- Must visit
National Museum of Civil War Medicine
Interactive museum explaining battlefield medicine, surgery, and care during the Civil War in a historic downtown building.
The best way to find a cheap bus ticket from Boston, MA to Frederick, MD is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Boston, MA to Frederick, MD will cost around €139 if you buy it on the day, but the cheapest tickets can be found for only €139.
On Wed, Nov 04, we found 1 buses from Boston, MA to Frederick, MD, including 1 direct services.
On Wed, Nov 04 the direct buses cover the 626 km distance in an average of 21 h 55 m but if you time it right, some buses will get you there in just 21 h 55 m .
On Wed, Nov 04 the slowest buses will take 21 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Boston, MA to Frederick, MD run on average 3 times per day, taking around 11h 22m. Cheap bus tickets for this journey start at €60 if you book in advance.
The earliest bus runs at 00:30, the last at 22:00. The fastest bus covers the 388 miles (626 km) distance in 10h 45m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Boston, MA to Frederick, MD.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Flixbus USA | Departure Time 01:00AM | Arrival Time 12:30PM | Duration 11h30 | Departure days Mon | Cheapest price €152 |
Operator Greyhound | Departure Time 01:30AM | Arrival Time 11:25PM | Duration 21h55 | Departure days Mon, Fri, Sat, Sun | Cheapest price €94 |
Operator FlixBus | Departure Time 01:50AM | Arrival Time 11:25PM | Duration 21h35 | Departure days Thu | Cheapest price €110 |
Operator Greyhound | Departure Time 02:30AM | Arrival Time 12:25AM | Duration 21h55 | Departure days Wed | Cheapest price €139 |
Operator Flixbus USA | Departure Time 07:15AM | Arrival Time 07:25PM | Duration 12h10 | Departure days Mon | Cheapest price €88 |
Operator Flixbus USA | Departure Time 08:00AM | Arrival Time 08:30PM | Duration 12h30 | Departure days Mon | Cheapest price €152 |
Operator Greyhound | Departure Time 11:20AM | Arrival Time 11:25PM | Duration 12h05 | Departure days Wed | Cheapest price €109 |
Operator Greyhound | Departure Time 08:45PM | Arrival Time 10:40AM | Duration 13h55 | Departure days Sat | Cheapest price €103 |
The table below shows live departures for Boston, MA to Frederick, MD buses for tomorrow, Tuesday, November 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:30 AM Boston, MA | 21h55 | 12:25 AM Frederick, MD | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Boston, MA to Frederick, MD with Greyhound and FlixBus. Overnight buses available on this route with Greyhound and FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Frederick, MD — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Frederick, MD trip today.
Interactive museum explaining battlefield medicine, surgery, and care during the Civil War in a historic downtown building.
Regional history museum with exhibits on Frederick County life, culture, and changing communities inside a restored historic home.
Contemporary art space in downtown Frederick presenting rotating exhibitions by regional and national artists in a modern gallery setting.
Linear downtown park and promenade with fountains, public art, bridges, and event spaces, ideal for walking day or evening.
Central historic district with preserved architecture, local shops, galleries, and easy access to many of Frederick’s main sights.
Popular downtown street lined with historic buildings, boutiques, public art, and one of the city’s best pedestrian atmospheres.
Maryland crab cakes are packed with blue crab and light seasoning. They are a regional staple near Frederick and widely served across Central Maryland.
Cream of crab soup is a rich Maryland favorite made with crab meat, cream, and seasoning. It reflects the state's strong Chesapeake seafood tradition.
Smith Island cake is Maryland's official state dessert, with many thin cake layers and frosting. It is a classic sweet treat found around Frederick.
Well-known farm brewery outside downtown with estate beer, pizza, and scenic grounds suited to relaxed afternoons.
Contemporary American restaurant known for wood-fired dishes, cocktails, and a polished but relaxed downtown atmosphere.
Casual local favorite for New York-style pizza, pasta, and Italian-American comfort food in the historic district.
Moderate for a U.S. mid-size city: hotels and dining are below major metros, but car-based transport and limited transit can raise visitor costs.
Tip 18-20% at restaurants, more for excellent service. Taxis usually 10-15%. Cafes often have tip jars; $1-2 is common.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Frederick, MD.
Find answers to the most common questions about traveling from Boston, MA to Frederick, MD by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Frederick, MD, this guide helps you travel smarter and with confidence.

Most Boston, MA to Frederick, MD buses use the Boston, Bus Terminal South Station to Frederick, East Street (Transit Center) station pair. Use this guide to compare Boston, MA and Frederick, MD bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Boston, Bus Terminal South Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Several fast food and cafe options available.
Free Wi-Fi available throughout the terminal. ATMs are aTMs located inside the terminal.
Ticket office support is available at Boston, Bus Terminal South Station.
Available at Boston, Bus Terminal South Station: Parking, Taxis, WC.
Accessibility facilities are available at Boston, Bus Terminal South Station: Fully accessible with ramps and elevators.
Frederick, East Street (Transit Center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Frederick, East Street (Transit Center). ATMs are available at Frederick, East Street (Transit Center).
Ticket office support is available at Frederick, East Street (Transit Center).
Available at Frederick, East Street (Transit Center): Parking, Taxis, WC.
Accessibility facilities are available at Frederick, East Street (Transit Center): Wheelchair accessible entry and exit points.
Check bus stations information for Boston, MA and Frederick, MD, including where buses depart and arrive on this route.