- Must visit
Museum of Fine Arts, Boston
One of the largest art museums in the United States, known for its encyclopedic collection spanning ancient to contemporary works.
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Travel Information
Compare bus, train, and flight for Depew, NY to Boston, MA
Omio recommends booking the train as it is the most popular option from Depew, NY to Boston, MA among Omio's users. If you are prioritising price take the bus with prices starting from $106. For those with little time consider booking a flight which can get you there in 4h 26m. The ticket price range depends on the travel mode: a bus costs an average of $106, and a flight costs an average of $159.
Distance: 389 miles (627 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$109 Average price Cheapest | $157 Average price | $192 Average price | $90 Average price (fuel + tolls) |
14h 50m Average total duration 14h 20m Onboard + 30m Additional time* | 13h 15m Average total duration 12h 45m Onboard + 30m Additional time* | 7h 26m Average total duration Fastest 4h 26m Onboard + 3h 0m Additional time* | 6h 33m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Depew, NY to Boston, MA is a bus with an average price of $109 (€89).
This is compared to other travel options from Depew, NY to Boston, MA:
A bus is $48 (€39) less than a train for this route with tickets for a train from Depew, NY to Boston, MA costing on average $157 (€128).
A bus is $83 (€67) less than a flight for this route with tickets for a flight from Depew, NY to Boston, MA costing on average $192 (€156).
The fastest way to travel from Depew, NY to Boston, MA is by flight with an average journey time of 4h 26m.
Other travel options to Boston, MA take longer:
Train takes on average 12h 45m.
Bus takes on average 14h 20m.
It's helpful to compare your options as there are 3 ways to travel between Depew, NY and Boston, MA including taking a bus, train, and flight.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Depew, NY to Boston, MA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 04:20AM | Arrival Time 06:25PM | Duration 14h05 | Departure days Tue | Cheapest price $112 |
Operator Greyhound | Departure Time 12:50PM | Arrival Time 03:25AM | Duration 14h35 | Departure days Thu | Cheapest price $106 |
Live departures
Depew, NY to Boston, MA bus times
The table below shows live departures for Depew, NY to Boston, MA buses for today, Thursday, June 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 12:50 PM Depew, NY | 14h35 | 3:25 AM Boston, MA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Depew, NY to Boston, MA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Depew, NY to Boston, MA
USAUSA
Buses from Depew, NY to Boston, MA run on average 17 times per day, taking around 14h 20m. Cheap bus tickets for this journey start at $106 (€87) if you book in advance.
The earliest bus runs at 00:15, the last at 22:00. The fastest bus covers the 389 miles (627 km) distance in 14h 5m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 389 miles (627 km) |
Average bus duration 14h 20m |
Cheapest ticket price $106 (€87) |
Buses per day 17 |
Fastest bus 14h 5m |
First bus 12:15 AM |
Last bus 10:00 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Jul - Sep |
Best time to book 2 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Complete guide to Boston
Things to do in Boston
Discover the best of Boston — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Boston trip today.
- Must visit
Isabella Stewart Gardner Museum
A distinctive Venetian-style museum with major European, Asian, and American art, famous for its intimate courtyard and historic 1990 art theft.
- Must visit
Museum of Science
A family-friendly science museum with hands-on exhibits, a planetarium, and broad appeal for visitors interested in technology and natural science.
- Must visit
Freedom Trail
Boston’s signature walking route linking many of the city’s most important historic sites, ideal for first-time visitors.
- Must visit
Boston Common
The oldest public park in the United States, serving as a central green space and gateway to the Freedom Trail.
- Must visit
Public Garden
A picturesque landscaped garden known for its lagoon, bridges, and swan boats, especially photogenic in spring and summer.
New England Clam Chowder
A creamy soup of clams, potatoes, and onions that is one of Boston’s signature comfort foods and a classic of New England cooking.
Lobster Roll
Sweet lobster meat served in a buttered split-top roll, often dressed lightly with mayo or warm butter. It is a beloved Boston-area seafood staple.
- Gluten-free
Boston Baked Beans
Slow-cooked beans traditionally baked with molasses and salt pork, tied to the city’s old nickname, 'Beantown,' and its colonial food history.
Oleana
Highly regarded restaurant in Cambridge near Boston, known for refined Eastern Mediterranean cooking, excellent ingredients, and a warm upscale atmosphere.
