- Must visit
National Museum of Civil War Medicine
Interactive museum explaining battlefield medicine, surgery, and care during the Civil War in a historic downtown building.
The best way to find a cheap bus ticket from Wilmington, DE to Frederick, MD is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Wilmington, DE to Frederick, MD will cost around $42 if you buy it on the day, but the cheapest tickets can be found for only $41.
It's difficult to get from Wilmington, DE to Frederick, MD without transferring at least once.

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Take a bus from Wilmington, DE to Frederick, MD and enjoy the approximately 101 miles (164 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 00:30, the last at 21:25.
Distance 101 miles (164 km) |
First bus 12:30 AM |
Last bus 9:25 PM |
Cheapest Month May |
Cheapest Day Fri |
High Season Apr - Jun |
Low Season Oct - Dec |
Best time to book 63 days |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Wilmington, DE to Frederick, MD.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:25AM | Arrival Time 10:40AM | Duration 9h15 | Departure days Sun | Cheapest price $64 |
Operator Greyhound USA | Departure Time 01:50PM | Arrival Time 07:25PM | Duration 5h35 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $41 |
Operator Greyhound USA | Departure Time 09:25PM | Arrival Time 06:40AM | Duration 9h15 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $44 |
The table below shows live departures for Wilmington, DE to Frederick, MD buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 1:50 PM Wilmington, DE | 5h35 | 7:25 PM Frederick, MD | 1 transfer | |
![]() | 9:25 PM Wilmington, DE | 9h15 | 6:40 AM Frederick, MD | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Frederick, MD — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Frederick, MD trip today.
Interactive museum explaining battlefield medicine, surgery, and care during the Civil War in a historic downtown building.
Regional history museum with exhibits on Frederick County life, culture, and changing communities inside a restored historic home.
Contemporary art space in downtown Frederick presenting rotating exhibitions by regional and national artists in a modern gallery setting.
Linear downtown park and promenade with fountains, public art, bridges, and event spaces, ideal for walking day or evening.
Central historic district with preserved architecture, local shops, galleries, and easy access to many of Frederick’s main sights.
Popular downtown street lined with historic buildings, boutiques, public art, and one of the city’s best pedestrian atmospheres.
Maryland crab cakes are packed with blue crab and light seasoning. They are a regional staple near Frederick and widely served across Central Maryland.
Cream of crab soup is a rich Maryland favorite made with crab meat, cream, and seasoning. It reflects the state's strong Chesapeake seafood tradition.
Smith Island cake is Maryland's official state dessert, with many thin cake layers and frosting. It is a classic sweet treat found around Frederick.
Well-known farm brewery outside downtown with estate beer, pizza, and scenic grounds suited to relaxed afternoons.
Contemporary American restaurant known for wood-fired dishes, cocktails, and a polished but relaxed downtown atmosphere.
Casual local favorite for New York-style pizza, pasta, and Italian-American comfort food in the historic district.
Moderate for a U.S. mid-size city: hotels and dining are below major metros, but car-based transport and limited transit can raise visitor costs.
Tip 18-20% at restaurants, more for excellent service. Taxis usually 10-15%. Cafes often have tip jars; $1-2 is common.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Frederick, MD.
Find answers to the most common questions about traveling from Wilmington, DE to Frederick, MD by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Frederick, MD, this guide helps you travel smarter and with confidence.

Most Wilmington, DE to Frederick, MD buses use the Wilmington, Amtrak Station @ ML King-French to Frederick, East Street (Transit Center) station pair. Use this guide to compare Wilmington, DE and Frederick, MD bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Frederick, East Street (Transit Center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Frederick, East Street (Transit Center). ATMs are available at Frederick, East Street (Transit Center).
Ticket office support is available at Frederick, East Street (Transit Center).
Available at Frederick, East Street (Transit Center): Parking, Taxis, WC.
Accessibility facilities are available at Frederick, East Street (Transit Center): Wheelchair accessible entry and exit points.
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