Travel Information
Compare train, bus, and flight for Independence, MO to Chicago, IL
Omio recommends booking the train as it is the most popular option from Independence, MO to Chicago, IL among Omio's users. If you are prioritising price take the train with prices starting from $67. For those with little time consider booking a flight which can get you there in 1h 44m. The ticket price range depends on the travel mode: a train costs an average of $67, and a flight costs an average of $394.
Distance: 403 miles (649 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
$167 Average price | $112 Average price Cheapest | $419 Average price |
13h 39m Average total duration 13h 9m Onboard + 30m Additional time* | 11h 7m Average total duration 10h 37m Onboard + 30m Additional time* | 4h 44m Average total duration Fastest 1h 44m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Independence, MO to Chicago, IL by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Independence, MO to Chicago, IL
Buses from Independence, MO to Chicago, IL run on average 4 times per day, taking around 13h 9m. Cheap bus tickets for this journey start at $138 (€112) but you can travel from only $67 (€54) by train.
The earliest bus runs at 00:15, the last at 23:50. The fastest bus covers the 403 miles (649 km) distance in 10h 55m.
Distance 403 miles (649 km) |
Average bus duration 13h 9m |
Cheapest ticket price $138 (€112) |
Buses per day 4 |
Fastest bus 10h 55m |
First bus 00:15 |
Last bus 23:50 |
Cheapest month Oct |
Cheapest day Fri |
High season Jul - Sep |
Low season Jan - Mar |
Busiest day Sun |
Least busy day Sun |
FAQs: Bus from Independence, MO to Chicago, IL
Find answers to the most common questions about traveling from Independence, MO to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
popular bus stations
Popular bus stations from Independence, MO to Chicago, IL
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