Travel Information
Compare bus, train, and flight for Depew, NY to Boston, MA
Omio recommends booking the train as it is the most popular option from Depew, NY to Boston, MA among Omio's users. If you are prioritising price take the bus with prices starting from €84. For those with little time consider booking a flight which can get you there in 7h 26m. The ticket price range depends on the travel mode: a bus costs an average of €84, and a train costs an average of €402.
Distance: 389 miles (627 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€84 Average price Cheapest | €402 Average price | €178 Average price |
15h 50m Average total duration 15h 20m Onboard + 30m Additional time* | 11h 45m Average total duration 11h 15m Onboard + 30m Additional time* | 10h 26m Average total duration Fastest 7h 26m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Depew, NY to Boston, MA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Depew, NY to Boston, MA
Buses from Depew, NY to Boston, MA run on average 15 times per day, taking around 15h 20m. Cheap bus tickets for this journey start at $103 (€84) if you book in advance.
The earliest bus runs at 00:55, the last at 23:20. The fastest bus covers the 389 miles (627 km) distance in 15h 20m.
Distance 389 miles (627 km) |
Average bus duration 15h 20m |
Cheapest ticket price $103 (€84) |
Buses per day 15 |
Fastest bus 15h 20m |
First bus 00:55 |
Last bus 23:20 |
FAQs: Bus from Depew, NY to Boston, MA
Find answers to the most common questions about traveling from Depew, NY to Boston, MA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Boston, MA, this guide helps you travel smarter and with confidence.

- Best sights: Freedom Trail, a 2.5-mile-long path through downtown Boston that passes by 16 significant historical sites
- Fenway Park, the iconic baseball stadium and home of the Boston Red Sox
- Museum of Fine Arts, one of the largest art museums in the United States with an extensive collection of artworks
- Boston Common, the oldest public park in the United States offering green space and historical landmarks
- New England Aquarium, a popular attraction featuring a wide variety of marine life and interactive exhibits.
- Things to do: Explore the historic streets of Beacon Hill, known for its charming cobblestone streets and Federal-style rowhouses
- Take a scenic walk along the Charles River Esplanade, offering beautiful views of the Boston skyline
- Visit the Boston Public Library, a stunning architectural landmark with impressive collections and exhibits
- Enjoy a guided tour of the historic USS Constitution, the world's oldest commissioned naval vessel still afloat
- Discover the vibrant atmosphere of Quincy Market, with its diverse food stalls and unique shops.
To find the cheapest bus tickets for your trip from Depew, NY to Boston, MA, follow these tips:
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Popular bus stations from Depew, NY to Boston, MA
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