Mike's Pastry
Iconic North End bakery best known for cannoli and other Italian pastries, popular with both locals and visitors seeking a classic Boston sweet stop.
Neptune Oyster
Small, celebrated North End seafood spot known for lobster rolls, oysters, and a lively atmosphere. A longtime favorite for classic Boston seafood.
United States Dollar
Boston is pricey by U.S. standards, especially for hotels and dining, though casual food and transit are manageable.
Average meal costs
- Budget
- USD 12-20 for casual or fast food.
- Mid-range
- USD 25-45 per person at a mid-range restaurant.
- Fine dining
- USD 80+ per person before drinks and tip.
- Coffee
- USD 4-7 for a coffee drink.
Tipping culture
Tip 18-20% in restaurants, 20%+ for great service. USD 1-2 per drink at bars, round up taxis, and tip hotel staff USD 2-5.
FAQs: Bus from Depew, NY to Boston, MA
Find answers to the most common questions about traveling from Depew, NY to Boston, MA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Boston, MA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Depew, NY to Boston, MA can start from as little as $106 (€87) when you book in advance. The average bus ticket price for Depew, NY to Boston, MA is $109 (€89) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Depew, NY to Boston, MA is 14h 5m to travel the 389 miles (627 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Depew, NY to Boston, MA leaves at 12:15 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Depew, NY to Boston, MA leaves at 10:00 PM.
A trip to Boston, MA from Depew, NY is worth doing but not as a day trip with a journey time of 14h 5m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Depew, NY to Boston, MA is July.
It's helpful to compare your options as there are 3 ways to travel between Depew, NY and Boston, MA including taking a bus, train, and flight.
No, the bus from Depew, NY to Boston, MA has no accessibility options.
No, there are no bathrooms on board the bus from Depew, NY to Boston, MA.
Some of the most interesting sights to explore in Boston, MA are:
- Best sights: Freedom Trail, a 2.5-mile-long path through downtown Boston that passes by 16 significant historical sites
- Fenway Park, the iconic baseball stadium and home of the Boston Red Sox
- Museum of Fine Arts, one of the largest art museums in the United States with an extensive collection of artworks
- Boston Common, the oldest public park in the United States offering green space and historical landmarks
- New England Aquarium, a popular attraction featuring a wide variety of marine life and interactive exhibits.
The best things to do in Boston, MA include:
- Things to do: Explore the historic streets of Beacon Hill, known for its charming cobblestone streets and Federal-style rowhouses
- Take a scenic walk along the Charles River Esplanade, offering beautiful views of the Boston skyline
- Visit the Boston Public Library, a stunning architectural landmark with impressive collections and exhibits
- Enjoy a guided tour of the historic USS Constitution, the world's oldest commissioned naval vessel still afloat
- Discover the vibrant atmosphere of Quincy Market, with its diverse food stalls and unique shops.
No, bikes are not allowed on board the bus from Depew, NY to Boston, MA.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Depew, NY to Boston, MA.
No, luggage for the bus from Depew, NY to Boston, MA needs to be booked in addition.
No, there are no additional luggage options for the bus from Depew, NY to Boston, MA.
Unfortunately, pets are not allowed on the bus from Depew, NY to Boston, MA.
No, there are no USB plugs on board the bus from Depew, NY to Boston, MA.
No, there is no WiFi on board the bus from Depew, NY to Boston, MA.
Since neither Depew, NY nor Boston, MA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Boston, MA, travelers should be aware of pickpocketing and bag theft, especially in crowded areas like public transit and popular tourist spots. Common scams include fake charity solicitations and overcharging by unlicensed taxi drivers. It's advisable to use official transportation services, stay alert in busy areas, and avoid sharing personal information with strangers to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Depew, NY to Boston, MA
Most Depew, NY to Boston, MA buses use the Buffalo, NFTA Metro Center to Boston, Bus Terminal South Station station pair. Use this guide to compare Depew, NY and Boston, MA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Depew
Arrival bus stations in Boston
Boston, Bus Terminal South Station
City-centre transport
Getting to Boston, Bus Terminal South Station from Boston city centre
SubwayRed Line · 2m · $4 · every ~26 min
Red Line · 4m · $4 · every ~26 min
More options for your journey from Depew, NY to Boston, MA
Here are some other resources that might have the information you need
Most popular buses to and from Boston, MA and Depew, NY
Most popular bus connections to Boston, MA
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