The cheapest and fastest trains from Florence Santa Maria Novella to Lyon Part Dieu
Cheapest price
$202
Average price
$252
Fastest journey
7 h 7 m
Average duration
7 h 56 m
Trains per day
28
Distance
550 km
The best way to find a cheap train ticket from Florence Santa Maria Novella to Lyon Part Dieu is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence Santa Maria Novella to Lyon Part Dieu will cost around $252 if you buy it on the day, but the cheapest tickets can be found for only $202.
It's difficult to get from Florence Santa Maria Novella to Lyon Part Dieu without transferring at least once.
Regionale 18654 · Regionale 17804 · Regionale Veloce TTPER 2462+
FRECCIAROSSA 1000 92965:41 AM14h51Florence Santa Maria Novella8:32 PMLyon Part Dieu$2021One-way3 transfers
Regionale 17800 · Regionale Veloce TTPER 2460+
FRECCIAROSSA 1000 92964:32 AM16h00Florence Santa Maria Novella8:32 PMLyon Part Dieu$2021One-way2 transfers
Regionale 18502 · Regionale 17808 · Regionale Veloce TTPER 2466+
FRECCIAROSSA 1000 92967:09 AM13h23Florence Santa Maria Novella8:32 PMLyon Part Dieu$2021One-way3 transfers
Intercity 580+
FRECCIAROSSA 1000 92968:21 AM12h11Florence Santa Maria Novella8:32 PMLyon Part Dieu$2151One-way1 transfer
Regionale 18508 · Autobus FI680+
Intercity 606+
FRECCIAROSSA 1000 92969:09 AM11h23Florence Santa Maria Novella8:32 PMLyon Part Dieu$2171One-way3 transfers
9928+
FRECCIAROSSA 1000 92961:25 PM7h07Florence Santa Maria Novella8:32 PMLyon Part Dieu$2311One-way1 transfer
FRECCIAROSSA 9514+
FRECCIAROSSA 1000 929612:55 PM7h37Florence Santa Maria Novella8:32 PMLyon Part Dieu$2391One-way1 transfer
9924+
FRECCIAROSSA 1000 929612:25 PM8h07Florence Santa Maria Novella8:32 PMLyon Part Dieu$2441One-way1 transfer
FRECCIAROSSA 9416 · FRECCIAROSSA 8814+
FRECCIAROSSA 1000 929612:20 PM8h12Florence Santa Maria Novella8:32 PMLyon Part Dieu$2701One-way2 transfers
FRECCIAROSSA 9524+
FRECCIAROSSA 1000 929611:55 AM8h37Florence Santa Maria Novella8:32 PMLyon Part Dieu$2451One-way1 transfer
Travel Information
Compare train, bus, and flight for Florence Santa Maria Novella to Lyon Part Dieu
Omio recommends booking the train as it is the most popular option from Florence Santa Maria Novella to Lyon Part Dieu among Omio's users. If you are prioritising price take the bus with prices starting from $19. For those with little time consider booking a flight which can get you there in 5h 2m. The ticket price range depends on the travel mode: a bus costs an average of $19, and a flight costs an average of $44.
Distance: 341 miles (550 km)
Compare train with
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$118 Average price | $41 Average price Cheapest | $180 Average price | $318 Average price (fuel + tolls) |
7h 8m Average total duration 6h 38m Onboard + 30m Additional time* | 8h 58m Average total duration 8h 28m Onboard + 30m Additional time* | 8h 2m Average total duration Fastest 5h 2m Onboard + 3h 0m Additional time* | 7h 24m Average total duration (door-to-door) |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Florence Santa Maria Novella to Lyon Part Dieu:
A bus is $77 (€62) less than a train for this route with tickets for a train from Florence Santa Maria Novella to Lyon Part Dieu costing on average $118 (€95).
A bus is $139 (€112) less than a flight for this route with tickets for a flight from Florence Santa Maria Novella to Lyon Part Dieu costing on average $180 (€146).
Other travel options to Lyon Part Dieu take longer:
Train takes on average 6h 38m.
Bus takes on average 8h 28m.
