- Must visit
Art Institute Of Chicago
One of the premier art museums in the US, known for Impressionist masterpieces, modern works, and the iconic bronze lions at its entrance.
Cheapest price
$147
Average price
$147
Fastest journey
10 h 55 m
Average duration
10 h 55 m
Buses per day
1
Distance
649 km
The best way to find a cheap bus ticket from Independence, MO to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Independence, MO to Chicago, IL will cost around $147 if you buy it on the day, but the cheapest tickets can be found for only $147.
Of the 1 buses that leave Independence, MO for Chicago, IL on Sun, Jun 21, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 21 the direct buses cover the 649 km distance in an average of 10 h 55 m but if you time it right, some buses will get you there in just 10 h 55 m .
On Sun, Jun 21 the slowest buses will take 10 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Omio recommends booking the train as it is the most popular option from Independence, MO to Chicago, IL among Omio's users. If you are prioritising price take the train with prices starting from $58. For those with little time consider booking a flight which can get you there in 2h 18m. The ticket price range depends on the travel mode: a train costs an average of $58, and a flight costs an average of $207.
Distance: 403 miles (649 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$146 Average price | $106 Average price Cheapest | $398 Average price | $101 Average price (fuel + tolls) |
13h 39m Average total duration 13h 9m Onboard + 30m Additional time* | 11h 5m Average total duration 10h 35m Onboard + 30m Additional time* | 5h 18m Average total duration Fastest 2h 18m Onboard + 3h 0m Additional time* | 7h 35m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Independence, MO to Chicago, IL:
A train is $41 (€33) less than a bus for this route with tickets for a bus from Independence, MO to Chicago, IL costing on average $146 (€120).
A train is $292 (€239) less than a flight for this route with tickets for a flight from Independence, MO to Chicago, IL costing on average $398 (€326).
Other travel options to Chicago, IL take longer:
Train takes on average 10h 35m.
Bus takes on average 13h 9m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:50AM | Arrival Time 11:45AM | Duration 10h55 | Departure days Sun | Cheapest price $171 |
Operator Greyhound | Departure Time 12:50AM | Arrival Time 08:10PM | Duration 19h20 | Departure days Sat | Cheapest price $137 |
Operator FlixBus | Departure Time 04:00AM | Arrival Time 04:05PM | Duration 12h05 | Departure days Mon | Cheapest price $146 |
Operator FlixBus | Departure Time 08:40AM | Arrival Time 10:05PM | Duration 13h25 | Departure days Mon | Cheapest price $164 |
Operator Greyhound | Departure Time 08:40AM | Arrival Time 08:00AM | Duration 23h20 | Departure days Mon | Cheapest price $163 |
Operator FlixBus | Departure Time 02:40PM | Arrival Time 04:05AM | Duration 13h25 | Departure days Tue, Fri | Cheapest price $151 |
Operator Greyhound | Departure Time 03:50PM | Arrival Time 05:45AM | Duration 13h55 | Departure days Mon | Cheapest price $122 |
Operator FlixBus | Departure Time 11:50PM | Arrival Time 10:45AM | Duration 10h55 | Departure days Tue, Wed, Thu, Sun | Cheapest price $128 |
Operator Greyhound | Departure Time 11:50PM | Arrival Time 07:10PM | Duration 19h20 | Departure days Fri | Cheapest price $170 |
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Independence, MO to Chicago, IL run on average 3 times per day, taking around 13h 9m. Cheap bus tickets for this journey start at $103 (€84) but you can travel from only $58 (€48) by train.
The earliest bus runs at 00:15, the last at 23:10. The fastest bus covers the 403 miles (649 km) distance in 10h 55m.
Distance 403 miles (649 km) |
Average bus duration 13h 9m |
Cheapest ticket price $103 (€84) |
Buses per day 3 |
Fastest bus 10h 55m |
First bus 12:15 AM |
Last bus 11:10 PM |
Cheapest Month Oct |
Cheapest Day Fri |
High Season Apr - Jun |
Low Season Oct - Dec |
Busiest Day Sun |
Least Busy Day Sun |
Discover the best of Chicago — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago trip today.
One of the premier art museums in the US, known for Impressionist masterpieces, modern works, and the iconic bronze lions at its entrance.
Major natural history museum famous for Sue the T. rex, ancient cultures, and extensive science collections that appeal to both adults and children.
Large hands-on science museum in Hyde Park featuring a submarine, space exhibits, engineering displays, and immersive family-friendly experiences.
The city’s signature public space, home to Cloud Gate, gardens, events, and major skyline views that define modern Chicago.
Famous stretch of Michigan Avenue lined with historic buildings, shops, hotels, and frequent first-time visitor photo stops.
Highly popular waterfront promenade with architecture views, bridges, and one of the best urban walks in the city.
Chicago’s iconic thick-crust pizza baked in a deep pan, layered with cheese, toppings, and chunky tomato sauce. It is one of the city’s most famous comfort foods.
An all-beef hot dog on a poppy seed bun topped with mustard, onions, neon relish, tomato, pickle spear, sport peppers, and celery salt. It is a classic local street food.
Thinly sliced roast beef piled onto an Italian roll, often dipped in seasoned jus and topped with sweet peppers or giardiniera. It is a defining Chicago sandwich.
A historic old-school steakhouse serving steaks, chops, and classic Italian-American dishes in a traditional setting.
Chicago’s internationally acclaimed fine-dining restaurant known for highly inventive tasting menus and exceptional service.
A long-established Chicago favorite known for buttery deep-dish pizza and a casual, family-friendly atmosphere.
Moderate for a major U.S. city: casual food is manageable, but hotels, attractions, and downtown dining can be pricey.
Tip 18-20% in restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, and hotel staff a few dollars.
Find answers to the most common questions about traveling from Independence, MO to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

Most Independence, MO to Chicago, IL buses use the Kansas City, Jefferson Lines to Chicago, Greyhound Bus Station station pair, with some services arriving at Chicago, Union Station (Amtrak). Use this guide to compare Independence, MO and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need