The cheapest and fastest trains from Florence Santa Maria Novella to Palermo Centrale
Cheapest price
$107
Average price
$119
Fastest journey
14 h 8 m
Average duration
16 h 15 m
Trains per day
3
Distance
655 km
The best way to find a cheap train ticket from Florence Santa Maria Novella to Palermo Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence Santa Maria Novella to Palermo Centrale will cost around $119 if you buy it on the day, but the cheapest tickets can be found for only $107.
Of the 3 trains that leave Florence Santa Maria Novella for Palermo Centrale on Thu, Jan 29, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Jan 29 the direct trains cover the 655 km distance in an average of 16 h 15 m but if you time it right, some trains will get you there in just 14 h 8 m .
On Thu, Jan 29 the slowest trains will take 18 h 17 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Travel Information
Compare train, bus, flight, and ferry for Florence Santa Maria Novella to Palermo Centrale
Omio recommends booking the train as it is the most popular option from Florence Santa Maria Novella to Palermo Centrale among Omio's users. If you are prioritising price take the ferry with prices starting from €37. For those with little time consider booking a flight which can get you there in 1h 43m. The ticket price range depends on the travel mode: a ferry costs an average of €37, and a flight costs an average of €30.
Distance: 406 miles (655 km)
Compare train with
Most popular Train | Flight | Bus | Ferry |
|---|---|---|---|
€110 Average price | €129 Average price | €73 Average price | €55 Average price Cheapest |
13h 9m Average total duration 12h 39m Onboard + 30m Additional time* | 4h 43m Average total duration Fastest 1h 43m Onboard + 3h 0m Additional time* | 16h 38m Average total duration 16h 8m Onboard + 30m Additional time* | 21h 0m Average total duration 20h 0m Onboard + 1h 0m Additional time* |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | ![]() Most popular ferry company |
Direct Options | Direct Options | Direct Options | Direct Options |
Live departures
Florence Santa Maria Novella to Palermo Centrale train times
The table below shows live departures for Florence Santa Maria Novella to Palermo Centrale trains for tomorrow, Thursday, January 29. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 4:35 AM Florence Santa Maria Novella | 16h20 | 8:55 PM Palermo Centrale | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence Santa Maria Novella to Palermo Centrale by train, bus, flight, or ferry
Compare train, bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jan 29
Jan 30
Jan 31
Feb 01
Feb 02
Feb 03
Feb 04
Why should you book Florence Santa Maria Novella to Palermo Centrale trains with Omio?
Why book with Omio vs Intercity Notte?
- Compare with other providers: On Omio, you can not only buy tickets for Intercity Notte, but also compare tickets for the likes of Intercity, Italo, Frecciargento or Frecciarossa to find the best option for your trip from Florence Santa Maria Novella to Palermo Centrale.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Intercity Notte with all available travel options, which are train, bus, flight and ferry to ensure you get the best deal for traveling from Florence Santa Maria Novella to Palermo Centrale.
Why book with Omio over Raileurope?
- Official reseller: Intercity Notte tickets can only be bought on Omio or Intercity Notte's website as Omio is the only official third party seller for Intercity Notte tickets. Raileurope do not sell Intercity Notte tickets as they are not official sellers.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus, flight and ferry to find the ideal travel option from Florence Santa Maria Novella to Palermo Centrale.
Journey information
Overview: Train from Florence Santa Maria Novella to Palermo Centrale
Train Ticket Prices
- Budget Options: Train tickets from Florence Santa Maria Novella to Palermo Centrale start from as low as $79 (€62) if booked well in advance.
- Standard Fares: Typically, trains cost $140 (€110) depending on the train type and class.
Journey Duration & Frequency
- On average there are 6 daily trains from Florence Santa Maria Novella to Palermo Centrale with 0 direct service.
- The fastest trains can take as little as 13h 2m but the average duration is 12h 39m
Train Operators
- Travel from Florence Santa Maria Novella to Palermo Centrale with Intercity Notte, Intercity, Italo, Frecciargento, and Frecciarossa
- The most booked train company for this route on Omio is Intercity Notte.
- High-speed trains are available.
Stations & Schedule
- First train typically departs at 03:45 AM and the last at 06:48 PM
Distance 406 miles (655 km) |
Average train duration 12h 39m |
Cheapest ticket price $79 (€62) |
Trains per day 6 |
Fastest train 13h 2m |
First train 03:45 |
Last train 18:48 |
Train companies: Intercity Notte, Intercity, Italo, Frecciargento, Frecciarossa from Florence Santa Maria Novella to Palermo Centrale trainsIntercity Notte, Intercity, Italo, Frecciargento, Frecciarossa trains will get you between Florence Santa Maria Novella and Palermo Centrale from $39 (€30). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Intercity Notte
Intercity
Italo
Frecciargento
Frecciarossa
FAQs: Trains from Florence Santa Maria Novella to Palermo Centrale
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Palermo Centrale by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Palermo Centrale, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Florence Santa Maria Novella to Palermo Centrale
- Mon - Sun: 06:00 - 21:00
- Free WiFi (30 minutes limit).
- Provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
- 12oz Coffee Joint
- Casa Maioli
- Don Nino
- Fratelli Cuore
- McDonald´s
- Panella
- Segafredo Zanetti
- Spizzico
- Venchi
- & many more
- Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
- Hotel Luxor Florence
- Joy Hotel Florence
- Diplomat Hotel Florence
- Mon - Sun: 06:00 - 21:00
- Located inside and outside the station.
- Tram lines: T1, T2
- Bus lines: 6, 11, 12, 13, 17, 23, 36, 37, C4
- Train lines: FR, FA, Italo
Most popular train connections from Florence Santa Maria Novella
More options for your journey from Florence Santa Maria Novella to Palermo Centrale
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