The cheapest and fastest trains from Palermo Centrale to Florence Santa Maria Novella
Cheapest price
$91
Average price
$110
Fastest journey
16 h 45 m
Average duration
17 h 55 m
Trains per day
2
Distance
655 km
The best way to find a cheap train ticket from Palermo Centrale to Florence Santa Maria Novella is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Palermo Centrale to Florence Santa Maria Novella will cost around $110 if you buy it on the day, but the cheapest tickets can be found for only $91.
Of the 2 trains that leave Palermo Centrale for Florence Santa Maria Novella on Fri, Mar 06, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Mar 06 the direct trains cover the 655 km distance in an average of 17 h 55 m but if you time it right, some trains will get you there in just 16 h 45 m .
On Fri, Mar 06 the slowest trains will take 19 h 4 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare train, bus, flight, and ferry for Palermo Centrale to Florence Santa Maria Novella
Omio recommends booking the train as it is the most popular option from Palermo Centrale to Florence Santa Maria Novella among Omio's users. If you are prioritising price take the bus with prices starting from $30. For those with little time consider booking a flight which can get you there in 1h 38m. The ticket price range depends on the travel mode: a bus costs an average of $30, and a train costs an average of $65.
Distance: 406 miles (655 km)
Compare train with
Most popular Train | Flight | Bus | Ferry |
|---|---|---|---|
$109 Average price | $97 Average price | $68 Average price Cheapest | $70 Average price |
13h 2m Average total duration 12h 32m Onboard + 30m Additional time* | 4h 38m Average total duration Fastest 1h 38m Onboard + 3h 0m Additional time* | 16h 45m Average total duration 16h 15m Onboard + 30m Additional time* | 21h 30m Average total duration 20h 30m Onboard + 1h 0m Additional time* |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | ![]() Most popular ferry company |
Direct Options | Direct Options | Direct Options | Direct Options |
Live departures
Palermo Centrale to Florence Santa Maria Novella train times
The table below shows live departures for Palermo Centrale to Florence Santa Maria Novella trains for tomorrow, Friday, March 6. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:05 AM Palermo Centrale | 16h45 | 10:50 PM Florence Santa Maria Novella | 0 transfersDirect | |
![]() | 5:48 PM Palermo Centrale | 19h04 | 12:52 PM Florence Santa Maria Novella | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Palermo Centrale to Florence Santa Maria Novella by train, bus, flight, or ferry
Compare train, bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 06
Mar 07
Mar 08
Mar 09
Mar 10
Mar 11
Mar 12
Why should you book Palermo Centrale to Florence Santa Maria Novella trains with Omio?
Why book with Omio vs Intercity Notte?
- Compare with other providers: On Omio, you can not only buy tickets for Intercity Notte, but also compare tickets for the likes of Intercity, Italo, Frecciarossa or Regionale to find the best option for your trip from Palermo Centrale to Florence Santa Maria Novella.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Intercity Notte with all available travel options, which are train, bus, flight and ferry to ensure you get the best deal for traveling from Palermo Centrale to Florence Santa Maria Novella.
Journey information
Overview: Train from Palermo Centrale to Florence Santa Maria Novella
Trains from Palermo Centrale to Florence Santa Maria Novella run on average 6 times per day, taking around 12h 32m. Cheap train tickets for this journey start at $65 (€52) but you can travel from only $21 (€17) by flight.
The earliest train runs at 06:05, the last at 19:25. The fastest train covers the 406 miles (655 km) distance in 12h 41m.
Distance 406 miles (655 km) |
Average train duration 12h 32m |
Cheapest ticket price $65 (€52) |
Trains per day 6 |
Fastest train 12h 41m |
First train 06:05 |
Last train 19:25 |
Cheapest month Apr |
Cheapest day Fri |
High season Jan - Mar |
Low season Oct - Dec |
Busiest day Thu |
Least busy day Wed |
Train companies: Intercity Notte, Intercity, Italo, Frecciarossa, Regionale from Palermo Centrale to Florence Santa Maria Novella trainsIntercity Notte, Intercity, Italo, Frecciarossa, Regionale trains will get you between Palermo Centrale and Florence Santa Maria Novella from $21 (€17). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Intercity Notte
Intercity
Italo
Frecciarossa
Regionale
FAQs: Trains from Palermo Centrale to Florence Santa Maria Novella
Find answers to the most common questions about traveling from Palermo Centrale to Florence Santa Maria Novella by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence Santa Maria Novella, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Palermo Centrale to Florence Santa Maria Novella
- Mon - Sun: 06:00 - 21:00
- Free WiFi (30 minutes limit).
- Provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
- 12oz Coffee Joint
- Casa Maioli
- Don Nino
- Fratelli Cuore
- McDonald´s
- Panella
- Segafredo Zanetti
- Spizzico
- Venchi
- & many more
- Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
- Hotel Luxor Florence
- Joy Hotel Florence
- Diplomat Hotel Florence
- Mon - Sun: 06:00 - 21:00
- Located inside and outside the station.
- Tram lines: T1, T2
- Bus lines: 6, 11, 12, 13, 17, 23, 36, 37, C4
- Train lines: FR, FA, Italo
Most popular train connections from Palermo Centrale
More options for your journey from Palermo Centrale to Florence Santa Maria Novella
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