4.9
4.6The cheapest and fastest buses from Chicago, IL to Depew, NY
Cheapest price on Sep 18
$74
Average ticket price on Sep 18
$76
Fastest journey on Sep 18
13 h
Average journey duration on Sep 18
18 h 5 m
Buses on Sep 18
3
Distance
745 km
The best way to find a cheap bus ticket from Chicago, IL to Depew, NY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Chicago, IL to Depew, NY will cost around $76 if you buy it on the day, but the cheapest tickets can be found for only $74.
It's difficult to get from Chicago, IL to Depew, NY without transferring at least once.
FlixBus+
· 7:15 PM20h30Chicago, Greyhound Bus Station4:45 PMBuffalo, NFTA Metro Center$741One-way2 transfers- · 6:00 PM13h00Chicago, Greyhound Bus Station8:00 AMBuffalo, NFTA Metro Center$751One-way1 transfer
- · · · 10:15 AM20h45Chicago, Union Station (Amtrak), IL8:00 AMBuffalo, NFTA Metro Center$801One-way3 transfers
- · 6:00 PM13h00Chicago, Greyhound Bus Station8:00 AMBuffalo, NFTA Metro Center$751One-way1 transfer
- FlixBus+ · 7:15 PM20h30Chicago, Greyhound Bus Station4:45 PMBuffalo, NFTA Metro Center$741One-way2 transfers
- · · · 10:15 AM20h45Chicago, Union Station (Amtrak), IL8:00 AMBuffalo, NFTA Metro Center$801One-way3 transfers
Travel Information
Compare bus, train, and flight for Chicago, IL to Depew, NY
Omio recommends booking the train as it is the most popular option from Chicago, IL to Depew, NY among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $85 For those with little time, consider booking a flight, which has an average total journey time of 5h 34m. Average ticket prices depend on the travel mode: a bus costs an average of $85, while a flight costs an average of $571.
Distance: 462 miles (745 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$85 Average price Cheapest | $161 Average price | $571 Average price | $110 Average price (fuel + tolls) |
16h 45m Average total duration 16h 15m Onboard + 30m Additional time* | 10h 53m Average total duration 10h 23m Onboard + 30m Additional time* | 5h 34m Average total duration Fastest 3h 34m Onboard + 2h 0m Additional time* | 7h 59m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Chicago, IL to Depew, NY:
A bus is $77 less than a train for this route with tickets for a train from Chicago, IL to Depew, NY costing on average $161.
A bus is $486 less than a flight for this route with tickets for a flight from Chicago, IL to Depew, NY costing on average $571.
Other travel options to Depew, NY take longer:
Train takes on average 10h 23m.
Bus takes on average 16h 15m.
Tickets start at around $85 compared to roughly $110 in fuel and tolls — a saving of about $25. The journey takes 16h 15m versus 7h 59m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Chicago, IL to Depew, NY Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:00AM | Arrival Time 09:15PM | Duration 21h15 | Departure days Wed | Cheapest price $57 |
Operator FlixBus | Departure Time 12:15AM | Arrival Time 08:15PM | Duration 20h00 | Departure days Thu, Sun | Cheapest price $58 |
Operator FlixBus | Departure Time 01:15AM | Arrival Time 09:15PM | Duration 20h00 | Departure days Mon, Tue, Fri | Cheapest price $57 |
Operator Greyhound | Departure Time 10:15AM | Arrival Time 08:00AM | Duration 20h45 | Departure days Fri | Cheapest price $80 |
Operator Greyhound | Departure Time 06:00PM | Arrival Time 08:00AM | Duration 13h00 | Departure days Fri | Cheapest price $75 |
Operator FlixBus | Departure Time 07:15PM | Arrival Time 04:45PM | Duration 20h30 | Departure days Fri | Cheapest price $74 |
Operator Greyhound | Departure Time 11:00PM | Arrival Time 12:00PM | Duration 13h00 | Departure days Mon, Tue, Thu | Cheapest price $72 |
Live departures
Chicago, IL to Depew, NY bus times
The table below shows live departures for Chicago, IL to Depew, NY buses for today, Thursday, September 17. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 11:00 PM Chicago, IL | 13h00 | 12:00 PM Depew, NY | 0 transfersDirect | |
| Friday, September 18 | |||||
| · · · | 10:15 AM Chicago, Union Station (Amtrak), IL | 20h45 | 8:00 AM Buffalo, NFTA Metro Center | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Chicago, IL to Depew, NY by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sep 18
Sep 19
Sep 20
Sep 21
Sep 22
Sep 23
Sep 24
Journey information
Overview: Bus from Chicago, IL to Depew, NY
USAUSA
Buses from Chicago, IL to Depew, NY run on average 2 times per day, taking around 16h 15m. Cheap bus tickets for this journey start at $65 if you book in advance.
The earliest bus runs at 06:55, the last at 23:15. The fastest bus covers the 462 miles (745 km) distance in 10h 40m.
Distance 462 miles (745 km) |
Average bus duration 16h 15m |
Cheapest ticket price $65 |
Buses per day 2 |
Fastest bus 10h 40m |
First bus 6:55 AM |
Last bus 11:15 PM |
Cheapest Month Jun |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Oct - Dec |
Busiest Day Wed |
Least Busy Day Wed |
Best time to book 14 days |
FAQs: Bus from Chicago, IL to Depew, NY
Find answers to the most common questions about traveling from Chicago, IL to Depew, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Depew, NY, this guide helps you travel smarter and with confidence.
popular bus stations
Popular bus stations from Chicago, IL to Depew, NY
Most Chicago, IL to Depew, NY buses use the Chicago, Greyhound Bus Station to Buffalo, NFTA Metro Center station pair. Use this guide to compare Chicago, IL and Depew, NY bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Which Chicago, IL station do buses to Depew, NY leave from?
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Chicago, Union Station (Amtrak) bus station facilities and services
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options are available inside the station.
Wi-Fi and ATMs
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Tickets and information
Ticket office support is available at Chicago, Union Station (Amtrak).
Parking, taxis and toilets
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Most popular bus connections from Chicago, IL
More options for your journey from Chicago, IL to Depew, NY
Here are some other resources that might have the information you need
Most popular buses to and from Depew, NY and Chicago, IL
Most popular bus connections to Depew, NY
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