- Recommended
East Tennessee History Center
Engaging museum on regional history with permanent and rotating exhibits covering people, places, and events from East Tennessee's past.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
Journey information
Overview: Chicago, IL to Knoxville, TN flight
USAUSA
Flights from Chicago, IL to Knoxville, TN depart on average 24 times per day, taking around 3h 42m. Cheap flight tickets for this journey start at $266 (€222) but you can travel from only $86 (€72) by bus.
There are 3 flights per day. The earliest flight runs at 05:00, the last at 22:05. The fastest flight covers the 453 miles (730 km) distance in 1h 41m. April is the cheapest month to fly.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $86 (€72)
Distance 453 miles (730 km) |
Average flight duration 3h 42m |
Cheapest ticket price $266 (€222) |
Flights per day 24 |
Direct flights 3 |
Fastest flight 1h 41m |
First flight 5:00 AM |
Last flight 10:05 PM |
Cheapest Month Apr |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Fri |
Least Busy Day Fri |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $86 (€72)
Live departures
Chicago, IL to Knoxville, TN flight times
The table below shows live departures for Chicago, IL to Knoxville, TN flights for today, Friday, October 16. You can also manually refresh the results below to see updated flight journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 8:02 PM Chicago, IL | 1h50 | 9:52 PM Knoxville, TN | 0 transfersDirect | |
| 11:06 PM Chicago, IL | 1h41 | 12:47 AM Knoxville, TN | 0 transfersDirect | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Why should you book Chicago, IL to Knoxville, TN flights with Omio?
American Airlines as well as piedmont airlines, Republic Airlines, psa airlines and more offer flights services from Chicago, IL to Knoxville, TN.
Omio is an official ticket reseller for all your travel options from Chicago, IL to Knoxville, TN.
Why book with Omio vs American Airlines?
- Compare with other providers: On Omio, you can not only buy tickets for American Airlines, but also compare tickets for the likes of piedmont airlines, Republic Airlines or psa airlines to find the best option for your trip from Chicago, IL to Knoxville, TN.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare American Airlines with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Chicago, IL to Knoxville, TN.
Why book with Omio over Trip, Edreams or Skyscanner?
- Compare with other providers: On Omio, you can also compare tickets for the likes of piedmont airlines, Republic Airlines or psa airlines to find the best option for your trip from Chicago, IL to Knoxville, TN.
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Chicago, IL to Knoxville, TN.
Airlines: American Airlines, psa airlines, Republic Airlines, piedmont airlines from Chicago, IL to Knoxville, TNFind the best flights between Chicago, IL to Knoxville, TN with Omio's travel partners American Airlines, psa airlines, Republic Airlines, piedmont airlines from $86 (€72). We can find you the best deals, schedules and tickets when comparing and booking the best trip.
American Airlines
About
American Airlines is one of the largest airlines in the world, connecting travelers to hundreds of destinations across the United States, Latin America, Europe, Asia, and beyond. Operating from major hubs such as Dallas/Fort Worth, Miami, and Charlotte, American offers a wide range of travel options. Passengers can choose from Economy with affordable fares, Premium Economy with extra space, or Business and First Class featuring flat-bed seats, premium dining, and lounge access. With a modern fleet and membership in the oneworld alliance, American Airlines combines global reach with comfort and reliability.
Luggage & cancellation policy
Average American Airlines Duration
3h 4m
Cheapest American Airlines Price
$276 (€230)
American Airlines frequency
15 a day
Luggage included
1 carry-on bag (22 x 14 x 9 inches) and 1 personal item (18 x 14 x 8 inches) included in most fares
Additional luggage
Checked bags fees vary by route. First checked bag typically $30, second $40 on domestic flights
Cancellation Policy
Basic Economy tickets cannot be changed or refunded. Other fares allow changes with fee, refunds subject to fare rules.
Pregnant on board
Passengers can fly up to 36 weeks for single pregnancies, 32 weeks for multiple pregnancies. Medical certificate required within 7 days of departure if within 4 weeks of due date.
Unaccompagned minor
Children ages 5-14 can travel alone using American Airlines Unaccompanied Minor Service. Service fee is $150 each way.
Amenities on board the airplane
Wifi
Food sold onboard
USB plugs
Accessibility
American Airlines provides wheelchair assistance and special services for passengers with disabilities. Assistance must be requested at least 48 hours before departure.
Pets
Small dogs and cats allowed in cabin for $125 fee. Must be in approved carrier under seat. Service animals allowed.
