The cheapest and fastest trains from Florence Santa Maria Novella to Palermo Centrale
Cheapest price
$173
Average price
$197
Fastest journey
12 h 47 m
Average duration
15 h 21 m
Trains per day
6
Distance
655 km
The best way to find a cheap train ticket from Florence Santa Maria Novella to Palermo Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence Santa Maria Novella to Palermo Centrale will cost around $197 if you buy it on the day, but the cheapest tickets can be found for only $173.
It's difficult to get from Florence Santa Maria Novella to Palermo Centrale without transferring at least once.
Regionale 18251+
InterCityNotte 799+
Intercity 723
ETRUSCHI LINE 18255+
Intercity 501 · Intercity 727
FRECCIAROSSA 9519+
Intercity 727
Regionale 18783+
Intercity 594+
InterCityNotte 1959
FRECCIAROSSA 9435+
InterCityNotte 1959
FRECCIAROSSA 9519+
Intercity 727
FRECCIAROSSA 1000 9555+
InterCityNotte 1955
FRECCIAROSSA 9435+
InterCityNotte 1959
ETRUSCHI LINE 18255+
Intercity 501 · Intercity 727
Regionale 18783+
Intercity 594+
InterCityNotte 1959Travel Information
Compare train, bus, flight, and ferry for Florence Santa Maria Novella to Palermo Centrale
Omio recommends booking the train as it is the most popular option from Florence Santa Maria Novella to Palermo Centrale among Omio's users. If you are prioritising price take the ferry with prices starting from €37. For those with little time consider booking a flight which can get you there in 1h 43m. The ticket price range depends on the travel mode: a ferry costs an average of €37, and a flight costs an average of €30.
Distance: 406 miles (655 km)
Compare train with
Most popular Train | Flight | Bus | Ferry |
|---|---|---|---|
€110 Average price | €129 Average price | €73 Average price | €55 Average price Cheapest |
13h 9m Average total duration 12h 39m Onboard + 30m Additional time* | 4h 43m Average total duration Fastest 1h 43m Onboard + 3h 0m Additional time* | 16h 38m Average total duration 16h 8m Onboard + 30m Additional time* | 21h 0m Average total duration 20h 0m Onboard + 1h 0m Additional time* |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | ![]() Most popular ferry company |
Direct Options | Direct Options | Direct Options | Direct Options |
Live departures
Florence Santa Maria Novella to Palermo Centrale train times
The table below shows live departures for Florence Santa Maria Novella to Palermo Centrale trains for today, Saturday, December 13. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FRECCIAROSSA 1000 9555+ InterCityNotte 1955 | 6:14 PM Florence Santa Maria Novella | 13h58 | 8:12 AM Palermo Centrale | 1 transfer | |
FRECCIAROSSA 9435+ InterCityNotte 1959 | 7:48 PM Florence Santa Maria Novella | 15h09 | 10:57 AM Palermo Centrale | 1 transfer | |
Regionale 18251+ InterCityNotte 799+ Intercity 723 | 11:40 PM Florence Santa Maria Novella | 18h32 | 6:12 PM Palermo Centrale | 2 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence Santa Maria Novella to Palermo Centrale by train, bus, flight, or ferry
Compare train, bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Dec 14
Dec 15
Dec 16
Dec 17
Dec 18
Dec 19
Dec 20
Why should you book Florence Santa Maria Novella to Palermo Centrale trains with Omio?
Intercity Notte as well as Intercity, Italo and Frecciargento offer trains services from Florence Santa Maria Novella to Palermo Centrale. Omio is an official ticket reseller for all your travel options from Florence Santa Maria Novella to Palermo Centrale.
Why book with Omio vs Intercity Notte?
- Compare with other providers: On Omio, you can not only buy tickets for Intercity Notte, but also compare tickets for the likes of Intercity, Italo and Frecciargento to find the best option for your trip from Florence Santa Maria Novella to Palermo Centrale.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Intercity Notte with all available travel options, which are train, bus, flight and ferry to ensure you get the best deal for traveling from Florence Santa Maria Novella to Palermo Centrale.
Why book with Omio over Trainline and Rail Europe?
- Multiple travel company options: While Intercity Notte tickets can be bought on Intercity Notte's website or third party sellers, Omio allows you to compare with the likes of Intercity, Italo and Frecciargento to help you choose the right option for your journey from Florence Santa Maria Novella to Palermo Centrale.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus, flight and ferry to find the ideal travel option from Florence Santa Maria Novella to Palermo Centrale.
Journey information
Overview: Train from Florence Santa Maria Novella to Palermo Centrale
Trains from Florence Santa Maria Novella to Palermo Centrale run on average 6 times per day, taking around 12h 39m. Cheap train tickets for this journey start at $77 (€62) but you can travel from only $38 (€30) by flight.
The earliest train runs at 03:45, the last at 18:48. The fastest train covers the 406 miles (655 km) distance in 13h 2m.
Distance 406 miles (655 km) |
Average train duration 12h 39m |
Cheapest ticket price $77 (€62) |
Trains per day 6 |
Fastest train 13h 2m |
First train 03:45 |
Last train 18:48 |
Train companies: Intercity Notte, Intercity, Italo, Frecciargento, Frecciarossa from Florence Santa Maria Novella to Palermo Centrale trainsIntercity Notte, Intercity, Italo, Frecciargento, Frecciarossa trains will get you between Florence Santa Maria Novella and Palermo Centrale from $38 (€30). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Intercity Notte
Intercity
Italo
Frecciargento
Frecciarossa
FAQs: Trains from Florence Santa Maria Novella to Palermo Centrale
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Palermo Centrale by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Palermo Centrale, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Florence Santa Maria Novella to Palermo Centrale
- Mon - Sun: 06:00 - 21:00
- Free WiFi (30 minutes limit).
- Provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
- 12oz Coffee Joint
- Casa Maioli
- Don Nino
- Fratelli Cuore
- McDonald´s
- Panella
- Segafredo Zanetti
- Spizzico
- Venchi
- & many more
- Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
- Hotel Luxor Florence
- Joy Hotel Florence
- Diplomat Hotel Florence
- Mon - Sun: 06:00 - 21:00
- Located inside and outside the station.
- Tram lines: T1, T2
- Bus lines: 6, 11, 12, 13, 17, 23, 36, 37, C4
- Train lines: FR, FA, Italo
Most popular train connections from Florence Santa Maria Novella
More options for your journey from Florence Santa Maria Novella to Palermo Centrale
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