- Recommended
Greenville County Museum of Art
A major art museum in downtown Greenville with American art, Southern works, and rotating exhibitions in a bright riverfront setting.
Flights from Buffalo, NY to Greenville, SC depart on average 43 times per day, taking around 3h 47m. Cheap flight tickets for this journey start at $433 but you can travel from only $106 by bus.
The earliest flight runs at 05:00, the last at 21:59. The fastest flight covers the 586 miles (944 km) distance in 2h 56m. May is the cheapest month to fly.
Distance 586 miles (944 km) |
Average flight duration 3h 47m |
Cheapest ticket price $433 |
Flights per day 43 |
Fastest flight 2h 56m |
First flight 5:00 AM |
Last flight 9:59 PM |
Cheapest Month May |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Apr - Jun |
Omio recommends booking the bus as it is the most popular option from Buffalo, NY to Greenville, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $166 For those with little time, consider booking a bus, which has an average total journey time of 24h 5m. Average ticket prices depend on the travel mode: a bus costs an average of $166, while a train costs an average of $514.
Distance: 586 miles (944 km)
Most popular Bus | Train | Driving |
|---|---|---|
$166 Average price Cheapest | $514 Average price | $151 Average price (fuel + tolls) |
24h 5m Average total duration Fastest 23h 35m Onboard + 30m Additional time* | 24h 21m Average total duration 23h 51m Onboard + 30m Additional time* | 11h 29m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Buffalo, NY to Greenville, SC:
A bus is $348 less than a train for this route with tickets for a train from Buffalo, NY to Greenville, SC costing on average $514.
A bus is $409 less than a flight for this route with tickets for a flight from Buffalo, NY to Greenville, SC costing on average $574.
Other travel options to Greenville, SC take longer:
Bus takes on average 23h 35m.
Train takes on average 23h 51m.
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Greenville, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville, SC trip today.
A major art museum in downtown Greenville with American art, Southern works, and rotating exhibitions in a bright riverfront setting.
A contemporary art center showing regional and international artists through rotating exhibitions in a modern downtown gallery space.
A local gallery and arts space featuring exhibitions, classes, and community-focused programming in Greenville's Village area.
A signature downtown park with waterfalls, gardens, river trails, and lawns. It is Greenville's most popular public space for walking and views.
Greenville's central street lined with shops, public art, and historic buildings. It is ideal for strolling between downtown attractions.
A swamp rabbit-themed riverside greenway popular for walking and cycling, linking downtown Greenville with parks and nearby districts.
Find answers to the most common questions about traveling from Buffalo, NY to Greenville, SC by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

Most Buffalo, NY to Greenville, SC flights use the Buffalo Niagara International Airport to Greenville-Spartanburg International Airport airport pair. Use this guide to compare Buffalo, NY and Greenville, SC airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Buffalo Niagara International Airport is 2 km from Buffalo city centre. Public transport options include:
Buffalo Niagara International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, and Car Rental.
Food options include: Restaurants available; Main terminal, fast food and sit-down options like Anchor Bar and Tim Hortons
Free Wi-Fi available throughout the airport. ATMs are located throughout the terminal.
Lost and found is available at the station.
Available at Buffalo Niagara International Airport: Parking, Taxis, WC.
Available at Buffalo Niagara International Airport: Car Rental.
Accessibility facilities are available at Buffalo Niagara International Airport: Elevators, ramps, assistance.
Nearby hotels include Hotels nearby, Courtyard by Marriott Buffalo Airport within walking distance..
Greenville-Spartanburg International Airport is 5 km from Greenville city centre. Public transport options include:
Greenville-Spartanburg International Airport has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Several dining options are available in the terminal.
Free Wi-Fi available throughout the terminal. ATMs are aTMs available near baggage claim.
Ticket office support is available at Greenville-Spartanburg International Airport.
Available at Greenville-Spartanburg International Airport: Parking, Taxis, WC.
Accessibility facilities are available at Greenville-Spartanburg International Airport: Elevators and ramps available for accessibility.
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