Entertaiment on board
piedmont airlines
About
Piedmont Airlines is an American regional airline and a wholly-owned subsidiary of the American Airlines Group. Headquartered in Salisbury, Maryland, Piedmont operates American Eagle flights, staffing, operating, and maintaining aircraft for American Airlines.The airline traces its roots back to Henson Aviation, founded in 1931, and was rebranded as Piedmont Airlines in 1993. Today, Piedmont operates a fleet of Embraer ERJ 145 regional jets, with nearly 400 daily departures to over 50 destinations, primarily throughout the eastern United States. Its main hubs include Philadelphia International Airport and Charlotte Douglas International Airport. Piedmont also provides ground handling and customer service for airports in the northeastern and western United States.
Luggage & cancellation policy
Average piedmont airlines Duration
4h 8m
Cheapest piedmont airlines Price
$626 (€523)
piedmont airlines frequency
2 a day
Luggage included
Piedmont Airlines, operating as American Eagle, follows American Airlines' baggage policy, which generally does not include free checked bags in Main Cabin fares. Passengers are allowed one carry-on bag and one personal item. The carry-on bag should not exceed 56 x 36 x 23 cm with a maximum weight of 10 kilograms, and the personal item should not exceed 45 x 35 x 20 cm.
Additional luggage
Additional luggage can be checked for a fee.
Cancellation Policy
If your flight is canceled or significantly changed, you are generally entitled to a refund if you decline alternative transportation or travel credits.
Refund
If your flight is canceled or significantly changed, you are generally entitled to a cash refund for your airfare and ancillary service fees if you decline any alternative transportation or travel credits offered by the airline.
Amenities on board the airplane
Food sold onboard
Complimentary non-alcoholic beverages are offered, and snacks and meals may be complimentary or available for purchase depending on the length and location of the flight.
USB plugs
Accessibility
Piedmont Airlines is committed to ensuring digital accessibility for people with disabilities and their website is fully conformant with WCAG 2.1 level AA. For in-flight or curbside assistance, including wheelchairs and help with luggage, passengers should contact the airline directly.
Pets
Small dogs and cats can accompany passengers in the cabin, provided they meet size and weight requirements. Pets are not allowed to travel in-cabin on international flights or any itinerary that includes an international flight.
psa airlines
About
PSA Airlines is an American regional airline and a wholly-owned subsidiary of the American Airlines Group, operating exclusively on behalf of American Airlines under the American Eagle brand. Headquartered in Charlotte, North Carolina, PSA Airlines operates over 800 daily flights to nearly 100 destinations across the United States. The airline maintains an all-jet fleet consisting of Bombardier CRJ700 and CRJ900 regional aircraft. With a team of over 5,000 employees, PSA Airlines plays a significant role in connecting smaller cities to major hubs within American Airlines' network.
Luggage & cancellation policy
Average psa airlines Duration
1h 41m
Cheapest psa airlines Price
$266 (€222)
psa airlines frequency
4 a day
Luggage included
One carry-on bag and one personal item are allowed.
Additional luggage
Additional luggage can be checked for a fee, with weight limits up to 32kg (70lbs) for a single piece.
Cancellation Policy
PSA Airlines' cancellation policy depends on the timeframe of cancellation and ticket flexibility, with some flexible ticket options offering easier cancellations.
Refund
Passengers are entitled to a refund if the airline cancels a flight and they choose not to travel.
Amenities on board the airplane
Food sold onboard
Non-alcoholic beverages are complimentary in Economy Class, while alcoholic drinks and snack boxes can be purchased.
Accessibility
Wheelchair assistance is available and should be requested at least 24 hours prior to flight departure.
Republic Airlines
About
Republic Airways is a major regional airline in the United States, operating as a subsidiary of Republic Airways Holdings. It provides scheduled passenger service for American Airlines (as American Eagle), Delta Air Lines (as Delta Connection), and United Airlines (as United Express) using a fleet of Embraer 170 and 175 regional jets. Headquartered in Indianapolis, Indiana, Republic Airways operates over 900 daily flights to more than 80 cities across the U.S. and Canada. The company is known for its large fleet of Embraer E-Jets and its state-of-the-art training facilities. In April 2025, Republic Airways Holdings announced its acquisition of Mesa Air Group, which is expected to create the second-largest regional carrier in the U.S.
Luggage & cancellation policy
Average Republic Airlines Duration
4h 22m
Cheapest Republic Airlines Price
$276 (€230)
Republic Airlines frequency
3 a day
Luggage included
One carry-on bag (24 x 16 x 10) and one personal item
Additional luggage
Checked bags for a fee
Cancellation Policy
Tickets are non-refundable but may be cancelled for future flight credit minus applicable fees
Pregnant on board
Passengers can fly up to the end of their 36th week for single pregnancies and the end of their 32nd week for multiple pregnancies
Unaccompagned minor
Unaccompanied minor service is available for children ages 5-14. Must be booked directly with Republic Airlines
Amenities on board the airplane
USB plugs
Accessibility
Republic Airlines offers assistance for passengers with reduced mobility, including wheelchair services and priority boarding. Passengers are advised to request these services in advance to ensure availability and proper arrangements.
