- Must visit
San Francisco Museum of Modern Art
Major modern and contemporary art museum with an internationally important collection and frequent blockbuster exhibitions.
We are not able to find a train between these two places.
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Omio recommends booking the bus as it is the most popular option from Des Moines, IA to San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from $229. For those with little time consider booking a flight which can get you there in 5h 0m. The ticket price range depends on the travel mode: a bus costs an average of $229, and a flight costs an average of $238.
Distance: 1547 miles (2490 km)
Most popular Bus | Flight | Driving |
|---|---|---|
$266 Average price Cheapest | $501 Average price | $368 Average price (fuel + tolls) |
47h 55m Average total duration 47h 25m Onboard + 30m Additional time* | 8h 0m Average total duration Fastest 5h 0m Onboard + 3h 0m Additional time* | 26h 10m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Des Moines, IA to San Francisco, CA:
A bus is $235 (€193) less than a flight for this route with tickets for a flight from Des Moines, IA to San Francisco, CA costing on average $501 (€412).
Other travel options to San Francisco, CA take longer:
Bus takes on average 47h 25m.
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Take a train from Des Moines, IA to San Francisco, CA and enjoy the approximately 1547 miles (2490 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
Distance 1547 miles (2490 km) |
High Season Jan - Mar |
Low Season Jul - Sep |
Discover the best of San Francisco — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Francisco trip today.
Major modern and contemporary art museum with an internationally important collection and frequent blockbuster exhibitions.
Hands-on science and art museum on the Embarcadero, especially popular for interactive exhibits and bay views.
Leading fine arts museum in Golden Gate Park, known for American art, textiles, and its observation tower.
Busy waterfront district known for classic San Francisco atmosphere, bay views, piers, and easy access to major sights.
Famous crooked block with steep curves, manicured gardens, and one of the city's most photographed street scenes.
Huge urban park with gardens, lakes, museums, and broad walking and cycling routes across the western city.
A tomato-based seafood stew created by Italian American fishermen in San Francisco, typically filled with crab, clams, mussels, shrimp, and fish.
San Francisco’s famous tangy sourdough loaf, shaped by the city’s historic wild yeast culture and long baking tradition.
A large foil-wrapped burrito associated with the Mission District, usually packed with rice, beans, meat, salsa, and extras.
Classic San Francisco institution serving carved prime rib with old-fashioned hospitality and a lively, upscale supper-club feel.
Iconic Mission District taqueria celebrated for Mission-style burritos and tacos with a simple, always-busy casual atmosphere.
Historic seafood counter famous for ultra-fresh oysters, crab, and cioppino ingredients in a classic old-school San Francisco setting.
Prices are high for hotels, dining, parking, and taxes. Budget options exist, but overall costs rank among the highest in the US.
Tip 18-20% in restaurants; 20%+ for great service. Bars: USD 1-2 per drink. Taxis/rideshares: 10-15% or round up. Hotels: USD 2-5 for porters, USD 3-5 daily for housekeeping.
Find answers to the most common questions about traveling from Des Moines, IA to San Francisco, CA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

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