Travel Information
Compare train, bus, and flight for Lyon Part Dieu to Florence Santa Maria Novella
Omio recommends booking the train as it is the most popular option from Lyon Part Dieu to Florence Santa Maria Novella among Omio's users. If you are prioritising price take the bus with prices starting from $22. For those with little time consider booking a flight which can get you there in 1h 21m. The ticket price range depends on the travel mode: a bus costs an average of $22, and a flight costs an average of $46.
Distance: 341 miles (550 km)
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
$159 Average price | $47 Average price Cheapest | $176 Average price |
7h 44m Average total duration 7h 14m Onboard + 30m Additional time* | 10h 31m Average total duration 10h 1m Onboard + 30m Additional time* | 4h 21m Average total duration Fastest 1h 21m Onboard + 3h 0m Additional time* |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Live departures
Lyon Part Dieu to Florence Santa Maria Novella train times
The table below shows live departures for Lyon Part Dieu to Florence Santa Maria Novella trains for today, Friday, April 10. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:23 PM Lyon Part Dieu | 20h52 | 2:15 PM Florence Santa Maria Novella | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Lyon Part Dieu to Florence Santa Maria Novella by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Apr 11
Apr 12
Apr 13
Apr 14
Apr 15
Apr 16
Apr 17
Apr 18
Apr 19
Apr 20
Apr 21
Apr 22
Apr 23
Apr 24
Why should you book Lyon Part Dieu to Florence Santa Maria Novella trains with Omio?
Why book with Omio vs Trenitalia?
- Compare with other providers: On Omio, you can not only buy tickets for Trenitalia, but also compare tickets for the likes of TGV INOUI or Regionale to find the best option for your trip from Lyon Part Dieu to Florence Santa Maria Novella.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Trenitalia with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Lyon Part Dieu to Florence Santa Maria Novella.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Lyon Part Dieu to Florence Santa Maria Novella.
Journey information
Overview: Train from Lyon Part Dieu to Florence Santa Maria Novella
Trains from Lyon Part Dieu to Florence Santa Maria Novella run on average 1 times per day, taking around 7h 14m. Cheap train tickets for this journey start at $108 (€87) but you can travel from only $22 (€18) by bus.
The earliest train runs at 08:31, the last at 08:31. The fastest train covers the 341 miles (550 km) distance in 7h 19m.
Distance 341 miles (550 km) |
Average train duration 7h 14m |
Cheapest ticket price $108 (€87) |
Trains per day 1 |
Fastest train 7h 19m |
First train 8:31 AM |
Last train 8:31 AM |
Train companies: Trenitalia, TGV INOUI, Regionale from Lyon Part Dieu to Florence Santa Maria Novella trainsTrenitalia, TGV INOUI, Regionale trains will get you between Lyon Part Dieu and Florence Santa Maria Novella from $22 (€18). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Trenitalia
TGV INOUI
Regionale
FAQs: Trains from Lyon Part Dieu to Florence Santa Maria Novella
Find answers to the most common questions about traveling from Lyon Part Dieu to Florence Santa Maria Novella by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence Santa Maria Novella, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Lyon Part Dieu to Florence Santa Maria Novella
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Free unlimited WiFi.
- Luggage lockers are available daily from 06:15 to 23:15. They are located near the station's reception desk.
- Alto Café
- Paul
- Paul The Café
- Starbucks
- Exki
- Sushi Shop
- Carrefour
- Complimentary personalized care is available.
- Radisson Blu Hotel Lyon
- Mercure Lyon Center
- ibis Styles Lyon Center
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Located in the station's main hall.
- Metro lines: A, B, C, D
- Tram lines: T4, K240, T3, K100
- Bus lines: 2960, C2, C3, C6, C9
- Train lines: TGV, TGV Lyria, TGV INOUI, OUIGO, TER, Intercités, Eurostar, AVE
- Mon - Sun: 06:00 - 21:00
- Free WiFi (30 minutes limit).
- Provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
- 12oz Coffee Joint
- Casa Maioli
- Don Nino
- Fratelli Cuore
- McDonald´s
- Panella
- Segafredo Zanetti
- Spizzico
- Venchi
- & many more
- Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
- Hotel Luxor Florence
- Joy Hotel Florence
- Diplomat Hotel Florence
- Mon - Sun: 06:00 - 21:00
- Located inside and outside the station.
- Tram lines: T1, T2
- Bus lines: 6, 11, 12, 13, 17, 23, 36, 37, C4
- Train lines: FR, FA, Italo
More options for your journey from Lyon Part Dieu to Florence Santa Maria Novella
Here are some other resources that might have the information you need