Complete guide to Knoxville, TN
Things to do in Knoxville, TN
Discover the best of Knoxville, TN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Knoxville, TN trip today.
- Recommended
McClung Museum of Natural History and Culture
University museum featuring changing exhibitions of American and international art in a modern gallery setting near campus.
- Recommended
Mabry-Hazen House
Historic house museum preserving the home of artist Adelia Armstrong Lutz, with decorative arts, local history, and period rooms.
- Must visit
Market Square
Lively pedestrian-friendly square lined with shops, events, and public seating. It is a central gathering place and a great base for exploring downtown.
- Must visit
World's Fair Park
Urban park from the 1982 World's Fair with lawns, walking paths, performance spaces, and easy access to the Sunsphere and museums.
- Recommended
Old City
Historic warehouse district with brick streets, galleries, murals, and nightlife. It blends railroad-era character with a creative local feel.
Pulled Pork Barbecue
Smoky pulled pork barbecue is a regional staple in East Tennessee, usually hickory-smoked and served with slaw and sauce at local cookouts and barbecue joints.
Fried Catfish
Fried catfish is a longtime Tennessee favorite, coated in cornmeal and served with hush puppies or sides, especially popular in casual Southern eateries.
Biscuits And Sausage Gravy
Biscuits with sausage gravy are a classic Southern breakfast in Knoxville, featuring flaky biscuits topped with rich peppery gravy made with pork drippings and milk.
Litton's Market Restaurant
Long-running neighborhood restaurant known for hearty Southern comfort food, pies, and a warm, traditional dining room.
Stock & Barrel
Upscale Southern restaurant in Market Square known for shrimp and grits, steaks, and a polished downtown atmosphere.
Sweet P's Barbeque And Soul House
Casual old-school barbecue spot serving hickory-smoked pork, ribs, and classic East Tennessee sides in a relaxed setting.
$ US dollar
Moderate for U.S. city breaks: hotels and dining are reasonable, while car travel is common and public transit is limited for tourists.
Average meal costs
- Budget
- $10-15 for fast food or a casual lunch.
- Mid-range
- $18-35 per person for a restaurant meal.
- Fine dining
- $50+ per person for upscale dining.
- Coffee
- $3-5 for a coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or coffee is appreciated at cafes.
FAQs: Chicago, IL to Knoxville, TN Flight
Find answers to the most common questions about traveling from Chicago, IL to Knoxville, TN by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Knoxville, TN, this guide helps you travel smarter and with confidence.
Cheap plane tickets from Chicago, IL to Knoxville, TN can start from as little as $266 (€222) when you book in advance. The average flight ticket price for Chicago, IL to Knoxville, TN is $362 (€303) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by plane from Chicago, IL to Knoxville, TN is 1h 41m to travel the 453 miles (730 km) long route. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest flight from Chicago, IL to Knoxville, TN leaves at 5:00 AM. Plan your trip with the Journey Planner from Omio.
The latest flight from Chicago, IL to Knoxville, TN leaves at 10:05 PM.
Yes, there are 3 direct flights a day from Chicago, IL to Knoxville, TN with psa airlines. Schedules can vary on holidays or weekends with fewer direct flights.
When taking a flight from Chicago, IL to Knoxville, TN, you can count on American Airlines, piedmont airlines, Republic Airlines, psa airlines for the best way to get you to Knoxville, TN. You can also check all possible airlines who offer a service between Chicago, IL and Knoxville, TN and compare the amenities they offer before buying a plane ticket.
Flights from Chicago, IL to Knoxville, TN generally leave from O'Hare International Airport and arrive in Knoxville.O'Hare International Airport is 1 miles (3 km) away from Chicago, IL city centre and Knoxville is 1 miles (2 km) from Knoxville, TN city centre.
It's helpful to compare your options as there are 2 ways to travel between Chicago, IL and Knoxville, TN including taking a bus and flight.
For domestic flights we recommend to arrive 1.5 to 2 hours before departure. Please check the website of your departure airport if in doubt. Some airports may offer booking time slots for security checks or offer additional information on when to get there based on time of day.
Most airlines permit carry-on bags that fit within specific dimensions (e.g., 22 x 14 x 9 inches or 56 x 36 x 23 cm), including handles and wheels. Bags must fit in the overhead bin or under the seat in front of you.
Many airlines impose weight limits, commonly ranging between 7 kg (15 lbs) and 12 kg (26 lbs). Typically, passengers are allowed one carry-on bag and one personal item (for example a purse, laptop bag, or backpack). Personal items must fit under the seat in front of you. Budget Airlines (like Ryanair or Wizz Air) have stricter size and weight limits, often requiring fees for larger carry-ons. Full-Service Airlines have more lenient policies, sometimes including more spacious dimensions or higher weight limits depending on your ticket class.
