4.9
4.6
Travel Information
Compare bus, train, and flight for Depew, NY to Chicago, IL
Omio recommends booking the train as it is the most popular option from Depew, NY to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from $65. For those with little time consider booking a flight which can get you there in 1h 53m. The ticket price range depends on the travel mode: a bus costs an average of $65, and a flight costs an average of $97.
Distance: 462 miles (745 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
$84 Average price Cheapest | $127 Average price | $171 Average price |
13h 40m Average total duration 13h 10m Onboard + 30m Additional time* | 11h 3m Average total duration 10h 33m Onboard + 30m Additional time* | 4h 53m Average total duration Fastest 1h 53m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Depew, NY to Chicago, IL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 22
Mar 23
Mar 24
Mar 25
Mar 26
Mar 27
Mar 28
Journey information
Overview: Bus from Depew, NY to Chicago, IL
USAUSA
Buses from Depew, NY to Chicago, IL run on average 2 times per day, taking around 13h 10m. Cheap bus tickets for this journey start at $65 (€52) but you can travel from only $58 (€47) by train.
The earliest bus runs at 06:55, the last at 23:15. The fastest bus covers the 462 miles (745 km) distance in 13h 10m.
Distance 462 miles (745 km) |
Average bus duration 13h 10m |
Cheapest ticket price $65 (€52) |
Buses per day 2 |
Fastest bus 13h 10m |
First bus 06:55 |
Last bus 23:15 |
Cheapest month Jan |
Cheapest day Tue |
High season Jan - Mar |
Low season Apr - Jun |
Best day to book ahead 70 days |
FAQs: Bus from Depew, NY to Chicago, IL
Find answers to the most common questions about traveling from Depew, NY to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
popular bus stations
Popular bus stations from Depew, NY to Chicago, IL
More options for your journey from Depew, NY to Chicago, IL
Here are some other resources that might have the information you need
Most popular buses to and from Chicago, IL and Depew, NY
Most popular bus connections to Chicago, IL
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
