- Must visit
Art Institute of Chicago
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Depew, NY to Chicago, IL
Showing times, prices and bookable tickets for Sep 18
Cheapest price on Sep 18
$110
Average ticket price on Sep 18
$110
Fastest journey on Sep 18
13 h 10 m
Average journey duration on Sep 18
13 h 10 m
Buses on Sep 18
1
Distance
745 km
Cheap tickets
The best way to find a cheap bus ticket from Depew, NY to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Depew, NY to Chicago, IL will cost around $110 if you buy it on the day, but the cheapest tickets can be found for only $110.
Fast buses
On Fri, Sep 18, we found 1 buses from Depew, NY to Chicago, IL, including 1 direct services.
On Fri, Sep 18 the direct buses cover the 745 km distance in an average of 13 h 10 m but if you time it right, some buses will get you there in just 13 h 10 m .
On Fri, Sep 18 the slowest buses will take 13 h 10 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
12:55 PM13h10Depew, NY2:05 AMChicago, IL$1101One-way0 transfers
- 12:55 PM13h10Depew, NY2:05 AMChicago, IL$1101One-way0 transfers
Depew, NY to Chicago, IL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 07:55AM | Arrival Time 08:05PM | Duration 13h10 | Departure days Sun | Cheapest price $75 |
Operator Greyhound | Departure Time 12:55PM | Arrival Time 02:05AM | Duration 13h10 | Departure days Fri | Cheapest price $110 |
Operator Greyhound | Departure Time 11:05PM | Arrival Time 10:00AM | Duration 11h55 | Departure days Sun | Cheapest price $75 |
Live departures
Depew, NY to Chicago, IL bus times
The table below shows live departures for Depew, NY to Chicago, IL buses for tomorrow, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 12:55 PM Depew, NY | 13h10 | 2:05 AM Chicago, IL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Depew, NY to Chicago, IL by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Fri
Sep 18
Sep 18
Sat
Sep 19
Sep 19
Sun
Sep 20
Sep 20
Mon
Sep 21
Sep 21
Tue
Sep 22
Sep 22
Wed
Sep 23
Sep 23
Thu
Sep 24
Sep 24
Journey information
Overview: Bus from Depew, NY to Chicago, IL
USAUSA
Buses from Depew, NY to Chicago, IL run on average 2 times per day, taking around 13h 24m. Cheap bus tickets for this journey start at $92 if you book in advance.
The earliest bus runs at 06:55, the last at 23:15. The fastest bus covers the 462 miles (745 km) distance in 10h 40m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 462 miles (745 km) |
Average bus duration 13h 24m |
Cheapest ticket price $92 |
Buses per day 2 |
Fastest bus 10h 40m |
First bus 6:55 AM |
Last bus 11:15 PM |
Cheapest Month Jan |
Cheapest Day Tue |
High Season Jan - Mar |
Low Season Oct - Dec |
Best time to book 70 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Complete guide to Chicago, IL
Things to do in Chicago, IL
Discover the best of Chicago, IL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago, IL trip today.
- Must visit
Field Museum
Major natural history museum with Sue the T. rex, ancient cultures, and strong family appeal.
- Must visit
Museum of Science and Industry
Hands-on science museum in a grand former fair building, popular for exhibits and a U-505 submarine.
- Must visit
Millennium Park
Lively lakefront park with Cloud Gate, Crown Fountain, gardens, and major public art in central Chicago.
- Must visit
Magnificent Mile
Famous shopping boulevard lined with architecture, hotels, riverfront views, and major city energy.
- Must visit
Chicago Riverwalk
Scenic pedestrian-friendly riverwalk with boat docks, public art, bridges, and standout skyline perspectives.
Deep-Dish Pizza
Deep-dish pizza is Chicago’s iconic pie with a tall buttery crust, layers of cheese and toppings, and chunky tomato sauce baked on top.
Chicago-Style Hot Dog
The Chicago-style hot dog is an all-beef frank on a poppy seed bun with mustard, relish, onion, tomato, pickle, peppers, and celery salt.
Italian Beef Sandwich
Italian beef is thin-sliced roast beef piled onto a roll, often dipped in savory juices and topped with sweet peppers or spicy giardiniera.
Johnnie's Beef
Classic spot for juicy Italian beef sandwiches, especially dipped and topped with spicy giardiniera, with a casual local feel.
