The cheapest and fastest buses from Chicago, IL to Depew, NY
- Cheapest price on Nov 04
- €47
- Average ticket price on Nov 04
- €53
- Fastest journey on Nov 04
- 13 h
- Average journey duration on Nov 04
- 17 h 8 m
- Buses on Nov 04
- 2
- Distance
- 745 km
The best way to find a cheap bus ticket from Chicago, IL to Depew, NY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Chicago, IL to Depew, NY will cost around €53 if you buy it on the day, but the cheapest tickets can be found for only €47.
On Wed, Nov 04, we found 2 buses from Chicago, IL to Depew, NY, including 2 direct services.
On Wed, Nov 04 the direct buses cover the 745 km distance in an average of 17 h 8 m but if you time it right, some buses will get you there in just 13 h .
On Wed, Nov 04 the slowest buses will take 21 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

12:00 AM 21h15 Chicago, IL 9:15 PM Depew, NY €47 1 One-way 0 transfers
11:00 PM 13h00 Chicago, IL 12:00 PM Depew, NY €59 1 One-way 0 transfers

11:00 PM 13h00 Chicago, IL 12:00 PM Depew, NY €59 1 One-way 0 transfers
12:00 AM 21h15 Chicago, IL 9:15 PM Depew, NY €47 1 One-way 0 transfers
Journey information
Overview: Bus from Chicago, IL to Depew, NY
Buses from Chicago, IL to Depew, NY run on average 2 times per day, taking around 15h 54m. Cheap bus tickets for this journey start at €48 if you book in advance.
The earliest bus runs at 06:55, the last at 23:15. The fastest bus covers the 462 miles (745 km) distance in 10h 40m.
Distance 462 miles (745 km) |
Average bus duration 15h 54m |
Cheapest ticket price €48 |
Buses per day 2 |
Fastest bus 10h 40m |
First bus 6:55 AM |
Last bus 11:15 PM |
Cheapest Month Jun |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Oct - Dec |
Busiest Day Wed |
Least Busy Day Wed |
Best time to book 14 days |
Frequently asked questions about your Chicago, IL to Depew, NY trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Chicago, IL to Depew, NY.
Chicago, IL to Depew, NY Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:00AM | Arrival Time 09:15PM | Duration 21h15 | Departure days Wed | Cheapest price €47 |
Operator FlixBus | Departure Time 12:15AM | Arrival Time 08:15PM | Duration 20h00 | Departure days Thu, Sat, Sun | Cheapest price €48 |
Operator FlixBus | Departure Time 01:15AM | Arrival Time 09:15PM | Duration 20h00 | Departure days Mon, Tue, Fri, Sat | Cheapest price €47 |
Operator Greyhound | Departure Time 11:00PM | Arrival Time 12:00PM | Duration 13h00 | Departure days Mon, Tue, Thu | Cheapest price €59 |
Live departures
Chicago, IL to Depew, NY bus times
The table below shows live departures for Chicago, IL to Depew, NY buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 1:15 AM Chicago, IL | 20h00 | 9:15 PM Depew, NY | 0 transfersDirect | |
![]() | 11:00 PM Chicago, IL | 13h00 | 12:00 PM Depew, NY | 0 transfersDirect | |
| Tuesday, November 3 | |||||
![]() | 12:00 AM Chicago, IL | 21h15 | 9:15 PM Depew, NY | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book Chicago, IL to Depew, NY buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Chicago, IL to Depew, NY.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Chicago, IL to Depew, NY.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Chicago, IL to Depew, NY.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Chicago, IL to Depew, NY.
Bus providers: Greyhound, FlixBus from Chicago, IL to Depew, NYYou can travel by bus between Chicago, IL to Depew, NY with Greyhound, FlixBus for as low as €48. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
Companies, tickets, and onboard amenities between Chicago, IL and Depew, NY
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
FAQs: Bus from Chicago, IL to Depew, NY
Find answers to the most common questions about traveling from Chicago, IL to Depew, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Depew, NY, this guide helps you travel smarter and with confidence.

popular bus stations
Popular bus stations from Chicago, IL to Depew, NY
Most Chicago, IL to Depew, NY buses use the Chicago, Greyhound Bus Station to station pair. Use this guide to compare Chicago, IL and Depew, NY bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Which Chicago, IL station do buses to Depew, NY leave from?
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Chicago, Union Station (Amtrak) bus station facilities and services
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options are available inside the station.
Wi-Fi and ATMs
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Tickets and information
Ticket office support is available at Chicago, Union Station (Amtrak).
Parking, taxis and toilets
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Most popular bus connections from Chicago, IL
More options for your journey from Chicago, IL to Depew, NY
Here are some other resources that might have the information you need

