- Must visit
Galleria degli Uffizi
World-famous Renaissance gallery with masterpieces by Botticelli, Leonardo, Michelangelo, and Caravaggio. One of Florence’s essential museum visits.
Cheapest price
$130
Average price
$173
Fastest journey
13 h 36 m
Average duration
16 h 1 m
Trains per day
6
Distance
655 km
The best way to find a cheap train ticket from Palermo Centrale to Florence Santa Maria Novella is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Palermo Centrale to Florence Santa Maria Novella will cost around $173 if you buy it on the day, but the cheapest tickets can be found for only $130.
It's difficult to get from Palermo Centrale to Florence Santa Maria Novella without transferring at least once.
Intercity 734+
Regionale Veloce 4110 · Regionale Veloce 5350
BUS LP964+
InterCityNotte 1962+
Regionale 18503
Intercity 588+
Regionale 18222+
InterCityNotte 1958
Intercity 724+
FRECCIAROSSA 9674+
Regionale Veloce 5506
FRECCIAROSSA 9516+
InterCityNotte 1956+
Regionale Veloce 5364
FRECCIAROSSA 9520+
InterCityNotte 1958
FRECCIAROSSA 9516+
InterCityNotte 1956+
Regionale Veloce 5364
Intercity 724+
FRECCIAROSSA 9674+
Regionale Veloce 5506
Intercity 588+
Regionale 18222+
InterCityNotte 1958
Intercity 734+
Regionale Veloce 4110 · Regionale Veloce 5350Omio recommends booking the train as it is the most popular option from Palermo Centrale to Florence Santa Maria Novella among Omio's users. If you are prioritising price take the ferry with prices starting from $50. For those with little time consider booking a flight which can get you there in 1h 38m. The ticket price range depends on the travel mode: a ferry costs an average of $50, and a train costs an average of $88.
Distance: 406 miles (655 km)
Most popular Train | Flight | Bus | Ferry | Driving |
|---|---|---|---|---|
$133 Average price | $88 Average price | $73 Average price | $60 Average price Cheapest | $62 Average price (fuel + tolls) |
13h 2m Average total duration 12h 32m Onboard + 30m Additional time* | 4h 38m Average total duration Fastest 1h 38m Onboard + 3h 0m Additional time* | 16h 45m Average total duration 16h 15m Onboard + 30m Additional time* | 21h 30m Average total duration 20h 30m Onboard + 1h 0m Additional time* | 12h 58m Average total duration (door-to-door) |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | ![]() Most popular ferry company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Palermo Centrale to Florence Santa Maria Novella:
A ferry is $13 (€10) less than a bus for this route with tickets for a bus from Palermo Centrale to Florence Santa Maria Novella costing on average $73 (€59).
A ferry is $28 (€22) less than a flight for this route with tickets for a flight from Palermo Centrale to Florence Santa Maria Novella costing on average $88 (€71).
A ferry is $72 (€59) less than a train for this route with tickets for a train from Palermo Centrale to Florence Santa Maria Novella costing on average $133 (€107).
Other travel options to Florence Santa Maria Novella take longer:
Train takes on average 12h 32m.
Bus takes on average 16h 15m.
Ferry takes on average 20h 30m.
You'll arrive about 26m sooner (12h 32m by train vs 12h 58m by car). Tickets start at around $133 (€107) compared to roughly $62 (€51) in fuel and tolls — so you're paying a bit more, but getting hours of your day back, a city-centre arrival, and the freedom to work or relax instead of drive.
Driving makes more sense if you're travelling as a group (where fuel costs split several ways), want to stop along the way, or need a car once you arrive.
