The cheapest and fastest trains from Palermo Centrale to Florence Santa Maria Novella
Cheapest price on Sep 05
$131
Average ticket price on Sep 05
$177
Fastest journey on Sep 05
12 h 46 m
Average journey duration on Sep 05
14 h 17 m
Trains on Sep 05
6
Distance
655 km
The best way to find a cheap train ticket from Palermo Centrale to Florence Santa Maria Novella is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Palermo Centrale to Florence Santa Maria Novella will cost around $177 if you buy it on the day, but the cheapest tickets can be found for only $131.
It's difficult to get from Palermo Centrale to Florence Santa Maria Novella without transferring at least once.
Intercity 736+
Regionale Veloce 41107:00 AM16h50Palermo Centrale11:50 PMFlorence Santa Maria Novella$1311One-way1 transfer
InterCityNotte 1958+
Intercity 588+
Regionale 182229:05 PM16h47Palermo Centrale1:52 PMFlorence Santa Maria Novella$1741One-way2 transfers
InterCityNotte 1954+
FRECCIAROSSA 95166:47 PM14h59Palermo Centrale9:46 AMFlorence Santa Maria Novella$1821One-way1 transfer
Intercity 730+
FRECCIAROSSA 967410:10 AM13h10Palermo Centrale11:20 PMFlorence Santa Maria Novella$1851One-way1 transfer
Intercity 736+
FRECCIAROSSA 95567:00 AM12h46Palermo Centrale7:46 PMFlorence Santa Maria Novella$1851One-way1 transfer
Intercity 736+
FRECCIAROSSA 95567:00 AM12h46Palermo Centrale7:46 PMFlorence Santa Maria Novella$1851One-way1 transfer
Intercity 730+
FRECCIAROSSA 967410:10 AM13h10Palermo Centrale11:20 PMFlorence Santa Maria Novella$1851One-way1 transfer
InterCityNotte 1958+
FRECCIAROSSA 95209:05 PM13h41Palermo Centrale10:46 AMFlorence Santa Maria Novella$2021One-way1 transfer
InterCityNotte 1954+
FRECCIAROSSA 95166:47 PM14h59Palermo Centrale9:46 AMFlorence Santa Maria Novella$1821One-way1 transfer
InterCityNotte 1958+
Intercity 588+
Regionale 182229:05 PM16h47Palermo Centrale1:52 PMFlorence Santa Maria Novella$1741One-way2 transfers
Travel Information
Compare train, bus, flight, and ferry for Palermo Centrale to Florence Santa Maria Novella
Omio recommends booking the train as it is the most popular option from Palermo Centrale to Florence Santa Maria Novella among Omio's users. If you are prioritising price, take the ferry, with an average ticket price of $80 For those with little time, consider booking a flight, which has an average total journey time of 4h 43m. Average ticket prices depend on the travel mode: a ferry costs an average of $80, while a flight costs an average of $360.
Distance: 406 miles (655 km)
Compare train with
Most popular Train | Flight | Bus | Ferry | Driving |
|---|---|---|---|---|
$148 Average price | $360 Average price | $102 Average price | $80 Average price Cheapest | $62 Average price (fuel + tolls) |
14h 36m Average total duration 14h 6m Onboard + 30m Additional time* | 4h 43m Average total duration Fastest 2h 43m Onboard + 2h 0m Additional time* | 17h 54m Average total duration 17h 24m Onboard + 30m Additional time* | 21h 0m Average total duration 20h 0m Onboard + 1h 0m Additional time* | 12h 58m Average total duration (door-to-door) |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | ![]() Most popular ferry company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Palermo Centrale to Florence Santa Maria Novella:
A ferry is $22 (€18) less than a bus for this route with tickets for a bus from Palermo Centrale to Florence Santa Maria Novella costing on average $102 (€83).
A ferry is $68 (€55) less than a train for this route with tickets for a train from Palermo Centrale to Florence Santa Maria Novella costing on average $148 (€120).
A ferry is $280 (€227) less than a flight for this route with tickets for a flight from Palermo Centrale to Florence Santa Maria Novella costing on average $360 (€291).
Other travel options to Florence Santa Maria Novella take longer:
Train takes on average 14h 6m.
Bus takes on average 17h 24m.
Ferry takes on average 20h 0m.
