The cheapest and fastest buses from Chicago, IL to Depew, NY
Cheapest price
$74
Average price
$74
Fastest journey
20 h
Average duration
20 h
Buses per day
1
Distance
745 km
The best way to find a cheap bus ticket from Chicago, IL to Depew, NY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Chicago, IL to Depew, NY will cost around $74 if you buy it on the day, but the cheapest tickets can be found for only $74.
Of the 1 buses that leave Chicago, IL for Depew, NY on Sun, Jun 21, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 21 the direct buses cover the 745 km distance in an average of 20 h but if you time it right, some buses will get you there in just 20 h .
On Sun, Jun 21 the slowest buses will take 20 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
12:15 AM20h00Chicago, IL8:15 PMDepew, NY$741One-way0 transfers
12:15 AM20h00Chicago, IL8:15 PMDepew, NY$741One-way0 transfers
Travel Information
Compare bus, train, and flight for Chicago, IL to Depew, NY
Omio recommends booking the train as it is the most popular option from Chicago, IL to Depew, NY among Omio's users. If you are prioritising price take the bus with prices starting from $57. For those with little time consider booking a flight which can get you there in 1h 55m. The ticket price range depends on the travel mode: a bus costs an average of $57, and a flight costs an average of $68.
Distance: 462 miles (745 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$84 Average price Cheapest | $120 Average price | $249 Average price | $108 Average price (fuel + tolls) |
19h 1m Average total duration 18h 31m Onboard + 30m Additional time* | 10h 53m Average total duration 10h 23m Onboard + 30m Additional time* | 4h 55m Average total duration Fastest 1h 55m Onboard + 3h 0m Additional time* | 7h 59m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Chicago, IL to Depew, NY:
A bus is $36 (€29) less than a train for this route with tickets for a train from Chicago, IL to Depew, NY costing on average $120 (€98).
A bus is $166 (€136) less than a flight for this route with tickets for a flight from Chicago, IL to Depew, NY costing on average $249 (€204).
Other travel options to Depew, NY take longer:
Train takes on average 10h 23m.
Bus takes on average 18h 31m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Chicago, IL to Depew, NY Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:15AM | Arrival Time 08:45PM | Duration 20h30 | Departure days Sat, Sun | Cheapest price $74 |
Operator FlixBus | Departure Time 01:15AM | Arrival Time 09:45PM | Duration 20h30 | Departure days Mon, Tue, Fri, Sat | Cheapest price $57 |
Operator Greyhound | Departure Time 10:15AM | Arrival Time 08:00AM | Duration 20h45 | Departure days Tue, Wed | Cheapest price $67 |
Operator Greyhound | Departure Time 06:00PM | Arrival Time 08:00AM | Duration 13h00 | Departure days Tue, Wed | Cheapest price $63 |
Operator FlixBus | Departure Time 07:15PM | Arrival Time 04:45PM | Duration 20h30 | Departure days Tue, Wed | Cheapest price $63 |
Operator Greyhound | Departure Time 11:00PM | Arrival Time 12:00PM | Duration 13h00 | Departure days Mon, Thu | Cheapest price $84 |
Live departures
Chicago, IL to Depew, NY bus times
The table below shows live departures for Chicago, IL to Depew, NY buses for tomorrow, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:15 AM Chicago, IL | 20h00 | 8:15 PM Depew, NY | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Chicago, IL to Depew, NY by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jun 20
Jun 21
Jun 22
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Jun 26
Journey information
Overview: Bus from Chicago, IL to Depew, NY
Buses from Chicago, IL to Depew, NY run on average 2 times per day, taking around 18h 31m. Cheap bus tickets for this journey start at $57 (€46) if you book in advance.
The earliest bus runs at 06:55, the last at 23:15. The fastest bus covers the 462 miles (745 km) distance in 13h 0m.
Distance 462 miles (745 km) |
Average bus duration 18h 31m |
Cheapest ticket price $57 (€46) |
Buses per day 2 |
Fastest bus 13h 0m |
First bus 6:55 AM |
Last bus 11:15 PM |
Cheapest Month Feb |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Jul - Sep |
Best time to book 42 days |
FAQs: Bus from Chicago, IL to Depew, NY
Find answers to the most common questions about traveling from Chicago, IL to Depew, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Depew, NY, this guide helps you travel smarter and with confidence.

popular bus stations
Popular bus stations from Chicago, IL to Depew, NY
Most Chicago, IL to Depew, NY buses use the Chicago, Greyhound Bus Station to Buffalo, NFTA Metro Center station pair. Use this guide to compare Chicago, IL and Depew, NY bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Most popular bus connections from Chicago, IL
More options for your journey from Chicago, IL to Depew, NY
Here are some other resources that might have the information you need
