Travel Information
Compare train, bus, and flight for Prague to Mannheim
Omio recommends booking the bus as it is the most popular option from Prague to Mannheim among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €43 For those with little time, consider booking a flight, which has an average total journey time of 4h 48m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.4kg. Average ticket prices depend on the travel mode: a bus costs an average of €43, while a flight costs an average of €317.
Distance: 267 miles (431 km)
Compare bus with
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
€43 Average price Cheapest | €135 Average price | €317 Average price | €93 Average price (fuel + tolls) |
7h 51m Average total duration 7h 21m Onboard + 30m Additional time* | 8h 30m Average total duration 8h 0m Onboard + 30m Additional time* | 4h 48m Average total duration Fastest 2h 48m Onboard + 2h 0m Additional time* | 5h 51m Average total duration (door-to-door) |
0.4 - 1.1kg CO2 emissions | 0.1 - 0.4kg CO2 emissions Lowest | 1.3 - 2.6kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Prague to Mannheim
Compare the available ways to get from Prague to Mannheim, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Prague to Mannheim:
A bus is €93 less than a train for this route with tickets for a train from Prague to Mannheim costing on average €135.
A bus is €274 less than a flight for this route with tickets for a flight from Prague to Mannheim costing on average €317.
Other travel options to Mannheim take longer:
Bus takes on average 7h 51m.
Train takes on average 8h 30m.
Tickets start at around €43 compared to roughly €93 in fuel and tolls — a saving of about €50. The journey takes 7h 21m versus 5h 51m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Travel optionsfrom Prague to Mannheim
How to get from Prague to Mannheim by train, bus or flight.
Our recommendation
The best way to travel from Prague to Mannheim is by taking a train because it’s the best combination of price and speed.
EX 356 · Bus RE25 · 3572 · 8862011:35 AM 8h25 Prague hlavní nádraží 8:00 PM Mannheim Hbf €30 1 One-way 4 transfers
Cheapest
EX 356 · Bus RE25 · 3572 · 8862011:35 AM 8h25 Prague hlavní nádraží 8:00 PM Mannheim Hbf €30 1 One-way 4 transfers
Fastest
DE44818:00 AM 1h05 Prague Vaclav Havel Airport 9:05 AM Frankfurt am Main Airport €144 1 One-way 0 transfers
Other options
EX 358 · Bus RE25 · 3568 · 886189:35 AM 8h25 Prague hlavní nádraží 6:00 PM Mannheim Hbf €30 1 One-way 4 transfers
IC 560 · 5290 · ICE 22 · ICE 6952:35 PM 7h55 Prague hlavní nádraží 10:30 PM Mannheim Hbf €33 1 One-way 3 transfers
EX 354 · 3576 · ICE 526 · ICE 7751:35 PM 8h22 Prague hlavní nádraží 9:57 PM Mannheim Hbf €33 1 One-way 3 transfers
FlixBus5:45 PM 7h20 Praha, Na Knížecí 1:05 AM Mannheim, ZOB (Heinrich-Von-Stephan-Straße) €40 1 One-way 0 transfers
FlixBus5:15 PM 7h50 Praha, ÚAN Florenc 1:05 AM Mannheim, ZOB (Heinrich-Von-Stephan-Straße) €40 1 One-way 0 transfers
FlixBus7:55 AM 7h40 Praha, Na Knížecí 3:35 PM Mannheim, ZOB (Heinrich-Von-Stephan-Straße) €54 1 One-way 0 transfers
LH139511:30 AM 1h10 Prague Vaclav Havel Airport 12:40 PM Frankfurt am Main Airport €99 1 One-way 0 transfers
LH14017:05 AM 1h10 Prague Vaclav Havel Airport 8:15 AM Frankfurt am Main Airport €99 1 One-way 0 transfers
LH13972:50 PM 1h10 Prague Vaclav Havel Airport 4:00 PM Frankfurt am Main Airport €99 1 One-way 0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
More than 1,000 travel companies trust us to sell their tickets all in one place.
FAQs: Travel from Prague to Mannheim
Travel to Mannheim easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Prague to Mannheim.

This is compared to other travel options from Prague to Mannheim:
A bus is €93 less than a train for this route with tickets for a train from Prague to Mannheim costing on average €135.
A bus is €274 less than a flight for this route with tickets for a flight from Prague to Mannheim costing on average €317.
Other travel options to Mannheim take longer:
Bus takes on average 7h 51m.
Train takes on average 8h 30m.
- Around 69 flights per day.
- Around 11 trains per day.
- Around 6 buses per day.
However, we recommend checking specific travel dates for your route between Prague and Mannheim as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Prague Vaclav Havel Airport and arrive in Frankfurt am Main Airport.
- Trains mostly depart from Prague hlavní nádraží and arrive in Mannheim Hbf.
- Buses mostly depart from Praha, ÚAN Florenc and arrive in Mannheim, ZOB (Heinrich-Von-Stephan-Straße).
- Travel with FlixBus to go to Mannheim by bus.
- Travel with Lufthansa, Lot Polish Airlines, KLM, Austrian Airlines, Turkish Airlines, Swiss, Condor Flugdienst, British Airways, Air Baltic, Air Dolomiti, KLM Cityhopper, Qatar Airways, Brussels Airlines, Eurowings, Lufthansa Cityline, Helvetic Airways, CitizenPlane, Edelweiss Air, TAP Portugal to go to Mannheim by flight.
- Travel with Deutsche Bahn, České dráhy to go to Mannheim by train.
- 6 direct buses per day with FlixBus.
- 8 direct flights per day with Lufthansa, Condor Flugdienst, Air Dolomiti.
Travelling from Prague to Mannheim: related information
Here are some other resources that might have the information you need
