The cheapest and fastest buses from Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA
Cheapest price
$31
Average price
$33
Fastest journey
1 h 15 m
Average duration
1 h 32 m
Buses per day
13
Distance
117 km
The best way to find a cheap bus ticket from Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA will cost around $33 if you buy it on the day, but the cheapest tickets can be found for only $31.
Of the 13 buses that leave Santa Fe Depot, San Diego, CA for Irvine Transportation Center, Irvine, CA on Mon, Dec 22, 13 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Dec 22 the direct buses cover the 117 km distance in an average of 1 h 32 m but if you time it right, some buses will get you there in just 1 h 15 m .
On Mon, Dec 22 the slowest buses will take 1 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus
FlixBus
FlixBus
FlixBus
FlixBus
FlixBus
FlixBus
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FlixBus
Santa Fe Depot, San Diego, CA - Irvine Transportation Center, Irvine, CACompare FlixBus, Greyhound


Travel Information
Compare bus and train for Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA
Omio recommends booking the train as it is the most popular option from Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA among Omio's users. If you are prioritising price take the bus with prices starting from €15. For those with little time consider booking a train which can get you there in 1h 49m. The ticket price range depends on the travel mode: a bus costs an average of €15, and a train costs an average of €24.
Distance: 72 miles (117 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
€18 Average price Cheapest | €25 Average price |
2h 37m Average total duration 2h 7m Onboard + 30m Additional time* | 2h 19m Average total duration Fastest 1h 49m Onboard + 30m Additional time* |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:45AM | Arrival Time 08:40AM | Duration 1h55 | Departure days Mon, Fri, Sun | Cheapest price $31 |
Operator FlixBus | Departure Time 08:20AM | Arrival Time 10:10AM | Duration 1h50 | Departure days Mon | Cheapest price $33 |
Operator FlixBus | Departure Time 08:45AM | Arrival Time 10:10AM | Duration 1h25 | Departure days Mon | Cheapest price $33 |
Operator FlixBus | Departure Time 11:55AM | Arrival Time 02:20PM | Duration 2h25 | Departure days Mon, Fri, Sun | Cheapest price $31 |
Operator FlixBus | Departure Time 12:15PM | Arrival Time 02:45PM | Duration 2h30 | Departure days Mon, Fri, Sun | Cheapest price $31 |
Operator FlixBus | Departure Time 12:40PM | Arrival Time 02:20PM | Duration 1h40 | Departure days Mon, Fri, Sun | Cheapest price $31 |
Operator FlixBus | Departure Time 03:55PM | Arrival Time 05:30PM | Duration 1h35 | Departure days Mon, Fri, Sun | Cheapest price $31 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 05:30PM | Duration 1h15 | Departure days Mon, Fri, Sun | Cheapest price $31 |
Operator Greyhound | Departure Time 07:35PM | Arrival Time 09:20PM | Duration 1h45 | Departure days Mon, Fri, Sun | Cheapest price $31 |
Live departures
Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA bus times
The table below shows live departures for Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA buses for today, Sunday, December 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 7:55 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 2h25 | 10:20 PM Irvine, West Peltason Dr (UCI Crawford Hall), CA | 0 transfersDirect | |
FlixBus | 7:55 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 2h50 | 10:45 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 0 transfersDirect | |
FlixBus | 8:15 PM San Diego, Congress Street (Old Town Park), CA | 2h30 | 10:45 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 0 transfersDirect | |
FlixBus | 8:15 PM San Diego, Congress Street (Old Town Park), CA | 2h05 | 10:20 PM Irvine, West Peltason Dr (UCI Crawford Hall), CA | 0 transfersDirect | |
FlixBus | 8:40 PM La Jolla, UCSD Health La Jolla Station, CA | 1h40 | 10:20 PM Irvine, West Peltason Dr (UCI Crawford Hall), CA | 0 transfersDirect | |
FlixBus | 8:40 PM La Jolla, UCSD Health La Jolla Station, CA | 2h05 | 10:45 PM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 0 transfersDirect | |
FlixBus | 11:55 PM San Diego, Congress Street (Old Town Park), CA | 1h35 | 1:30 AM Irvine, West Peltason Dr (UCI Crawford Hall), CA | 0 transfersDirect | |
| Monday, December 22 | |||||
FlixBus | 12:15 AM La Jolla, UCSD Health La Jolla Station, CA | 1h15 | 1:30 AM Irvine, West Peltason Dr (UCI Crawford Hall), CA | 0 transfersDirect | |
![]() | 3:35 AM San Diego, Congress Street (Old Town Park), CA | 1h45 | 5:20 AM Santa Ana, E Santa Ana Blvd (Train Station) | 0 transfersDirect | |
![]() | 3:35 AM San Diego, Congress Street (Old Town Park), CA | 2h00 | 5:35 AM Anaheim, Regional Transportation Intermodal Center (ARTIC) | 0 transfersDirect | |
![]() | 2:45 PM San Diego, Congress Street (Old Town Park), CA | 1h55 | 4:40 PM Santa Ana, E Santa Ana Blvd (Train Station) | 0 transfersDirect | |
This is the last bus of the day. | |||||
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Compare prices and tickets Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA by bus or train
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Journey information
Overview: Bus from Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA
Buses from Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA run on average 8 times per day, taking around 2h 7m. Cheap bus tickets for this journey start at $19 (€15) if you book in advance.
There are 7 buses per day. The earliest bus runs at 13:45, the last at 23:15. The fastest bus covers the 72 miles (117 km) distance in 1h 40m.
Distance 72 miles (117 km) |
Average bus duration 2h 7m |
Cheapest ticket price $19 (€15) |
Buses per day 8 |
Direct buses 7 |
Fastest bus 1h 40m |
First bus 13:45 |
Last bus 23:15 |
Bus providers: FlixBus, Greyhound from Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CAYou can travel by bus between Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA with FlixBus, Greyhound for as low as $19 (€15). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
FAQs: Bus from Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA
Find answers to the most common questions about traveling from Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Irvine Transportation Center, Irvine, CA, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Santa Fe Depot, San Diego, CA to Irvine Transportation Center, Irvine, CA, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- Additional luggage can be purchased for a fee.
- Greyhound
- $15 per additional bag.
- FlixBus
- Small pets in carriers allowed
- Guide dogs travel for free.
Most popular bus connections from Santa Fe Depot, San Diego, CA
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