The journey is about 46m faster (6h 38m by train vs 7h 24m by car) and roughly $200 (€161) cheaper once you factor in fuel and tolls ($118 (€95) vs $318 (€257)). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
Live departures
Florence Santa Maria Novella to Lyon Part Dieu train times
The table below shows live departures for Florence Santa Maria Novella to Lyon Part Dieu trains for tomorrow, Thursday, May 28. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Regionale 18251+ InterCityNotte 796+ Regionale Veloce 3019+ FRECCIAROSSA 1000 9296 | 12:40 AM Florence Santa Maria Novella | 19h52 | 8:32 PM Lyon Part Dieu | 3 transfers | |
Regionale 17800 · Regionale Veloce TTPER 2460+ FRECCIAROSSA 1000 9296 | 4:32 AM Florence Santa Maria Novella | 16h00 | 8:32 PM Lyon Part Dieu | 2 transfers | |
Regionale 18654 · Regionale 17804 · Regionale Veloce TTPER 2462+ FRECCIAROSSA 1000 9296 | 5:41 AM Florence Santa Maria Novella | 14h51 | 8:32 PM Lyon Part Dieu | 3 transfers | |
FRECCIAROSSA 9504+ FRECCIAROSSA 1000 9296 | 6:55 AM Florence Santa Maria Novella | 13h37 | 8:32 PM Lyon Part Dieu | 1 transfer | |
Regionale 18502 · Regionale 17808 · Regionale Veloce TTPER 2466+ FRECCIAROSSA 1000 9296 | 7:09 AM Florence Santa Maria Novella | 13h23 | 8:32 PM Lyon Part Dieu | 3 transfers | |
FRECCIAROSSA 9400 · FRECCIAROSSA 9802+ FRECCIAROSSA 1000 9296 | 7:20 AM Florence Santa Maria Novella | 13h12 | 8:32 PM Lyon Part Dieu | 2 transfers | |
9904+ FRECCIAROSSA 1000 9296 | On time 7:25 AM Florence Santa Maria Novella | 13h07 | 8:32 PM Lyon Part Dieu | 1 transfer | |
FRECCIAROSSA 9508+ FRECCIAROSSA 1000 9296 | 7:55 AM Florence Santa Maria Novella | 12h37 | 8:32 PM Lyon Part Dieu | 1 transfer | |
FRECCIAROSSA 9404 · FRECCIAROSSA 9610+ FRECCIAROSSA 1000 9296 | 8:20 AM Florence Santa Maria Novella | 12h12 | 8:32 PM Lyon Part Dieu | 2 transfers | |
Intercity 580+ FRECCIAROSSA 1000 9296 | 8:21 AM Florence Santa Maria Novella | 12h11 | 8:32 PM Lyon Part Dieu | 1 transfer | |
9908+ FRECCIAROSSA 1000 9296 | On time 8:25 AM Florence Santa Maria Novella | 12h07 | 8:32 PM Lyon Part Dieu | 1 transfer | |
Regionale 18466 · Regionale 17816 · Regionale Veloce TTPER 2470+ FRECCIAROSSA 1000 9296 | 8:37 AM Florence Santa Maria Novella | 11h55 | 8:32 PM Lyon Part Dieu | 3 transfers | |
Regionale 18466 · Regionale 17816+ Intercity 604+ FRECCIAROSSA 1000 9296 | 8:37 AM Florence Santa Maria Novella | 11h55 | 8:32 PM Lyon Part Dieu | 3 transfers | |
FRECCIAROSSA 9512+ FRECCIAROSSA 1000 9296 | 8:55 AM Florence Santa Maria Novella | 11h37 | 8:32 PM Lyon Part Dieu | 1 transfer | |
Regionale 18508 · Autobus FI680+ Intercity 606+ FRECCIAROSSA 1000 9296 | 9:09 AM Florence Santa Maria Novella | 11h23 | 8:32 PM Lyon Part Dieu | 3 transfers | |
FRECCIAROSSA 9406 · FRECCIAROSSA 9616+ FRECCIAROSSA 1000 9296 | 9:20 AM Florence Santa Maria Novella | 11h12 | 8:32 PM Lyon Part Dieu | 2 transfers | |
9912+ FRECCIAROSSA 1000 9296 | On time 9:25 AM Florence Santa Maria Novella | 11h07 | 8:32 PM Lyon Part Dieu | 1 transfer | |
FRECCIAROSSA 9516+ FRECCIAROSSA 1000 9296 | 9:55 AM Florence Santa Maria Novella | 10h37 | 8:32 PM Lyon Part Dieu | 1 transfer | |
FRECCIAROSSA 9490 · FRECCIAROSSA 8810+ FRECCIAROSSA 1000 9296 | 10:20 AM Florence Santa Maria Novella | 10h12 | 8:32 PM Lyon Part Dieu | 2 transfers | |
9916+ FRECCIAROSSA 1000 9296 | On time 10:25 AM Florence Santa Maria Novella | 10h07 | 8:32 PM Lyon Part Dieu | 1 transfer | |
FRECCIAROSSA 9520+ FRECCIAROSSA 1000 9296 | 10:55 AM Florence Santa Maria Novella | 9h37 | 8:32 PM Lyon Part Dieu | 1 transfer | |
FRECCIAROSSA 9414 · FRECCIAROSSA 9806+ FRECCIAROSSA 1000 9296 | 11:20 AM Florence Santa Maria Novella | 9h12 | 8:32 PM Lyon Part Dieu | 2 transfers | |
9920+ FRECCIAROSSA 1000 9296 | On time 11:25 AM Florence Santa Maria Novella | 9h07 | 8:32 PM Lyon Part Dieu | 1 transfer | |
FRECCIAROSSA 9524+ FRECCIAROSSA 1000 9296 | 11:55 AM Florence Santa Maria Novella | 8h37 | 8:32 PM Lyon Part Dieu | 1 transfer | |