The table below shows live departures for Palermo Centrale to Florence Santa Maria Novella trains for today, Friday, June 5. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Intercity 736+ Regionale Veloce 4110 | 7:05 AM Palermo Centrale | 16h45 | 11:50 PM Florence Santa Maria Novella | 1 transfer | |
Intercity 736+ FRECCIAROSSA 9556 | 7:05 AM Palermo Centrale | 12h41 | 7:46 PM Florence Santa Maria Novella | 1 transfer | |
Intercity 730+ Regionale 18250+ InterCityNotte 796 | 10:15 AM Palermo Centrale | 19h13 | 5:28 AM Florence Santa Maria Novella | 2 transfers | |
Intercity 730+ FRECCIAROSSA 9568 | 10:15 AM Palermo Centrale | 12h43 | 10:58 PM Florence Santa Maria Novella | 1 transfer | |
InterCityNotte 1954+ FRECCIAROSSA 9516 | 5:37 PM Palermo Centrale | 16h09 | 9:46 AM Florence Santa Maria Novella | 1 transfer | |
Regionale Veloce 5364+ FRECCIAROSSA 9516+ InterCityNotte 37502 | 6:33 PM Palermo Centrale | 15h13 | 9:46 AM Florence Santa Maria Novella | 2 transfers | |
Intercity 588+ Regionale 18222+ InterCityNotte 1958 | 8:25 PM Palermo Centrale | 17h27 | 1:52 PM Florence Santa Maria Novella | 2 transfers | |
InterCityNotte 1958+ FRECCIAROSSA 9520 | 8:25 PM Palermo Centrale | 14h21 | 10:46 AM Florence Santa Maria Novella | 1 transfer | |
| Saturday, June 6 | |||||
Regionale Veloce 5350+ Intercity 734+ Regionale Veloce 4110 | 5:06 AM Palermo Centrale | 18h44 | 11:50 PM Florence Santa Maria Novella | 2 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Palermo Centrale to Florence Santa Maria Novella run on average 6 times per day, taking around 12h 32m. Cheap train tickets for this journey start at $88 (€71) but you can travel from only $21 (€17) by flight.
The earliest train runs at 05:02, the last at 19:25. The fastest train covers the 406 miles (655 km) distance in 12h 43m.
Distance 406 miles (655 km) |
Average train duration 12h 32m |
Cheapest ticket price $88 (€71) |
Trains per day 6 |
Fastest train 12h 43m |
First train 5:02 AM |
Last train 7:25 PM |
Cheapest Month Sep |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Oct - Dec |
Busiest Day Thu |
Least Busy Day Mon |
Discover the best of Firenze Santa Maria Novella — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Firenze Santa Maria Novella trip today.
World-famous Renaissance gallery with masterpieces by Botticelli, Leonardo, Michelangelo, and Caravaggio. One of Florence’s essential museum visits.
Best known for Michelangelo’s David, this museum also holds important Florentine paintings and sculptures. Timed-entry tickets are commonly used.
Outstanding museum preserving original works from the Florence Cathedral complex, including sculptures by Michelangelo, Donatello, and Ghiberti.
The ceremonial heart of Florence, surrounded by the cathedral, baptistery, and bell tower. Essential for first-time visitors and iconic photos.
Historic civic square filled with sculpture and framed by Palazzo Vecchio and the Loggia dei Lanzi. One of Florence’s most atmospheric public spaces.
The city’s classic panoramic viewpoint, especially popular at sunset and on social media for sweeping views over Florence’s rooftops and dome.
Thick-cut Chianina beef steak grilled rare over coals, one of Florence's most iconic and celebratory dishes.
Hearty Tuscan soup of bread, cannellini beans, and vegetables, traditionally reheated the next day for deeper flavor.
Rustic tomato and bread soup with garlic, olive oil, and basil, a classic example of Tuscan cucina povera.
Renowned fine dining institution with Michelin-starred cuisine and one of Italy's most celebrated wine cellars.
Popular steakhouse known for Bistecca Alla Fiorentina, with a polished yet approachable atmosphere near Santa Maria Novella.
Historic, lively trattoria near the central market, famous for Florentine steak and classic Tuscan dishes.
Moderate by Italian standards. Cafes and casual meals are reasonable, but hotels and central dining near the station cost more.
Service is often included or covered by a coperto. Tipping is not required, but rounding up or leaving EUR 1-3 for good service is appreciated. Taxis are usually rounded up.
Official public transport app
Firenze Santa Maria Novella -> Piazza del Duomo, Florence
Find answers to the most common questions about traveling from Palermo Centrale to Florence Santa Maria Novella by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence Santa Maria Novella, this guide helps you travel smarter and with confidence.

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