |
Operator FlixBus | Departure Time 03:55PM | Arrival Time 07:30AM | Duration 15h35 | Departure days Thu | Cheapest price $89 |
Operator FlixBus | Departure Time 07:35PM | Arrival Time 07:20AM | Duration 11h45 | Departure days Fri | Cheapest price $69 |
The table below shows live departures for Nyon to Florence buses for today, Friday, June 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:35 PM Nyon | 11h45 | 7:20 AM Florence | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Nyon to Florence run on average 4 times per day, taking around 15h 31m. Cheap bus tickets for this journey start at $62 (€51) if you book in advance.
The earliest bus runs at 02:20, the last at 23:25. The fastest bus covers the 303 miles (489 km) distance in 11h 45m.
Distance 303 miles (489 km) |
Average bus duration 15h 31m |
Cheapest ticket price $62 (€51) |
Buses per day 4 |
Fastest bus 11h 45m |
First bus 2:20 AM |
Last bus 11:25 PM |
Cheapest Month Mar |
Cheapest Day Mon |
High Season Jan - Mar |
Low Season Oct - Dec |
Busiest Day Wed |
Least Busy Day Wed |
Best time to book 35 days |
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
Florence’s premier art museum, famed for Renaissance masterpieces by Botticelli, Leonardo, Michelangelo, and Raphael. One of Italy’s essential museum visits.
Best known for Michelangelo’s David, this museum also holds important Florentine paintings and sculpture. Advance booking is strongly advisable.
Vast palace museum complex with royal apartments, Palatine Gallery, and decorative arts. A major stop for art, Medici history, and grand interiors.
Florence’s monumental heart, where the cathedral, baptistery, and bell tower stand together. Essential for first-time visitors and photographers.
Historic civic square filled with sculpture and dominated by Palazzo Vecchio. One of the city’s most important and lively public spaces.
Florence’s most famous viewpoint, especially popular at sunset and widely shared on social media for its sweeping skyline panorama.
A Thick-Cut T-Bone Steak From Chianina Beef, Grilled Rare Over Coals. It Is Florence’s Signature Dish And A Classic Of Tuscan Cuisine.
A Traditional Florentine Street Food Made From The Fourth Stomach Of The Cow, Slow-Cooked In Broth And Served In A Roll, Often With Green Sauce.
A Rustic Tomato, Bread, Garlic, And Olive Oil Soup. It Is A Beloved Tuscan Dish That Turns Stale Bread Into Rich Comfort Food.
A Michelin-Starred Restaurant Offering Refined Tuscan Cuisine With Creative Technique, Elegant Service, And A Contemporary Fine-Dining Atmosphere.
A Small, Long-Running Florentine Favorite Known For Traditional Cooking, Especially Butter Chicken And Simple Tuscan Classics In An Old-School Setting.
A Historic, Casual Trattoria Near Mercato Centrale, Famous For Bistecca Alla Fiorentina, Tuscan Soups, And A Lively Local Atmosphere.
Generally moderate for Italy: museums and central hotels cost more, while casual food and coffee remain fairly affordable.
Service is often included or covered by a coperto. Tipping is not required, but leaving EUR 1-2 at cafes or 5-10% for excellent restaurant service is appreciated.
Official public transport app
Scandicci Villa Costanza, Florence -> Firenze Santa Maria Novella, Florence
Find answers to the most common questions about traveling from Nyon to Florence by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, this guide helps you travel smarter and with confidence.

Most Nyon to Florence buses use the Genève, Aéroport to Scandicci, Villa Costanza (Firenze) station pair, with some services arriving at Firenze, Piazzale Montelungo. Use this guide to compare Nyon and Florence bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Scandicci, Villa Costanza (Firenze) is 1 km from Florence city centre. Public transport options include:
Scandicci, Villa Costanza (Firenze) has practical services for this route, including Wifi, Parking, ATM, Accessibility, WC, and Ticket Office.
Free Wi-Fi. ATMs are located near the entrance.
Ticket office support is available at Scandicci, Villa Costanza (Firenze).
Available at Scandicci, Villa Costanza (Firenze): Parking, WC.
Accessibility facilities are available at Scandicci, Villa Costanza (Firenze): Elevators, ramps.
Firenze, Piazzale Montelungo is 1 km from Florence city centre. Public transport options include:
Firenze, Piazzale Montelungo has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, and Ticket Office.
Free Wi-Fi. ATMs are located near the entrance.
Ticket office support is available at Firenze, Piazzale Montelungo.
Available at Firenze, Piazzale Montelungo: Parking, Taxis, WC.
Accessibility facilities are available at Firenze, Piazzale Montelungo: Elevators, ramps.
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