FRECCIAROSSA 9416 · FRECCIAROSSA 8814+ FRECCIAROSSA 1000 9296 | 12:20 PM Florence Santa Maria Novella | 8h12 | 8:32 PM Lyon Part Dieu | 2 transfers | |
9924+ FRECCIAROSSA 1000 9296 | On time 12:25 PM Florence Santa Maria Novella | 8h07 | 8:32 PM Lyon Part Dieu | 1 transfer | |
FRECCIAROSSA 9514+ FRECCIAROSSA 1000 9296 | 12:55 PM Florence Santa Maria Novella | 7h37 | 8:32 PM Lyon Part Dieu | 1 transfer | |
9928+ FRECCIAROSSA 1000 9296 | On time 1:25 PM Florence Santa Maria Novella | 7h07 | 8:32 PM Lyon Part Dieu | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence Santa Maria Novella to Lyon Part Dieu by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Florence Santa Maria Novella to Lyon Part Dieu trains with Omio?
Why book with Omio vs Trenitalia?
- Compare with other providers: On Omio, you can not only buy tickets for Trenitalia, but also compare tickets for the likes of Italo to find the best option for your trip from Florence Santa Maria Novella to Lyon Part Dieu.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Trenitalia with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Florence Santa Maria Novella to Lyon Part Dieu.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Florence Santa Maria Novella to Lyon Part Dieu.
Journey information
Overview: Train from Florence Santa Maria Novella to Lyon Part Dieu
Trains from Florence Santa Maria Novella to Lyon Part Dieu run on average 1 times per day, taking around 6h 38m. Cheap train tickets for this journey start at $104 (€84) but you can travel from only $19 (€15) by bus.
The earliest train runs at 13:25, the last at 22:25. The fastest train covers the 341 miles (550 km) distance in 6h 53m.
Distance 341 miles (550 km) |
Average train duration 6h 38m |
Cheapest ticket price $104 (€84) |
Trains per day 1 |
Fastest train 6h 53m |
First train 1:25 PM |
Last train 10:25 PM |
Cheapest Month Jun |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Jan - Mar |
Busiest Day Fri |
Least Busy Day Sat |
Train companies: Trenitalia, Italo from Florence Santa Maria Novella to Lyon Part Dieu trainsTrenitalia, Italo trains will get you between Florence Santa Maria Novella and Lyon Part Dieu from $19 (€15). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Trenitalia
Italo
FAQs: Trains from Florence Santa Maria Novella to Lyon Part Dieu
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Lyon Part Dieu by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lyon Part Dieu, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Florence Santa Maria Novella to Lyon Part Dieu
- Mon - Sun: 06:00 - 21:00
- Free WiFi (30 minutes limit).
- Provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
- 12oz Coffee Joint
- Casa Maioli
- Don Nino
- Fratelli Cuore
- McDonald´s
- Panella
- Segafredo Zanetti
- Spizzico
- Venchi
- & many more
- Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
- Hotel Luxor Florence
- Joy Hotel Florence
- Diplomat Hotel Florence
- Mon - Sun: 06:00 - 21:00
- Located inside and outside the station.
- Tram lines: T1, T2
- Bus lines: 6, 11, 12, 13, 17, 23, 36, 37, C4
- Train lines: FR, FA, Italo
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Free unlimited WiFi.
- Luggage lockers are available daily from 06:15 to 23:15. They are located near the station's reception desk.
- Alto Café
- Paul
- Paul The Café
- Starbucks
- Exki
- Sushi Shop
- Carrefour
- Complimentary personalized care is available.
- Radisson Blu Hotel Lyon
- Mercure Lyon Center
- ibis Styles Lyon Center
- Mon - Wed: 05:00 - 20:45
- Thu - Sat: 05:00 - 21:45
- Sun: 06:45 - 21:45
- Located in the station's main hall.
- Metro lines: A, B, C, D
- Tram lines: T4, K240, T3, K100
- Bus lines: 2960, C2, C3, C6, C9
- Train lines: TGV, TGV Lyria, TGV INOUI, OUIGO, TER, Intercités, Eurostar, AVE
Most popular train connections from Florence Santa Maria Novella
More options for your journey from Florence Santa Maria Novella to Lyon Part Dieu
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