Superdawg Drive-In
Legendary stand for Chicago-style hot dogs and char-grilled sausages, served fast in a no-frills local landmark.
Alinea
World-famous fine dining destination offering a highly creative tasting menu and refined service in an elegant setting.
US dollar ($)
Moderate for a major US city: hotels can be pricey, but transit is affordable and dining ranges from cheap eats to upscale options.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a restaurant meal.
- Fine dining
- $75+ per person for upscale restaurants.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and optional small change at cafes.
FAQs: Bus from Depew, NY to Chicago, IL
Find answers to the most common questions about traveling from Depew, NY to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Depew, NY to Chicago, IL can start from as little as $92 when you book in advance. The average bus ticket price for Depew, NY to Chicago, IL is $96 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Depew, NY to Chicago, IL is 10h 40m to travel the 462 miles (745 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Depew, NY to Chicago, IL leaves at 6:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Depew, NY to Chicago, IL leaves at 11:15 PM.
When departing from Depew, NY , you have various bus station options to start your journey from including Buffalo, NFTA Metro Center, Fort Erie, 27 Municipal Centre Dr, Fort Erie, ON . When arriving in Chicago, IL , you can end your journey in bus stations like Chicago, Union Station (Amtrak), IL, Chicago, Greyhound Bus Station .Passengers board the bus most frequently from Buffalo, NFTA Metro Center, which is located around away from the city centre, and they get off the bus at Chicago, Greyhound Bus Station, located 2 away from the city centre.
A trip to Chicago, IL from Depew, NY is worth doing but not as a day trip with a journey time of 10h 40m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Depew, NY to Chicago, IL is January.
Yes, you can take a between Depew, NY and Chicago, IL.
No, the bus from Depew, NY to Chicago, IL has no accessibility options.
No, there are no bathrooms on board the bus from Depew, NY to Chicago, IL.
Some of the most interesting sights to explore in Chicago, IL are:
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
The best things to do in Chicago, IL include:
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
No, bikes are not allowed on board the bus from Depew, NY to Chicago, IL.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Depew, NY to Chicago, IL.
No, luggage for the bus from Depew, NY to Chicago, IL needs to be booked in addition.
No, there are no additional luggage options for the bus from Depew, NY to Chicago, IL.
Unfortunately, pets are not allowed on the bus from Depew, NY to Chicago, IL.
No, there are no USB plugs on board the bus from Depew, NY to Chicago, IL.
No, there is no WiFi on board the bus from Depew, NY to Chicago, IL.
Since neither Depew, NY nor Chicago, IL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Depew, NY to Chicago, IL among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Chicago, IL, travelers should be cautious of pickpocketing and purse snatching, especially in crowded areas like public transit and popular tourist spots. Common scams include fake charity solicitations and distraction thefts. It is advisable to stay alert in neighborhoods outside downtown after dark and use authorized transportation services to avoid unlicensed taxi scams. Keeping valuables secure and being aware of surroundings helps mitigate these risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Depew, NY to Chicago, IL
Most Depew, NY to Chicago, IL buses use the Buffalo, NFTA Metro Center to Chicago, Union Station (Amtrak) station pair, with some services arriving at Chicago, Greyhound Bus Station. Use this guide to compare Depew, NY and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Depew
Arrival bus stations in Chicago
Which Chicago, IL station do buses from Depew, NY arrive at?
Buses from Depew, NY to Chicago, IL most often arrive at Chicago, Union Station (Amtrak). Some services arrive at Chicago, Greyhound Bus Station, so check your ticket before travel to confirm your Chicago, IL arrival station.
Chicago, Union Station (Amtrak)Chicago Union Station, 225 S Canal St, Chicago, IL 60606, USA
City-centre transport
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Bus28, 151 · 7m · $4 · every ~13 min
Chicago, Union Station (Amtrak) bus station facilities and services
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options are available inside the station.
Wi-Fi and ATMs
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Tickets and information
Ticket office support is available at Chicago, Union Station (Amtrak).
Parking, taxis and toilets
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Chicago, Greyhound Bus Station630 W Harrison St, Chicago, IL 60607, USA
City-centre transport
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Bus7 · 8m · $4 · every ~6 min
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
More options for your journey from Depew, NY to Chicago, IL
Here are some other resources that might have the information you need
Most popular buses to and from Chicago, IL and Depew, NY
Most popular bus connections to Chicago, IL
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