Tickets start at around $148 (€120) compared to roughly $62 (€51) in fuel and tolls — a saving of about $-85.69 (€-69.27). The journey takes 14h 6m versus 12h 58m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Live departures
Palermo Centrale to Florence Santa Maria Novella train times
The table below shows live departures for Palermo Centrale to Florence Santa Maria Novella trains for tomorrow, Saturday, September 5. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Intercity 736+ Regionale Veloce 4110 | 7:00 AM Palermo Centrale | 16h50 | 11:50 PM Florence Santa Maria Novella | 1 transfer | |
Intercity 736+ FRECCIAROSSA 9556 | 7:00 AM Palermo Centrale | 12h46 | 7:46 PM Florence Santa Maria Novella | 1 transfer | |
Intercity 730+ FRECCIAROSSA 9674 | 10:10 AM Palermo Centrale | 13h10 | 11:20 PM Florence Santa Maria Novella | 1 transfer | |
InterCityNotte 1954+ FRECCIAROSSA 9516 | 6:47 PM Palermo Centrale | 14h59 | 9:46 AM Florence Santa Maria Novella | 1 transfer | |
InterCityNotte 1958+ Intercity 588+ Regionale 18222 | 9:05 PM Palermo Centrale | 16h47 | 1:52 PM Florence Santa Maria Novella | 2 transfers | |
InterCityNotte 1958+ FRECCIAROSSA 9520 | 9:05 PM Palermo Centrale | 13h41 | 10:46 AM Florence Santa Maria Novella | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Palermo Centrale to Florence Santa Maria Novella by train, bus, flight, or ferry
Compare train, bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sep 05
Sep 06
Sep 07
Sep 08
Sep 09
Sep 10
Sep 11
Why should you book Palermo Centrale to Florence Santa Maria Novella trains with Omio?
Why book with Omio vs Intercity Notte?
- Compare with other providers: On Omio, you can not only buy tickets for Intercity Notte, but also compare tickets for the likes of Intercity, Italo, Frecciarossa or Regionale to find the best option for your trip from Palermo Centrale to Florence Santa Maria Novella.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Intercity Notte with all available travel options, which are train, bus, flight and ferry to ensure you get the best deal for traveling from Palermo Centrale to Florence Santa Maria Novella.
Journey information
Overview: Train from Palermo Centrale to Florence Santa Maria Novella
Trains from Palermo Centrale to Florence Santa Maria Novella run on average 5 times per day, taking around 14h 6m. Cheap train tickets for this journey start at $76 (€62) but you can travel from only $21 (€17) by flight.
The earliest train runs at 02:11, the last at 20:40. The fastest train covers the 406 miles (655 km) distance in 11h 48m.
Distance 406 miles (655 km) |
Average train duration 14h 6m |
Cheapest ticket price $76 (€62) |
Trains per day 5 |
Fastest train 11h 48m |
First train 2:11 AM |
Last train 8:40 PM |
Cheapest Month Sep |
Cheapest Day Thu |
High Season Apr - Jun |
Low Season Oct - Dec |
Busiest Day Wed |
Least Busy Day Thu |
Train companies: Intercity, Intercity Notte from Palermo Centrale to Florence Santa Maria Novella trainsIntercity, Intercity Notte trains will get you between Palermo Centrale and Florence Santa Maria Novella from $21 (€17). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Intercity
Intercity Notte
FAQs: Trains from Palermo Centrale to Florence Santa Maria Novella
Find answers to the most common questions about traveling from Palermo Centrale to Florence Santa Maria Novella by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence Santa Maria Novella, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Palermo Centrale to Florence Santa Maria Novella
Most Palermo Centrale to Florence Santa Maria Novella trains use the Enna to Firenze Santa Maria Novella station pair. Use this guide to compare Palermo Centrale and Florence Santa Maria Novella train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Getting to Firenze Santa Maria Novella from Florence city centre
Firenze Santa Maria Novella is 1 km from Florence city centre. Public transport options include:
Firenze Santa Maria Novella train station facilities and services
Firenze Santa Maria Novella has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food and drink
Food options include: 12oz Coffee Joint, Casa Maioli, Don Nino, Fratelli Cuore, McDonald´s, Panella, Segafredo Zanetti, Spizzico, Venchi, & many more
Wi-Fi and ATMs
Free WiFi (30 minutes limit). ATMs are located in the basement in the shopping center next to the Feltrinelli bookshop and between Celio and Mango shops.
Tickets and information
The ticket office is open Mon - Sun: 06:00 - 21:00. Information desks are located inside and outside the station.
Luggage and lost property
Luggage storage is provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
Parking, taxis and toilets
Available at Firenze Santa Maria Novella: Parking, Taxis, WC.
Bike and car services
Available at Firenze Santa Maria Novella: Bike Parking, Bike Rental, Car Rental.
Accessibility
Accessibility facilities are available at Firenze Santa Maria Novella: Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
Shops, hotels and contact
Nearby hotels include Hotel Luxor Florence, Joy Hotel Florence, Diplomat Hotel Florence.
More options for your journey from Palermo Centrale to Florence Santa Maria Novella
Here are some other resources that might have the information you need



