The cheapest and fastest buses from Independence, MO to Chicago, IL
Cheapest price
$96
Average price
$105
Fastest journey
13 h 55 m
Average duration
16 h 38 m
Buses per day
2
Distance
649 km
The best way to find a cheap bus ticket from Independence, MO to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Independence, MO to Chicago, IL will cost around $105 if you buy it on the day, but the cheapest tickets can be found for only $96.
Of the 2 buses that leave Independence, MO for Chicago, IL on Fri, Nov 07, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Nov 07 the direct buses cover the 649 km distance in an average of 16 h 38 m but if you time it right, some buses will get you there in just 13 h 55 m .
On Fri, Nov 07 the slowest buses will take 19 h 20 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare train, bus, and flight for Independence, MO to Chicago, IL
Omio recommends booking the train as it is the most popular option from Independence, MO to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from €43. For those with little time consider booking a flight which can get you there in 1h 43m. The ticket price range depends on the travel mode: a bus costs an average of €43, and a flight costs an average of €102.
Distance: 403 miles (649 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€77 Average price Cheapest | €95 Average price | €229 Average price |
14h 43m Average total duration 14h 13m Onboard + 30m Additional time* | 11h 3m Average total duration 10h 33m Onboard + 30m Additional time* | 4h 43m Average total duration Fastest 1h 43m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Independence, MO to Chicago, IL bus times
The table below shows live departures for Independence, MO to Chicago, IL buses for today, Thursday, November 6. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 11:50 PM Independence, MO | 19h45 | 7:35 PM Chicago, IL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Independence, MO to Chicago, IL by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 07
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Nov 13
Journey information
Overview: Bus from Independence, MO to Chicago, IL
Distance 403 miles (649 km) |
Average bus duration 14h 13m |
Cheapest ticket price $53 (€43) |
Buses per day 4 |
Fastest bus 10h 55m |
First bus 00:15 |
Last bus 23:50 |
Key Takeaways
Train Ticket Prices
- Budget Options: Train tickets from Independence, MO to Chicago, IL start from as low as $53 (€43) if booked well in advance.
- Standard Fares: Typically, trains cost $94 (€77) depending on the train type and class.
FAQs: Bus from Independence, MO to Chicago, IL
Find answers to the most common questions about traveling from Independence, MO to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. Rex skeleton, Sue.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U. S. Offering free admission.
To find the cheapest bus tickets for your trip from Independence, MO to Chicago, IL, follow these tips:
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