- Must visit
Galleria degli Uffizi
World-famous Renaissance gallery with masterpieces by Botticelli, Leonardo, Michelangelo, and Caravaggio. One of Florence’s essential museum visits.
Cheapest price
$103
Average price
$103
Fastest journey
20 h 52 m
Average duration
20 h 52 m
Trains per day
1
Distance
550 km
The best way to find a cheap train ticket from Lyon Part Dieu to Florence Santa Maria Novella is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lyon Part Dieu to Florence Santa Maria Novella will cost around $103 if you buy it on the day, but the cheapest tickets can be found for only $103.
It's difficult to get from Lyon Part Dieu to Florence Santa Maria Novella without transferring at least once.


Omio recommends booking the train as it is the most popular option from Lyon Part Dieu to Florence Santa Maria Novella among Omio's users. If you are prioritising price take the bus with prices starting from $20. For those with little time consider booking a flight which can get you there in 1h 21m. The ticket price range depends on the travel mode: a bus costs an average of $20, and a train costs an average of $225.
Distance: 341 miles (550 km)
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$225 Average price | $45 Average price Cheapest | $197 Average price | $311 Average price (fuel + tolls) |
7h 47m Average total duration 7h 17m Onboard + 30m Additional time* | 10h 57m Average total duration 10h 27m Onboard + 30m Additional time* | 4h 21m Average total duration Fastest 1h 21m Onboard + 3h 0m Additional time* | 7h 10m Average total duration (door-to-door) |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Lyon Part Dieu to Florence Santa Maria Novella:
A bus is $152 (€123) less than a flight for this route with tickets for a flight from Lyon Part Dieu to Florence Santa Maria Novella costing on average $197 (€159).
A bus is $180 (€145) less than a train for this route with tickets for a train from Lyon Part Dieu to Florence Santa Maria Novella costing on average $225 (€181).
Other travel options to Florence Santa Maria Novella take longer:
Train takes on average 7h 17m.
Bus takes on average 10h 27m.
Tickets start at around $225 (€181) compared to roughly $311 (€251) in fuel and tolls — a saving of about $86 (€69). The journey takes 7h 17m versus 7h 10m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Lyon Part Dieu to Florence Santa Maria Novella trains for tomorrow, Wednesday, May 27. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:23 PM Lyon Part Dieu | 20h52 | 2:15 PM Florence Santa Maria Novella | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Lyon Part Dieu to Florence Santa Maria Novella run on average 1 times per day, taking around 7h 17m. Cheap train tickets for this journey start at $225 (€181) but you can travel from only $20 (€16) by bus.
The earliest train runs at 08:31, the last at 08:31. The fastest train covers the 341 miles (550 km) distance in 7h 19m.
Distance 341 miles (550 km) |
Average train duration 7h 17m |
Cheapest ticket price $225 (€181) |
Trains per day 1 |
Fastest train 7h 19m |
First train 8:31 AM |
Last train 8:31 AM |
Cheapest Month Oct |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Oct - Dec |
Busiest Day Sun |
Least Busy Day Sun |
Discover the best of Firenze Santa Maria Novella — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Firenze Santa Maria Novella trip today.
World-famous Renaissance gallery with masterpieces by Botticelli, Leonardo, Michelangelo, and Caravaggio. One of Florence’s essential museum visits.
Best known for Michelangelo’s David, this museum also holds important Florentine paintings and sculptures. Timed-entry tickets are commonly used.
Outstanding museum preserving original works from the Florence Cathedral complex, including sculptures by Michelangelo, Donatello, and Ghiberti.
The ceremonial heart of Florence, surrounded by the cathedral, baptistery, and bell tower. Essential for first-time visitors and iconic photos.
Historic civic square filled with sculpture and framed by Palazzo Vecchio and the Loggia dei Lanzi. One of Florence’s most atmospheric public spaces.
The city’s classic panoramic viewpoint, especially popular at sunset and on social media for sweeping views over Florence’s rooftops and dome.
Thick-cut Chianina beef steak grilled rare over coals, one of Florence's most iconic and celebratory dishes.
Hearty Tuscan soup of bread, cannellini beans, and vegetables, traditionally reheated the next day for deeper flavor.
Rustic tomato and bread soup with garlic, olive oil, and basil, a classic example of Tuscan cucina povera.
Renowned fine dining institution with Michelin-starred cuisine and one of Italy's most celebrated wine cellars.
Popular steakhouse known for Bistecca Alla Fiorentina, with a polished yet approachable atmosphere near Santa Maria Novella.
Historic, lively trattoria near the central market, famous for Florentine steak and classic Tuscan dishes.
Moderate by Italian standards. Cafes and casual meals are reasonable, but hotels and central dining near the station cost more.
Service is often included or covered by a coperto. Tipping is not required, but rounding up or leaving EUR 1-3 for good service is appreciated. Taxis are usually rounded up.
Official public transport app
Florence Santa Maria Novella, Florence -> Piazza del Duomo, Florence
Find answers to the most common questions about traveling from Lyon Part Dieu to Florence Santa Maria Novella by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence Santa Maria Novella, this guide helps you travel smarter and with confidence.

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