The list of items prohibited on an airplane varies by country and airline, but in general, the following items are not allowed in carry-on or checked baggage: Weapons and self-defence items, sharp objects, flammable materials, explosives, toxic substances, or liquids over 100ml (except for medications and baby essentials). In checked baggage, firearms (without authorization), explosives, large lithium batteries, and hazardous chemicals are prohibited. Electronic cigarettes must be in carry-on bags, while alcohol and dry ice have restrictions. Always check with your airline for specific regulations.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Knoxville, TN, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Avoid accepting unsolicited offers for transportation or tours, as unlicensed operators may overcharge or provide unsafe services. It's also advisable to stay in well-lit areas at night and be aware of local traffic patterns when using ride-share or public transportation to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular airports
Popular airports from Chicago, IL to Knoxville, TN
Most Chicago, IL to Knoxville, TN flights use the O'Hare International Airport to Knoxville airport pair. Use this guide to compare Chicago, IL and Knoxville, TN airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Departure airports in Chicago
Arrival airports in Knoxville
Which Chicago, IL airport do flights to Knoxville, TN leave from?
Flights from Chicago, IL to Knoxville, TN depart from O'Hare International Airport. The airport is 2 miles (4 km) from Chicago, IL city centre at 10000 W O'Hare Ave, Chicago, IL 60666, USA.
O'Hare International Airport (ORD)10000 W O'Hare Ave, Chicago, IL 60666, USA
City-centre transport
Getting to O'Hare International Airport from Chicago city centre
O'Hare International Airport is 3 km from Chicago city centre. Public transport options include:
SubwayBlue Line · 1h 7m · $6 · every ~23 min
O'Hare International Airport airport facilities and services
O'Hare International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food and drink
Food options include: Restaurants are located in all terminals, offering a variety of cuisines including American and intertiol. Top options include Tortas Frontera and Publican Tavern.
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are located throughout all terminals.
Luggage and lost property
Lost and found is available at the station.
Parking, taxis and toilets
Available at O'Hare International Airport: Parking, Taxis, WC.
Bike and car services
Available at O'Hare International Airport: Car Rental.
Accessibility
Accessibility facilities are available at O'Hare International Airport: Elevators, ramps, toilets.
Shops, hotels and contact
Nearby hotels include Hotels such as Hilton Chicago O'Hare are located on airport grounds, with others like the Hyatt Regency nearby..
Midway International Airport (MDW)5700 S Cicero Ave, Chicago, IL 60638, USA
City-centre transport
Getting to Midway International Airport from Chicago city centre
Midway International Airport is 4 km from Chicago city centre. Public transport options include:
Bus62 · 40m · $4
62 · 52m · $5 · every ~12 min
SubwayOrange Line · 20m · $6 · every ~15 min
Orange Line · 34m · $6 · every ~15 min
Midway International Airport airport facilities and services
Midway International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, and Car Rental.
Food and drink
Food options include: Restaurants are available, including locations like Concourse A and B with options like Harry Caray's and Potbelly Sandwich Shop.
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are located throughout the airport, including near gates and baggage claim.
Luggage and lost property
Lost and found is available at the station.
Parking, taxis and toilets
Available at Midway International Airport: Parking, Taxis, WC.
Bike and car services
Available at Midway International Airport: Car Rental.
Accessibility
Accessibility facilities are available at Midway International Airport: Ramps, toilets.
Shops, hotels and contact
Nearby hotels include Hotels are available within walking distance, such as the Hyatt Place Chicago Midway Airport..
Which Knoxville, TN airport do flights from Chicago, IL arrive at?
Flights from Chicago, IL to Knoxville, TN arrive at Knoxville. Knoxville is 1 miles (2 km) from Knoxville, TN city centre.
Knoxville (TYS)McGhee Tyson Airport, 2055 Alcoa Hwy, Alcoa, TN 37701, USA
City-centre transport
Getting to Knoxville from Knoxville city centre
Knoxville is 2 km from Knoxville city centre. Public transport options include:
Bus Route 20, Knoxville Station, 12 miles
Knoxville airport facilities and services
Knoxville has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, and Car Rental.
Food and drink
Food options include: Restaurants in Concourse A and B, including Ruby Tuesday and Quiznos
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are located near ticketing and baggage claim.
Luggage and lost property
Lost and found is available at the station.
Parking, taxis and toilets
Available at Knoxville: Parking, Taxis, WC.
Bike and car services
Available at Knoxville: Car Rental.
Accessibility
Accessibility facilities are available at Knoxville.
Shops, hotels and contact
Nearby hotels include Hotels within walking distance, including Hilton Knoxville Airport..
Most popular flights from Chicago, IL
More options for your journey from Chicago, IL to Knoxville, TN
Here are some other resources that might have the information you need
Most popular flights to and from Knoxville, TN and Chicago, IL
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
